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Search results for: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR
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Expression of ghrelin and ghrelin functional receptor GHSR1a in human pituitary adenomas
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Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
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Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020
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The FMO analysis of the molecular interaction of fentanyl derivatives with the μ-opioid receptor
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Angiotensin II receptor blocker combinations: From guidelines to clinical practice
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The surge of Japanese studies supporting the use of angiotensin receptor blockers in hypertension
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Computational methods for calculation of binding free energy for ligand-receptor complexes
PublicationAccurate description of the molecular complexes energetic influence is required for understanding of many biological functions carried out by proteins. Therefore, estimation of binding free energy for ligand-receptor complexes is of highest importance for structure-based ligand design and drug discovery approaches.Experimental methods of determination of difference in Gibbs'es free energy have many limitations. Thus, computational...
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Salicylaldimine-based receptor as a material for iron(III) selective optical sensing
Publicationα,α-Bis(salicylimino)-m-xylene (L) was prepared using both conventional and microwave-assisted procedure. The compound exhibits ability to colorimetric recognition of iron(III) ions in aqueous environment, what is shown by significant color change from yellow to purple. In DMSO : water (9:1 v/v) solvent system receptor creates with iron(III) cations complexes of 2:1 stoichiometry (L:Fe3+) with stability constant (log K) 7.54±0.21....
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Olfactory receptor-based biosensors as potential future tools in medical diagnosis
PublicationThe detection of biomarkers is the future of non-invasive medical diagnosis and screening. Discovery and identification of reliable disease specific volatile organic compounds is dependent on repeatable, accurate analysis of trace level gaseous analytes mainly in breath samples. Natural variety of the olfactory systems and the compounds capable of gas molecules binding creates wide possibilities of acquisition and implementation...
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Temperature modeling in activated sludge systems: a case study
PublicationPrzedstawiono model dynamiki temperatury jako część ogólnego modelu komory osadu czynnego. Transport ciepła opisano za pomocą jednowymiarowego równania adwekcyjno-dyspersyjnego z członem źródłowym opisującym teoretyczny bilans ciepła dla komory. Model został zweryfikowany w oczyszczalni ścieków Rock Creek w stanie Oregon (USA) w oparciu o dane eksploatacyjne oraz pomiary meteorologiczne z pobliskiej stacji meteorologicznej. Wyniki...
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Wetting Properties of Polyetheretherketone Plasma Activated and Biocoated Surfaces
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Hydrogen activated axial inter-conversion in SiC nanowires
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Effect of neoteric solvents on the activated sewage sludge activity
PublicationCiecze jonowe (ILs) cieszą sie rosnącym zainteresowaniem z uwagi na fakt, iż znajdują coraz więcej zastosowań jako alternatywa dla rozpuszczalników organicznych. W związku z zaistnieniem możliwości zastosowania ILs w nowych czystych technologiach nastała potrzeba zbadania ich toksyczności w stosunku do organizmów żywych i środowiska. Celem badań było oszacowanie wpływu cieczy jonowych na wyselekcjonowane mikroorganizmy osadu czynnego....
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Modeling organic nitrogen conversions in activated sludge bioreactors
PublicationOpracowano model przemian azotu organicznego (Norg)jako rozszerzenie Modelu Osadu Czynnego Nr 2d (ASM2d). Nowy model zawiera trzy frakcje Norg: rozpuszczoą, koloidalną i zawesinową. Każda frakcja została podzielona na dwie podfrakcje - rozkładalną i nierozkładalną. Model został zweryfikowany w oparciu o wyniki badań eksperymentalnych w oczyszczalni ścieków Gdańsk-Wschód.
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Mathematical Modelling and Computer Simulation of Activated Sludge Systems
PublicationPrzegląd systemów osadu czynnego. Rozwój modeli procesu osadu czynnego. Podstawowe definicje z zakresu modelowania matematycznego i symulacji komputerowej. Proces budowy modelu (model biokinetyczny, hydrodynamiczny, transferu tlenu, temperatury). Modelowanie procesów biochemicznych zachodzących w systemach osadu czynnego. Organizacja badań symulacyjnych. Praktyczne zastosowania modeli osadu czynnego.
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Adsorption of CCl4 from Aqueous Solution on Activated Carbons
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Desorption of chloroorganic compounds from a bed of activated carbon
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The improvement and evaluation methods of settling properties of activated sludge
PublicationW biologicznych oczyszczalniach ścieków często pojawiają się problemy z sedymentacją osadu czynnego. Złe właściwości sedymentacyjne osadu często powodowane są nadmiernym rozwojem bakterii nitkowatych. W pracy przedstawiono koncepcję poprawy właściwości sedymentacyjnych osadu czynnego, opartą na kontroli parametrów pracy reaktorów SBR - temperatury, stężenia tlenu oraz czasu opadania osadu w komorze.
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Hierarchical dissolved oxygen control for activated sludge processes
PublicationA hierarchical controller for tracking the dissolved oxygen reference trajectory in activated sludge processes is proposed and investigated. The removal of nitrogen and phosphorous from wastewater is considered. Typically, an aeration system itself is a complicated hybrid nonlinear dynamical system with faster dynamics compared to the internal dynamics of the dissolved oxygen in a biological reactor. It is a common approach to...
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A new route for preparation of TiO2-mounted activated carbon
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Modeling organic nitrogen conversions in activated sludge bioreactors
PublicationFor biological nutrient removal (BNR) systems designed to maximize nitrogen removal, the effluent total nitrogen (TN) concentration may range from 2.0 to 4.0 g N/m3 with about 25-50% in the form of organic nitrogen (ON). In this study, current approaches to modeling organic N conversions (separate processes vs. constant contents of organic fractions) were compared. A new conceptual model of ON conversions was developed and combined...
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All Nonclassical Correlations Can Be Activated into Distillable Entanglement
PublicationWe devise a protocol in which general nonclassical multipartite correlations produce a physically relevant effect, leading to the creation of bipartite entanglement. In particular, we show that the relative entropy of quantumness, which measures all nonclassical correlations among subsystems of a quantum system, is equivalent to and can be operationally interpreted as the minimum distillable entanglement generated between the system...
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Degradation kinetics and mechanism of pentoxifylline by ultraviolet activated peroxydisulfate
PublicationDegradation of pentoxifylline (PTX) by sodium peroxydisulfate (SPDS) assisted by UV irradiation has been investigated in deionized water. The treatment was more favorable over direct photolysis or peroxydisulfate oxidation alone. The effects of various parameters, including different dosage of oxidant agent, PTX concentration, initial solution pH levels, and the presence of inorganic ions like chloride, nitrate and carbonate have...
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Toxicity of cylindrospermopsin in human lymphocytes: Proliferation, viability and cell cycle studies
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Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor
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CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations
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Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding
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Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants
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NK1 receptor binding of a few low molecular weight 3,5-bistrifluoromethylbenzene derivatives
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Structural Insights into σ1 Receptor Interactions with Opioid Ligands by Molecular Dynamics Simulations
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Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
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Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma
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Will we ever use angiotensin receptor neprilysin inhibition (ARNi) for the treatment of hypertension?
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Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
PublicationCoordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During...
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In vivoevaluation of the CB1allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
PublicationIn the present study, we examined whether LDK1258, which produces strong CB1receptor allosteric effects ininvitroassays, would elicitin vivoeffects consistent with allosteric activity. In initial studies, LDK1258 reducedfood consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciaticnerve (CCI) model of neuropathic pain, which unexpectedly emerged 4 h post-injection. UPLC-MS/MS analysisquantified...
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Expression of hCG and GnRHs and Their Receptors in Endometrial Carcinoma and Hyperplasia
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new analogues of agmatine with higher activity to imidazoline receptors
PublicationOpracowano syntezę nowych pochodnych imidazoliny, będących kompilacją struktury agmatyny i imidazoliny w wyniku zaprojektowanej przez nas drogi syntezy. Kluczowymi substratami w syntezie były pochodne 1,2,4 -triaminobutanu, otrzymane z chronionego kwasu glutaminowego. Otrzymane nowe pochodne imidazoliny wykazywały zróżnicowane powinowactwo do receptorów imidazolinowych I1, I2 oraz do receptorów alfa -adrenergicznych.
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Acceptor doping of barium cerate
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Portable reactor with LTCC electrodes for production of plasma activated water
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Chestnut-Derived Activated Carbon as a Prospective Material for Energy Storage
PublicationIn this work, we present the preparation and characterization of biomass-derived activatedcarbon (AC) in view of its application as electrode material for electrochemical capacitors. Porouscarbons are prepared by pyrolysis of chestnut seeds and subsequent activation of the obtainedbiochar. We investigate here two activation methods, namely, physical by CO2and chemical usingKOH. Morphology, structure and specific surface area (SSA)...
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Photoluminescence Kinetics of YAG Crystals Activated with Ce, and Ce and Mg
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Changes in rheological properties during anaerobic digestion of activated sludge
PublicationWykonane pomiary właściwości reologicznych osadwo nadmiernych poddawanych procesowi dezintegracji mechanicznej wskazują na znaczny spadek lepkości sięgający 60%. Wraz ze stopniem dezintegracji rosły również właściwości pseudoplastyczne oraz malała granica płynięcia. Podobnie istotne zmiany właściwosci reologicznych nastepowały w osadach poddawanych fermentacji metanowej.
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Nonlinear fuzzy control of the dissolved oxygen in activated sludge processes
PublicationWastewater treatment plant is generally a complex, multivariable, time varying and nonlinear large scale industrial system. Moreover, interactions between the components are very strong. The dissolved oxygen tracking problem is one of the most complex and fundamental issues of biological processes. Air for the aerated tanks is supplied by aeration system (blowers, pipes, diffusers). It is a complex dynamic system. The new control...
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The process generation of WWTP models for optimization of activated sludge systems
PublicationThe objective of water and wastewater utilities, which are responsible for optimization of wastewater treatment plant operation, is threefold: environmental protection, saving money, and mitigation of pollutant emissions, both to water and air. The performed study aimed to assess the process generation of WWTP models that improve activated sludge systems operation, by means of new developed Mantis2 model. This model accounts for...
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ACTIVATED BIOCHAR AS AN ADSORBENT OF ORGANIC POLLUTANTS FOR WATER AND WASTEWATER TREATMENT
PublicationThe use of biomass, especially waste biomass, as an alternative energy source is a very important issue today. Pyrolysis is a process of thermal degradation of raw material and one of its products is biochar. This product is mainly distinguished by its high carbon content, and by improving its quality through activation, it can be more widely used. Activated biocarbon has a strongly developed surface and porous structure, and as...
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Evidence of mutations conferring resistance to clarithromycin in wastewater and activated sludge
PublicationThe occurrence of clarithromycin in wastewater samples and of the activated sludge bacteria possibly resistant to this pharmaceutical was the object of the study. Samples of wastewater or activated sludge were taken from a municipal wastewater treatment plant in summer and winter and characterised regarding their clarithromycin concentrations and the presence of nucleic acid fragments (Cla-sequences) known to be responsible for...
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The use of mathematical models for diagnosis of activated sludge systems in WWTP
PublicationIn this study diagnosis of activated sludge systems in wastewater treatment plant (WWTP) was investigated. Diagnosis of technical objects can be realized in many ways. One of the divisions of the diagnostic methods include modelling with or without a model of the object. The first of these is the analysis of the symptoms for which, based on the parameter values, the abnormality in the diagnosed objects are sought. Another way is...
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Mathematical modelling and computer simulation of activated sludge systems.Second edition
PublicationMathematical Modelling and Computer Simulation of Activated Sludge Systems – Second Edition, provides, from the process engineering perspective, a comprehensive and up-to-date overview regarding various aspects of the mechanistic (“white box”) modelling and simulation of advanced activated sludge systems performing biological nutrient removal. In the new edition of the book, a special focus is given to nitrogen removal and an overview...
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...