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Density functional theory-based simulations of sum frequency generation spectra involving methyl stretching vibrations: effect of the molecular model on the deduced molecular orientation and comparison with an analytical approach
PublicationThe knowledge of the first hyperpolarizability tensor elements of molecular groups is crucial for a quantitative interpretation of the sum frequency generation (SFG) activity of thin organic films at interfaces. Here, the SFG response of the terminal methyl group of a dodecanethiol (DDT) monolayer has been interpreted on the basis of calculations performed at the density functional theory (DFT) level of approximation. In particular,...
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Architectural and urban theories in urban regeneration
e-Learning CoursesThis course deals with key issues associated with contemporary architectural and urban teories associated with transformation and revitalization of the distressed / degradated areas and buildings / objects. The architectural topics will be presented by dr Ksenia Piątkowska and Prof. Lucyna Nyka, while urban topics will be discussed by Prof. Piotr Lorens. Particular topics and themes will be presented according to the individual...
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Aleksandra Romanowska dr inż.
PeopleEmployee in the Highway and Transportation Engineering Department at the Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Poland. Her research interests include: modelling of road traffic, road safety, trip generation, transport behaviour and preferences of academic societies, planning sustainable urban mobility. In 2019 she was granted a PhD degree, under the supervision of Prof. Kazimierz Jamroz...
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Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats
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The effect of interleukin-35 on the integrity, ICAM-1 expression and apoptosis of human aortic smooth muscle cells
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Comparison of the effects of rosuvastatin monotherapy and atorvastatin-ezetimibe combined therapy on the structure of erythrocyte membranes in patients with coronary artery disease
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Effect of intensive lipid-lowering therapies on cholinesterase activity in patients with coronary artery disease
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Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease
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Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics
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The influence of the time of day on midazolam pharmacokinetics and pharmacodynamics in rabbits
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Proof-of-concept study on improved efficacy of rHuEPO administered as a long-term infusion in rats
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Pharmacokinetics and pharmacodynamics of propofol in children undergoing different types of surgeries
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Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial
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Assessing circadian rhythms during prolonged midazolam infusion in the pediatric intensive care unit (PICU) children
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Pharmacokinetics and pharmacodynamics of propofol in patients undergoing abdominal aortic surgery
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Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs
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Catalase activity in blood fractions of patients with sporadic ALS
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Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
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Possible contribution of IGF-1 to depressive disorder
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Mesoporous silica nanoflakes – Biocompatibility, cellular uptake and drug transport
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Gαi-derived peptide binds the µ-opioid receptor
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Stress-opioid interactions: a comparison of morphine and methadone
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Diversity of frequency-modulated 50-kHz vocalization response to intermittent amphetamine treatment in Sprague-Dawley rats
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High-dose testosterone enanthate supplementation boosts oxidative stress, but exerts little effect on the antioxidant barrier in sedentary adolescent male rat liver
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Behavioral and arginine catabolism dissimilarities between Warsaw high alcohol preferring (WHP) and Warsaw low alcohol preferring (WLP) rats
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublicationTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Temozolomide and sorafenib as programmed cell death inducers of human glioma cells
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Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?
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New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity
PublicationOpisano syntezę nowych koniugatów MDP i nor-MDP z pochodnymi tuftsyny i retro-tuftsyny zawierającymi wiązanie izopeptydowe pomiędzy epsilon-aminową grupą lizyny, a karboksylową grupą Ala, Gly czy Val. Zbadano ich aktywność biologiczną, m.in. profil cytokinowy.
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Therapeutic potential of adenosine analogues and conjugates
PublicationZaprezentowano przegląd literatury chemicznej na temat analogów i koniugatów adenozyny oraz ich potencjalne zastosowanie terapeutyczne. Zwrócono także uwagę na ich oddziaływanie z receptorami adenozyny.
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Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
PublicationPraca stanowi przegląd opisanych w literaturze chemicznej modyfikacji struktur naturalnych i syntetycznych pochodnych akrydyny i akrydonu. Artykuł obejmuje swym zakresem metody syntezy, a także wpływ budowy cząsteczek tych związków na ich aktywność przeciwnowotworową oraz mechanizm działania.
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublicationBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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The analgesic hybrid of dermorphin/substance P and analog of enkephalin improve wound healing in streptozotocin‐induced diabetic rats
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Thermal imaging in automatic rodent’s social behaviour analysis
PublicationLaboratory rodent social behaviour analysis is an extremely important task for biological, medical and pharmacological researches. In this work thermal images features that facilitate analysis are presented. Methods to distinguish objects on the basis of thermal distribution are tested. Actions of grooming or biting one rodent by another - important social behaviour incidents - are clearly visible...
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Spectroscopic evaluation of a low power atmospheric pressure mixed argon–helium microwave induced plasma combined with the chemical generation of volatile species for the optical emission spectrometric determination of arsenic, antimony and mercury
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Koncepcja i symulacja polowa generatora o zmiennej częstotliwości. Zastosowanie w autonomicznych systemach elektroenergetycznych = Conception and field simulations of a variable frequency generator. Application for autonomous power generation system
PublicationStreszczenie angielskie: This paper covers a conception and simulation results for a brushless synchronous generator working with variable speed in an autonomous energy generation system (e.g. airplane power grid, hybrid vehicle, micro-CHP). The papers has two parts: presentation of the generator conception used in modern autonomous energy generation systems, and simulation results using filed model elaborated in Flux2D software....
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Marek Moszyński dr hab. inż.
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Jerzy Kowalski dr hab. inż.
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Biopolymer-based composites for tissue engineering applications: A basis for future opportunities
PublicationBiomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for tissue engineering and regenerative medicine. Biopolymers, which have a wide range of properties, can be obtained from different natural sources. Depending on the target tissue, biopolymers can be engineered to meet a series...
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Design analysis of combined gas-vapour micro power plant with 30 kW air turbine
PublicationThe article presents basic results of the design analysis of a combined gas-vapour micro power plant with a waste-heat boiler without exhaust reheat, working in the vapour section in the Organic Rankine Cycle (ORC) system. The analysis concerned working media most frequently used in those types of power plants and planned to be used in future. The object of the analysis was a micro power plant with a 30 kW gas (air) turbine for...
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Design analysis of combined gas-vapour micro power plant with 30 kW air turbine
PublicationThe article presents basic results of the design analysis of a combined gas-vapour micro power plant with a waste-heat boiler without exhaust reheat, working in the vapour section in the Organic Rankine Cycle (ORC) system. The analysis concerned working media most frequently used in those types of power plants and planned to be used in future. The object of the analysis was a micro power plant with a 30 kW gas (air) turbine for...
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Wykorzystanie kamery termowizyjnej nowej generacji do oceny wpływu sił ortodontycznych na dziąsło = The application of a new-generation thermal imaging camera for the assessment of hemodynamic changes in gingiva during orthodontic treatment
PublicationIntroduction. One ot the most interesting modern methods of assessing microcirculation is thermovisiual examination. Thermovision cameras are commonly used in general medicine. As the periodontium is one of the most vascularized tissues in the human body, the application of high-sensitivity thermovision cameras may allow tor noninvasive asses- sment and early detection ot pathological changes in the gingiva by giving a complete...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublicationBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Anna Kuczyńska-Łażewska dr inż.
PeopleAnna Kuczyńska-Łażewska graduated from the Faculty of Chemistry of the Gdańsk University of Technologyin the field of Chemistry (1st degree) and Environmental Protection Technologies, specialization: environmental protection systems (2nd degree). She completed an internship at the Leibniz-Institut für Katalyse in Rostock. She defended her doctorate in recycling of 1st and 2nd generation modules in 2018 at the Department of Energy...
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International Conference on Next Generation Web Services Practices
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IEEE International Workshop on Databases for Next-Generation Researchers
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Laser stimulated third harmonic generation studies in ZnO–Ta 2 O 5 –B 2 O 3 glass ceramics entrenched with Zn 3 Ta 2 O 8 crystal phases
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In-situ generation of Ag, Cd, Hg, In, Pb, Tl and Zn volatile species by flowing liquid anode atmospheric pressure glow discharge operated in gaseous jet mode – Evaluation of excitation processes and analytical performance
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