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Search results for: V2X, C-ITS
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublicationThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Comments on ''Incremental construction and maintenance of minimal finite-state automata'' by Rafael C. Carrasco and Mikel L. Forcada.
PublicationW opublikowanym niedawno artykule (czerwiec 2002) Rafael Carrasco i Mikel Forcada przedstawili dwa algorytmy: jeden dotyczący przyrostowego dodawania łańcuchów znaków do języka minimalnego, deterministycznego, cyklicznego automatu skończonego, drugi dotyczący przyrostowego usuwania łańcuchów znaków z automatu. Pierwszy algorytm jest uogólnieniem ,,algorytmu dla danych nieuporządkowanych'' - drugiego z dwóch przyrostowych algorytmów...
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Rearrangeable clos networks C(n,r_1,n^2-1,n,r_2) with certain restrictions for connections
PublicationW pracy została zaproponowana nowa metoda sprawdzania przestrajalności pól Closa dla połączeń jeden do wiele. W rozważaniach zakładamy grupowanie połączeń.In the article we will propose new method of checking rearrangeability of multicast Clos networks. In the literature there is no precise method for checking rearrangeability. We focused on three-stage Clos networks without any constraints about fan-out capability. We show the...
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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublicationJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
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32P-postabeling detection of DNA adducts formed by 4-methyl-1-nitro-9-aminoacridine C-1748
PublicationWykazano zdolność do tworzenia przez nową pochodną 1-nitroakrydyny o symbolu C-1748, adduktów z DNA komórek nowotworowych oraz z DNA w systemie bezkomórkowym.
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Geier R., Angelmaier V., Gaubner C.-A., Kohoutek J.: Integrale Brücken. Entwurf, Berechnung, Ausführung, Monitoring
PublicationGeier R., Angelmaier V., Gaubner C.-A., Kohoutek J.: Integrale Brücken. Entwurf, Berechnung, Ausführung, Monitoring. Ernst & Sohn, Berlin 2017.
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Higher Absorption of Vitamin C from Food than from Supplements by Breastfeeding Mothers at Early Stages of Lactation
PublicationThe aim of the present study was to determine the effect of vitamin C supply in the diet of lactating women on vitamin C concentra¬tions in human milk (n = 97) sampled at different stages of lactation. Vitamin C levels were measured by liquid chromatography. Dietary intake of vitamin C was determined based on 3-day food dairies kept by breastfeeding mothers. Maternal dietary intakes of vitamin C from natural sources on lactation...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublicationC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Weak hydrogen bonding interaction S-H···O=C studied by FT-IR spectroscopy and DFT calculations
PublicationInteractions between the thiolate group of tri-tert-butoxysilanethiol (TBST) and carbonyl group of acetone are studied with the use of FT-IR spectroscopy and DFT calculations.
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Scattering of electrons from 1-butene, H2C=CHCH2CH3, and 2-methylpropene,H2C=C(CH3)2, molecules
PublicationZmierzono, wykorzystując liniową technikę transmisyjną, całkowite absolutne przekroje czynne (TCS) na rozpraszanie elektronów na cząsteczce 1-butenu (H2C=CHCH2CH3) oraz 2-metylpropene (H2C=C(CH3)2) w zakresie energii padających elektronów, od 1 do 400 eV oraz od 1 do 350 eV. Kształt przekroju czynnego dla obu badanych izomerów butenu jest podobny. Dwie struktury w uzyskanych krzywych TCS, są wyraźnie widoczne: mały pik w okolicy...
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublicationSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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Wykop z paragrafem. Systemy przewodów rurowych z tworzyw termoplastycznych – nowa norma PN-C-89224
PublicationPrzedstawienie nowoprzyjętej (marzec 2018) normy krajowej dotyczącej budowy przewodów z tworzyw termoplastycznych. Problemy posadowienia w podłożu. Kategoryzacje.
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Very accurate time propagation of coupled Schrödinger equations for femto- and attosecond physics and chemistry, with C++ source code
PublicationIn this article, I present a very fast and high-precision (up to 33 decimal places) C++ implementation of the semi-global time propagation algorithm for a system of coupled Schrödinger equations with a time-dependent Hamiltonian. It can be used to describe time-dependent processes in molecular systems after excitation by femto- and attosecond laser pulses. It also works with an arbitrary user supplied Hamiltonian and can be used...
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Filtry Gm-C czasu ciągłego - ogólna struktura i zastosowania w zagadnieniach analizy i projektowania
PublicationW pracy przedstawiono ogólny model filtrów Gm-C czasu ciągłego oraz jego opis macierzowy. Wykazano, że dowolny filtr aktywny tej klasy jest szczególnym przypadkiem zaprezentowanej struktury. Struktura ta jest szczególnie przydatna do analizy i projektowania filtrów Gm-C wysokiego rzędu, między innymi filtrów z wielopętlowym sprzężeniem zwrotnym takich jak Leap-Frog(LF) czy Follow-the-Leader (FLF). W pracy zaprezentowano szereg...
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Marek Kubale prof. dr hab. inż.
PeopleDetails concerning: Qualifications, Experiences, Editorial boards, Ph.D. theses supervised, Books, and Recent articles can be found at http://eti.pg.edu.pl/katedra-algorytmow-i-modelowania-systemow/Marek_KubaleGoogle ScholarSylwetka prof. Marka Kubalego Prof. Marek Kubale pracuje na Wydziale ETI Politechniki Gdańskiej nieprzerwanie od roku 1969. W tym czasie napisał ponad 150 prac naukowych, w tym ponad 40 z listy JCR. Ponadto...
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Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
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The Role and Importance of a Footbridge Suspended over a Highway in the Opinion of Its Users—Trabzon (Turkey)
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Territorial Extrapolation of Basic Data as a Solution of the Problem of Its Deficiency during Mass Appraisal
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The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
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Atmospheric emission of nitric oxide and processes involved in its biogeochemical transformation in terrestrial environment
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Empirical Analysis of Forest Penalizing Attribute and Its Enhanced Variations for Android Malware Detection
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Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
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Antimicrobial and antioxidant activities of Cinnamomum cassia essential oil and its application in food preservation
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Forced degradation studies of ivabradine and in silico toxicology predictions for its new designated impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API againstdegradation. There is a necessity to monitor impurities from all classification groups,hence ivabradine forced degradation studies were performed. Ivabradine was provedto be quite durable active substance, but still new and with insufficient stability data.Increased temperature, acid, base, oxidation reagents and...
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Precise regulation of defect concentration in MOF and its influence on photocatalytic overall water splitting
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The critical rotational speed of circular saw: simple measurement method and its practical implementations.
PublicationProducenci pił tarczowych są zobligowani do podawania ich dopuszczalnych prędkości obrotowych. Jednakże, umieszczane przez nich prędkości na piłach są często bliskie prędkościom krytycznym lub je przewyższają. Przecinanie takimi narzędziami może być więc niebezpieczne dla obsługującego. Praca przedstawia prostą metodologię wyznaczania prędkości obrotowych krytycznych pił tarczowych. Badania były prowadzone z wykorzystaniem technik...
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Eveningness and its possibility of predicting burnout symptoms among physicians and nurses – preliminary results
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Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women
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Solvent effects on fluorescence properties of protochlorophyll and its derivatives with various porphyrin side chains
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Salt stress vs. salt shock - the case of sugar beet and its halophytic ancestor
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Apoptosis induction in C32 human melanoma cells by Jasione montana and its main phytoconstituents
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In vitro evaluation of the effect of Bidens tripartita extract and its main constituents on the intestine contractility
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Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities
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Seasonal differences in the content of phenols and pigments in thalli of freshwater Cladophora glomerata and its habitat
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Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
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Health Risk Assessment of Exposure to Nitrates in Drinking Water Depending on the Source of Its Origin
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Cadmium in edible plants from Silesia, Poland, and its implications for health risk in populations
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Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies
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Sunshine duration and its variability in the main ridge of the Karkonosze Mountains in relation to with atmospheric circulation
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The covalent and non-covalent conjugation of graphene oxide with hydroxycamptothecin in hyperthermia for its anticancer activity
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Gypsum dehydration in cement and its impact on air-void structure in air-entrained concrete
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Digitalization Process and Its Impact on Economic Growth A Panel Data Study for Developing Countries
PublicationThis book analyses the impact of Information and Communication Technologies (ICTs) on economic development. It contains theoretical and empirical studies, including panel studies on various issues facing developing countries, such as education, corruption, economic growth, government expenditure, financial inclusion, foreign direct investment, infrastructure, economic and social welfare, and inequality. Each chapter offers a well-conceived...
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From Individual to Collective: Intelligence Amplification with Bio-Inspired Decisional DNA and its Extensions
PublicationIn nature, deoxyribonucleic acid (DNA) contains the genetic instructions used in the development and functioning of all known living organisms. The idea behind our vision is to develop an artificial system, an architecture that would support discovering, adding, storing, improving and sharing information and knowledge among agents and organizations through experience. We propose a novel Knowledge Representation (KR) approach in...
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Empirical Analysis of Forest Penalizing Attribute and Its Enhanced Variations for Android Malware Detection
PublicationAs a result of the rapid advancement of mobile and internet technology, a plethora of new mobile security risks has recently emerged. Many techniques have been developed to address the risks associated with Android malware. The most extensively used method for identifying Android malware is signature-based detection. The drawback of this method, however, is that it is unable to detect unknown malware. As a consequence of this problem,...
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Torque capacity of multidisc wet clutch with reference to friction occurrence on its spline connections
PublicationIn this article developed mathematical model that includes friction occurrence on spline connections is presented. The work also contains results of experimental research on torque capacity of multidisc wet clutch. These results are expressed as a function of contact pressure for different number of friction surfaces. Due to increased interest in research concerning multidisc wet clutches it is essential to determine impact of...
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Scaling Up the Process of Titanium Dioxide Nanotube Synthesis and Its Effect on Photoelectrochemical Properties
PublicationIn this work, for the first time, the influence of scaling up the process of titanium dioxide nanotube (TiO2NT) synthesis on the photoelectrochemical properties of TiO2 nanotubes is presented. Titanium dioxide nanotubes were obtained on substrates of various sizes: 2 × 2, 4 × 4, 5 × 5, 6 × 6, and 8 × 8 cm2. The electrode material was characterized using scanning electron microscopy as well as Raman and UV–vis spectroscopy in order...
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Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases
PublicationFourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...
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Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics
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An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12
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