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Search results for: OSTEOGENIC CELLS
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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives
PublicationNew conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl...
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Cell and Bioscience
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EUKARYOTIC CELL
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Cell Reports
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Cell Surface
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TISSUE & CELL
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Pulse-Modulated Radio-Frequency Alternating-Current-Driven Atmospheric-Pressure Glow Discharge for Continuous-Flow Synthesis of Silver Nanoparticles and Evaluation of Their Cytotoxicity toward Human Melanoma Cells
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The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells.
PublicationZaprezentowano wyniki badań biologicznych przeprowadzonych dla nowej grupy związków: estrów benzoperymidyny z zastosowaniem wybranych linii komórek nowotworowych: wrażliwych i opornych o oporności P-gp-zależnej, MRP1-zależnej i o oporności związanej z nadekspresją białek MRP1/LRP. Metodą spektrofluorymetryczną zbadano zdolność estrów benzoperymidyny do hamowania eksportu aktywnego pirarubicyny z komórek opornych. Estry benzoperymidyny...
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Resistance of human prostate carcinoma cells to a new antitumor compound capridine beta is associated with changed drug metabolism combined with both inherent and drug-induced overexpression of ABC transporters
PublicationW pracy charakteryzujemy mechanizm oporności na nową pochodną 1-nitroakrydyny, związku capridine beta (C-1748) o wysokiej aktywności przeciwnowotworowej, znajdującego się w badaniach klinicznych. Nasze dane wskazują, że oporność na ten związek jest wynikiem zmienionego metabolizmu inaktywującego C-1748 oraz wzrostem ekspresji pompy błonowej ABCG2 a także innych białek transportowych typu ABC.
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Evolution of left ventricular function after Wharton's jelly mesenchymal stem cells transcoronary administration: 5-year follow up in a pilot cohort of CIRCULATE-AMI Randomized Trial
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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublicationMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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Photovoltaic effect in the single-junction DBP/PTCBI organic system under low intensity of monochromatic light
PublicationPhotoelectric properties of the planar ITO/MoO3/DBP/PTCBI/BCP/Ag system were characterized on the basis of short-circuit current, open-circuit voltage and absorption spectra, and current-voltage measurements in the dark and under monochromatic illumination of low intensity. Photovoltaic performance of the system was compared with the performance of ideal semiconductor and excitonic cells of chosen bandgaps. Such analysis shows,...
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Evaluation of empirical formulae for estimation of the longitudinal dispersion in activated sludge reactors
PublicationBadania traserowe są szeroko stosowane do oceny hydrauliki reaktorów. Jednak w komorach osadu czynnego interpretacja wyników jest trudna z uwagi na recyrkulacje wewnętrzne i recyrkulację osadu z osadnika. Wzory empiryczne mogą być alternatywną metodą oceny warunków hydraulicznych w komorach. Celem tych badań było sprawdzenie czterech wzorów empirycznych na obliczanie współczynnika dyspersji hydrodynamicznej w oparciu o wyniki badań...
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Intraoperative, Radio-Guided Sentinel Lymph Node Mapping in 110 Nonsmall Cell Lung Cancer Patients
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Blue-dye intraoperative sentinel lymph node mapping in early non-small cell lung cancer
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Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes
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Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublicationLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings
PublicationZbadano aktywność cytotoksyczną, in vitzo dwóch nowych grup cytostatyków akrydynowych zawierających skondensowane pierścienie heterocykliczne w stosunku do komórek nowotworowych linii wrażliwych i opornych. Otrzymane wyniki potwierdziły naszą wcześniejszą hipotezę o istotnej roli pierścieni hetero-cyklicznych w pokonywaniu krzyżowej oporności wielolekowej.
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Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation
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The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model
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The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines
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New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines
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Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines
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Nuclear localization of P-glycoprotein is responsible for protection of the nucleus from doxorubicin in the resistant LoVo cell line
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Cross-talk between DNA damage and cell survival checkpoints during G2 and mitosis: pharmacological implications
PublicationW pracy wyjaśnialiśmy rolę surwiwiny w ochronie komórek w czasie przejścia między G2 i mitozą, traktowanych związkiem uszkadzającym DNA. Jako model komórkowy wybraliśmy komórki ludzkiej białaczki MOLT-4, które wykazują zwiększoną ekspresję białka surwiwiny i niefunkcjonalnym p53. Ekspozycja tych komórek na melfalan, klasyczny związek uszkadzający DNA, prowadzi do uruchomienia punktu kontrolnego w G2 i zablokowania progresji cyklu...
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Cabbage Juices and Indoles Modulate the Expression Profile of AhR, ERα, and Nrf2 in Human Breast Cell Lines
PublicationOur previous studies showed the diversified effect of cabbage juices and indoles on the estrogen metabolism key enzymes (CYP1A1, CYP1A2, CYP1B1) in breast epithelial cells differing in ER status, i.e., in tumorigenic—MCF7, MDA-MB-231 and non-tumorigenic—MCF10A cells. The aim of the present study was to further investigate the mechanism of chemopreventive action of cabbage juice and its active components by evaluating their effect...
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Działalność Studenckiego Koła Naukowego CELL przy Katedrze Systemów i Sieci Radiokomunikacyjnych Politechniki Gdańskiej
PublicationZarys działalności i osiągnięć Studenckiego Koła Naukowego CELL zajmującego się popularyzacją zagadnień związanych z telekomunikacją bezprzewodową.
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Application analysis of a hybrid solid oxide fuel cell-gas turbine system for marine power plants
PublicationThe results of theoretical studies of the possibilities of using hybrid solid oxide fuel cell–gas turbine (SOFC-GT) systems for marine power plants are presented. A 500 kW auxiliary marine power plant scheme using stacks of SOFCs in combination with a regenerative gas turbine operating with over-expansion based on our recent patent application is proposed. The results of mathematical modelling showed the opportunity to obtain a...
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Modulation of G2 arrest enhances cell death induced by the antitumor 1-nit-roacridine derivative, Nitracrine
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Chemical composition of Polish propolis and its antiproliferative effect in combination with Bacopa monnieri on glioblastoma cell lines
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New polymethoxyflavones from Hottonia palustris and their effects in an oral squamous carcinoma (SCC-25) cell line
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Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent <i>CARD11</i> mutations
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Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy
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Erratum to: Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
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The cell surface protein Ag43 facilitates phage infection of Escherichia coli in the presence of bile salts and carbohydrates
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Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
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The Co-Culture of Staphylococcal Biofilm and Fibroblast Cell Line: The Correlation of Biological Phenomena with Metabolic NMR1 Footprint
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Nanostructured graphene oxide enriched with metallic nanoparticles as a biointerface to enhance cell adhesion through mechanosensory modifications
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Initial assessment of suitability of MCF-7 and HepG2 cancer cell lines for AQP3 research in cancer biology
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Lipid membranes exposed to dispersions of phytantriol and monoolein cubosomes: Langmuir monolayer and HeLa cell membrane studies
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In-situ Cu-doped MnCo-spinel coatings for solid oxide cell interconnects processed by electrophoretic deposition
PublicationThe Cu doping of the Mn–Co spinel is obtained “in-situ” by electrophoretic co-deposition of CuO and Mn1.5Co1.5O4 powders and subsequent two-step reactive sintering. Cu-doped Mn1.5Co1.5O4 coatings on Crofer22APU processed by electrophoretic co-deposition method are tested in terms of long term oxidation resistance and area specific resistance tests up to 3600 h. The introduction of Cu in the spinel lead to higher level of densification...
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Fe-modified Mn2CuO4 spinel oxides: coatings based on abundant elements for solid oxide cell interconnects
PublicationThe current state of the art steel interconnect coating materials are based on critical raw material - Co-oxide spinels. Replacing Co-oxide spinels with alternative, abundant materials can reduce the dependence on the critical raw materials. Cobalt-free coatings with the general formula Mn2-xCuFexO4, where x = 0, 0.1, 0.3, were electrophoretically deposited on a ferritic stainless-steel support and evaluated. Prior to deposition,...
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Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
PublicationIntestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively...
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Exploring the Beam Squint Effects on Reflectarray Perfromance: A Comprehensive Analysis of the Specular and Scattered Reflection of the Unit Cell
PublicationIn this article, the phenomena of beam deviation in reflectarray is discussed. The radiation pattern of the unit cell, which plays a vital role in shaping the beam of the reflectarray, is analyzed by considering undesired specular and scattered reflections. These unwanted reflections adversely affect the pattern of the single unit cell, thereby reducing the overall performance of the reflectarray. To conduct our investigations,...
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Single-Phase 15-Level Switched-Capacitor Boost Multilevel Inverter Topology for Renewable Energy Applications
PublicationGalvanic isolation is a vital part of a grid-connected solar PV system. With the growth of multilevel inverters for grid-connected applications, the multilevel inverters having isolation are not sufficiently discussed in the literature. In this paper, a 15-level isolated multilevel inverter topology requiring only thirteen switches is proposed. The envisaged configuration includes two cells, designated as upper and lower cells....
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Selecting wells for an optimal design of groundwater monitoring network based on monitoring priority map: A Kish Island case study
PublicationThis paper presents a novel approach, i.e. a combination of gamma test and monitoring priority map, for optimal design of groundwater monitoring network (GMN) by considering the cumulative effects of industries, human activities, and natural factors on the groundwater quality. The proposed method was successfully applied to design an optimal network for groundwater salinity monitoring on Kish Island, Persian Gulf. The priority...
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Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
Publicationnthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones. BS-154, the most potent derivative, had IC50 values close to 1 nM, however, it was toxic in animal studies. Here, we characterize another...