Search results for: epigenetic drugs

• Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?

  Publication

  • J. Boros-Majewska
  • N. Salewska
  • M. J. Milewska
  • S. Milewski
  • E. Borowski

  - MYCOSES - Year 2012

  Although the contemporary medicine keeps moving forward, disseminated infections caused by fungal pathogens are an emerging challenge. The dramatic rise of fungal diseases, especially the most life-threatening systemic mycoses is associated with a permanently growing number of immunodeficient patients. Undoubted difficulties in the treatment of fungal infections are caused by lack of highly effective and selective antifungal drugs,...

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• Ahmer Bin Hafeez

  People

  I have experience in Microbiology & Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational methods for the identification of novel targets and to...

• Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration

  Publication

  • P. Sosnowski

  - Year 2021

  Despite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...

• A new silylating reagent – dimethyl(3,3,3-trifluoropropyl)silyldiethylamine – for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas chromatography–mass spectrometry analysis

  Publication

  • M. Caban
  • K. Mioduszewska
  • P. Łukaszewicz
  • N. Migowska
  • P. Stepnowski
  • M. Kwiatkowski
  • J. Kumirska

  - Journal of Chromatography A - Year 2014

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• Theoretical Encapsulation of Fluorouracil (5-FU) Anti-Cancer Chemotherapy Drug into Carbon Nanotubes (CNT) and Boron Nitride Nanotubes (BNNT)

  Publication

  • M. Zarghami Dehaghani
  • F. Yousefi
  • S. M. Sajadi
  • M. Tajammal Munir
  • O. Abida
  • S. Habibzadeh
  • A. H. Mashhadzadeh
  • N. Rabiee
  • E. Mostafavi
  • M. Saeb

  - MOLECULES - Year 2021

  Introduction: Chemotherapy with anti-cancer drugs is considered the most common approach for killing cancer cells in the human body. However, some barriers such as toxicity and side effects would limit its usage. In this regard, nano-based drug delivery systems have emerged as cost-effective and efficient for sustained and targeted drug delivery. Nanotubes such as carbon nanotubes (CNT) and boron nitride nanotubes (BNNT) are promising...

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• Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin

  Publication

  • K. Bobrowska
  • K. Sadowska
  • K. Stolarczyk
  • M. Prześniak-Welenc
  • P. Golec
  • R. Bilewicz

  - International Journal of Nanomedicine - Year 2023

  Introduction: Hybrid nanoflowers are structures consisting of organic (enzymes, proteins, nucleic acids) and inorganic components (mostly metal phosphates) with a flower-like hierarchical structure. Novel hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were obtained and characterized. Study on BSA-HA nanoflowers as potential drug delivery system is reported for the first time. Methods: Embedding ciprofloxacin...

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• Bioactive silica-based drug delivery systems containing doxorubicin hydrochloride: In vitro studies

  Publication

  • M. Prokopowicz
  • J. Żegliński
  • A. Gandhi
  • W. Sawicki
  • S. Tofail

  - COLLOIDS AND SURFACES B-BIOINTERFACES - Year 2012

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• Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole

  Publication

  • K. Czarnobaj
  • M. Prokopowicz
  • K. Greber

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2019

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• Cisplatin filled multiwalled carbon nanotubes – a novel molecular hybrid of anticancer drug container

  Publication

  • C. Tripisciano
  • S. Costa
  • R. Kalenczuk
  • E. Borowiak-Palen
  • E. Mijowska

  - EUROPEAN PHYSICAL JOURNAL B - Year 2010

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• The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells

  Publication

  • D. Przystupski
  • O. Michel
  • J. Rossowska
  • S. Kwiatkowski
  • J. Saczko
  • J. Kulbacka

  - MEDICINAL CHEMISTRY RESEARCH - Year 2019

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• Acinetobacter baumannii isolated from hospital‐acquired infection: biofilm production and drug susceptibility

  Publication

  • P. Krzyściak
  • A. Chmielarczyk
  • M. Pobiega
  • D. Romaniszyn
  • J. Wójkowska‐Mach

  - APMIS - Year 2017

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• Fulminant hepatic failure in woman with iron and non-steroidal anti-inflammatory drug intoxication

  Publication

  • J. Magdalan
  • M. Zawadzki
  • T. Sozański

  - HUMAN & EXPERIMENTAL TOXICOLOGY - Year 2011

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• Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery

  Publication

  • D. Urry
  • K. Urry
  • W. Szaflarski
  • M. Nowicki

  - ADVANCED DRUG DELIVERY REVIEWS - Year 2010

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• Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line

  Publication

  • R. Januchowski
  • P. Zawierucha
  • M. Ruciński
  • M. Andrzejewska
  • K. Wojtowicz
  • M. Nowicki
  • M. Zabel

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2014

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• Microneedle‐Based Generation of Microbubbles in Cancer Tumors to Improve Ultrasound‐Assisted Drug Delivery

  Publication

  • A. Zandi
  • M. Khayamian
  • M. Saghafi
  • S. Shalileh
  • P. Katebi
  • S. Assadi
  • A. Gilani
  • M. Salemizadeh
  • S. Vanaei
  • M. Esmailinejad... and 4 others

  - Advanced Healthcare Materials - Year 2019

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• Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis

  Publication

  • K. Steckiewicz
  • P. Cieciórski
  • E. Barcińska
  • M. Jaśkiewicz
  • M. Narajczyk
  • M. Bauer
  • W. Kamysz
  • E. Megiel
  • I. Inkielewicz-Stepniak

  - International Journal of Nanomedicine - Year 2022

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• ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

  Publication

  • P. Gadziński
  • A. Froelich
  • U. Kowalska
  • M. Soból
  • M. Szybowicz
  • T. Osmałek

  - Acta Poloniae Pharmaceutica - Drug Research - Year 2020

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• Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

  Publication

  • K. AbouAitah
  • M. Bil
  • E. Pietrzykowska
  • U. Szałaj
  • D. Fudala
  • B. Woźniak
  • J. Nasiłowska
  • A. Swiderska-Sroda
  • M. Lojkowski
  • B. Sokołowska... and 3 others

  - Nanomaterials - Year 2021

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• New Life of an Old Drug: Caffeine as a Modulator of Antibacterial Activity of Commonly Used Antibiotics

  Publication

  • A. Woziwodzka
  • M. Krychowiak-Maśnicka
  • G. Gołuński
  • A. Łosiewska
  • A. Borowik
  • D. Wyrzykowski
  • J. Piosik

  - Pharmaceuticals - Year 2022

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• The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena

  Publication

  • P. Kawczak
  • T. Baczek

  - Medicinal Chemistry - Year 2016

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• Activity of Phage–Lactoferrin Mixture against Multi Drug Resistant Staphylococcus aureus Biofilms

  Publication

  • K. Kosznik-Kwaśnicka
  • N. Kaźmierczak
  • L. Piechowicz

  - Antibiotics-Basel - Year 2022

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• Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug

  Publication

  • I. Gabriel
  • N. D. Vetter
  • D. R. J. Palmer
  • M. J. Milewska
  • M. Wojciechowski
  • S. Milewski

  - FEMS YEAST RESEARCH - Year 2013

  The LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg2+- and K+-dependent oxidative decarboxylation of homoisocitrate to alpha-ketoadipate. The recombinant enzyme demonstrates strict specificity for homoisocitrate. SDS-PAGE of CaHIcDH revealed its molecular mass of 42.6±1 kDa, while in size-exclusion...

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• Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy

  Publication

  • M. Sieczkowski
  • A. Gibas
  • A. Wasik
  • A. Kot-Wasik
  • L. Piechowicz
  • J. Namieśnik
  • M. Matuszewski

  - TECHNOLOGY IN CANCER RESEARCH & TREATMENT - Year 2017

  OBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated...

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• Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

  Publication

  • M. Miotke
  • J. Strankowska
  • J. Kwela
  • M. Strankowski
  • Ł. Piszczyk
  • M. Józefowicz
  • M. Gazda

  - European Physical Journal Plus - Year 2017

  Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing....

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• Glucosamine-6-phosphate synthase,a novel target for antifungalagents.Molecular modelling studies in drug design

  Publication

  • M. Wojciechowski
  • S. Milewski
  • J. Mazerski
  • E. Borowski

  - Year 2005

  Praca dotyczy modelowania zarówno samych inhibitorów syntazy glukozamino-6-fosforanu jak i ich oddziaływania z obydwiema domenami tego enzymu. Enzym syntaza glukozamino-6-fosforanu został zaproponowany jako nowy cel molekularny w chemoterapii infekcji grzybowych. Zaprojektowano i zsyntezowano szereg inhibitorów tego enzymu - potencjalnych nowych leków przeciwgrzybowych. Dzięki modelowaniu molekularnemu udało się wyjaśnić mechanizm...

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• Modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models

  Publication

  • M. Wieczerzak
  • B. Kudłak
  • G. Yotova
  • M. Nedyalkova
  • S. Tsakovski
  • V. Simeonov
  • J. Namieśnik

  - SCIENCE OF THE TOTAL ENVIRONMENT - Year 2016

  The present study deals with assessment of ecotoxicological parameters of 9 drugs (diclofenac (sodium salt), oxytetracycline hydrochloride, fluoxetine hydrochloride, chloramphenicol, ketoprofen, progesterone, estrone, androstenedione and gemfibrozil), present in the environmental compartments at specific concentration levels, and theirmutual combinations by couples against Microtox® and XenoScreen YES/YAS® bioassays. As the quantitative...

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• DRUGS OF THE FUTURE

  Journals

  ISSN: 0377-8282 , eISSN: 2013-0368

• Analiza modalna konstrukcji podpierającej stanowiska badawczego dynamiki małogabarytowych wirników część druga - badania symulacyjne

  Publication

  • Ł. Breńkacz
  • P. Bagiński
  • G. Żywica

  - Year 2012

  Celem niniejszej pracy było przedstawienie badań eksperymentalnych oraz symulacyjnych stanowiska VIBstand. W pracy przedstawiono dokładne wyniki badań symulacyjnych, oraz skrótowo wyniki badań eksperymentalnych w celu porównania wyników. Dokładne wyniki badań eksperymentalnych przedstawione zostały części pierwszej artykułu (Analiza modalna konstrukcji podpierającej stanowiska badawczego dynamiki małogabarytowych wirników. Część...

• DRUG AND CHEMICAL TOXICOLOGY

  Journals

  ISSN: 0148-0545 , eISSN: 1525-6014

• DRUG METABOLISM AND DISPOSITION

  Journals

  ISSN: 0090-9556 , eISSN: 1521-009X

• DRUG DEVELOPMENT RESEARCH

  Journals

  ISSN: 0272-4391 , eISSN: 1098-2299

• DRUG METABOLISM REVIEWS

  Journals

  ISSN: 0360-2532 , eISSN: 1097-9883

• ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

  Journals

  ISSN: 1540-658X , eISSN: 1557-8127

• ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

  Journals

  ISSN: 0004-4172

• CURRENT CANCER DRUG TARGETS

  Journals

  ISSN: 1568-0096 , eISSN: 1873-5576

• Expert Opinion On Drug Safety

  Journals

  ISSN: 1474-0338 , eISSN: 1744-764X

• American Health and Drug Benefits

  Journals

  ISSN: 1942-2962 , eISSN: 1942-2970

• Drug Delivery and Translational Research

  Journals

  ISSN: 2190-393X , eISSN: 2190-3948

• Expert Opinion on Drug Delivery

  Journals

  ISSN: 1742-5247 , eISSN: 1744-7593

• Drug Design Development and Therapy

  Journals

  ISSN: 1177-8881

• Journal of Drug Metabolism & Toxicology

  Journals

  ISSN: 2157-7609

• International Journal of Drug Discovery

  Journals

  ISSN: 0975-4423

• Expert Opinion on Drug Discovery

  Journals

  ISSN: 1746-0441 , eISSN: 1746-045X

• DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

  Journals

  ISSN: 0363-9045 , eISSN: 1520-5762

• FOOD AND DRUG LAW JOURNAL

  Journals

  ISSN: 1064-590X

• Drug Healthcare and Patient Safety

  Journals

  ISSN: 1179-1365

• Clinical Pharmacology in Drug Development

  Journals

  ISSN: 2160-7648

• INTERNATIONAL JOURNAL OF DRUG POLICY

  Journals

  ISSN: 0955-3959 , eISSN: 1873-4758

• Journal of Drug Policy Analysis

  Journals

  ISSN: 1941-2851

• Current drug abuse reviews

  Journals

  ISSN: 1874-4737