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Neuroinflammation in Dementia—Therapeutic Directions in a COVID-19 Pandemic Setting
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Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients
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Role of Platelets in Osteoarthritis—Updated Systematic Review and Meta-Analysis on the Role of Platelet-Rich Plasma in Osteoarthritis
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Molecular cloning and initial characterization of African green monkey (Cercopithecus aethiops) corticotropin releasing factor receptor type 1 (CRF1) from COS-7 cells
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Genes involved in angiogenesis and circulatory system development are differentially expressed in porcine epithelial oviductal cells during long-term primary in vitro culture – a transcriptomic study
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Influence of Estradiol-17beta on Progesterone and Estrogen Receptor mRNA Expression in Porcine Follicular Granulosa Cells during Short-Term, In Vitro Real-Time Cell Proliferation
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A comparison of the effects of monotherapy with rosuvastatin, atorvastatin or ezetimibe versus combination treatment with rosuvastatin-ezetimibe and atorvastatin-ezetimibe on the integrity of vascular endothelial cells damaged by oxidized cholesterol
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4-methyl-1-nitroacridine derivative C-1748 induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
PublikacjaPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia apoptozy, katastrofy mitotycznej lub procesu starzenia komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wykazano, że pochodna C-1748 indukuje apoptozę w komórkach obu linii HCT116 w sposób zależny od czasu inkubacji, przy czym komórki HCT116 p53+/+ wykazują...
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Bio and slide bearings: their lubrication by non-Newtonian fluids and application in non conventional systems. Vol.3. Tribology processes for cells human joints and micro-bearings
PublikacjaW niniejszej monografii przedstawiony został aktualny pogląd dotyczący procesu smarowania stawów człowieka od strony mechaniki, a szczególnie hydromechaniki i metod matematycznych. Wyznaczono pola prędkości przepływu lepkiej, odżywczej nie Newtonowskiej cieczy biologicznej, a także powstające siły tarcia w trakcie ruchu cieczy w warstwie granicznej wokoło współpracujących powierzchni. Dodatkowo rozpatrywano przepływy potencjalne...
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis
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Argyrophilic nucleolar organizer regions (AgNORs) in interphases and metaphases of normal and neoplastic gill cells of Macoma balthica (Bivalvia: Tellinidae) from the Gulf of Gdansk, Baltic Sea
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Modification of Rapana thomasiana hemocyanin with choline amino acid salts significantly enhances its antiproliferative activity against MCF-7 human breast cancer cells
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Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia
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Adenylate Kinase 4—A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways
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Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model
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P774Transcoronary transfer of Wharton's jelly mesenchymal pluripotent stem cells in patients with chronic ischaemic heart failure shows safety and unprecedented high-grade myocardial uptake
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Harman and norharman, metabolites of the entomopathogenic fungus Conidiobolus coronatus (Entomophthorales), affect the serotonin levels and phagocytic activity of hemocytes, insect immunocompetent cells, in Galleria mellonella (Lepidoptera)
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P4604Insights into left ventricular remodelling and clinical outcomes after Wharton's jelly multipotent stem cells transcoronary administration in a pilot cohort of CIRCULATE-AMI Trial (NCT03404063)
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Designing high-performance quasi-symmetrical solid oxide cells with a facile chemical modification strategy for Sr2Fe2−xWxO6−δ ferrites electrodes with in situ exsolution of nanoparticles
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Analysis of cellular response induced by imidazoacridinone derivative C-1311 in Chinese hamster ovary carcinoma cells CHO with vorious expression level of cytochrome P450 reductase
PublikacjaRodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311 badany był w komórkach CHO o różnym poziomie reduktazy cytochromu P450. Wszystkie eksperymenty zostały przeprowadzone przy zastosowaniu stężenia związku odpowiadającego dawce EC80. Poziom ekspresji reduktazy cytochromu P450 nie miał istotnego wpływu na rodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311. Głównym efektem biologicznym wywieranym przez badany...
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Mitotic catastrophe followed by necrosis versus pro-survival autophagy - two opposite cellular effects triggered upon C-1311 treatment in MCF-7 cells
PublikacjaPrzeprowadzone badania miały na celu określenie zdolności imidazoakrydonu C-1311 do indukcji katastrofy mitotycznej, nekrozy i autofagii w komórkach ludzkiego raka piersi MCF-7. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 80%. Wykazano, że pochodna C-1311 powoduje przejściową akumulację komórek MCF-7 w fazie G2 cyklu życiowego (59% po 48 godz. inkubacji) z równoczesnym...
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The electrical properties mesurements of SOFC with Ce0.9Cu0.1O2-s functional layer
Dane BadawczeThe dataset includes the electrical properties mesurements of SOFC with Ce0.9Cu0.1O2-s layer. Samples were produced using aqueous soft chemistry methods (microemulsion method) and applied in form of a layer onto the anode of the commercial SOFC. The SOFC was working under biogas feeding at 750oC. The layers were sintered at 1100oC.
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The electrical properties mesurements of SOFC with Ce0.9Co0.1O2-s functional layer
Dane BadawczeThe dataset includes the electrical properties mesurements of SOFC with Ce0.9Co0.1O2-s layer. Samples were produced using aqueous soft chemistry methods (microemulsion method) and applied in form of a layer onto the anode of the commercial SOFC. The SOFC was working under biogas feeding at 750oC. The layers were sintered at 1100oC.
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The electrical properties mesurements of SOFC with Ce0.8Co0.1Cu0.1O2-s functional layer
Dane BadawczeThe dataset includes the electrical properties mesurements of SOFC with Ce0.8Co0.1Cu0.1O2-s layer. Samples were produced using aqueous soft chemistry methods (microemulsion method) and applied in form of a layer onto the anode of the commercial SOFC. The SOFC was working under biogas feeding at 750oC. The layers were sintered at 1100oC.
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The electrical properties mesurements of SOFC with Ce0.8Co0.15Cu0.05O2-s functional layer
Dane BadawczeThe dataset includes the electrical properties mesurements of SOFC with Ce0.8Co0.15Cu0.05O2-s layer. Samples were produced using aqueous soft chemistry methods (microemulsion method) and applied in form of a layer onto the anode of the commercial SOFC. The SOFC was working under biogas feeding at 750oC. The layers were sintered at 1100oC.
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HIERARCHICAL CYCLES IN MODERN POWER SYSTEMS – EXERGY ANALYSIS UNDER PART LOADS
PublikacjaThe aim of the paper is to investigate thermodynamic efficiency of advanced hierarchic power cyclesunder partial loads by using of exergy analyze. Advanced hierarchical power systems arecomposed of few energy conversion cycles, most common are steam and gas cycles in various configurations, but they may contain fuel cells, ORC, lithium bromide absorption chillers and others. Moreover hierarchical cycles can be powered by several...
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Prototype design and development of low-load-roof photovoltaic modules for applications in on-grid systems
PublikacjaFour prototypes of lightweight photovoltaic modules for applications in on-grid systems have been designed, developed, manufactured and tested for compliance with relevant IEC standards. Selected, commercially available materials characterized by thermogravimetry, differential scanning calorimetry, dilatometry, scanning electron microscopy and nanoindentation technique were used in frameless, adhesively-bonded sandwich-structures...
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Oxidative modification induced by photodynamic therapy with Photofrin®II and 2-methoxyestradiol in human ovarian clear carcinoma (OvBH-1) and human breast adenocarcinoma (MCF-7) cells
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Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells
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Antitumor imidazoacridinone derivative C-1311 induces cell cycle arrest and cellular senescence-like phenotypic changes in human non-small lung A549 cancer cells
PublikacjaPrzeprowadzone badania miały na celu zbadanie rodzaju odpowiedzi komórkowej indukowanej przez pochodną C1311 w komórkach ludzkiego, niedrobnokomórkowego raka płuc A549, wyselekcjonowanych do badań ze względu na wysoką wrażliwość na działanie pochodnej C-1311. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 80%. Badania z wykorzystaniem techniki cytometrii przepływowej oraz...
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
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A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains
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Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
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On the Possibility of Improving the Oxidation Resistance of High-Chromium Ferritic Stainless Steel Using Reactive Element Oxide Nanoparticles
PublikacjaHigh-chromium ferritic steels are current the only viable candidates for cheap interconnect materials for application in high-temperature solid oxide fuel and electrolyzer cells (HT-SOFCs/SOECs). The durability and operating characteristics of interconnects manufactured using these materials may be improved significantly by applying a protective-conducting MoCo2O4 coating and depositing an intermediate layer consisting of nanoparticles...
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The time-dependent cellular uptake of C−2028, CD−C−2028, QDgreen−C−2028, and QDgreen−CD−FA−C−2028 conjugates at IC80 value to cancer LNCaP cells
Dane BadawczeThe time-dependent (1, 24, 48, and 72 h) cellular uptake of C−2028, CD−C−2028, QDgreen−C−2028, and QDgreen−CD−FA−C−2028 conjugates at IC80 value to cancer LNCaP cells performed by Confocal Laser Scanning Microscopy (63× magnification; ZEISS LSM T-PMT, Magdeburg, Germany). Based on the fluorescence properties of these compounds, green and orange fluorescence...
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The time-dependent cellular uptake of C−2028, CD−C−2028, QDgreen−C−2028, and QDgreen−CD−FA−C−2028 conjugates at IC80 value to cancer H460 cells
Dane BadawczeThe time-dependent (1, 24, 48, and 72 h) cellular uptake of C−2028, CD−C−2028, QDgreen−C−2028, and QDgreen−CD−FA−C−2028 conjugates at IC80 value to cancer H460 cells performed by Confocal Laser Scanning Microscopy (63× magnification; ZEISS LSM T-PMT, Magdeburg, Germany). Based on the fluorescence properties of these compounds, green and orange fluorescence...
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The time-dependent cellular uptake of C−2028, CD−C−2028, QDgreen−C−2028, and QDgreen−CD−FA−C−2028 conjugates at IC80 value to normal PNT1A cells
Dane BadawczeThe time-dependent (1, 24, 48, and 72 h) cellular uptake of C−2028, CD−C−2028, QDgreen−C−2028, and QDgreen−CD−FA−C−2028 conjugates at IC80 value to normal PNT1A cells performed by Confocal Laser Scanning Microscopy (63× magnification; ZEISS LSM T-PMT, Magdeburg, Germany). Based on the fluorescence properties of these compounds, green and orange fluorescence...
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Hydrogen production from ethanol In nitrogen microwave plasma At atmospheric pressure
PublikacjaHydrogen seems to be one of the most promising alternative energy sources. It is a renewable fuel as it could be produced from e.g. waste or bio-ethanol. Furthermore hydrogen is compatible with fuel cells and is environmentally clean. In contrast to conventional methods of hydrogen production such as water electrolysis or coal gasification we propose a method based on atmospheric pressure microwave plasma. In this paper we present...
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Impact of dyes isomerization effect on the charge transfer phenomenon occurring on the dye/nanosemiconductor interface
PublikacjaThe present work aimed to find the answer how does the isomerization of the Ru based dyes affect the overall photon-to-current efficiency of the DSSCs and to explain the charge transfer phenomenon occurring on the dye/ nanosemiconductor interface. Therefore, electronic and optical properties of three bipyridine derivatives anchored on the TiO2 electrode were investigated by computational simulations based on quantum chemistry codes...
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Change of catalytic parameters for SOFC fueled by H2 and biogas mixture at 750 C
Dane BadawczeThe dataset contains the Change of catalytic parameters for SOFC fueled by H2 and biogas mixture at 750 C (60:40 CH4:CO2). The outlet concentration of the gases from SOFC were measured using novel FTIR-based unit. The parameters are conversion rates, selectivities and yields of products
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Cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst LNCaP cancer cells
Dane BadawczeTis study presents absorbance values of formazan product (converted from MTT) which corresponds the cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst LNCaP cancer cells. FA (folic acid) with cyclodextrin (CD) was used as a linker between quantum dots (QDs) and compound (C-2028).
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Cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst H460 cancer cells
Dane BadawczeThis study presents absorbance values of formazan product (converted from MTT) which corresponds the cytotoxicity of C-2028, QDgreen, QDred, QDgreen-CD-FA, QDred-CD-FA, QDgreen-CD-FA-C-2028 and QDred-CD-FA-C-2028 aginst H460 cancer cells. FA (folic acid) with cyclodextrin (CD) was used as a linker between quantum dots (QDs) and compound (C-2028).
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublikacjaHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Pulse-Modulated Radio-Frequency Alternating-Current-Driven Atmospheric-Pressure Glow Discharge for Continuous-Flow Synthesis of Silver Nanoparticles and Evaluation of Their Cytotoxicity toward Human Melanoma Cells
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Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance
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Short-term Cultivation of Porcine Cumulus Cells Influences the Cyclin-dependent Kinase 4 (Cdk4) and Connexin 43 (Cx43) Protein Expression—A Real-time Cell Proliferation Approach
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<p>Mechano-signalling, induced by fullerene C<sub>60</sub> nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells</p>
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Resistance of human prostate carcinoma cells to a new antitumor compound capridine beta is associated with changed drug metabolism combined with both inherent and drug-induced overexpression of ABC transporters
PublikacjaW pracy charakteryzujemy mechanizm oporności na nową pochodną 1-nitroakrydyny, związku capridine beta (C-1748) o wysokiej aktywności przeciwnowotworowej, znajdującego się w badaniach klinicznych. Nasze dane wskazują, że oporność na ten związek jest wynikiem zmienionego metabolizmu inaktywującego C-1748 oraz wzrostem ekspresji pompy błonowej ABCG2 a także innych białek transportowych typu ABC.
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Evolution of left ventricular function after Wharton's jelly mesenchymal stem cells transcoronary administration: 5-year follow up in a pilot cohort of CIRCULATE-AMI Randomized Trial
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The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells.
PublikacjaZaprezentowano wyniki badań biologicznych przeprowadzonych dla nowej grupy związków: estrów benzoperymidyny z zastosowaniem wybranych linii komórek nowotworowych: wrażliwych i opornych o oporności P-gp-zależnej, MRP1-zależnej i o oporności związanej z nadekspresją białek MRP1/LRP. Metodą spektrofluorymetryczną zbadano zdolność estrów benzoperymidyny do hamowania eksportu aktywnego pirarubicyny z komórek opornych. Estry benzoperymidyny...