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Wyniki wyszukiwania dla: alzheimer's disease.
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Reduced order models of refined Yee´s cells.
PublikacjaArtykuł opisuje nowe podejście zwiększające dokładność metody różnic skończonych za pomocą lokalnego zagęszczenia siatki. Obszar niewiele większy niż pojedyncza komórka Yee jest pokrywany gęstą siatką, a jej makromodel jest stworzony metodą redukcji rzędu modelu równań stanu w dziedzinie częstotliwości. Makromodele są użyte w metodach różnic skończonych w dziedzinie częstotliwości i czasu całej struktury. Inaczej niż w przypadku...
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Vitamin D receptor(s): In the nucleus but also at membranes?
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Quantum morphogenesis: A variation on Thom`s catastrophe theory.
PublikacjaZaproponowano nowy opis morfogenezy na poziomie kwantowym w oparciu o rozwiązania samo przełączające nieliniowego równania von Neumanna.
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Synthesis of S-thioacyl dithiophosphates, efficient and chemoselectivethioacylating agents
PublikacjaŁatwo dostępne ditiofosforany acylu izomeryzują do monotiofosforanów O- iS-tioacylu. Reakcja jest odwracalna, więc ogrzewanie ditiofosforanów acylu prowadzi zazwyczaj do powstania mieszaniny izomerycznych bezwodników, która nie może być wykorzystana do wydajnego tioacylowania. Jednak działaniem kwasu ditiofosforowego na mieszaninę izomerycznych bezwodników można wydajnie otrzymać ditiofosforany tioacylu. Związki te to doskonałe...
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S-thioacyldithiophosphates in the synthesis of thiohydroxamic acids and O-thioacylhydroxylamines
PublikacjaDitiofosforany tioacylu to trwałe, łatwo osiągalne z kwasów karboksylowych środki tioacylujące. Z powodu ich niskiej reaktywności wobec nukleofili tlenowych i wysokiej wobec nukleofili azotowych znalazły zastosowanie w syntezie kwasów tiohydroksamowych bezpośrednio z hydroksyloamin z niechronioną grupą hydroksylową. W przypadku dużej zawady przestrzennej można otrzymać O-tioacylohydroksyloaminy.
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Correction to: Azo group(s) in selected macrocyclic compounds
PublikacjaIn the original publication of the article, a part of Scheme 12 was missed. The correct version of Scheme 12 was provided in this correction article. The original article has also been corrected.
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Shub’s conjecture for smooth longitudinal maps of S^m
PublikacjaLet f be a smooth map of the m-dimensional sphere Sm to itself, preserving the longitudinal foliation. We estimate from below the number of fixed points of the iterates of f , reduce Shub’s conjecture for longitudinal maps to a lower dimensional classical version, and prove the conjecture in case m = 2 and in a weak form for m = 3.
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S&YP + Mentors + Peace + Love = Science and Growing
PublikacjaIn this extraordinarily difficult time, we understand better that only peace, love, and cooperation are the keys to growing in technology for humanity. Let us learn from our mentors how they grow from their hard work and international cooperation. Thanks to Prof. Giuseppe Buja and Prof. Zbigniew Krzemiński, we have unique schools of adjustable speed drives that are helping people convert electrical to mechanical power and vice...
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(S)-trans-cyclohexane-1,2-dicarboximide. Acta Cryst. Sect.C Crystal Struct.Commun.**2002 vol. 58 s. 0661-0662, 2 rys. 2 tab. bibliogr. 12 poz. Imid kwasu (S)-trans-cykloheksanodikarboksylowego.
PublikacjaAnaliza rentgenograficzna monokryształów imidu kwasu (S)-trans-cykloheksano-dikarboksylowego wykazała, że imidowy chromofor jest znacznie odkształconyod planarności. Fragment pięcioczłonowego pierścienia zawierający funkcjęimidową jest silnie pofałdowany i przyjmuje konformację typu półkrzesła.Pierścień sześcioczłonowy występuje w nieznacznie zniekształconej konforma-cji typu krzesło. W sieci krystalicznej cząsteczki...
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Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
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Knowledge and Attitudes of Future Healthcare Professionals Toward Rare Diseases
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Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases
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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
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Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
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Metals in the environment as risk factors for infectious diseases: gaps and opportunities
PublikacjaThis chapter aims to provide insights into current knowledge and gaps in our understanding of the influence that trace metals in the environment have on the pathogenesis of infectious diseases. By reducing immune function, trace metal deficiencies may substantially contribute to the global burden of diarhea, pneumonia, and malaria. Improved methods and biomarkers for assessing the risk of trace metals deficiencies and toxicities...
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Sample preparation and recent trends in volatolomics for diagnosing gastrointestinal diseases
PublikacjaThe analysis of the human volatilome can be successfully used for rapid and non-invasive diagnostics of gastrointestinal diseases. However, the introduction of techniques based on detection of volatiles is limited, among other factors, by difficulties which arise during the sampling stage and instrumental analysis. The aim of this article was to review and discuss medical and analytical literature on the analysis of volatiles in...
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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases
PublikacjaDespite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around theworld. The resistance of cancer cells to the drugs remains a significant problem in oncology today,while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new...
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Tetra-n-butylammonium iodido(pyrrolidine-1-carbodithioato-κ2S,S')(tris-tert-butoxysilane-thiolato-κS)cadmate(II)
PublikacjaTytułowy (N,N tetrametylenoditiokarbaminiano)(tri-tert-butoksysilanotiolano)jodokadmian tetra-n-butyloamoniowy krystalizuje w układzie jednoskośnym, w grupie P21/c. W anionie [Cd{SSi(OtBu)3}(S2CNC4H9)I]() wyróżnić można centralny rdzeń o składzie CdS3I. Ułożenie atomów donorowych może być, w pierwszym przybliżeniu, opisane jako zniekształcony (ze względu na obecność S,S'-chelatującego liganda) tetraedr z największym kątem S1-Cd1-S2...
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Augmentation index, pulse pressure amplification and superoxide anion production in patients with coronary artery disease
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Influence of increased arterial stiffness on myocardial work efficiency in patients with stable coronary artery disease
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Integrative multiomics study for validation of mechanisms in radiation-induced ischemic heart disease in Mayak workers
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
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Interaction of HLA-DRB1 Alleles with CTLA-4 in the Predisposition to Graves' Disease: The Impact of DRB1*07
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High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
PublikacjaBACKGROUND: It is not clear which species of bacteria may be involved in inflammatory bowel disease (IBD). One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls. AIMS: (1) To assess the diversity of microbial communities of biopsy tissue using culture-independent methods; (2) to culture the bacteria...
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Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats
PublikacjaHuntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the extension of the CAG repeats in exon 1 of the HTT gene and is transmitted in a dominant manner. The present study aimed to assess whether patients’ sex, in the context of mutated and normal allele length, contributes to age on onset (AO) of HD. The study population comprised a large cohort of 3723 HD patients from the European Huntington’s Disease...
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublikacjaIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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Artificial intelligence support for disease detection in wireless capsule endoscopy images of human large bowel
PublikacjaIn the work the chosen algorithms of disease recognition in endoscopy images were described and compared for theirs efficiency. The algorithms were estimated with regard to utility for application in computer system's support for digestive system's diagnostics. Estimations were achieved in an advanced testing environment, which was built with use of the large collection of endoscopy movies received from Medical University in Gdańsk....
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Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
PublikacjaAmong cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease...
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis
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Alzheimer's and Dementia: Translational Research and Clinical Interventions
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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ADVANCES IN CHRONIC KIDNEY DISEASE
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DISEASE MANAGEMENT & HEALTH OUTCOMES
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Degenerative Neurological and Neuromuscular Disease
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Therapeutic Advances in Respiratory Disease
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American Journal of Cardiovascular Disease
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Allergy Asthma & Respiratory Disease
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Current Infectious Disease Reports
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Australasian Plant Disease Notes
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Functional Foods in Health and Disease
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Travel Medicine and Infectious Disease
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Journal of Clinical Neuromuscular Disease
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Journal of Cardiovascular Development and Disease
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Therapeutic Advances in Musculoskeletal Disease
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Journal of Cardiovascular Disease Research
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npj Aging and Mechanisms of Disease
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Therapeutic Advances in Cardiovascular Disease
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Nature Reviews Disease Primers
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Therapeutic Advances in Chronic Disease
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Endoscopic Forum for Digestive Disease
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