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Wyniki wyszukiwania dla: John Schroeder
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Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor
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Elemental and water-insoluble organic carbon in Svalbard snow: a synthesis of observations during 2007–2018
PublikacjaLight-absorbing carbonaceous aerosols emitted by biomass or fossil fuel combustion can contribute to amplifying Arctic climate warming by lowering the albedo of snow. The Svalbard archipelago, being near to Europe and Russia, is particularly affected by these pollutants, and improved knowledge of their distribution in snow is needed to assess their impact. Here we present and synthesize new data obtained on Svalbard between 2007...
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Cancer-selective, single agent chemoradiosensitising gold nanoparticles
PublikacjaTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and...
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Inhibitor kinazy Brutona u chorych z nawrotowym lub opornym na leczenie chłoniakiem z komórek płaszcza – wyniki międzynarodowego, wieloośrodkowego, badania II fazy z ibrutynibem (PCI-32765) – EHA Encore
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Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
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Considerations for artificial intelligence clinical impact in oncologic imaging: an AI4HI position paper
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Global Trends 2022
Kursy OnlineThe course reflects on the different models of capitalism, starting with the debate on "Varieties of capitalism". It will deal with the relationships between historical dimension, juridical and economic cultures, institutions, financial markets and ownership structures in today's world economy. The aim of the course is trying to give an answer to a couple of very simple questions: why economic systems react in a different way...
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Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study
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Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study
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Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline
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Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
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Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT
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Corrigendum: Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
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Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
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Smart Garden Suburb_Urban design II 2022/23
Kursy OnlineIn the twenty-first century the idea of living in a perfect place combines the need for beauty&identity of the place with the ecology. Metropolises around the world are waiting for concepts that will expose the landscape values and give life in the suburbs high quality including energy efficiency and climate neutrality. A new concepts of are being discussed. Join this trend and look for solutions which merge expression of beauty...
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Urban Design II _ New Urban Living 2023/24
Kursy OnlineIn the twenty-first century the idea of living in a perfect place combines the need for beauty&identity of the place with the ecology. Metropolises around the world are waiting for concepts that will expose the landscape values and give life in the suburbs high quality including energy efficiency and climate neutrality. A new concepts of are being discussed. Join this trend and look for solutions which merge expression of beauty...
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Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study
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Lenalidomide versus investigator's choice in relapsed or refractory mantle cell lymphoma (MCL-002; SPRINT): a phase 2, randomised, multicentre trial
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Sposób modyfikowania grupami bisfosfonowymi i/lub fosfonowymi materiałów węglowych zwłaszcza nanomateriałów
WynalazkiModyfikacji grupami bisfosfonowymi i/lub fosfonowymi poddaje się nanomateriały węglowe np. nanorurki, tlenek grafenu, węgiel aktywny, tlenek grafitu, węgiel podobny do diamentu. Zastosowanie tego sposobu umożliwia jednoetapowe, proste i niedrogie otrzymywanie materiałów węglowych z grupami bisfosfonowymi. Z procesu technologicznego łatwo usuwa się nadmiar ciekłych reagentów, z możliwością zawrócenia...
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Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial
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Crystal growth of CsCl-type Yb0.24Sn0.76Ru
PublikacjaWzrost kryształów o stechiometrii Yb0.24Sn0.76Ru został przeprowadzony metodą topnikową. Kryształy poddano badaniom dyfrakcyjnym a także mikroskopii elektornowej. Yb0.24Sn0.76Ru krystalizuje w sześciennej strukturze typu chlorku cezu (CsCl).
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Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma
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Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?
PublikacjaDuring the last decade, there has been a growing interest in understanding food's digestive fate in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore, simple in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments. Thus,...
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2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)
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2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension
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2013 ESH/ESC Guidelines for the management of arterial hypertension
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2013 ESH/ESC Guidelines for the management of arterial hypertension
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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
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Impacts of salvage logging on biodiversity: A meta-analysis
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublikacjaThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea
PublikacjaAmong nanomaterials, silver nanoparticles (AgNPs) have the broadest and most commercial applications due to their antibacterial properties, highlighting the need for exploring their potential toxicity and underlying mechanisms of action. Our main aim was to investigate whether AgNPs exert toxicity by inducing oxidative damage to DNA in human kidney HEK 293 cells. In addition, we tested whether this damage could be counteracted...
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Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
PublikacjaIn eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...
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2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
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2018 Practice guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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International Expert Consensus Statement
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Direct brain stimulation modulates encoding states and memory performance in humans
PublikacjaPeople often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting,...
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Progress in upscalingMiscanthusbiomass production for the European bio-economy with seed-based hybrids
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Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document
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Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document
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A standardised static in vitro digestion method suitable for food – an international consensus
PublikacjaSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
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Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study
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Belief in a zero-sum game and subjective well-being across 35 countries
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Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment
PublikacjaCritical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute the structures of the most structurally challenging proteins coded for in the SARS-CoV-2 genome. Forty-seven research groups submitted over 3000 three-dimensional models and 700 sets of accuracy estimates on...
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INFOGEST static in vitro simulation of gastrointestinal food digestion
PublikacjaDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
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Zdolni z Pomorza 2020/21 - O kompleksach słów kilka…
Kursy OnlineKompleksy towarzyszą każdemu z nas – nawet osobom najbardziej pogodnym. Mamy je we krwi. Dzięki związkom kompleksowym życie (jakie znamy) jest w ogóle możliwe… Związki kompleksowe to połączenia metali i ich jonów z ligandami (którymi mogą być organiczne lub nieorganiczne cząsteczki lub jony) poprzez wiązania koordynacyjne. Wiązania takie powstają gdy wolna para elektronowa liganda jest uwspólniana z centrum metalicznym – atom metalu...
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2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
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