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DNA methylation in cancer development, diagnosis and therapy-multiple opportunities for genotoxic agents to act as methylome disruptors or remediators
PublikacjaThe role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number...
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Development and validation of a GC–MS/MS method for the determination of 11 amphetamines and 34 synthetic cathinones in whole blood
PublikacjaPurpose Psychoactive compounds that contain a phenylethylamine structure (such as amphetamine-type stimulants and synthetic cathinones) are one of the major classes of stimulants on the recreational drug market. Approximately 670 new psychoactive substances (NPS) are monitored only in Europe; however, new psychoactive compounds are being developed for illicit trade each year. In this context, the development of new analytical procedures...
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Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
PublikacjaLow-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evaluated experimentally in terms of their lipophilicity by means of reverse-phase and immobilized artificial membrane high-performance liquid chromatography. Subsequently, the selected compounds...
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The Development of a Combined Method to Quickly Assess Ship Speed and Fuel Consumption at Different Powertrain Load and Sea Conditions
PublikacjaDecision support systems (DSS) recently have been increasingly in use during ships operation. They require realistic input data regarding different aspects of navigation. To address the optimal weather routing of a ship, which is one of the most promising field of DSS application, it is necessary to accurately predict an actually attainable speed of a ship and corresponding fuel consumption at given loading conditions and predicted...
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Wind Conditions at Pedestrian Level in Different Types of Residential Urban Development for a High Degree of Land Use Efficiency
PublikacjaThe paper concerns wind conditions around urban building development at the pedestrian level. The article aims to identify aerodynamic phenomena around three types of multi-family housing developmentswith different forms and the same urban parameters of building development intensity (high intensity was taken into account). The aim of the research was mainly to achieve qualitative results that would lead to understanding fundamental...
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Challenges associated with development of AUV - unmanned autonomous underwater vehicles to be operated using the AI-based control systems
PublikacjaThe last decade has been devoted towards further development of the UUV unmanned underwater vehicles which may be of two types. There are the USV unmanned surface vehicles and UUV unmanned underwater vehicles. There is a growing interest to work out and implement the fully advanced AUV autonomous underwater vehicles. The main drivers towards development of such the vehicles are the technologies of autonomous systems, sensors and...
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Development of cluster analysis methodology for identification of model rainfall hyetographs and its application at an urban precipitation field scale
PublikacjaDespite growing access to precipitation time series records at a high temporal scale, in hydrology, and particularly urban hydrology, engineers still design and model drainage systems using scenarios of rainfall temporal distributions predefined by means of model hyetographs. This creates the need for the availability of credible statistical methods for the development and verification of already locally applied model hyetographs....
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From the Concept to Results: A Case Study on the Collection Development for the ODC–Opening Day Collection at Qatar National Library
Publikacja"A library collection should fit the mission for which it is created. The number of books it holds does not determine its worth." (E. J. Loveland, 2000) If so, how do we create a national library, and how do we build its collection from scratch without making many mistakes? Since 2012, when the plans for the new national library were announced, Qatar National Library (QNL) envisioned as carrying out its mission to "spread knowledge,...
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The Impact of Spatiotemporal Changes in Land Development (1984–2019) on the Increase in the Runoff Coefficient in Erbil, Kurdistan Region of Iraq
PublikacjaNowadays, geospatial techniques are a popular approach for estimating urban flash floods by considering spatiotemporal changes in urban development. In this study, we investigated the impact of Land Use/Land Cover (LULC) changes on the hydrological response of the Erbil basin in the Kurdistan Region of Iraq (KRI). In the studied area, the LULC changes were calculated for 1984, 1994, 2004, 2014 and 2019 using the Digital Elevation...
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublikacjaThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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The Application of a Multi-Criteria Decision-Making for Indication of Directions of the Development of Renewable Energy Sources in the Context of Energy Policy
PublikacjaThis paper presents the application of multi-criteria decision-making (MCDM) for evaluating what technologies using renewable energy sources (RES) for electricity production have the chance to develop in Poland under the current socio-economic conditions. First, the Analytical Hierarchy Process (AHP) method was used to determine the weights of the optimization criteria. Five main criteria and 30 sub-criteria were identified. Next,...
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Review of intelligent software architectures for the development of an intelligent decision support system for design process planning in concurrent engineering
PublikacjaW artykule poddano dogłębnej analizie szereg inteligentnych technik miękkie-go modelowania pod katem ich przydatności w obszarze wspomagania procesówplanowania dla inżynierii współzadaniowej. Skoncentrowano się na wspomaganiujednego z najważniejszych obszarów inżynierii współzadaniowej, a mianowicieprocesu projektowania. W wyniku analizy zaproponowano architekturę wspomaga-nia opartą na tablicowej bazie wiedzy modelującej wnioskowanie...
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ASIA PACIFIC JOURNAL OF SOCIAL WORK AND DEVELOPMENT
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Early Years: An International Journal of Research & Development
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International Journal of Human Resources Development and Management
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Journal of Cultural Heritage Management and Sustainable Development
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International Review for Spatial Planning and Sustainable Development
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Almatourism-Journal of Tourism Culture and Territorial Development
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African Journal of Science Technology Innovation & Development
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Journal of Agriculture Food Systems and Community Development
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International Journal of Renewable Energy Development-IJRED
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ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT
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Expert Review of Precision Medicine and Drug Development
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Indian Journal of Public Health Research and Development
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World Journal of Entrepreneurship Management and Sustainable Development
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International Journal of Technological Learning, Innovation and Development
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World Review of Entrepreneurship, Management and Sustainable Development
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African Journal of Food, Agriculture, Nutrition and Development
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International Journal of Social Ecology and Sustainable Development
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World Review of Science, Technology and Sustainable Development
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World Journal of Science Technology and Sustainable Development
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International Journal of Technology Management and Sustainable Development
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Central European Journal of Geography and Sustainable Development
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International Journal of Teacher Education and Professional Development
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INTERNATIONAL JOURNAL OF SUSTAINABLE DEVELOPMENT AND WORLD ECOLOGY
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JOURNAL OF AGRICULTURE AND RURAL DEVELOPMENT IN THE TROPICS AND SUBTROPICS
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Journal of Scientific Papers “Social development & Security”
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The Unique Mechanisms of Cellular Proliferation, Migration and Apoptosis are Regulated through Oocyte Maturational Development—A Complete Transcriptomic and Histochemical Study
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Pomoszcz Ministerstwa Inostrannych del Polszy Armenji, Azerbejdzżany i Gruzji = Polish Development Assistance for Armenia, Azerbaijan and Georgia
PublikacjaGeorgia has been one of the priority areas of development assistance of Polish Ministry of Foreign Affairs from 2004, because it plays a important role in Polish forsign policy in the framework of the Eastern Partnership. The largest amounts of development aid supporting the transformation were allocated for this country. Since founding the Eastern Partnership initiative in 2009 also Azerbaijan and Armenia have been included to...
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Fatigue damage development in 10CrMo9-10 steel for power plant pipes in as-received state and after 280,000 h of exploitation
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Monitoring of fatigue damage development in as-received and exploited 10CrMo9-10 power engineering steel supported by Digital Image Correlation
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Using AOP-Wiki to support the ecotoxicological risk assessment of nanomaterials: first steps in the development of novel adverse outcome pathways
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Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro
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Potential Predictive Value of Serum Pentraxin 3 and Paraoxonase 1 for Cardiometabolic Disorders Development in Patients with Psoriasis—Preliminary Data
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Five years of innovations in development of glow discharges generated in contact with liquids for spectrochemical elemental analysis by optical emission spectrometry
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Influence of some anthropometric parameters on the risk of development of distal complications after mastectomy carried out because of breast carcinoma
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Development and Validation of a Gas Chromatography Method for the Trace Level Determination of Allylamine in Sevelamer Hydrochloride and Sevelamer Carbonate Drug Substances
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The Influence of Limiters UEL and OEL (The power angle, stator's current and excitation current) ot the possibility of voltage collapse development
PublikacjaVoltage stability has been a major concern for power system utilities because of event of voltage collapses in the recent past. Sometimes, power system events have shown the need for generators to operate in the overexcited and underexcited region to support stable operation. Modern excitation systems include devices for controlling or limiting machine terminal voltage (overvoltage limiters), volts per hertz ratio (V/Hz limiters),...
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Planowanie rozwoju sieci dystrybucji energii elektrycznej na obszarach miejskich = Planning of development of the urban electricity distribution network
PublikacjaReferat przedstawia opis rozwiązania problemu planowania rozwoju sieci dystrybucji energii elektrycznej na obszarach miejskich. Rozwiązanie uzyskuje się w drodze zaprogramowania rozwoju z wykorzystaniem algorytmu genetycznego. Uwzględniane są dane o zawodności istniejącej infrastruktury i jej ograniczenia przesyłowe. Podjęto również próbę odwzorowania możliwych do wyboru tras prowadzenia linii kablowych. Funkcja zdatności rozwiązania...
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Assessment of the Development Potential of Post-Industrial Areas in Terms of Social, Economic and Environmental Aspects: The Case of Wałbrzych Region (Poland)
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