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Search results for: RATIONAL DRUG DESIGN
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Design of dimensionally stable composites using efficient global optimization method
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Design and numerical testing of 5-box gfrp shell footbridge
PublicationThe paper formulates new design conditions for composite footbridges, taking into account the material and structural specificity of these objects, i.e. the strength condition, the serviceability condition and the frequency condition. A GFRP composite footbridge labelled with CFB2 code has been designed, with the original superstructure in the form of an opened-closed 5-box girder. The foot and cycle track bridge is simply supported,...
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Structural Health Monitoring of Composite Shell Footbridge for Its Design Validation
PublicationThe paper presents the structural health monitoring system of the composite bridge for pedestrians and cyclists. The footbridge was designed and manufactured within the FOBRIDGE project. It is the first bridge in the world, which is classified as a consistent single element structural girder, made of sandwich shells, entirely produced in a single cycle. The developed structural health monitoring system, supported design process,...
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Kierunki wykorzystania koncepcji design - thinking w doskonaleniu obszaru rejestracji i poczekalni przychodni
PublicationW niniejszym rozdziale przedstawiono podstawowe aspekty wykorzystania koncepcji design-thinking w doskonaleniu jakości usług zdrowotnych. Autorzy zaprezentowali specyficzny charakter usług zdrowotnych w odnisieniu do samej usługi, jej jakości oraz metod jej doskonalenia. Następnie poprzez zdiagnozowanie składowych łańcucha wydarzeń chronologicznych związanych z realizacją usługi medycznej, wydzielono obszar rejestracji i poczekalni,...
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Low-Cost Unattended Design of Miniaturized 4 × 4 Butler Matrices with Nonstandard Phase Differences
PublicationDesign of Butler matrices dedicated to Internet of Things and 5th generation (5G) mobile systems—where small size and high performance are of primary concern—is a challenging task that often exceeds capabilities of conventional techniques. Lack of appropriate, unified design approaches is a serious bottleneck for the development of Butler structures for contemporary applications. In this work, a low-cost bottom-up procedure for...
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PARAMETERS OF BUILDING GEOMETRY THAT AFFECT WIND FLOW WITH REGARDS TO THE POSSIBILITIES FOR THEIR IMPLEMENTATION IN URBAN AND ARCHITECTURAL DESIGN IN POLAND
PublicationIn recent years, there has been a surge in Computational Fluid Dynamics (CFD) research into how urban morphology affects ventilation in cities. However, studies are scattered, with varying parameter definitions, limiting their application in architectural and urban design. This article aims to review and assess the relevance of geometric parameters studied in aerodynamics field to urban planning and architectural design in polish...
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CAD. Integrated Architectural Design BSc in Arch., sem 3 2022/2023
e-Learning CoursesDuring the course students will learn how to use BIM (Building Information Modelling) tools to model the project site and to develop preliminary design concept.Students will work in pairs or groups, using Autodesk Revit software for terrain, site and building modelling.
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Applications of Cannabis Sativa L. in Food and Its Therapeutic Potential: From a Prohibited Drug to a Nutritional Supplement
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Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles
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<p>Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials</p>
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Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines
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Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug
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Molecular characterization of drug-resistant Mycobacterium tuberculosis strains from Poland by use of multiple genetic markers
PublicationW pracy przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis, izolowanych od pacjentów z Polski.
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Eucalyptol/ β-cyclodextrin inclusion complex loaded gellan/PVA nanofibers as antifungal drug delivery system
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Novel “soft” biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system
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Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers
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Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
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Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study
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In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system
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Discovery of the anticancer drug vinblastine from the endophytic Alternaria alternata and yield improvement by gamma irradiation mutagenesis
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Electrochemical and biological characterization of lyotropic liquid crystalline phases – retardation of drug release from hexagonal mesophases
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Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima
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Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process
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Expedited Trust-Region-Based Design Closure of Antennas by Variable-Resolution EM Simulations
PublicationThe observed growth in the complexity of modern antenna topologies fostered a widespread employment of numerical optimization methods as the primary tools for final adjustment of the system parameters. This is mainly caused by insufficiency of traditional design closure approaches, largely based on parameter sweeping. Reliable evaluation of complex antenna structures requires full-wave electromagnetic (EM) analysis. Yet, EM-driven...
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SPACIAL FORM DESIGN scale 1:1
e-Learning CoursesBrief description: The subject matter of the spatial form design classes is transformation. First, a black square becomes a flat graphic composition, which is then converted to color. The final stage of the transformation process is a spatial object, which is by assumption devoid of any utilitarian functions. Course content / classes schedule: 1. Graphic. The task is to create an achromatic flat composition in the contrast...
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Mechatronic Design Towards Investigation of the Temporo-Mandibular Joint Behaviour
PublicationA significant problem of the temporo-mandibular joint (TMJ) research is lack of data concerning geometry and position of TMJ discs. It leads to necessity of developing a driving method of the process optimization, which is based on chosen techniques of mechatronic design. In particular, the latter concerns a technique of experimentally supported virtual prototyping. On this stage, the research is characterized by well-verified...
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Design of three control algorithms for an averaging tank with variable filing
PublicationAn averaging tank with variable filling is a nonlinear multidimensional system and can thus be considered a complex control sys-tem. General control objectives of such object include ensuring stability, zero steady state error and achieving simultaneously shortest possible settling time and minimal overshoot. The main purpose of this research work was the modelling and synthesis of three control systems for an averaging tank. In...
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On Alternative Approaches to Design of Corporate Feeds for Low-Sidelobe Microstrip Linear Arrays
PublicationTwo design approaches, illustrated by simulations and measurements, aiming at a systematic computer-aided design of printed circuit feeds for low-sidelobe microstrip antenna arrays are described. The novelty of these approaches resides in identification of the optimal feed architectures with subsequent simulation-based optimization of the feed and array aperture dimensions. In this work, we consider microstrip corporate feeds realizing...
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Short review on the design and application of fractionl delay Hilbert transform filter using Farrow structure
PublicationThis paper is treated as a brief summary of our hitherto research on the design and utilization of the FDHTF, particularly in the sub-samole delay estimator.
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Logistical Aspects of Energy Conversion Efficiency in Marine Steam Power Plants in Off-Design Conditions
PublicationThe paper presents logistical aspects of energy conversion efficiency in off-design conditions. The main part of the article is based on results of thermodynamic calculation for large propulsion steam turbine under partial loads. Calculations are made on extended mathematical model of two proposed steam turbine thermodynamic cycles using Stodola’s cone law. The conclusion based on calculation re-sults contains importance of off-design...
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Coupled-Resonator Waveguide Filter in Quadruplet Topology With Frequency-Dependent Coupling - A Design Based on Coupling Matrix
PublicationThis letter presents an application of a recently developed coupling matrix synthesis technique to design of coupled-resonator filters with dispersive inter-resonator couplings. This technique is used to design a novel coupled-cavity bandpass filter. Measurements validate the design and confirm effectiveness of the synthesis method. The filter is a four-pole generalized Chebyshev filter with three transmission zeros. Resonators...
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20232024_Elective design II_CULTURAL HERITAGE ROUTES_Gdańsk Drawing architecture to understand the city
e-Learning CoursesCultural Heritage Routes – Gdańsk. This course explores challenges, conflicts and concepts of cultural heritage preservation and protection at urban level, their connection to architectural and urban design in the time of digitalisation and their importance for a future of the cities. The aim of this course, based on the case study city of Gdańsk, is to understand the problem of cultural heritage and develop innovative...
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Designing learning spaces through international and interdisciplinary collaborative design studio: The case of engineer architects and pedagogic students
PublicationThe study explores the dynamics and outcomes of an international interdisciplinary design studio focusing on innovative learning spaces. Conducted over two years between students of Faculty of Architecture at Gdansk Tech and pedagogic students from Kibbutzim College in Tel Aviv, this design-based study examines the contributions of unique educational program to student learning, the evolution of the design process, collaboration,...
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Accurate design of pseudoelliptic inline SIW filters with frequency-dependent couplings
PublicationThis paper presents an accurate synthesis method for inline SIW (Substrate Integrated Waveguide) generalized Chebyshev bandpass filters with frequency-dependent couplings. The technique is based on the synthesis of a coupling matrix that takes into account the impedance of the frequency-dependent stub. Thus, a loading effect compensation in adjacent resonators (via resonant frequency adjustment) and coupling elements (via coupling-value...
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An interactive system for remote modeling and design validation of hybrid photovoltaic systems
PublicationIn the paper a multi-functional demonstrator of the interactive system designed to modeling, monitoring and validation of hybrid photovoltaic systems assisted by fuel cells and thermoelectric generators is presented. The purpose of this paper is to report the system solution expressed in the form of a block diagram. Technical parameters of demonstrator components such as: silicon photovoltaic modules, fuel cells, thermoelectric...
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Rapid design closure of linear microstrip antenna array apertures using response features
PublicationA simple yet reliable approach to a rapid design closure of linear antenna array apertures at the electromagnetic (EM)-simulation level is proposed. Our methodology exploits an underlying array factor (AF) model suitably corrected by means of characteristic points (angles and levels) of the radiation pattern of the EM model of the antenna array aperture. This conveniently allows for controlling both the side lobe levels...
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Expedited Design Closure of Antennas By Means Of Trust-Region-Based Adaptive Response Scaling
PublicationIn the letter, a reliable procedure for expedited design optimization of antenna structures by means of trust-region adaptive response scaling (TR-ARS) is proposed. The presented approach exploits two-level electromagnetic (EM) simulation models. A predicted high-fidelity model response is obtained by applying nonlinear frequency and amplitude correction to the low-fidelity model. The surrogate created this way is iteratively rebuilt...
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HILS for the Design of Three-Wheeled Mobile Platform Motion Surveillance System with a Use of Energy Performance Index
PublicationCurrent tendency in mechatronic design requires the use of comprehensive development of an environment, which gives the possibility to prototype, design, simulate and integrate with dedicated hardware. The paper discusses the Hardware-In-the-Loop Simulations (HILS) mechatronic technique, used during the design of the surveillance system based on energy performance index. The presented test configuration (physical controller – emulated...
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A structure and design optimization of novel compact microscrip dual-band rat-race coupler with enhanced bandwidth
PublicationIn the letter, a topology of a novel compact wideband dual-band rat-race coupler has been presented along with its computationally efficient design optimization procedure. Reduction of the circuit size has been achieved by meandering transmission lines of the conventional circuit. At the same time, the number of independent geometry parameters has been increased so as to secure sufficient flexibility of the circuit, necessary in...
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Computer Aided Design - 2022/23
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Design thinking 2021/2022 NSZ
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Design Thinking ZI 2024/2025
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Computer Aided Design 23/24
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Urban design IV (Breś, Krośnicka)
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Urban design IV Krośnicka Breś
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Rapid multi-objective design optimization of miniaturized impedance transformer by Pareto front exploration
PublicationFast multi-objective optimization of compact impedance transformer is discussed. A set of alternative designs representing possible trade-offs between conflicting design criteria, i.e., electrical performance (here, wideband matching) and the structure size, is obtained through Pareto front exploration by means of surrogate-assisted methods.
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Cost-efficient multi-objective design optimization of antennas in highly-dimensional parameter spaces
PublicationMulti-objective optimization of antenna structures in highly-dimensional parameter spaces is investigated. For expedited design, variable-fidelity EM simulations and domain patching algorithm are utilized. The results obtained for a monopole antenna with 13 geometry parameters are compared with surrogate-assisted optimization involving response surface approximation modeling.
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PODEJŚCIE WARIANTOWE WE WSTĘPNYM PROJEKTOWANIU STATKÓW Variant methods approach to the preliminary ship design.
PublicationKlasyczna metoda projektowania okrętów jest metodą iteracyjną, bazującą na zgromadzonym doświadczeniu ze statków już zbu-dowanych. Natomiast w przypadku statku całkowicie nowego typu, bez „posagu wcześniejszych doświadczeń”, projektowanie polega na opracowaniu szeregu równoległych, wariantowych rozwiązań z wykorzystaniem optymalizacji. Artykuł wskazuje wybrane metody projektowe wykorzystujące optymalizacje, używane we wstępnym...
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Nested Kriging with Variable Domain Thickness for Rapid Surrogate Modeling and Design Optimization of Antennas
PublicationDesign of modern antennas faces numerous difficulties, partially rooted in stringent specifications imposed on both electrical and field characteristics, demands concerning various functionalities (circular polarization, pattern diversity, band-notch operation), but also constraints imposed upon the physical size of the radiators. Conducting the design process at the level of full-wave electromagnetic (EM) simulations, otherwise...
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Design and Implementation of Multi-Band Reflectarray Metasurface for 5G Millimeter Wave Coverage Enhancement
PublicationA compact low-profile multi-band millimeter-wave (mm-wave) reflectarray metasurface design is presented for coverage enhancement in 5G and beyond cellular communication. The proposed single-layer metasurface exhibits a stable reflection response under oblique incidence angles of up to 60o at 24 and 38 GHz, and transmission response at 30 GHz, effectively covering the desired 5G mm-wave frequency bands. The proposed reflectarray...