Search
displaying 1000 best results Help
Search results for: cholinesterase inhibitory activity
-
Chemical Composition and Antimicrobial Activity of Selected Essential Oils against Staphylococcus spp. Isolated from Human Semen
Publication -
Chemical Composition, Antioxidant, In Vitro and In Situ Antimicrobial, Antibiofilm, and Anti-Insect Activity of Cedar atlantica Essential Oil
Publication -
Effect of psoriasis activity and topical treatment on plasma epidermal growth factor (EGF) and its soluble receptor (sEGFR)
Publication -
Effect of psoriasis activity on epidermal growth factor (EGF) and the concentration of soluble EGF receptor in serum and plaque scales
Publication -
Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity
Publication -
FBG Strain Monitoring of a Road Structure Reinforced with a Geosynthetic Mattress in Cases of Subsoil Deformation in Mining Activity Areas
Publication -
Glycerol and Natural Deep Eutectic Solvents Extraction for Preparation of Luteolin-Rich Jasione montana Extracts with Cosmeceutical Activity
Publication -
Occupational Burnout as a Consequence of Workaholism – An Outline of the Problem Based on Studies of Polish Women Running Their Own Business Activity
Publication -
Chitosan pyrolysis in the presence of a ZnCl2/NaCl salts for carbons with electrocatalytic activity in oxygen reduction reaction in alkaline solutions
PublicationThe one-step carbonization of low cost and abundant chitosan biopolymer in the presence of salt eutectics ZnCl2/NaCl results in nitrogen-doped carbon nanostructures (8.5 wt.% total nitrogen content). NaCl yields the spacious 3D structure, which allows external oxygen to easily reach the active sites for the oxygen reduction reaction (ORR) distinguished by their high onset potential and the maximum turnover frequency of 0.132 e...
-
Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
-
The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublicationJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
-
Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc
PublicationGlucosamine-6-phosphate (GlcN-6-P) synthase catalyses the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5' diphospho N-acetyl-D-glucosamine (UDPGlcNAc), is an essential substrate for assembly of bacterialand fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which makes it a potential target...
-
Surface properties and visible light activity of W-TiO2 photocatalysts prepared by surface impregnation and sol-gel method
PublicationTiO2 modyfikowany wolframem otrzymano dwiema metodami: metodą zol-żel oraz metodą impregnacji powierzchniowej. Fotokatalizatory kalcynowano w temperaturze 400C. Jako matrycę TiO2 zastosowano ST-01 (Ishihara Sangyo, Japonia, 300m2/g). jako prekursory wolframu zastosowano tlenek wolframu oraz heksakarbonylek wolframu. Badania obejmowały wpływ ilości domieszki na aktywność fotokatalityczną. Charakterystyka otrzymanych fotokatalizatorów...
-
Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity
PublicationHerein, the synthesis and application of functionalized quantum dot-based protease probes is described. Such probes are composed of nontoxic ZnO nanocrystals decorated by amino groups followed by linker and labeled peptide attachment. Spherical NH2-terminated ZnO quantum dots (QDs) with the average size ranging from 4 to 8 nm and strong emission centered at 530 nm were prepared using the sol−gel method. The fluorescence of ZnO...
-
Fatty acids as molecular carriers in cleavable antifungal conjugates
PublicationConjugates composed of C2-18 fatty acid (FA) residues as a molecular carrier and 5-fluorocytosine (5-FC) as an active agent, released upon the action of intracellular esterases on the ester bond between FA and “trimethyl lock” intramolecular linker, demonstrate good in vitro activity against human pathogenic yeasts of Candida spp. The minimal inhibitory concentrations (MIC) values for the most active conjugates containing caprylic...
-
Effects of Eccentric Speed during Front Squat Conditioning Activity on Post-activation Performance Enhancement of Hip and Thigh Muscles
Publication -
Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti-tumour imidazoacridinone C-1311 in human hepatoma cells
Publication -
Influence of pH of sol-gel solution on phase composition and photocatalytic activity of TiO 2 under UV and visible light
Publication -
Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C
Publication -
Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro
Publication -
Xanthine Oxidoreductase Activity in Platelet-Poor and Rich Plasma As a Oxidative Stress Indicator in Patients Required Renal Replacement Therapy
Publication -
Xanthine oxidoreductase activity in platelet-poor and rich plasma as a oxidative stress indicator in patients required renal replacement therapy
Publication -
Synthesis of Novel Phosphonic‐Type Activity‐Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms
Publication -
The Effect of Subinhibitory Concentrations of trans-Anethole on Antibacterial and Antibiofilm Activity of Mupirocin Against Mupirocin-Resistant Staphylococcus aureus Strains
Publication -
Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
PublicationPraca zawiera wyniki badań przedklinicznych pochodnej 1-nitroakrydyny C-1748 wobec komórek ludzkiego raka prostaty CaP in vitro, jak i przeszczepialnego na zwierzęta. W oparciu o fosforylację histonu H2AX jako markera podwójnych cięć DNA wykazano, że C-1748 jest bardziej aktywny w komórkach CaP niż HL60. Zidentyfikowano poza tym receptor androgenny (AR) jako cel molekularny badanego związku. W doświadczeniach na zwierzętach stwierdzono...
-
Photocatalytic activity of boron-modified TiO2 under visible light: The effect of boron content, calcination temperature and TiO2 matrix
PublicationPrzedstawiono wpływ temperatury kalcynacji (200, 300, 350, 400, 450 oraz 600oC) na fotoaktywność w świetle widzialnym (l> 400 nm) oraz właściwości powierzchniowe TiO2 modyfikowanego borem. B-TiO2 został przygotowany metodą impregnacji powierzchniowej. Jako prekursor bory wykorzystano ester trietylowy kwasu borowego (BATE). Charakterystyka otrzymywanych fotokatalizatorów obejmowała wyznaczenie powierzchni właściwej, właściwości...
-
Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension
Publication -
The activity of different extracts from Panax quinquefolium L. cultures against pathogenic Staphylococcus aureus with respect to ginsenoside content
Publication -
Quantification of Biodiversity Related to the Active Protection of Grassland Habitats in the Eastern Lublin Region of Poland Based on the Activity of Soil Enzymes
Publication -
Acute effects of unilateral and bilateral conditioning activity on countermovement jump, linear speed, and muscle stiffness: A randomized crossover study
Publication -
Inulin-type fructans trigger changes in iron concentration and activity of bone metabolism biomarkers in blood plasma of growing pigs
Publication -
Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives
Publication -
Phytotoxic Activity of Metabolites Isolated from Rutstroemia sp.n., the Causal Agent of Bleach Blonde Syndrome on Cheatgrass (Bromus tectorum)
Publication -
Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium
Publication -
Towards plant-mediated chemistry – Au nanoparticles obtained using aqueous extract of Rosa damascena and their biological activity in vitro
Publication -
Transmembrane Transport and Anticancer Activity of Strontium Ranelate Delivered with Nanosecond Pulsed Electric Fields (nsPEFs) into Human Cells in Vitro
Publication -
Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D2 Against Human Malignant Melanoma Cell Lines
Publication -
EFFECTS OF DOWNHILL AND UPHILL EXERCISES OF EQUIVALENT SUBMAXIMAL INTENSITIES ON SELECTED BLOOD CYTOKINE LEVELS AND BLOOD CREATINE KINASE ACTIVITY
Publication -
Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches
Publication -
Levels of Antioxidant Activity and Fluoride Content in Coffee Infusions of Arabica, Robusta and Green Coffee Beans in According to their Brewing Methods
Publication -
Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study
Publication -
Enhanced Activity and Sustained Release of Protocatechuic Acid, a Natural Antibacterial Agent, from Hybrid Nanoformulations with Zinc Oxide Nanoparticles
Publication -
Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16
Publication -
Influence of Dimerization of Lipopeptide Laur-Orn-Orn-Cys–NH2 and an N-terminal Peptide of Human Lactoferricin on Biological Activity
Publication -
Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12—Structural Analysis, Surface-Active Properties and Antimicrobial Activity
Publication -
Red phosphorus as self-template to hierarchical nanoporous nickel phosphides toward enhanced electrocatalytic activity for oxygen evolution reaction
Publication -
Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile—The Example of SRXN1 Gene
PublicationThe role of catechins in the epigenetic regulation of gene expression has been widely studied; however, if and how this phenomenon relates to the redox properties of these polyphenols remains unknown. Our earlier study demonstrated that exposure of the human colon adenocarcinoma HT29 cell line to these antioxidants affects the expression of redox-related genes. In particular, treatment with (−)-epigallocatechin (EGC) downregulated...
-
SOLUTIONS OF THE INTERMEDIATE SUPPORT STRUC- TURES OF THE NORTHERN MARMARA HIGHWAY (ISTAN- BUL’S RING ROAD) IN THE CONTEXT OF SEISMIC ACTIVITY
PublicationIn 2014–2018, as a result of the expansion of the city of Istanbul in Turkey, a project was imple- mented consisting of building a northern ring road, called the Northern Marmara Highway. The concept of the structural design of the ring road’s intermediate supports aims at constructing sup- ports that according to the TURKISH DLH 2008 standard must comply with the design require- ments for the three calculated earthquake insensitivity...
-
Design and Microwave-Assisted Synthesis of TiO2-Lanthanides Systems and Evaluation of Photocatalytic Activity under UV-LED Light Irradiation
PublicationThe TiO2-Eu and TiO2-La systems were successfully synthesized using the microwave method. Based on the results of X-ray diffraction analysis, it was found that regardless of the analyzed systems, two crystal structures were noted for the obtained samples: anatase and rutile. The analysis, such as XPS and EDS, proved that the doped lanthanum and europium nano-particles are present only on the TiO2 surface without disturbing the...
-
Activity of antimicrobial peptides and conventional antibiotics against superantigen positive Staphylococcus aureus isolated from patients with atopic dermatitis
Publication