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Search results for: cellular metabolism and energetics
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublicationBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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The complete list of two-dimensional number-conserving ternary cellular automata
Open Research DataThis dataset contains a complete list of all 1327 two-dimensional number-conserving cellular automata with the state set {0,1,2} (the so-called ternary cellular automata) based on adjacent cells only, i.e. with the von Neumann neighborhood. The detailed definitions and the method of enumerating are given in the paper:
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On the decomposition of stochastic cellular automata
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Coastal cellular distress system
PublicationPrzedstawiono koncepcję systemu bezpieczeństwa w morskiej strefie A1, opartego o istniejące sieci komórkowe GSM. System ten został opracowany dla potrzeb małych jednostek pływających (nieinstytucjonalnych), które mają ograniczony dostęp do zasobów systemu GMDSS. Zostały przeprowadzone również badania symulacyjne efektywności lokalizowania terminala ruchomego w warunkach morskich. Otrzymane rezultaty w wybranych warunkach spełniają...
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Oxidative Medicine and Cellular Longevity
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Updates in the Metabolism of Lactic Acid Bacteria
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Aberrations in Lipid Expression and Metabolism in Psoriasis
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Cellular blue nevus - Male, 38 - Tissue image [7110729594546711]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CELLULAR IMMUNOLOGY
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CELLULAR ONCOLOGY
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CELLULAR MICROBIOLOGY
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Cellular Reprogramming
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Cellular Logistics
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Theoretical study of the structure, energetics and vibrational frequencies of water-acetone and water-2-butanone complexes
PublicationKompleksy acetonu i 2-butanonu z 0-2 cząsteczkami wody połączonymi wiązaniem wodorowym z tlenem karbonylowym zbadano z wykorzystaniem teorii funkcjonału gęstości (DFT) na poziomie B3LYP/6-311++G(d,p). Obliczenia w fazie gazowej uzupełniono o optymalizacje w otoczeniu rozpuszczalnika, symulowanego za pomocą modelu polaryzowalnego kontinuum (PCM). Częstości drgań oscylacyjnych otrzymane na podstawie zależności empirycznej sa zgodne...
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Development of Biocompatible Fe3O4@SiO2 Nanoparticles as Subcellular Delivery Platform for Glucosamine-6-phosphate Synthase Inhibitors
PublicationNumerous inhibitors of glucoseamine-6-phophate synthase (GlcN-6-P), the enzyme responsible from catalysis of the first step of metabolic pathway leading to metabolism 5’-diphospho-N-acetyl-D- glucosamine, were reported as effective agents for inhibiting the growth of various fungal pathogens. Among the reported inhibitors,...
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Cellular Response to Unfolded Proteins in Depression
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Cellular and molecular basis of thyroid autoimmunity
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Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism
PublicationIn spite of the current advances and achievements in cancer treatments, colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in both men and women worldwide. Drug resistance, adverse side effects and high rate of angiogenesis, metastasis and tumor relapse remain one of the greatest challenges in long-term management of CRC and urges need for new leads of anticancer drugs. We demonstrate that CRC...
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Glucose metabolism disorders in patients with non-functioning adrenal adenomas — single-centre experience
PublicationIntroduction: The presence of glucose metabolism disorders and their possible correlation with degree of cortisol secretion were evaluated in patients with non-functioning adrenal incidentalomas (NFAIs). Material and methods: The study group consisted of 131 patients with hormonally inactive adrenal incidentalomas....
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Design of a Cellular Dual-Band Sticker Antenna for Thickness-Independent 3D-Printed Substrates
PublicationAdditive manufacturing technology provides high flexibility in designing custom enclosures for prototype devices such as nodes of distributed sensor networks. Although integration of components is desired from the perspective of sensor mobility, it might negatively affect the performance of radio-connectivity due to couplings between the antenna and system peripherals, as well as other unaccounted effects of the 3D printed enclosure....
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Cell Metabolism
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Molecular Metabolism
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Endocrinology and Metabolism
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Cancer & Metabolism
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Heart and Metabolism
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Obesity and Metabolism
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Nutrition & Metabolism
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Nature Metabolism
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Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects
PublicationDistinguishing feature of the outer membrane (OM) of Gram-negative bacteria is its asymmetry due to the presence of lipopolysaccharide (LPS) in the outer leaflet of the OM and phospholipids in the inner leaflet. Recent studies have revealed the existence of regulatory controls that ensure a balanced biosynthesis of LPS and phospholipids, both of which are essential for bacterial viability. LPS provides the essential permeability...
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublicationNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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Gene Expression and Activity Profiling Reveal a Significant Contribution of Exo‐Phosphotransferases to the Extracellular Nucleotides Metabolism in HUVEC Endothelial Cells
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublicationIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
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Molecular mechanism and energetics of coupling between substrate binding and product release in the F 1 -ATPase catalytic cycle
PublicationF1-ATPase is a motor protein that couples the rotation of its rotary γ subunit with ATP synthesis or hydrolysis. Single-molecule experiments indicate that nucleotide binding and release events occur almost simultaneously during the synthesis cycle, allowing the energy gain due to spontaneous binding of ADP to one catalytic β subunit to be directly harnessed for driving the release of ATP from another rather than being dissipated...
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Planning cellular machining systems for lean production.
PublicationRozważano zagadnienie projektowania struktur systemów obróbki o zdeterminowanych możliwościach technologicznych, odpowiadających wymaganiom oszczędnej produkcji. Przedstawiono model matematyczny wyznaczania struktur systemów grupowego wytwarzania, wykorzystujący zasady formalizmu relacji i grafów rozmytych. Zawarto wyniki badań symulacyjnych efektywności procesów wytwarzania określonego spektrum przedmiotowego, przebiegających...
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Cellular Interactions in the Intestinal Stem Cell Niche
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Applying artificial intelligence for cellular networks optimization
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A Statistical Approach to the Identification of Diploid Cellular Automata
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Non invasive optical cellular imaging in humans.
PublicationOne of the most appealing and still unsolved problems in biological and medical imaging is the possibility of noninvasive visualization of tissue in vivo with an accuracy of microscopic examination. A major difficulty to solve in biomedical imaging is a degradation of image quality caused by the presence of optical inhomogeneity of tissue. Is there any chance to develop a microscopic method that allows non-invasive observation...
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Application of a cellular automata model to granular flow
PublicationPrzedstawiono wyniki modelowania przepływów granulowanych przy zastosowaniu automatu komórkowego. Obliczenia wykonano dla silosów ze wstawkami i ścianką szczelną. Przyjęto różne schematy propagacji ziaren.
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Application of an improved cellular automaton for granular flow.
PublicationW artykule omówiono wyniki numeryczne z zastosowaniem ulepszonego aparatu komórkowego do przepływów silosowych materiałów granulowanych. W modelu uwzgledniono zderzenia cząstek i dysypację energii. Wyniki porównano z wynikami badań modelowych.
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Integrating conventional nitrogen removal with anammox in wastewater treatment systems: Microbial metabolism, sustainability and challenges
PublicationThe various forms of nitrogen (N), including ammonium (NH4+), nitrite (NO2−), and nitrate (NO3−), present in wastewaters can create critical biotic stress and can lead to hazardous phenomena that cause imbalances in biological diversity. Thus, biological nitrogen removal (BNR) from wastewaters is considered to be imperatively urgent. Therefore, anammox-based systems, i.e. partial nitrification and anaerobic ammonium oxidation (PN/anammox)...
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Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
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Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc
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Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
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Vascular Aging and Damage in Patients with Iron Metabolism Disorders
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Parametric imaging in dynamic glucose metabolism studies in brain
PublicationArtykuł analizuje badania dynamiczne 18FDG-PET, które służą do estymacji metabolizmu glukozy w mózgu. Zbadano w nim wpływ zakłóceń na wyznaczanie interesującego nas parametru LCMRGlc.
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Unsymmetrical Bisacridines’ Interactions with ABC Transporters and Their Cellular Impact on Colon LS 174T and Prostate DU 145 Cancer Cells
PublicationMultidrug resistance (MDR) is a process that constitutes a significant obstacle to effective anticancer therapy. Here, we examined whether unsymmetrical bisacridines (UAs) are substrates for ABC transporters and can influence their expression in human colon LS 174T and prostate DU 145 cancer cells. Moreover, we investigated the cytotoxicity and the cellular response induced by UAs in these cells. The ATPase activities of MDR1,...
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Selected symmetrically substituted carbazoles: Investigation of anticancer activity and mechanisms of action at the cellular and molecular levels
PublicationDNA topoisomerases play a critical role as essential enzymes in controlling alterations in the topology of DNA. They achieve this by orchestrating the coordinated process of breaking and rejoining DNA strands, which is crucial for maintaining the proper structure of DNA during regular cellular development. The search for and development of new potential anticancer drugs is a challenging yet immensely important area of research...