Search results for: elisa

• The first study on the usefulness of recombinant tetravalent chimeric proteins containing fragments of SAG2, GRA1, ROP1 and AMA1 antigens in the detection of specific anti-Toxoplasma gondii antibodies in mouse and human sera

  Publication

  • B. Ferra
  • L. Holec-Gąsior
  • J. Gatkowska
  • B. Dziadek
  • K. Dzitko
  • W. Grąźlewska
  • D. Lautenbach

  - PLOS ONE - Year 2019

  This study presents an evaluation of four tetravalent recombinant chimeric proteins containing fragments of the Toxoplasma gondii antigens, SAG2, GRA1, ROP1 and AMA1, as potential replacements of a the soluble, whole-cell tachyzoite lysate (TLA) used in serological assays. Recombinant chimeric proteins (SAG2-GRA1-ROP1-AMA1N, AMA1N-SAG2-GRA1-ROP1, AMA1C-SAG2-GRA1-ROP1, and AMA1-SAG2-GRA1-ROP1) obtained by genetic engineering were...

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• First report of seroprevalence of Toxoplasma gondii infection in sheep in Pomerania, northern Poland

  Publication

  • L. Holec-Gąsior
  • D. Bartosz
  • J. Kur

  - Annals of Agricultural and Environmental Medicine - Year 2015

  Introduction and objective. Toxoplasmosis is parasitic disease which has economic relevance for both veterinary and human medicine. In sheep, toxoplasmosis is a major cause of abortion and can thus cause reproductive problems. The current study aimed to determine the occurrence of anti-Toxoplasma gondii IgG antibodies in sheep from 13 districts of northern Poland and thereby obtain actual data about T. gondii seroprevalence in...

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• Identification of evolutionary conserved DNA sequence and corresponding S21 ribosomal protein region for diagnostic purposes of all Borrelia spirochetes

  Publication

  • R. Kotlowski
  • L. Holec-Gąsior

  - Acta Biochimica Polonica - Year 2019

  It is still under investigation, whether all Borrelia sp. causing Lyme borreliosis and other diseases are already identified and properly classified as human pathogens. For this reason, it is of great importance to develop a diagnostic ELISA test that detects all Borrelia sp. The aim of this study was to identify conserved DNA and protein regions present in all currently known Borrelia sp. In experimental studies 31 available Borrelia...

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• The usefulness of Toxoplasma gondii MIC1-MAG1-SAG1 chimeric antigen in the serodiagnosis of ovine toxoplasmosis

  Publication

  • B. Ferra
  • L. Holec-Gąsior

  - Annals of Parasitology - Year 2013

  Toxoplasmosis is a zoonotic disease caused by the protozoan Toxoplasma gondii, which infects humans and most warm-blooded animals throughout the world. Although human toxoplasmosis in healthy adults is usually asymptomatic, a serious disease can occur in the case of congenital infection and immunocompromised individuals. Among food animals, sheep, along with goats and pigs, possess the highest incidence of T. gondii cysts in meat,...

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• New recombinant chimeric antigens, P35-MAG1, MIC1-ROP1, and MAG1-ROP1, for the serodiagnosis of human toxoplasmosis

  Publication

  • D. Drapała
  • L. Holec-Gąsior
  • J. Kur

  - DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE - Year 2015

  The aim of the study was to evaluate the usefulness of 3 chimeric Toxoplasma gondii antigens, P35-MAG1,MIC1-ROP1 andMAG1-ROP1, in the serodiagnosis of an acute toxoplasmosis in humans. Proteins were produced as fusion proteins containing His tags ends and then further purified by metal affinity chromatography. Their application for the diagnosis of recently acquired T. gondii infection was tested in IgG and IgM enzyme-linked immunosorbent...

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• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen AMA1-MIC3-ROP1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA7

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-AMA1F

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-P35

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA9

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA6

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-MIC1L

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-MAG1L

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-LDH2

  Open Research Data

  restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-ROP1

  Open Research Data

  restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-AMA1

  Open Research Data

  restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA5

  Open Research Data

  restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-GRA2

  Open Research Data

  restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Use of MAG1 recombinant antigen for diagnosis of Toxoplasma gondii infection in humans

  Publication

  • L. Holec-Gąsior
  • E. Hiszczyńska-Sawicka
  • A. Gąsior
  • A. Brillowska-Dąbrowska
  • J. Kur

  - CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY - Year 2007

  Praca opisuje klonowanie, oczyszczanie oraz zastosowanie w immunodiagnostyce toksoplazmozy antygenu rekombinantowego macierzy cyst tkankowych (MAG1) Toxoplasma gondii. Zastosowany system ekspresyjny pozwolił uzyskać dużą ilość rekombinantowego antygenu, który następnie wykorzystano w teście ELISA do wykrywania specyficzych przeciwciał anty-T. gondii klasy IgG w surowicach pacjentów chorych na toksoplazmozę. W przeprowadzonych badaniach...

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• Antitumor triazoloacridinone C-1305 as a potent FLT3 tyrosine kinase inhibitor in human acute myeloid leukemia (AML) cells.

  Publication

  • E. Augustin
  • A. Skwarska
  • J. Polewska
  • I. Pelikant-Małecka
  • J. Konopa

  - EUROPEAN JOURNAL OF CANCER - Year 2010

  Jednym z defektów molekularnych u pacjentów z ostrą białaczką szpikową (AML) jest konstytutywna aktywacja receptoroweej kinazy tyrozynowj FLT3.Najczęstszą mutacją genu kodującego FLT3 jest wewnętrzna tandemowa duplikacja ITD we fragmencie okołobłonowym receptora. W pracy zbadano, czy przeciwnowotworowy triazoloakrydon C-1305 może być inhibitorem kinazy tyrozynowej FLT3. Badania przeprowadzono na dwóch liniach komórkowych białaczek...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-MAG1S

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen AMA1-MIC1-MIC3

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen MIC3-MAG1-ROP1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen MIC1-MIC3-ROP1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen MIC3-MAG1-AMA1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen AMA1-MIC1-ROP1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen SAG1-SAG2-MIC1S

  Open Research Data

  restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Optical fiber aptasensor for label-free bacteria detection in small volumes

  Publication

  • M. Janik
  • E. Brzozowska
  • P. Czyszczoń
  • A. Celebańska
  • M. Koba
  • A. Gamian
  • W. J. Bock
  • M. Śmietana

  - SENSORS AND ACTUATORS B-CHEMICAL - Year 2021

  Highly sensitive devices for fast bacteria detection are sought to be developed with the task of quantifying the worldwide problem of pathogenic bacteria and thus helping to take control over spreading bacterial infections. This work concerns a sensing solution based on microcavity in-line Mach-Zehnder interferometer (μIMZI) induced in an optical fiber. Such a device exhibits ultrahigh sensitivity to refractive index changes...

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• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen MIC1-MAG1-MIC3

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen MIC1-MAG1-ROP1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Construction, production and evaluation of the diagnostic utility of a recombinant Toxoplasma gondii chimeric antigen MIC1-MAG1-AMA1

  Open Research Data

  version 1.1 restricted access

  • B. Ferra

  The intracellular parasite Toxoplasma gondii has the ability to infect a wide range of warm-blooded animals, including humans. Currently, diagnosis of toxoplasmosis is based mainly on the use of the native antigens in enzyme immunoassay which allow for detection of IgG, IgM and IgA antibody classes. However, in some cases the performed studies give...

• Differential expression profile between amygdala and blood during chronic lithium treatment in a rat model of depression – a pilot study

  Publication

  • K. Sakrajda
  • D. Szczepankiewicz
  • J. Nowakowska
  • P. Celichowski
  • E. Banach
  • P. Zakowicz
  • P. Kołodziejski
  • E. Pruszyńska-Oszmałek
  • J. Pawlak
  • A. Szczepankiewicz

  - ACTA NEUROBIOLOGIAE EXPERIMENTALIS - Year 2022

  Lithium is a mood stabilizer widely used in the pharmacotherapy of bipolar disorder and treatment‑resistant depression. Taking into account dysregulated inflammatory activity in depression and the immunomodulatory role of lithium, we hypothesized that genes associated with inflammatory responses may be potential biomarkers of lithium action. We aimed to compare gene expression changes between the brain and the periphery after...

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• Investigations on the immunosuppressive activity of derivatives of mycophenolic acid in immature dendritic cell

  Publication

  • D. Iwaszkiewicz-Grześ
  • G. Cholewiński
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka
  • D. Iwaszkiewicz-Grzes

  - INTERNATIONAL IMMUNOPHARMACOLOGY - Year 2017

  The main activity of mycophenolic acid (MPA) and its analogs is the inhibition of proliferation of T cells. Here, we hypothesized that MPA and its conjugates inhibits also the activity of antigen-presenting cells (APC) including dendritic cells (DCs). We tested the effect of novel amino acid derivatives of MPA and conjugates of MPA with acridines/acridones on DCs by flow cytometry, ELISA and MLR assay. Both acridines/acridone derivatives...

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• The Effect of Hyperbaric Storage on the Nutritional Value and Retention of Certain Bioactive Proteins in Human Milk

  Publication

  • K. Mazur
  • B. Kusznierewicz
  • D. Martysiak-Żurowska
  • I. Drążkowska
  • E. Malinowska-Pańczyk

  - Nutrients - Year 2024

  Human milk (HM) contains the essential macronutrients and bioactive compounds necessary for the normal growth and development of newborns. The milk collected by human milk banks is stored frozen and pasteurized, reducing its nutritional and biological value. The purpose of this study was to determine the effect of hyperbaric storage at subzero temperatures (HS-ST) on the macronutrients and bioactive proteins in HM. As control samples,...

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• Nutrients and Bioactive Components of Human Milk After one Year of Lactation. Implication for Human Milk Banks

  Publication

  • E. Sinkiewicz-Darol
  • D. Martysiak-Żurowska
  • M. Puta
  • I. Adamczyk
  • O. Barbarska
  • A. Wesołowska
  • U. Bernatowicz-Łojko

  - JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION - Year 2022

  Objective: Specifying the nutrient content and bioactive compounds in milk from long-term lactation for the purpose of finding additional sources of donors’ milk for HMBs. Method: Human milk samples were collected from 43 mothers of term infants (term infant human milk, TIHM) (3–6 weeks of lactation) and 50 mothers who have breastfed for over a year (long-nursing human milk, LNHM). The milk collection time was 24 hours. The analyses...

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• Neurotrophic factors in human milk in early lactation and the effect of Holder and microwave pasteurization on their concentrations

  Publication

  • D. Martysiak-Żurowska
  • M. Puta
  • B. Kiełbratowska
  • A. Wesołowska

  - JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION - Year 2021

  Objective: The objective of this study was to determine the level of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in human milk in the first two weeks of breastfeeding and compare of the effects of Holder pasteurization (HoP, 62.5°C, 30 minutes) and microwave pasteurization (MP) at constant temperature (62.5°C) on the concentraion of both neurotrophic factors (NFs). Methods: Concentration...

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• ANTYGENY REKOMBINANTOWE W DIAGNOSTYCE SEROLOGICZNEJ BORELIOZY

  Publication

  • W. Grąźlewska
  • L. Holec-Gąsior

  - Postępy Mikrobiologii - Year 2019

  Borelioza jest najczęstszą chorobą odkleszczową dotykającą mieszkańców półkuli północnej. Chorobę tę wywołują bakterie zakwalifikowane do grupy Borrelia burgdorferi sensu lato. Współcześnie podstawą diagnostyki laboratoryjnej boreliozy jest dwustopniowe badanie serologiczne. Pierwszym etapem jest test immunoenzymatyczny (ELISA), jeżeli wynik badania jest dodatni lub wątpliwy jako test potwierdzający stosuje się technikę Western...

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• Determination of estrogenic endocrine disruptors in environmental samples - a review of chromatographic methods

  Publication

  • K. Kozłowska-Tylingo
  • J. Namieśnik
  • T. Gorecki

  - Year 2010

  Wśród związków endokrynnych to estrogeny zarówno naturalne jak i syntetyczne zostały wskazane i opisane jako związki niosące ze sobą największy potencjał aktywności estrogennej. Wysoki potencjał estrogenny jaki posiadają związki z grupy hormonów płciowych potwierdziły badania przeprowadzone zarówno in vitro jak i in vivo. W dużej części (50-95%) próbek ścieków pochodzących z oczyszczalni ścieków zostały wykryte związki z grupy...

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• Synthesis and Structure of Novel Hybrid Compounds Containing Phthalazin-1(2H)-imine and 4,5-Dihydro-1H-imidazole Cores and Their Sulfonyl Derivatives with Potential Biological Activities

  Publication

  • Ł. Balewski
  • M. Gdaniec
  • A. Herring
  • C. Furman
  • A. Ghinet
  • J. Kokoszka
  • A. Ordyszewska
  • A. Kornicka

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2024

  A novel hybrid compound—2-(4,5-dihydro-1H-imidazol-2-yl)phthalazin-1(2H)-imine (5) was synthesized and converted into di-substituted sulfonamide derivatives 6a–o and phthalazine ring opening products—hydrazonomethylbenzonitriles 7a–m. The newly prepared compounds were characterized using elemental analyses, IR and NMR spectroscopy, as well as mass spectrometry. Single crystal X-ray diffraction data were collected for the representative...

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• Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

  Publication

  • M. Podda
  • G. Pellino
  • S. Di
  • F. Coccolini
  • D. Pacella
  • F. Virdis
  • A. Balla
  • B. Ielpo
  • F. Pata
  • G. Poillucci... and 561 others

  - Updates in Surgery - Year 2023

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• coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit

  Publication

  • S. Di
  • D. Damaskos
  • V. Agnoletti
  • D. Mole
  • C. Gerardi
  • F. Virdis
  • D. Pacella
  • K. Jayant
  • M. Sartelli
  • A. Leppaniemi... and 568 others

  - PANCREATOLOGY - Year 2022

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• Considerations and consequences of allowing DNA sequence data as types of fungal taxa

  Publication

  • J. Zamora
  • M. Svensson
  • R. Kirschner
  • I. Olariaga
  • S. Ryman
  • L. Parra
  • J. Geml
  • A. Rosling
  • S. Adamčík
  • T. Ahti... and 402 others

  - IMA Fungus - Year 2018

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• The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.

  Publication

  • E. Augustin
  • A. Skwarska
  • A. Weryszko
  • I. Pelikant-Małecka
  • E. Sankowska
  • B. Borowa-Mazgaj

  - ACTA PHARMACOLOGICA SINICA - Year 2015

  Aim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...

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• Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency

  Publication

  • A. Kobiela
  • W. Hewelt-Belka
  • J. Frackowiak
  • N. Kordulewska
  • L. Hovhannisyan
  • A. Bogucka
  • R. Etherington
  • A. Piróg
  • I. Dapic
  • S. Gabrielsson... and 3 others

  - Frontiers in Immunology - Year 2024

  Introduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...

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• 13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting

  Publication

  • A. Bagheri
  • X. Liu
  • A. Chaloupka
  • M. Pietrosanu
  • E. Redford
  • S. Schmidt
  • K. Vlasis
  • K. Michas
  • J. Griffith
  • C. Xue... and 310 others

  - Scoliosis and Spinal Disorders - Year 2017

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• The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

  Publication

  • B. De
  • F. Abu-Zidan
  • E. Chouillard
  • S. Di
  • M. Sartelli
  • M. Podda
  • C. Gomes
  • E. Moore
  • S. Moug
  • L. Ansaloni... and 367 others

  - World Journal of Emergency Surgery - Year 2022

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• Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

  Publication

  • M. Reichert
  • M. Sartelli
  • M. Weigand
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