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Search results for: drug%20discovery
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Function and Frustration of Multi-Drug ABC Exporter Protein and Design of Model Proteins for Drug Delivery Using Protein Hydration Thermodynamics
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A concept of a decision function discovery method in a workflow system
PublicationW pracy przedstawiono koncepcyjny model wykrywania zalezności funkcynnych pomiedzy elementami systemu przepływu pracy.
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Ahmer Bin Hafeez
PeopleI have experience in Microbiology & Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational methods for the identification of novel targets and to...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Feasibility study of a Raman spectroscopic route to drug detection
PublicationWe present an surface-enhanced Raman spectroscopy (SERS) approach for detection of drugs of abuse in whole human blood. We utilize a near infrared laser with 830 nm excitation wavelength in order to reduce the influence of fluorescence on the spectra of blood. However, regular plasmon resonance peak of plasmonic nanoparticles, such as silver or gold fall in a much lower wavelength regime about 400 nm. Therefore, we have shifted...
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Biopolymer based nanomaterials in drug delivery systems: A review
PublicationDrug delivery systems (DDS) are used to achieve a higher therapeutic effects of a pharmaceutical drug or natural compound in a specific diseased site with minimal toxicological effect and these systems consists of liposomes, microspheres, gels, prodrugs and many. Nanotechnology is a rapidly developing multi-disciplinary science that ensures the fabrication of the polymers to nanometer scale for various medical applications. Uses...
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Microbial Drug Resistance
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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Drugs and driving
PublicationW referacie przedstawiono we wprowadzeniu pojawienie się nowego zagrożenia, jakim jest kierowanie pojazdów przez osoby będące pod wpływek narkotyków. W drugiej części przedstawiono obecnie obowiązujące sankcje, jakie mogą spotkać kierującego oraz definicję środków odurzających, po zażyciu których nie można prowadzić samochodu. W trzeciej części przedstawiono badania naukowe przeprowadzone w Polsce i Niemczech, które pokazują jak...
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Cancer Discovery
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DISCOVERY AND INNOVATION
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Cell Discovery
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Materials Discovery
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Tradition & Discovery
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SLAS Discovery
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QRB Discovery
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Topology Discovery of Hierarchical Ethernet LANs without SNMP support
PublicationThis paper presents an algorithm that allows for discovery of layer-2 hierarchical Ethernet network topology using agents running on selected end nodes. No SNMP, MIB, hardware, firmware, or operating system-level software modification is required. The method is based on transmission of customized Ethernet frames among installed software agents. It can be used to discover the topology of LAN or one VLAN segment as long as no MAC...
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New kagome prototype materials: discovery of KV3Sb5, RbV3Sb5, and CsV3Sb5
PublicationIn this work, we present our discovery and characterization of a new kagome prototype structure, KV3Sb5. We also present the discovery of the isostructural compounds RbV3Sb5 and CsV3Sb5. All materials exhibit a structurally perfect two-dimensional kagome net of vanadium. Density-functional theory calculations indicate that the materials are metallic, with the Fermi level in close proximity to several Dirac points. Powder and single-crystal...
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Human Feedback and Knowledge Discovery: Towards Cognitive Systems Optimization
PublicationCurrent computer vision systems, especially those using machine learning techniques are data-hungry and frequently only perform well when dealing with patterns they have seen before. As an alternative, cognitive systems have become a focus of attention for applications that involve complex visual scenes, and in which conditions may vary. In theory, cognitive applications uses current machine learning algorithms, such as deep learning,...
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Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery
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Recent Advances in Polymer-Based Vaginal Drug Delivery Systems
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Controlled Drug Release by the Pore Structure in Polydimethylsiloxane Transdermal Patches
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Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review
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Mesoporous silica nanoflakes – Biocompatibility, cellular uptake and drug transport
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography
PublicationTHE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC...
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Synthetic strategies in construction of organic macromolecular carrier–drug conjugates
PublicationMany metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit verylimited ability to cross the biological membranes of target cells. The restricted cellular penetration ofthose molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is aconjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should beable to penetrate...
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Diatomaceous earth as a drug-loaded carrier in a glass-ionomer cement
PublicationThe effect of a natural filler (diatomaceous earth [DE], a promising drug-delivery agent) and its content was investigated on the performance of a model glass-ionomer cement (GIC). Three sample series, differing in DE content (0, 2.5 and 5 wt%), were prepared using a commercial GIC as a matrix (3M Ketac Molar Easymix). The resultant surface microhardness and roughness, wear performance, and compressive strength of the samples were...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
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Statistical Integration of p-values for Enhancing Discovery of Radiotoxicity Gene Signatures
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Discovery of Stylistic Patterns in Business Process Textual Descriptions: IT Ticket Case
PublicationGrowing IT complexity and related problems, which are reflected in IT tickets,create a need for new qualitative approaches. The goal isto automate the extraction of main topics described in tickets in order to provide high quality support for the IT process workers and enablea smooth service delivery to the end user. Present paper proposes a method of knowledge extraction in a form of stylistic patterns in business...
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Method of Decision-Making Logic Discovery in the Business Process Textual Data
PublicationGrowing amount of complexity and enterprise data creates a need for novel business process (BP) analysis methods to assess the process optimization opportunities. This paper proposes a method of BP analysis while extracting the knowledge about Decision-Making Logic (DML) in a form of taxonomy. In this taxonomy, researchers consider the routine, semi-cognitive and cognitive DML levels as functions of BP conceptual aspects of Resources,...
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Miasta krótkich dróg
PublicationNależy zrewidować poglądy na temat wielkopowierzchniowych obiektów handlowo-usługowych. Modernistyczne wizje miast zakładały tworzenie schierarchizowanych ośrodków usługowych - osiedlowych, dzielnicowych i centralnych. Socjalistyczne miasta nigdy w pełni nie wykształciły powyższych ośrodków. W wielu przypadkach ułomne struktury polskich miast zostały w ostatnim czasie dopełnione, niezbędnymi dla właściwego funkcjonowania, centrami...
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BIOPHARMACEUTICS & DRUG DISPOSITION
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CLINICAL DRUG INVESTIGATION
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DRUG NEWS & PERSPECTIVES
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DRUG INFORMATION JOURNAL
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Drug Target Insights
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Drug Discoveries and Therapeutics
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Drug Testing and Analysis
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CNS DRUG REVIEWS
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Journal of Drug Delivery
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DRUG RESISTANCE UPDATES
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Current Drug Safety
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BIOINFO Drug targets
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Drug Metabolism and Pharmacokinetics
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Current Drug Therapy
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JOURNAL OF DRUG ASSESSMENT
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DRUG AND ALCOHOL REVIEW
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