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Search results for: AAP GENE
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Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer’s disease
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Enterococci from ready-to-eat food - horizontal gene transfer of antibiotic resistance genes and genotypic characterization by PCR melting profile
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Analysis of a gene expression model
PublicationWe study a mathematical model of gene transcription and protein synthesis with negative feedback. We consider a system of equations taking into account the number of active binding sites, the way in which dimers bind to DNA and time delay in translation process. For a simplified model that consist of three ordinary differential equations with time delay we derive conditions for stability of the positive steady state and for the...
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Metoda AHP/ANP jako narzędzie wyboru wariantów inwestycji drogowej z uwzględnieniem aspektu bezpieczeństwa ruchu drogowego
PublicationCelem artykułu było opracowanie wielokryterialnego modelu decyzyjnego wykorzystującego metodę AHP/ANP na potrzeby usprawnienia procedury wyboru wariantów inwestycji drogowej. Poszukiwanie nowego rozwiązania w tym zakresie było związane z ograniczeniami analizy kosztów korzyści w zakresie wyceny skutków inwestycji. W związku z tym zaproponowano dwuetapowe podejście obejmujące w pierwszym etapie dobór wag kryteriów decyzyjnych za...
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Biofilm Production and Presence of ica and bap Genes in Staphylococcus aureus Strains Isolated from Cows with Mastitis in the Eastern Poland
PublicationThe aim of the study was phenotypic and genotypic analysis of 132 S. aureus strains isolated from mastitis in eastern Poland in respect to their biofilm formation ability. The analysis of the size polymorphism of fragment X in the gene encoding protein A (spa) revealed high genetic differentiation of the analyzed group of isolates. The ability of biofilm formation by the isolates was tested using two phenotypic methods. The Congo...
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An examination of an Antarctic soil metagenomic-derivate putative methylthioadenosine phosphorylase gene as a novel reporter gene for promoter trapping
PublicationThe rsfp gene was discovered during examination ofan Antarctic soil-derived metagenome library and encodesa bacterial methylthioadenosine phosphorylase (GenBank accession number GQ202582). In a previous study, we found that E. coli colonies expressing the rsfp gene reveal strong pink fluorescence after exposure to UV light when grown on culture medium supplemented with rhodamine B (Cieśliński et al., 2009). In contrast to that,...
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Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy
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Genistein modulates gene activity in psoriatic patients
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Modelling gene expression of a self-regulating protein
PublicationWe analyze a model of gene transcription and protein synthesis. We take into account the number of sites on the protein’s promoter at which the protein’s dimers can bind blocking transcription of protein mRNA.
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ANALYSIS OF THE p53 PROTEIN GENE EXPRESSION MODEL
PublicationWe study the asymptotic behaviour of the solutions of the p53-Mdm2 model proposed by Monk (2003). The p53 gene is crucial for cellular inhibition of the angiogenesis process, while Mdm2 is a negative regulator of the p53 tumor-suppressor. We investigate the stability of the positive steady state and perform some numerical experiments.
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Identyfikacja i izolacja genu kodującego zaadaptowaną do zimna β-galaktozydazę Paracoccus sp. = Identification and izolation of the gene encoding cold-active β-galactosidase from paracoccus sp.
PublicationZaprezentowane badania były prowadzone u eehi wyizolowania ze środo¬wiska organizmu psychrofilnego, zdolnego do hydrolizy laktozy w niskiej tempe¬raturze, oraz zidentyfikowania genu kodującego (i-galaktozydazę zaadaptowaną do zimna.Poszukiwan gen został w izolowany z psychrofilnego szczepu autarkicz¬nego Paracoccus sp. 321). Na podstawie sekwencji nukleotydowej genu kodują¬cego fS-galaktozdaze ustalono skład aminokwasów),...
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Estrogen Receptor 2 Gene Polymorphism in Idiopathic Scoliosis
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CHD7 gene polymorphisms in female patients with idiopathic scoliosis
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Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility
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Gene copy numbers of HER family in breast cancer
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Gene-based identification of bacterial colonies with an electric chip
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Cognitive decline in Huntington's disease expansion gene carriers
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublicationA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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Phenotypic consequences of the LYS4 gene disruption in Candida albicans
PublicationThe main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...
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A note on the multiplicative AHP
PublicationPraca dotyczy porównań parami skończonej liczby obiektów w celu obliczeniach uporządkowania w skali liczbowej. W celu obliczenia uporządkowania stosuje się metodę logarytmicznych najmniejszych kwadratów. Pokazuje się multiplikatywne własności otrzymanego rozwiązania. Metodę ilustruje się przykładem obliczeniowym.
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A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream
PublicationAn analysis of the phylogenetic distribution and virulence genes of Escherichia coli isolates which predispose this bacteria to translocate from the urinary tract to the bloodstream is presented. One-dimensional analysis indicated that the occurrence of P fimbriae and α-hemolysin coding genes is more frequent among the E. coli which cause bacteremia. However, a two-dimensional analysis revealed that a combination of genes coding...
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Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
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Beta-2 adrenoreceptor gene polymorphisms and sympathetic outflow in humans
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Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene
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Reproducibility of Finding Enriched Gene Sets in Biological Data Analysis
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Ranking metrics in gene set enrichment analysis: do they matter?
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Newborn screening and gene therapy in SMA: Challenges related to vaccinations
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Delay induced oscillations in gene expression of Hes1 protein model
PublicationW pracy został omówiony model produkcji białka Hes1. Stężenie Hes1 jest kontrolowane przez ujemne sprzężenie zwrotne wbudowane w białko i jego mRNA. Przeprowadzona analiza potwierdziła znane wyniki numeryczne, że oscylacje wywołane są przez opóźnienie. Pokazaliśmy również, że jeśli współczynnik Hilla jest większy niż 1, to istnieje krytyczna wartość opóźnienia, dla której ma miejsce bifurkacja Hopfa i pojawiają się rozwiązania...
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Hopf bifurcation in time‐delayed gene expression model with dimers
PublicationWe study a mathematical model of gene transcription and protein synthesis with negative feedback. We consider a system of equations taking into account the formation of dimers (i.e., complex formed by two protein monomers), the way in which dimers bind to DNA and time delay in translation process. For the model consisting of three ordinary differential equations with time delay, we derive conditions for stability of the positive...
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Quantitative Analysis of Biofilm Formed on Vascular Prostheses by Staphylococcus Epidermidis with Different ica and aap Genetic Status
PublicationOBJECTIVES: This study aims to examine biofilm formed on vascular prostheses by Staphylococcus epidermidis with different ica and aap genetic status, and to evaluate the effect of antibiotic-modified prostheses on bacterial colonization. METHODS: Biofilm formation was determined using fluorescence microscopy imaging. Quantitative analysis was conducted using the biofilm coverage ratio (BCR) calculations. RESULTS: Our investigations...
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ActiveX dla serwera ASP
PublicationPrzedstawiono instruktaż projektowania komponentu ActiveX, rozszerzającego funkcjonalność serwera WWW o usługę chat-room. Opisano zasady osadzania komponentu w środowisku Active Server Pages i metody wymiany informacji pomiędzy komponentem a dokumentem hipertekstowym.
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An absorbing set for the Chialvo map
PublicationThe classical Chialvo model, introduced in 1995, is one of the most important models that describe single neuron dynamics. In order to conduct effective numerical analysis of this model, it is necessary to obtain a rigorous estimate for the maximal bounded invariant set. We discuss this problem, and we correct and improve the results obtained by Courbage and Nekorkin (2010). In particular, we provide an explicit formula for an...
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Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
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Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
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Adverse Childhood Experiences and Methylation of the FKBP5 Gene in Patients with Psychotic Disorders
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A common nonsense mutation of the BLM gene and prostate cancer risk and survival
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First recurrent large genomic rearrangement in the BRCA1 gene found in Poland
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Robustness of Pathway Enrichment Analysis to Transcriptome-Wide Gene Expression Platform
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HPV16 E6 Gene Transcripts in Primary Type II Endometrial Carcinomas
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Statistical Integration of p-values for Enhancing Discovery of Radiotoxicity Gene Signatures
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Iron overload and HFE gene mutations in Polish patients with liver cirrhosis
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K-ras gene mutation as an early prognostic marker of colon cancer
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Clinical presentation of Y189C mutation of the NOTCH3 gene in the Polish family with CADASIL
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Stability of delay induced oscillations in gene expression of Hes1 protein model
PublicationW pracy prezentowana jest matematyczna analiza modelu ekspresji genu białka Hes1. Rozważamy układ równań z dwoma opóźnieniami - w produkcji białka Hes1 oraz jego mRNA. Dowodzimy istnienia i jednoznaczności oraz nieujemności rozwiązań. Pokazujemy istnienie dokładnie jednego dodatniego stanu stacjonarnego. Wykazujemy, że stabilność stanu stacjonarnego zależy od sumy opóźnień. Podajemy warunek dostateczny na wystąpienie bifurkacji...
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Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
PublicationWe propose the generalisation of the p53-Mdm2 protein gene expression model introduced by Monk (2003). We investigate the stability of a unique positive steady state and formulate conditions which guarantee the occurrence of the Hopf bifurcation. We show that oscillatory behaviour can be caused not only by time lag in protein transcription process, but also can be present in the model without time delay. Moreover, we investigate...
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublicationBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
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Pin-on-Substrate Gap Waveguide: An Extremely Low-Cost Realization of High-Performance Gap Waveguide Components
PublicationConsidering the limitations of currently available technologies for the realization of microwave components and antennas, a trade-off between different factors including the efficiency and fabrication cost is required. The main objective of this letter is to propose a novel method for the realization of gap waveguides (GWGs) that take advantage of conventional PCB fabrication technology, thus are low cost and light weight. Moreover,...
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The Relationship Between Gene Polymorphisms and Dipping Profile in Patients With Coronary Heart Disease
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The role of TGF superfamily gene expression in the regulation of folliculogenesis and oogenesis in mammals: a review
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Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer
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