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Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublicationReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
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Numerical and quantitative analysis of HIV/AIDS model with modified Atangana-Baleanu in Caputo sense derivative
PublicationFractional calculus plays an important role in the development of control strategies, the study of the dynamical transmission of diseases, and some other real-life problems nowadays. The time-fractional HIV/AIDS model is examined using a novel method in this paper. Based on the Atangana-concept Baleanu’s of a derivative in the Caputo sense, the current modified fractional derivative operator uses singular and non-local kernels....
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Letter to the Editor: Discussion on the Paper “State-of-the-Art of Research on Seismic Pounding Between Buildings with Aligned Slabs”
PublicationThe paper “State-of-the-art of research on seismic pounding between buildings with aligned slabs” (by Kharazian and López-Almansa) has recently been published in the journal of Archives of Computational Methods in Engineering. It can be considered as a kind of continuation of previous ‘state-of-the-art’ publications, including two papers and a book. Unfortunately, the paper contains a number of misleading or wrong statements as...
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Evaluation of brain volume alterations in HCV-infected patients after interferon-free therapy: A pilot study
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The Use of USV to Develop Navigational and Bathymetric Charts of Yacht Ports on the Example of National Sailing Centre in Gdańsk
PublicationApart from extensive infrastructure protection, modern yacht ports should primarily provide vessels with navigational safety associated with their maneuvering on the approach fairway, as well as mooring in the port aquatory. For this reason, yachts entering the harbor should have up-to-date, accurate, and reliable charts of the port and its surroundings. This article presents hydrographic surveys conducted in the National Sailing...
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublicationHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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The Use of USV to Develop Navigational and Bathymetric Charts of Yacht Ports on the Example of National Sailing Centre in Gdańsk
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Localization of key amino acid residues in the dominant conformational epitopes on thyroid peroxidase recognized by mouse monoclonal antibodies
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Response to Letter to the Editor re ‘Urinary tract infection in children: Diagnosis, treatment, imaging – Comparison of current guidelines’
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Authors’ response (March 5, 2019) to the letter to the Editor concerning the paper “Impact of air pollution on depression and suicide”
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Comparative molecular dynamics study of dimeric and monomeric forms of HIV-1 protease in ligand bound and unbound state
PublicationHuman immunodeficiency virus type 1 protease (HIV-1 PR) is a viral-encoded enzyme that forms a homodimer. HIV-1 PR is essential for replication and assembly of the virus and inactivation of HIV-1 PR enzyme causes production of immature, noninfectious viral particles and thus HIV-1 PR is an attractive target in anti-AIDS drug design. In our current work, we performed molecular dynamics (MD) calculations (500 ns) for two different...
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Letter to the Editor: Complete resonance assignments of the 'donor-strand' AfaD: The afimbrial invasin from Diffusely Adherent E. coli.
PublicationUstalono strukturę NMR rekombiantowego białka AfaD-dsc. Uzyskane wyniki są podstawą do badań rentgenograficznych struktury białek AfaD/DraD.
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Method for determining of shallow water depths based on data recorded by UAV/USV vehicles and processed using the SVR algorithm
PublicationBathymetric measurements in waters shallower than 1 m are necessary to monitor seafloor relief changes in the coastal zone. This is especially important for ensuring the safety of navigation, navigation efficiency, as well as during the design and monitoring of hydrotechnical structures. Therefore, the aim of this article is to present a method for determining of shallow water depths based on data recorded by Unmanned Aerial Vehicle...
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Visual and brainstem auditory evoked potentials in HCV-infected patients before and after interferon-free therapy — A pilot study
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Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches
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Determining the Seasonal Variability of the Territorial Sea Baseline in Poland (2018–2020) Using Integrated USV/GNSS/SBES Measurements
PublicationThe Territorial Sea Baseline (TSB) allows coastal states to define the maritime boundaries, such as: contiguous zone, continental shelf, exclusive economic zone and territorial sea. Their delimitations determine what rights (jurisdiction and sovereignty) a given coastal state is entitled to. For many years, the problem of delimiting baseline was considered in two aspects: legal (lack of clear-cut regulations and different interpretations)...
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Response to the letter to the Editor regarding the article “Vaccine versus infection - COVID-19-related loss of training time in elite athletes”
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Problems of Connecting Wind Farms to the Power System with HV Cables
PublicationThis paper presents problems caused by connecting wind farms to a power system with high voltage cables. The author highlights possible problems with reactive power compensation, depending on the arrangement of the shunt reactor connection and settings of control systems for reactive power and voltage of the wind farm. The paper also discusses issues of increasing active power losses caused by a shunt reactor installation.
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A Paradigm for HV, MV, LV Distribution Grid Development Planning
PublicationIn the literature, including that relating to businesses in the energy (and power) sector, the concept of these organizations’ operating paradigm may be found. The paper discusses the concept of the paradigm, with a focus on the power grid development planning paradigm. Against this background, issues related to energy security and power systems development trends and problems are presented. A new paradigm is proposed for distribution...
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An initial assessment of correlations between host- and virus-related factors affecting analogues antiviral therapy in HBV chronically infected patients
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Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein
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Assessment of the Steering Precision of a Hydrographic USV along Sounding Profiles Using a High-Precision GNSS RTK Receiver Supported Autopilot
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Letter to the editor on the article “Alteration of redox status by commonly used antimalarial drugs in the north-western region of Nigeria” by Muhammad A et al.
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Response to the queries raised by Dr M.M. Awad in a letter to editor comments on “Pressure drop of HFE7000 and HFE7100 during flow condensation in minichannels”
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Validation of the HS-GC-FID method for the determination of athanol residue in tablets
PublicationW pracy opisano proces walidacji metody oznaczania zawartości pozostałości etanolu w tabletkach. W pomiarach wykorzystano technikę HS-GC-FID. Wyznaczono następujące parametry walidacyjne:- selektywność- liniowość- poprawność- precyzję (powtarzalność i precyzję pośrednią)- granice wykrywalności i oznaczalności- zakres pomiarowy- niepewność
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Validation of the HS-GC-FID method for the determination of ethanol residue in tablets
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Calculations of Short-Circuit Current Flows in Earth Wires of HV Lines
PublicationThis paper presents a method which enables calculating flows of short-circuit currents in earth wires of high voltage transmission lines, and its implementation in the form of a computer programme. The algorithm enables performing calculations for a double-fed line and starconnected lines (three terminal lines). The developed programme enables verifying dimensioning of earth wires in the context of their short-circuit thermal withstand...
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Solvent residue determination in Uncaria Tomentosa Bark by HS-GC technique
PublicationPrzedstawiono wyniki oznaczeń pozostałości rozpuszczalników organicznych w preparacie uzyskanym z kory liany U. Tomentosa, wykorzystywanej do produkcji farmaceutyków i dodatków do żywności. 1,1,2-trichloroeten oraz dichlorometan są powszechnie stosowane do usunięcia z kory kilku grup alkaloidów o znanych właściwościach biologicznych, co umożliwia zbadanie pozostałych jej związków. Ilościowe oznaczanie tych rozpuszcalników jest...
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Heat shock proteins (HSP 90, 70, 60, and 27) in Galleria mellonella (Lepidoptera) hemolymph are affected by infection with Conidiobolus coronatus (Entomophthorales)
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Mosaic Structure of p1658/97, a 125-Kilobase Plasmid Harboring an Active Amplicon with the Extended-Spectrum β-Lactamase Gene bla SHV-5
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Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
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Discussion on “Dynamic soil-structure interaction: A three-dimensional numerical approach and its application to the Lotung case study”. Poor performance of the HSS model
PublicationThe Hardening Soil Small (HSS) is a constitutive model being extension to the well established Hardening Soil Model (HS) accounting for the nonlinearity of small strain stiffness. It is implemented in commercial finite element computer codes for geotechnical analyses and used widely in research and design. The article deals with a problem known as overshooting after very small load reversals. It induces much higher stiffness than...
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Optical Fibre Control-Measurement Systems Of Compound HV/HP Electrical Equipment
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Structural Insights into Autoreactive Determinants in Thyroid Peroxidase Composed of Discontinuous and Multiple Key Contact Amino Acid Residues Contributing to Epitopes Recognized by Patients’ Autoantibodies
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Risk factors for chronic kidney disease do not influence the serum levels of asymmetric dimethylarginine in HIV-1-infected patients without significant renal disease
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Promising effects of xanthine oxidase inhibition by allopurinol on autonomic heart regulation estimated by heart rate variability (HRV) analysis in rats exposed to hypoxia and hyperoxia
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Refinement of the Hardening Soil model within the small strain range
PublicationThe popularity of the elasto-plastic Hardening Soil (HS) model is based on simple parameter identification from standard testing and empirical formulas. The HS model is implemented in many commercial FE codes designed to analyse geotechnical problems. In its basic version, the stress–strain behaviour within the elastic range is subject to the hypoelastic power law, which assures the barotropy of the elastic stiffness. However,...
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Reliability assessment of an OVH HV power line truss transmission tower subjected to seismic loading
PublicationThe study focuses on the reliability of a transmission tower OS24 ON150 + 10, an element of an OVH HV power line, under seismic loading. In order to describe the seismic force, the real-life recording of the horizontal component of the El Centro earthquake was adopted. The amplitude and the period of this excitation are assumed random, their variation is described by Weibull distribution. The possible space state of the phenomenon...
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Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
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Solar light driven degradation of norfloxacin using as-synthesized Bi 3+ and Fe 2+ co-doped ZnO with the addition of HSO 5 – : Toxicities and degradation pathways investigation
PublicationIn this study, solar light responsive Bi3+ and Fe2+ doped ZnO were synthesized and used for photocatalytic degradation of norfloxacin (NOR), an emerging water pollutant. Analysis with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), selected area electron...
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublicationA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method
PublicationApplications of bioactive peptides and polypeptides are emerging in areas such as drug development and drug delivery systems. These compounds are bioactive, biocompatible and represent a wide range of chemical properties, enabling further adjustments of obtained biomaterials. However, delivering large quantities of peptide derivatives is still challenging. Several methods have been developed for the production of concatemers –...
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Validation of SPME-GC and HS-GC procedures for the determination of selected solvent residues in edible oil matrices
PublicationW pracy przedstawiono przebieg procesu walidacji, przeprowadzonej zgodnie ze wskazaniami ICH (International Conference on Harmonization), procedur wykorzystywanych do oznaczania pozostałości wybranych rozpuszczalników w olejach jadalnych i preparatach farmaceutycznych. W celu izolacji i wzbogacania analitów wykorzystano dwie bezrozpuszczalnikowe techniki ekstrakcyjne: ekstrakcję do fazy nadpowierzchniowej (HS) i mikroekstrakcję...
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublicationA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
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Dielectric Barrier Discharge Systems with HV Generators and Discharge Chambers for Surface Treatment and Decontamination of Organic Products
PublicationThe article presents applications of systems with power electronic converters, high voltage transformers, and discharge chambers used for nonthermal, dielectric barrier discharge plasma treatment of a plastic surface and decontamination of organic loose products. In these installations, the inductance of the high voltage transformers and the capacitances of the electrode sets form resonant circuits that are excited by inverters....
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Comprehensive two-dimensional gas chromatography and three-dimensional fluorometry for detection of volatile and bioactive substances in some berries
PublicationThe volatilefractionsofCapegooseberryandblueberryweredeterminedbyheadspacesolid-phase microextractioncoupledwithcomprehensivetwo-dimensionalgaschromatographywithtime-of-flight mass spectrometry(HS-SPME/GCGC-TOFMS).Thehighestamountofalcohol(51.8%),ester(32.8%)and carboxylicacid(6.9%)wasinblueberryincomparisonwithgooseberryandoppositelyketones(14.7%), aldehydes(9.9%)andterpenes(8%)werefoundingooseberry.Thebioactivecompoundsandantioxidant capacities...
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Assessment of the Steering Precision of a Hydrographic Unmanned Surface Vessel (USV) along Sounding Profiles Using a Low-Cost Multi-Global Navigation Satellite System (GNSS) Receiver Supported Autopilot
Publicationhe performance of bathymetric measurements by traditional methods (using manned vessels) in ultra-shallow waters, i.e., lakes, rivers, and sea beaches with a depth of less than 1 m, is often difficult or, in many cases, impossible due to problems related to safe vessel maneuvering. For this reason, the use of shallow draft hydrographic Unmanned Surface Vessels (USV) appears to provide a promising alternative method for performing...
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Determination of Terpene Profile in Cape gooseberry (Physalis peruviana L.) with Use of HS-SPME/GCxGC-TOFMS Method
PublicationFresh fruits and products made of them, especially fruit juice, provide the basic energetic substances (simple and complex sugars) and are a source of health beneficial vitamins, macro and microelements, antioxidants and compounds which are classified together with essential oils (for example terpenes), which positively affect human s health. The terpenes profile of cape gooseberry was determined by headspace solid--phase microextraction...
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Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
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HS-SPME-CGC-PID determination of aldehydes in rectified spirits and vodkas after derivatisation with 2,4,6-trichlorophenylhydrazine (TCPH)
PublicationW pracy przedstawiono nową metodę oznaczania aldehydów w spirytusach i wyrobach spirytusowych czystych z zastosowaniem 2,4,6-trichlorofenylohydrazyny (TCPH) jako odczynnika derywatyzującego. Zaproponowana metoda jest co najmniej 100-krotnie tańsza od mikroekstrakcji do fazy stacjonarnej z fazy nadpowierzchniowej (HS-SPME) i chromatografii gazowej z zastosowaniem często zalecanej o-2,3,4,5,6-pentafluorobenzylohydroxyloaminy (PFBHA)....