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Search results for: a. fumigatus
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Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles
PublicationWe studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wrocław, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole...
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Activity of isavuconazole and other triazole derivatives against clinical isolates of Aspergillus fumigatus
PublicationAspergillus fumigatus is the most frequent pathogen of the genus Asperillus, which is highly susceptible to triazole derivatives, especially to isavuconazole and voriconazole. Many countries face a growing problem of infections due to A. fumigatus showing acquired resistance to one or several triazoles. In medical centres, monitoring the susceptibility of isolated Aspergillus spp. is recommended. The aim of this study was to collect...
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The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance
PublicationTriazoles are the only compounds used as antibiotics in both medicine and agriculture. The presence of triazoles in the environment can contribute to the acquisition of azole resistance among isolates of Aspergillus fumigatus. The objective of this study was to investigate the effect of A. fumigatus exposure to triazoles on susceptibility to these compounds. Seventeen triazole-resistant and 21 triazole-sensitive A. fumigatus isolates...
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Low frequency of itraconazole resistance found among avian Aspergillus fumigatus isolates
PublicationAspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H...
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Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima
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Agro‐industrial wastes for production of paclitaxel by irradiated Aspergillus fumigatus under solid‐state fermentation
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Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima
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Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate
PublicationAspergillus fumigatus is one of the most prevalent airborne fungal pathogens causing infections worldwide. Most A. fumigatus strains are susceptible to azoles, which are administered as the first line therapeutics. However, during last decade the acquired resistance to triazoles by these species has been described. There is a number of publications concerning the examination of clinical A. fumigatus strains from different countries,...
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Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads
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Występowanie oraz charakterystyka molekularna oporności na azole wśród klinicznych i środowiskowych izolatów Aspergillus fumigatus
PublicationCelem badań prowadzonych w ramach niniejszej pracy doktorskiej było sprawdzenie występowania oporności na azole grzybów A. fumigatus pochodzących z Polski oraz jej molekularna charakterystyka. W toku badań utworzono kolekcję 200 izolatów A. fumigatus pochodzących z różnych miejsc Polski. W skład kolekcji wchodziły izolaty kliniczne, środowiskowe i weterynaryjne. Przynależność gatunkową badanych grzybów potwierdzono metodami diagnostyki...
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Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods
PublicationThe aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the β-tubulin gene,...
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Bioprocess optimization using response surface methodology for production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima: Enhanced production by ultraviolet and gamma irradiation
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Structural changes of bacterial cellulose due to incubation in conditions simulating human plasma in the presence of selected pathogens
PublicationBacterial nanocellulose (BNC) is a natural biomaterial with a wide range of medical applications. However, it cannot be used as a biological implant of the circulatory system without checking whether it is biodegradable under human plasma conditions. This work aimed to investigate the BNC biodegradation by selected pathogens under conditions simulating human plasma. The BNC was incubated in simulated biological fluids with or...
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Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in Candida and Aspergillus Species for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods
PublicationAlthough the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candida or Aspergillus species. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans, 215 C. dubliniensis, 4,418 C. glabrata species complex,...
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In vitro biodegradation of bacterial nanocellulose under conditions simulating human plasma in the presence of selected pathogenic microorganisms
PublicationThe Biodegradability of bacterial nanocellulose (BNC) was assessed based on a change in its properties under conditions simulating human plasma in the presence or absence of the pathogens Staphylococcus aureus, Candida albicans and Aspergillus fumigatus. It was shown that the dry mass of BNC did not change during 6 months of incubation, except for samples stored in the presence of moulds, where the dry mass reduced by 40 %. The...
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The effect of impacted third molars on second molar external root resorption, a cross-sectional cone beam computed tomography study
PublicationBackground: Third molars have the highest prevalence of impaction in teeth and can cause pathological damage on the adjacent second molars. This study aims to evaluate the effects of factors related to impacted third molars on external root resorption (ERR) in adjacent second molars using cone-beam computed tomography (CBCT). Material and Methods: In CBCTs, the effect of impacted third molars on the root surface of adjacent second...
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Room temperature depinning of the charge-density waves in quasi-two-dimensional 1T-TaS2 devices
PublicationWe report on the depinning of nearly commensurate charge-density waves in 1T-TaS2 thin films at room temperature. A combination of the differential current–voltage measurements with the low-frequency noise spectroscopy provides unambiguous means for detecting the depinning threshold field in quasi-2D materials. The depinning process in 1T-TaS2 is not accompanied by an observable abrupt increase in electric current—in striking contrast...
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Phenotypic consequences of the LYS4 gene disruption in Candida albicans
PublicationThe main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...
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Hot spot identification by ligand-protein surface interactions mapping – in silico study
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Low-temperature reactivity of the surface species of vanadia–tungsta catalyst
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P04.06 Temozolomide influence on global DNA methylation in glioblastoma cell lines
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Improved Uniform Sampling in Constrained Domains for Data-Driven Modelling of Antennas
PublicationData-driven surrogate modelling of antenna structures is an attractive way of accelerating the design process, in particular, parametric optimization. In practice, construction of surrogates is hindered by curse of dimensionality as well as wide ranges of geometry parameters that need to be covered in order to make the model useful. These difficulties can be alleviated by constrained performance-driven modelling with the surrogate...
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Design-Oriented Constrained Modeling of Antenna Structures
PublicationFast surrogate models are crucially important to reduce the cost of design process of antenna structures. Due to curse of dimensionality, standard (data-driven) modeling methods exhibit serious limitations concerning the number of independent geometry parameters that can be handled but also (and even more importantly) their parameter ranges. In this work, a design-oriented modeling framework is proposed in which the surrogate is...
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An update on medium- and low-abundant blood plasma proteome of horse
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Microscopic calculation of the energetics of ions in polyethylene
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Experimental and numerical study on spontaneous ignition of hydrogen and hydrogen-methane jets in air
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Large eddy simulation predictions of absolutely unstable round hot jet
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A new insight into understanding the Crow and Champagne preferred mode: a numerical study
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Enzymatic assays confirm the toxicity reduction after manure treatment of heavy metals contaminated soil
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Simultaneous determination of polyphenolics in extracts of Potentilla species
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Development of HPTLC method for quantification of flavonoids in extracts of the selected Potentilla species
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Growth and ginsenoside production in Panax quinquefolium hairy roots cultivated in flasks and nutrient sprinkle bioreactor
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Variations in the near-surface atmospheric electric field at high latitudes and ionospheric potential during geomagnetic perturbations
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Differentially expressed proteins in the blood serum of piglets in response to a diet supplemented with inulin
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In-plane and out-of-plane temperature dependencies of the resistivity in single crystals and films of Nd2CuO4
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Evolution of functionally important compartments of proteins – what can we learn from studying epoxide hydrolases?
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Association between susceptibility to photodynamic oxidation and the genetic background of Staphylococcus aureus
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Effect of dietary inclusion of 1% or 3% of native chicory inulin on the large intestinal mucosa proteome of growing pigs
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Understanding element composition of medicinal plants used in herbalism—A case study by analytical atomic spectrometry
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Proteome changes in ileal mucosa of young pigs resulting from different levels of native chicory inulin in the diet
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Trendy w kreowaniu przestrzeni publicznych znajdujących się pod ziemią
PublicationDynamiczny rozwój miast rzadko, kiedy pozostaje w zgodzie z zasadami zrównoważonego rozwoju. Korki uliczne, zanieczyszczenie powietrza, brak przestrzeni zielonych sprawiają, iż po upływie kilku stuleci, ponownie zwracamy się w stronę ziemi, która może zapewnić nam nową przestrzeń dla rozwoju miasta. Istniejące historyczne przestrzenie podziemne: jaskinie, kopalni, obiekty militarne zaadaptowane na konkretne potrzeby, dają możliwość...
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Sterowanie systemami ściekowymi.
PublicationArtykuł przedstawia opracowaną strukturę sterowania oraz podstawową informację dotycząca rozwiązań algorytmicznych jednostek monitorowania i sterowania tej struktury.
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The suitability of DNA extracted from formalin-fixed, paraffin-embedded tissues for double differential polymerase chain reaction analysis
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Evolution of the surface species of the V2O5–WO3 catalysts
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Copper(i) complexes with phosphine derived from sparfloxacin. Part III: multifaceted cell death and preliminary study of liposomal formulation of selected copper(i) complexes
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New “one‐pot” Pd(II) and Zn(II) complexes of Schiff bases, derivatives of 1‐amino‐1‐deoxy‐d‐sorbitol: Spectroscopic studies and biological and catalytic activities
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Liquid residence time in vortex separators
PublicationCentrifugal force enhances gravitational separation of suspension (vortex separators), as well as allows regulation of liquid discharge (vortex flow controls). Furthermore, it elongates the effective residence time of liquid inside the chamber in comparison to non-circulative flow. Laboratorz measurements, described in the paper, indicate that average liquid residence time for circulative flow exceeds 50% of plug-flow time,...
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Hydraulic equations for vortex separators dimensioning
PublicationThe paper presents a set of hydraulic expressions developed to design vortex separators. These devices are used for gravitational removal of suspensions from wastewater. Measurements and theoretical considerations allowed the authors to formulate a mathematically simple velocity field model. Than, equations describing particle motion in the separator were derived. Finally, a technical procedure for hydraulic design of vortex separators...
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PRZEBIEG TEMPERATURY ZIM NA OBSZARZE POLSKI W LATACH 1720–2015
PublicationThe work discusses the air temperature course of winter periods (December–March) in Poland in the years 1720–2015. The analysis is carried out for area mean values calculated from 5 stations: Szczecin, Wrocław, Warsaw, Wilno and Lwów. The time series of the mean area winter temperature (hereinafter PLZ) consists of combined observational (140 years) and reconstructed (156 years) data. PLZ reconstruction is based on independent...
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WSPÓŁCZESNE OCHŁODZENIE REJONU SZETLANDÓW POŁUDNIOWYCH I PÓŁNOCO-ZACHODNICH KRAŃCÓW PÓŁWYSPU ANTARKTYCZNEGO
PublicationThe paper discusses changes of hydro-climatic conditions occurring in the South Shetland Islands and in NW parts of the Antarctic Peninsula in the 1979–2016 years period. These changes are important for evaluation of the transformation of marine and coastal ecosystems. The general feature of these changes was a transition from the strong warming phase to the cooling phase, which took place around the year 2000. The paper presents...