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Search results for: prostate biopsy
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Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy
PublicationOBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated...
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The presence of prostate cancer at biopsy is predicted by a number of genetic variants
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PROSTATE CANCER AND PROSTATIC DISEASES
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PROSTATE
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Prostate Cancer
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Prostate International
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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Lipidomics as a Diagnostic Tool for Prostate Cancer
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Effects of an immunosuppressive treatment on the rat prostate
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Biopsy needles coated with the antimicrobial coatings
PublicationDrug delivery systems are used to achieve higher therapeutic effects of medicaments in a specific diseased site with minimal toxicological effect. The used of biopolymers in drug delivery systems ensure the biocompatibility, biodegradability and low immunogenicity. Drug delivery systems enhance the drug delivery actively and can be used in different diseases. In this study, two types of polymer coatings were prepared and were...
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Diagnostic Accuracy of Liquid Biopsy in Endometrial Cancer
PublicationBackground: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in endometrial cancer (EC) remains poorly explored. We studied the utility of tumor educated platelets (TEPs) and circulating tumor DNA (ctDNA) for preoperative EC diagnosis, including histology determination. Methods:...
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Towards Cancer Patients Classification Using Liquid Biopsy
PublicationLiquid biopsy is a useful, minimally invasive diagnostic and monitoring tool for cancer disease. Yet, developing accurate methods, given the potentially large number of input features, and usually small datasets size remains very challenging. Recently, a novel feature parameterization based on the RNA-sequenced platelet data which uses the biological knowledge from the Kyoto Encyclopedia of Genes and Genomes, combined with a classifier...
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Common variants of xeroderma pigmentosum genes and prostate cancer risk
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An inherited NBN mutation is associated with poor prognosis prostate cancer
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Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
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Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring
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Prognostic factors in postoperative radiotherapy for prostate cancer – tertiary center experience
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A common nonsense mutation of the BLM gene and prostate cancer risk and survival
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Prepubic Minilaparotomy as the Surgical Approach in Treatment of Prostate Disorders in Dogs. A Cadaver Study
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A personalised approach to prostate cancer screening based on genotyping of risk founder alleles
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Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease.
PublicationBACKGROUND: Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition without any known cause or cure. An imbalance in normal gut biota has been identified as an important factor in the inflammatory process. METHODS: Fifty-eight biopsies from Crohn's disease (CD, n = 10), ulcerative colitis (UC, n = 15), and healthy controls (n = 16) were taken from a population-based case-control study. Automated ribosomal intergenic...
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Deep Learning-Based, Multiclass Approach to Cancer Classification on Liquid Biopsy Data
PublicationThe field of cancer diagnostics has been revolutionized by liquid biopsies, which offer a bridge between laboratory research and clinical settings. These tests are less invasive than traditional biopsies and more convenient than routine imaging methods. Liquid biopsies allow studying of tumor-derived markers in bodily fluids, enabling the development of more precise cancer diagnostic tests for screening, disease monitoring, and...
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Deep Learning-Based, Multiclass Approach to Cancer Classification on Liquid Biopsy Data
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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma
PublicationIntroduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with...
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Robust HPLC–MS/MS method for levofloxacin and ciprofloxacin determination in human prostate tissue
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New approach in determination of urinary diagnostic markers for prostate cancer by MALDI-TOF/MS
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Potential of Liquid Biopsy in Papillary Thyroid Carcinoma in Context of miRNA, BRAF and p53 Mutation
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Methylene Blue Near-Infrared Fluorescence Imaging in Breast Cancer Sentinel Node Biopsy
PublicationIntroduction: Fluorescence-based navigation for breast cancer sentinel node biopsy is a novel method that uses indocyanine green as a fluorophore. However, methylene blue (MB) also has some fluorescent properties. This study is the first in a clinical series presenting the possible use of MB as a fluorescent dye for the identification of sentinel nodes in breast sentinel node biopsy. Material and methods: Forty-nine patients with...
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Energetyczne wykorzystanie biomasy
PublicationW artykule przedstawiono energetyczne wykorzystanie biomasy jako alternatywy dla paliwa pierwotnego. Szczególną uwagę poświecono rodzajom, właściwościom i sposobom przygotowania biomasy do procesu spalania.Spalanie stanowi najstarszy sposób pozyskiwania energii z biomasy,jednak ze względu na technologiczno-ekonomiczne aspekty częściej wykorzystywany jest proces współspalania. Wzrost proekologicznej świadomości i rozwój lokalnego...
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GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
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The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men
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Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells
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The Prognostic Value of PI-RADS Score in CyberKnife Ultra-Hypofractionated Radiotherapy for Localized Prostate Cancer
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublicationAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Immunohistochemical detection of galectin-1 in renal biopsy specimens of children and its possible role in proteinuric glomerulopathies
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Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents
PublicationW pracy przedstawiono wyniki przedklinicznych badań toksykologicznych zwiazków C-1748 i C-857 na szczurach Copenhagen i myszach BALB/c, po podaniu dootrzewnowym lub dożylnym. U myszy dawki letalne (LD50) dla C-1748 wynosiły odpowiednio 9 i 13,4 mg/kg w porównaniu z 2,2 i 3 mg/kg dla C-857. U szczurów po podaniu dootrzewnowym lub dożylnym dla C-1748 dawki LD50 wynosiły odpowiednio 4 i 1,3 mg/kg. Nie stwierdzono zmian w liczbie komórek...
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
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Exploring the Antitumor Efficacy of N-Heterocyclic Nitrilotriacetate Oxidovanadium(IV) Salts on Prostate and Breast Cancer Cells
PublicationThe crystal structures of two newly synthesized nitrilotriacetate oxidovanadium(IV) salts, namely [QH][VO(nta)(H2O)](H2O)2 (I) and [(acr)H][VO(nta)(H2O)](H2O)2 (II), were determined. Additionally, the cytotoxic effects of four N-heterocyclic nitrilotriacetate oxidovanadium(IV) salts— 1,10-phenanthrolinium, [(phen)H][VO(nta)(H2O)](H2O)0.5 (III), 2,2′-bipyridinium [(bpy)H][VO(nta)(H2O)](H2O) (IV), and two newly synthesized compounds...
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Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer
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PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties
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The role of fine‑needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls
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Partial-Body Irradiation in Patients with Prostate Cancer Treated with IMRT Has Little Effect on the Composition of Serum Proteome
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Energetyczne wykorzystanie biomasy-zagadnienia wybrane.
PublicationW artykule przedstawiono analizę warunków rozwoju rynku drewna i odpadów drzewnych jako paliwa energetycznego. Omówiono problemy techniczne i ekonomiczne możliwe przy wdrażaniu technologii wykorzystujących biomasę.
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Wykorzystanie biomasy jako surowca energetycznego
PublicationZasoby biomasy w Polsce ocenia się na 15-20 milionów ton równoważnika węglowego. W Polsce produkuje się kotły do spalania słomy, drewna i osadów ściekowych. Powstają agrociepłownie, agroelektrownie i agrorafinerie. Energetyczne wykorzystanie biomasy okazuje się na ogól opłacalne, ekonomiczne i bezpieczne pod względem ekologicznym.
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Perspektywy peletyzacji biomasy w Polsce
PublicationWskazuje się na konsekwencje obowiązującego Rozporządzenia Ministra Gospodarki (Dz.U. 122/1336/2002) o obowiązku zakupu energii ze źródeł odnawialnych. Wskazuje się, że w przypadku współspalania węgla z biomasą konieczne będzie uszlachetnienia paliwa pochodzącego z drewna, słomy osadów ściekowych poprzez peletyzację czyli wytwarzanie minibrykietów. Podaje się parametry fizyczne, ekonomiczne i środowiskowe takiego postępowania....
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Zagospodarowanie biomasy metodą fermentacji metanowej
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Termiczne przetwarzanie biomasy i odpadów
PublicationPrzedmiotem wystąpienia był proces pirolizy tworzyw sztucznych, biomasy oraz hydroliza osadów ściekowych. Przedstawiono wyniki i charakterystykę powstałych w procesie produktów ciekłych, stałych i gazowych.
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Regarding “Accuracy, predictability and prognostic implications of fine‐needle aspiration biopsy for parotid gland tumours: A retrospective case series”
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Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
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