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Search results for: candida krusei
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The role of glucuronidation in drug resistance
PublicationThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
PublicationWe present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody–antigen complexes, and 7 large assemblies. On average 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups...
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Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications
PublicationTissue engineering requires suitable polymeric scaffolds, which act as a physical support for regenerated tissue. A promising candidate might be polyurethane (PUR) scaffold, due to the ease of the PUR properties design, which can be adjusted directly to the intended purpose. In this study, we report a successful fabrication of porous polyurethane scaffolds (PPS) using solvent casting/particulate leaching technique combined with...
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Exploring thiophene-2-acetate and thiophene-3-acetate binding modes towards the molecular and supramolecular structures and photoluminescence properties of Pb(ii) polymers
PublicationTo evaluate the impact of the flexible positional isomeric ligands thiophene-2-acetate (2tpacCOO) andthiophene-3-acetate (3tpacCOO) on the construction and self-assembly process of Pb(II) polymers, twonovel compounds, [Pb(2tpacCOO)2(H2O)]n(1) and [Pb(3tpacCOO)2]n(2), were preparedviaanonhydro-thermal method with respect to green chemistry rules. The obtained polymers were fully characterized byelemental analysis, TG/DTG and PXRD,...
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Synergistic effects of hybrid advanced oxidation processes (AOPs) based on hydrodynamic cavitation phenomenon – A review
PublicationHigh-performance water treatment systems based on cavitational processes have received an increasing interest of scientific community in the past few decades. Numerous studies indicated the advantageous application of hydrodynamic cavitation as an alternative, reagent-free treatment method of various pollutants in water. Both approaches were proved as an effective method to achieve mineralization of many organic contaminants as...
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Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes
PublicationRhododendron tomentosum (Ledum palustre) is an aromatic plant traditionally used for alleviating rheumatic complaints which makes it a potential candidate for a natural drug in rheumatoid arthritis (RA) treatment. However, the effects of plants’ volatiles on apoptosis of synovial fibroblasts and infiltrating leucocytes of RA synovia, have not been reported. Volatile fraction of R. tomentosum is chemically variable and chemotypes...
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Chemia fizyczna TOŚ II - ćwiczenia rachunkowe
e-Learning CoursesKierunek - Technologie Ochrony Środowiska, semestr III. Na kursie przedstawiane będą definicje podstawowych pojęć, wzory z termodynamiki, kinetyki i równowag fazowych. Przygotowane będą zadania i pytania na różnym stopniu trudności.
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Detektory promieniowania 2023/2024
e-Learning CoursesNa kursie omawiane są podstawowe zjawiska wykorzystywane w detekcji promieniowania e-m oraz budowa i parametry detektorów pracujące w oparciu o te zjawiska. Szczególna uwaga poświęcona jest promieniowaniu jonizującemu.
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Deep sea habitats in the chemical warfare dumping areas of the Baltic Sea
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The Influence of COD Fraction Forms and Molecules Size on Hydrolysis Process Developed by Comparative OUR Studies in Activated Sludge Modelling
PublicationThe activated sludge models (ASMs) commonly used by the International Water Association (IWA) task group are based on chemical oxygen demand (COD) fractionations. However, the proper evaluation of COD fractions, which is crucial for modelling and especially oxygen uptake rate (OUR) predictions, is still under debate. The biodegradation of particulate COD is initiated by the hydrolysis process, which is an integral part of an ASM....
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Technologie Membranowe
e-Learning CoursesKurs stanowi wprowadzenie do technologii membranowych, w szczególności jako technik separacyjnych. W kursie zostaną omówione techniki membranowe klasyfikowane wg wielkości separowanych cząstek i siły napędowych procesu.
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The KLC Cultures, Tacit Knowledge, and Trust Contribution to Organizational Intelligence Activation
PublicationIn this paper, the authors address a new approach to three organizational, functional cultures: knowledge culture, learning culture, and collaboration culture, named together the KLC cultures. Authors claim that the KLC approach in knowledge-driven organizations must be designed and nourished to leverage knowledge and intellectual capital. It is suggested that they are necessary for simultaneous implementation because no one of...
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Operational control on environmental safety of potentially toxic elements during thermal conversion of metal-accumulator invasive ragweed to biochar
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Alireza Tabrizikahou Master of Science
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METODA ELEMENTÓW SKOŃCZONYCH - ZASTOSOWANIA, r.a. 2022/2023, sem. letni
e-Learning CoursesPrzedmiot ma na celu zapoznanie studentów z wybranymi aspektami praktycznego zastosowania MES w inżynierii.
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Fundamenty Specjalne - Niestacjonarne - 22_23
e-Learning CoursesKurs przeznaczony jest dla studentów kierunku Budownictwo, studiów niestacjonarnych II stopnia. W kursie zamieszczone są materiały pomocnicze do zajęć wykładowych i ćwiczeniowych oraz prowadzone będą ewentualne zajęcia zdalne (webinaria, czaty, konsultacje itp.)
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Modelowanie symulacyjne procesów
e-Learning CoursesWitam na kursie Modelowanie symulacyjne procesów! Mam nadzieję, że wiedza i umiejętności zdobyte podczas zajęć będą przydatne w Państwa życiu zawodowym :) Do zobaczenia wkrótce, Marzena Grzesiak
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Katedra Mechaniki Konstrukcji
Research TeamsMechanika konstrukcji obiektów badawczych takich jak kadłuby statków i jachtów, platformy wiertnicze, elektrownie wiatrowe, rurociągi, zbiorniki oraz osprzęt żaglowy jednostek pływających - zarówno stalowe jak i kompozytowe.
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A new cold-adapted beta-D-galactosidase from the Antarctic Arthrobacter sp. 32c - gene cloning, overexpression, purification and properties
PublicationThe development of a new cold-active β-D-galactosidases and microorganisms that efficiently ferment lactose is of high biotechnological interest, particularly for lactose removal in milk and dairy products at low temperatures and for cheese whey bioremediation processes with simultaneous bio-ethanol production. In this article, we present a new β-D-galactosidase as a candidate to be applied in the above mentioned biotechnological...
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Tuning of microstructure in engineered poly (trimethylene terephthalate) based blends with nano inclusion as multifunctional additive
PublicationImmiscible blends and their composites are heterogeneous and have variable morphology due to variation in mesophase regions. Tuning, i.e. controlling the phase dimension is important, thereof we report a “super-combo” effect of multiwalled carbon nanotubes (MWCNTs) in poly (trimethylene terephthalate)/polypropylene (PTT/ PP) blend system. MWCNTs act as a good reinforcing agent and compatibilizer in the otherwise immiscible PTT/...
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Enzyme-conjugated MXene nanocomposites for biosensing and biocatalysis acuities
PublicationEngineered two-dimensional (2-D) MXenes-based materials with tunable characteristics and multi-functionalities have brought up new paradigms in the biosensing and catalysis of chemical compounds. The profusion of electroactive functional moieties on the surface of few/multi-layer MXenes facilitates their ability to retain biomolecules such as enzymes resulting in unique dimensions for bioanalytical and biosensing applications....
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The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication
PublicationIn this paper we describe the synthesis of poly(ester ether urethane)s (PEEURs) by using selected raw materials to reach a biocompatible polyurethane (PU) for biomedical applications. PEEURs were synthesized by using aliphatic 1,6-hexamethylene diisocyanate (HDI), poly(ethylene glycol) (PEG), α,ω-dihydroxy(ethylene-butylene adipate) (Polios), 1,4-butanediol (BDO) as a chain extender and calcium glycerolphosphate salt (GPCa) as...
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Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering
PublicationThis paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially...
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Deep learning for ultra-fast and high precision screening of energy materials
PublicationSemiconductor materials for energy storage are the core and foundation of modern information society and play important roles in photovoltaic system, integrated circuit, spacecraft technology, lighting applications, and other fields. Unfortunately, due to the long experiment period and high calculation cost, the high-precision band gap (the basic characteristic parameter) of semiconductor is difficult to obtain, which hinders the...
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Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants
PublicationThe genome feature of SARS-CoV-2 leads the virus to mutate and creates new variants of concern. Tackling viral mutations is also an important challenge for the development of a new vaccine. Accordingly, in the present study, we undertook to identify B- and T-cell epitopes with immunogenic potential for eliciting responses to SARS-CoV-2, using computational approaches and its tailoring to coronavirus variants. A total of 47 novel...
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Globalized Simulation-Driven Miniaturization of Microwave Circuits by Means of Dimensionality-Reduced Constrained Surrogates
PublicationSmall size has become a crucial prerequisite in the design of modern microwave components. Miniaturized devices are essential for a number of application areas, including wireless communications, 5G/6G technology, wearable devices, or the internet of things. Notwithstanding, size reduction generally degrades the electrical performance of microwave systems. Therefore, trade-off solutions have to be sought that represent acceptable...
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Hydrogeologia 2023
e-Learning CoursesHydrogeologia to nauka o wodach podziemnych. Na kursie zajmiemy się warunkami występowania i krążenia wód podziemnych, ich składem chemicznym, jakością, ochroną i zagrożeniami oraz problemami inżynierskimi związanymi z obecnością i przepływem wód podziemnych w gruntach.
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Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats
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The importance of evaluating metal exposure and predicting human health risks in urban–periurban environments influenced by emerging industry
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Measurement of Seafloor Acoustic Backscatter Angular Dependence at 150 kHz Using a Multibeam Echosounder
PublicationAcoustic seafloor measurements with multibeam echosounders (MBESs) are currently often used for submarine habitat mapping, but the MBESs are usually not acoustically calibrated for backscattering strength (BBS) and cannot be used to infer absolute seafloor angular dependence. We present a study outlining the calibration and showing absolute backscattering strength values measured at a frequency of 150 kHz at around 10–20 m water...
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Urządzenia do uzdatniania wody
e-Learning CoursesKurs przeznaczony jest dla studentów I stopnia - inżynierskie, studiów niestacjonarnych, w semestrze 6, specjalności: Technologie w inżynierii środowiska (WILiŚ), Na kursie omówione zostaną zagadnienia związane z przeznaczeniem, budową oraz zasadą działania urządzeń na stacjach uzdatniania wody.
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Fotogrametria Cyfrowa z Elementami Widzenia Komputerowego
e-Learning CoursesFotogrametria Cyfrowa z Elementami Widzenia Komputerowego jest kursem na sem. II stuidów magisterskich kierunku Geodezja i Kartografia. Studenci w sposób aktywny poznają metody przetwarzania cyfrowego danych fotogrametrycznych oraz nauczą się podstaw widzenia komputerowego, wykorzystywanego w fotogrametrii.
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Zarządzanie procesami - niestacjonarne online 2024
e-Learning CoursesWitamy na kursie Zarządzanie procesami! Mamy nadzieję, ze wiedza i umiejętności zdobyte podczas zajęć będą przez Państwa wykorzystane w życiu zawodowym :) Do zobaczenia wkrótce, Marzena Grzesiak Piotr Sliż
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Zarządzanie procesami - niestacjonarne
e-Learning CoursesWitamy na kursie Zarządzanie procesami! Mamy nadzieję, ze wiedza i umiejętności zdobyte podczas zajęć będą przez Państwa wykorzystane w życiu zawodowym :) Do zobaczenia wkrótce, Marzena Grzesiak Piotr Sliż
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Zarządzanie procesowe - stacjonarne 2024
e-Learning CoursesWitamy na kursie Zarządzanie procesowe! Mamy nadzieję, ze wiedza i umiejętności zdobyte podczas zajęć będą przez Państwa wykorzystane w życiu zawodowym :) Do zobaczenia wkrótce, Marzena Grzesiak Piotr Sliż
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Oskar Ronda
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AutoCad II + Elementy BIM
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Phytocomponents and evaluation of acetylcholinesterase inhibition by Ginkgo biloba L. leaves extract depending on vegetation period
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Deep submarine groundwater discharge indicated by pore water chloride anomalies in the Gulf of Gdańsk, southern Baltic Sea
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Hepatic fibrosis - Female, 52 - Tissue image [5250730010642031]
Open Research DataThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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STACJE UZDATNIANIA WODY
e-Learning CoursesKurs przeznaczony jest dla studentów II stopnia studiów stacjonarnych, w semestrze 1, specjalności: Technologie w inżynierii środowiska (WILiŚ), Na kursie omówione zostaną zagadnienia związane z przeznaczeniem, budową oraz zasadą działania urządzeń na stacjach uzdatniania wody.
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Cloning and characterization of a novel cold-active glycoside hydrolase family 1 enzyme with beta-glucosidase, beta-fucosidase and beta-galactosidase activities.
PublicationBackground: Cold-active enzymes, sourced from cold-adapted organisms, are characterized by high catalytic efficiencies at low temperatures compared with their mesophilic counterparts, which have poor activity. This property makes them advantageous for biotechnology applications as it: (i) saves energy costs, (ii) shortens the times for processes operated at low temperatures, (iii) protects thermosensitive substrates or products...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
PublicationAmphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...
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Expedited Machine-Learning-Based Global Design Optimization of Antenna Systems Using Response Features and Multi-Fidelity EM Analysis
PublicationThe design of antenna systems poses a significant challenge due to stringent per-formance requirements dictated by contemporary applications and the high com-putational costs associated with models, particularly full-wave electromagnetic (EM) analysis. Presently, EM simulation plays a crucial role in all design phases, encompassing topology development, parametric studies, and the final adjustment of antenna dimensions. The latter...
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A comprehensive evaluation of flexible FDM/FFF 3D printing filament as a potential material in medical application
PublicationThe use of FDM/FFF in 3D printing for medical sciences is becoming common. This is due to the high availability and decent price of both 3D printers and filaments useful for FDM/FFF. Currently, researchers' attention is focused mainly on the study of medical filaments based on PLA, PCL or their modifications. This contributes to insufficient diversity of medical-grade filaments on the market. Moreover, due to the lack of specified...
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Agnieszka Kurdyn mgr inż.
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Zdolni z Pomorza - Kółko olimpijskie z chemii (szkoła ponadpodstawowa) 2021/2022
e-Learning CoursesNa tym kursie zamieszczane będą materiały do realizacji zajęć stacjonarnych w ramach Kółka Olimpijskiego z chemii dla uczniów szkół ponadpodstawowych realizowanego w w roku szkolnym 2021/22 w ramach projektu "Zdolni z Pomorza – Politechnika Gdańska".
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Zdolni z Pomorza - Kółko olimpijskie z chemii (szkoła ponadpodstawowa) 2022/2023
e-Learning CoursesNa tym kursie zamieszczane będą materiały do realizacji zajęć stacjonarnych w ramach Kółka Olimpijskiego z chemii dla uczniów szkół ponadpodstawowych realizowanego w w roku szkolnym 2022/23 w ramach projektu "Zdolni z Pomorza – Politechnika Gdańska".
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Przygotowanie do egzaminu dyplomowego - Fotogrametria
e-Learning CoursesKurs ma na celu przygotowanie prowadzonych dyplomantów do egzaminu dyplomowego, zebranie materiałów dydaktycznych i metodycznych w ramach kursu, oraz ujednolicenie wymiany informacji w ramach dyplomów. W kursie znajdują się materiały, szablony oraz informacje dotyczące poprawnego przygotowania pracy dyplomowej.