Search results for: inhibicja enzymu

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024691751]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024693691]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [322063002469601]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [322063002469531]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024699141]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024693041]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024691131]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024683321]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024693971]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024691011]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024697541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [322063002469181]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [322063002469461]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024695681]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024687421]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024692621]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024694951]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024699241]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024692871]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024691971]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024695961]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024699711]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024694631]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024697411]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [322063002468831]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024682841]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024699551]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024693361]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024682351]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024681271]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024693081]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• A Comparative Study on the Toxicity of Chlorides and Tri-tert-butoxysilanethiolates of Zinc(II), Cadmium(II) and Mercury(II) Towards Candida albicans and Escherichia coli.

  Publication

  • M. Wieczerzak
  • S. Godlewska
  • I. Chabowska
  • P. Szweda
  • A. Dołęga

  - Year 2010

  Metale przejściowe, czyli cynk, kadm i rtęć należą do XII grupy układu okresowego. Cynk jako element strukturalny białek odgrywa zróżnicowaną rolę biologiczną i jest pierwiastkiem niezbędnym do zachowania funkcji życiowych. W odróżnieniu od niego kadm i rtęć są metalami wykazującymi działanie toksyczne i podejrzanymi o działanie rakotwórcze. Kadm w szkodliwy sposób wpływa na uprawy oraz organizm ludzki. Toksyczne działanie rtęci...

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• An MTA-phosphorylase gene discovered in the metagenomic library derived from Antarctic top soil during screening for lipolytic active clones confers strong pink fluorescence in the presence of rhodamine B.

  Publication

  • H. Cieśliński
  • A. Długołecka
  • J. Kur
  • M. Turkiewicz

  - FEMS MICROBIOLOGY LETTERS - Year 2009

  In this work, we present the construction of a metagenomic library in Escherichiacoli using the pUC19 vector and environmental DNA directly isolated fromAntarctic topsoil and screened for lipolytic enzymes. Unexpectedly, the screeningon agar supplemented with olive oil and rhodamine B revealed one unusual pinkfluorescent clone (PINKuv) out of 85 000 clones. This clone harbored a plasmid,pPINKuv, which has an insert of 8317 bp that...

• Identification and molecular modeling of a novel lipase from an Antarctic soil metagenomic library.

  Publication

  • H. Cieśliński
  • A. Białkowska
  • K. Tkaczuk
  • A. Długołęcka
  • J. Kur
  • M. Turkiewicz

  - Polish Journal of Microbiology - Year 2009

  In this work, we present the construction of a metagenomic library in Escherichia coli using pUC19 vector and environmental DNA directly isolated from Antarctic topsoil and screened for lipolytic enzymes. The screening on agar supplemented with olive oil and rhodamine B revealed one clone with lipolytic activity (Lip1) out of 11,000 E. coli clones. This clone harbored a plasmid, pLip1, which has an insert of 4722 bp that has been...

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• The Effect of Marginal Zn2+ Excess Released from Titanium Coating on Differentiation of Human Osteoblastic Cells

  Publication

  • M. Bartmański
  • Ł. Pawłowski
  • A. Knabe
  • S. Mania
  • A. Banach-Kopeć
  • M. Sakowicz-Burkiewicz
  • A. Ronowska

  - ACS Applied Materials & Interfaces - Year 2024

  Composite coatings based on chitosan and zinc nanoparticles (ZnNPs) were successfully produced on Ti13Zr13Nb substrates by cathodic electrophoretic deposition (EPD). The unfavorable phenomenon of water electrolysis-induced nonuniformity was reduced by applying a low voltage (20 V) and a short deposition time (1 min). Surface analysis (roughness and hydrophilicity) reveals the potential of these coatings for enhancing cell attachment...

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• Cabbage Juices and Indoles Modulate the Expression Profile of AhR, ERα, and Nrf2 in Human Breast Cell Lines

  Publication

  • H. Szaefer
  • V. Krajka-Kuźniak
  • B. Licznerska
  • A. Bartoszek-Pączkowska
  • W. Baer-Dubowska

  - NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL - Year 2015

  Our previous studies showed the diversified effect of cabbage juices and indoles on the estrogen metabolism key enzymes (CYP1A1, CYP1A2, CYP1B1) in breast epithelial cells differing in ER status, i.e., in tumorigenic—MCF7, MDA-MB-231 and non-tumorigenic—MCF10A cells. The aim of the present study was to further investigate the mechanism of chemopreventive action of cabbage juice and its active components by evaluating their effect...

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• Effect of Ethanol Extracts of Propolis (EEPs) against Staphylococcal Biofilm—Microscopic Studies

  Publication

  • K. Grecka
  • Z. R. Xiong
  • H. Chen
  • K. Matejczuk
  • R. Worobo
  • P. Szweda

  - Pathogens - Year 2020

  Staphylococci growing in the form of biofilm exhibit high resistance to a plethora of antibiotics. The aim of the study was to assess the influence of ethanolic extract of propolis (EEPs) on S. epidermidis ATCC 35984 biofilm using fluorescent microscopy. Propidium iodide (PI) and SYTO 9 were used for differentiation of live and dead cells, and calcofluor white was used to stain the extracellular matrix, the self-produced extracellular...

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• Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.

  Publication

  • A. Potęga

  - MOLECULES - Year 2022

  The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...

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• Hydrogen Production from Energy Poplar Preceded by MEA Pre-Treatment and Enzymatic Hydrolysis

  Publication

  • K. Kucharska
  • R. Łukajtis
  • E. Słupek
  • H. Cieśliński
  • P. Rybarczyk
  • M. A. Kamiński

  - MOLECULES - Year 2018

  The need to pre-treat lignocellulosic biomass prior to dark fermentation results primarily from the composition of lignocellulose because lignin hinders the processing of hard wood towards useful products. Hence, in this work a two-step approach for the pre-treatment of energy poplar, including alkaline pre-treatment and enzymatic saccharification followed by fermentation has been studied. Monoethanolamine (MEA) was used as the...

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• Study of pH and temperature effect on lipophilicity of catechol-containing antioxidants by reversed phase liquid chromatography

  Publication

  • C. Numviyimana
  • T. Chmiel
  • A. Kot-Wasik
  • J. Namieśnik

  - MICROCHEMICAL JOURNAL - Year 2019

  Lipophilicity of selected antioxidant phytochemicals, including flavonoids, phenolic acids and xanthonoids, was determined by reversed phase high performance liquid chromatography with UV detection (RP-HPLC-UV). The analyses run at different temperature and pH conditions in isocratic mode suggested that lipophilicity as distribution coefficient (logD) between aqueous and organic phase decreases with increasing temperature. For...

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• The bile salt content of human bile impacts on simulated intestinal proteolysis of β-lactoglobulin

  Publication

  • D. Dulko
  • R. Staroń
  • L. Krupa
  • N. Rigby
  • A. Mackie
  • K. Gutkowski
  • A. Wasik
  • A. Macierzanka

  - FOOD RESEARCH INTERNATIONAL - Year 2021

  The gastrointestinal hydrolysis of food proteins has been portrayed in scientific literature to predominantly depend on the activity and specificity of proteolytic enzymes. Human bile has not been considered to facilitate proteolysis in the small intestine, but rather to assist in intestinal lipolysis. However, human bile can potentially influence proteins that are largely resistant to gastric digestion, and which are mainly hydrolysed...

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• Metabolism of antitumor 9-amino-1-nitroacridine derivatives in HepG2 cells and its influence on cytochrome P450 isoenzymes

  Publication

  • M. Niemira
  • A. Wiśniewska
  • J. Konopa
  • Z. Mazerska

  - FEBS Journal - Year 2009

  Celem przeprowadzonych badań było określenie wpływu pochodnych C-857 i C-1748 na poziom enzymów cytochromu P450 w powiązaniu z kinetyką metabolizmu badanych związków. Eksperymenty zostały przeprowadzone na komórkach ludzkiego nowotworu wątroby HepG2. Uzyskane wyniki metodą Western blotting wykazały, że za metaboliczną transformacje pochodnych C-857 i C-1748 odpowiada izoenzym CYP3A4.Analiza metabolitów (Western blotting, HPLC)...

• Implementing fermentation technology for comprehensive valorisation of seafood processing by-products: A critical review on recovering valuable nutrients and enhancing utilisation

  Publication

  • S. A. Siddiqui
  • D. Lakshmikanth
  • C. Pradhan
  • Z. Farajinejad
  • R. Castro Munoz
  • A. Sasidharan

  - CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION - Year 2024

  Fermentation technology is a biorefining tool that has been used in various industrial processes to recover valuable nutrients from different side streams. One promising application of this technique is in the reclamation of nutritional components from seafood side streams. Seafood processing generates significant amounts of waste, including heads, shells, and other side streams. These side streams contain high quantities of valued...

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• Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response

  Publication

  • M. Pawłowska
  • A. Kwaśniewska
  • Z. Mazerska
  • E. Augustin

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2020

  Activity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...

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• Optimization of Saccharification Conditions of Lignocellulosic Biomass under Alkaline Pre-Treatment and Enzymatic Hydrolysis

  Publication

  • R. Łukajtis
  • P. Rybarczyk
  • K. Kucharska
  • D. Konopacka-Łyskawa
  • E. Słupek
  • K. Wychodnik
  • M. A. Kamiński

  - ENERGIES - Year 2018

  Pre-treatment is a significant step in the production of second-generation biofuels from waste lignocellulosic materials. Obtaining biofuels as a result of fermentation processes requires appropriate pre-treatment conditions ensuring the highest possible degree of saccharification of the feed material. An influence of the following process parameters were investigated for alkaline pre-treatment of Salix viminalis L.: catalyst concentration...

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• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [322063002469591]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024689581]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Podstawy chemii fizycznej i biofizycznej -- ćwiczenia

  e-Learning Courses

  • J. Czub
  • J. Słabońska
  • A. Brillowska-Dąbrowska
  • M. Badocha
  • J. Stangret
  • P. Chodnicki
  • C. Kleist

  Celem przedmiotu jest dostarczenie formalizmu służącego do opisu i przewidywania przebiegu reakcji biochemicznych oraz innych procesów biomolekularnych. Plan kursu: 1. Oddziaływania międzycząsteczkowe (elektrostatyka, oddziały-wania van der Waalsa, wiązania wodorowe, oddziaływania hydro-fobowe) 2. Podstawy termodynamiki z elementami teorii statystycznej (zasady termodynamiki, entropia i jej interpretacja statystyczna, rozkład...

• Podstawy chemii fizycznej i biofizycznej -- wykład

  e-Learning Courses

  • J. Czub
  • J. Słabońska
  • A. Brillowska-Dąbrowska
  • M. Badocha
  • J. Stangret
  • P. Chodnicki
  • C. Kleist

  Celem przedmiotu jest dostarczenie formalizmu służącego do opisu i przewidywania przebiegu reakcji biochemicznych oraz innych procesów biomolekularnych. Plan kursu: 1. Oddziaływania międzycząsteczkowe (elektrostatyka, oddziały-wania van der Waalsa, wiązania wodorowe, oddziaływania hydro-fobowe) 2. Podstawy termodynamiki z elementami teorii statystycznej (zasady termodynamiki, entropia i jej interpretacja statystyczna, rozkład...

• Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells

  Publication

  • A. Mieszkowska
  • A. M. Nowicka
  • A. Kowalczyk
  • A. Potęga
  • M. Pawłowska
  • M. Kosno
  • E. Augustin
  • Z. Mazerska

  - Pharmaceuticals - Year 2021

  New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...

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