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Search results for: DŁAWIK UZIEMIAJĄCY
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Lactoferrin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Corrigendum to “Gynaecology, physiotherapy and balneoclimatology – An interdisciplinary approach” [Eur. J. Obstet. Gynecol. Reprod. Biol. 293 (2024) 170–300]
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublicationEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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In Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
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Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublicationAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
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A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond
PublicationAccording to the World Health Organization (WHO), almost 2 billion people each year are infected worldwide with flu-like pathogens including influenza. This is a contagious disease caused by viruses belonging to the family Orthomyxoviridae. Employee absenteeism caused by flu infection costs hundreds of millions of dollars every year. To successfully treat influenza virus infections, detection of the virus during the initial development...
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Acute myocardial infarction reparation/regeneration strategy using Wharton’s jelly multipotent stem cells as an ‘unlimited’ therapeutic agent: 3-year outcomes in a pilot cohort of the CIRCULATE-AMI trial
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Dynamika Budowli (2024/2025)
e-Learning CoursesKurs przedmiotu Dynamika Budowli, kierunek Budownictwo, studia stacjonarne I stopnia, V semestr, rok. akad. 2024/25.
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Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Acute impact of blood flow restriction on strength-endurance performance during the bench press exercise
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublicationSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Highly selective impedimetric determination of Haemophilus influenzae protein D using maze-like boron-doped carbon nanowall electrodes
PublicationThis study reports a novel impedimetric immunosensor for protein D detection in purified and bacterial (Haemophilus influenzae, Hi) samples. The detection was based on antigen recognition by anti-protein D antibodies (apD) immobilised at the maze-like boron-doped carbon nanowall electrodes (B:CNW). The B:CNW electrodes were synthesised, and their surface was characterised by scanning electron microscopy (SEM) and X-ray photoelectron...
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Stardust - Investigation of Microbes in the Stratosphere
PublicationThe stratospheric microbiome has been investigated several times using the methods of classical microbiology. In this experiment, we have combined them with some novel approaches including whole- metagenome amplification, Maldi TOF mass spectrometry and Sanger DNA sequencing. The results of the experiment may provide the scientists with knowledge about the mechanisms of survivability of microorganisms in stratospheric conditions...
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Multi-modality imaging in the CIRCULATE-AMI pilot study cohort: a framework for an imaging-based randomized controlled trial of Wharton jelly mesenchymal stem cell use to stimulate myocardial repair/regeneration
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mRNA adenosine methylase (MTA) deposits m 6 A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana
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Structural, optical and magnetic properties of Y3−0.02−xEr0.02Yb x Al5O12 (0 < x < 0.20) nanocrystals: effect of Yb content
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No relationship between the digit ratios (2D:4D) and salivary testosterone change: Study on men under an acute exercise
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CAD z elementami BIM - 2022/2023
e-Learning CoursesKurs dla Budownictwa 4 semestr
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Evaluation of ferrofluid-coated rotating magnetic field-assisted bioreactor for biomass production
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Impact of agricultural farms on the environment of the Puck Commune: Integrated agriculture calculator—CalcGosPuck
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Excess nitrogen responsive HvMADS27 transcription factor controls barley root architecture by regulating abscisic acid level
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Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers
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Interlaboratory Test to Characterize the Cyclic Behavior of Bituminous Interlayers: An Overview of Testing Equipment and Protocols
PublicationThe performance assessment of multi-layered pavements strongly depends on the mechanical behavior of the interface between bituminous layers. So far, comprehensive studies have been carried out mainly using quasi-static laboratory tests focusing on the interlayer shear strength at failure. However, it is generally recognized that cyclic shear testing will lead to the determination of parameters which are more closely linked to...
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Interlaboratory Test to Characterize the Cyclic Behavior of Bituminous Interlayers: An Overview of Testing Equipment and Protocols
PublicationThe performance assessment of multi-layered pavements strongly depends on the mechanical behavior of the interface between bituminous layers. So far, comprehensive studies have been carried out mainly using quasi-static laboratory tests focusing on the interlayer shear strength at failure. However, it is generally recognized that cyclic shear testing will lead to the determination of parameters which are more closely linked to...
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PING 2023/2024
e-Learning CoursesNa potrzeby koła naukowego PING
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Performance of protein-structure predictions with the physics-based UNRES force field in CASP11
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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iTre-es The impact of institutional framework change on ecosystem services provided by trees/shrubs to local communities.
ProjectsProject realized in Uniwersytet im. Adama Mickiewicza w Poznaniu according to 2017/25/B/HS6/00954 agreement from 2017-11-23
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Dynamika Budowli (2022/2023)
e-Learning CoursesKurs przedmiotu Dynamika Budowli, kierunek Budownictwo, studia stacjonarne I stopnia, V semestr, rok. akad. 2022/23.
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Inżynieria dla klimatu
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EMPATHY AND BURNOUT SYNDROME IN THE PRACTICE OF EMERGENCY SERVICES — PILOT STUDY
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality
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Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds-synthesis and applications
PublicationThis article describes the synthesis and enzymatic study of newly synthesized analogs of trypsin inhibitors SFTI-1 that were fluorescent labeled on their N-terminal amino groups. Two fluorescent derivatives of benzoxazole (3-[2-(4-diphenylaminophenyl) benzoxazol-5-yl]-L-alanine[(4NPh(2)) Ph] Box-Ala and 3-[2-(2', 4', 5'-trimethoxyphenyl) benzoxazol-5-yl]-l-alanine-[2,4,5-(OMe)3Ph] Box-Ala) were used as efficient fluorescent labels....
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A unified coarse-grained model of biological macromolecules based on mean-field multipole–multipole interactions
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Geometria Wykreślna na kierunku Budownictwo 2024/2025
e-Learning CoursesPrzedmiot o nazwie Geometria Wykreślna dla I sem. studiów stacjonarnych kierunku Budownictwo. Geometria Wykreślna na kierunku Budownictwo 2024/2025 (zima), kurs wspierający przedmiot Geometria Wykreślna, (PG_00043984) przeznaczony dla studentów: Kierunek studiów: BudownictwoPoziom kształcenia: I stopnia - inżynierskie Rok akademicki realizacji przedmiotu: 2024/2025Forma studiów: stacjonarne Rok studiów: 1 Semestr: 1 (zimowy)
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Transcriptome Changes in Three Brain Regions during Chronic Lithium Administration in the Rat Models of Mania and Depression
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Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders
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PING 2021/2022
e-Learning CoursesNa potrzeby koła naukowego PING
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Seminarium dyplomowe mgr Inżynieria Dźwięku i Obrazu
e-Learning CoursesPrezentacje postępów w realizacji prac dyplowych.
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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A New Approach for Investigating the Impact of Pesticides and Nutrient Flux from Agricultural Holdings and Land-Use Structures on Baltic Sea Coastal Waters
PublicationKnowledge related to land-use management impacts on the Baltic Sea ecosystem is limited. The constant release of pollutants into water bodies has resulted in water quality degradation. Therefore, only the innovative approaches integrated with research will provide accurate solutions and methods for proper environment management and will enable understanding and prediction of the impacts of land-use in the Baltic Sea region. Modelling...
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rSMA2 Development of guidelines for the re-use of reclaimed asphalt from SMA layers for new wearing courses laid using the same technology
ProjectsProject realized in Department of Transportation Engineering
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Integrated information and prediction Web Service WaterPUCK General concept
PublicationIn this paper, general concept of a new method as ‘Integrated information and prediction Web Service WaterPUCK’ for investigation influence of agricultural holdings and land-use structures on coastal waters of the southern Baltic Sea is presented. WaterPUCK Service is focused on determination of the current and future environmental status of the surface water and groundwater located in the Puck District (Poland) and its impact...
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Karol Grębowski dr inż.
PeopleKarol Grębowski (M.Sc.) works as an assistant at the Department of Technical Fundamentals of Architecture Design of the Faculty of Architecture at Gdansk University of Technology. His scientific research deals with dynamic phenomena occurring during the vibration of structures, bridges, and studies the design methodology of the elements forming passive protection system of the vehicles degraded by struck or explosion in the context...
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Abdominoplasty Skin-Based Dressing for Deep Wound Treatment—Evaluation of Different Methods of Preparation on Therapeutic Potential
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Wytrzymałość Materiałów (2022/2023)
e-Learning CoursesKurs przedmiotu Wytrzymałość Materiałów, kierunek Budownictwo, studia stacjonarne I stopnia, III semestr, rok akademicki 2022/23.