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Search results for: METABOLIC NEOTENY
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C -1305
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I metabolism. The...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublicationPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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The Mineral Character and Geomechanical Properties of the Transitional Rocks from the Mesozoic-Neogene Contact Zone in the Bełchatów Lignite Deposit
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Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
PublicationMouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression...
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Machining by abrasive-metallic lapping tools.
PublicationPrzedstawiono kontrukcję niekonwencjonalnych narzędzi ścierno-metalowych do docierania. Opracowane narzędzia wykorzystano do badań wydajności i jakości docierania elementów ceramicznych. Określono wpływ podstawowych warunków docierania na efekty obróbki powierzchni płaskich.
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Conducting polymers for biodegradable metallic implants
PublicationNowadays permanent metallic cardiovascular stents are long-term implants. The long-time presence of such an implant in human body can cause overgrowth of tissue within the treated portion of the vessel, blockage of the circulatory system and many other clinical complications, such as thrombosis, prolonged physical irritations or chronic inflammation. Therefore, in recent years, there is an interest to create biodegradable metallic...
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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview
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Metabolic Syndrome and Related Disorders
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Journal of Diabetes and Metabolic Disorders
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Nutrition, Obesity & Metabolic Surgery
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Journal of Obesity & Metabolic Syndrome
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JOURNAL OF INHERITED METABOLIC DISEASE
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REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
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Clinical Lipidology and Metabolic Disorders
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GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
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Comparison of RP-HPLC columns used for determination of nucleoside metabolic patterns in urine of cancer patients
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Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: A pilot study
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The studies of imidazoacridinone antitumor agent, C-1311, in the field of metabolic transformations with cytochrome P450 isoenzymes
PublicationPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowej pochodnej imidazoakrydonu C-1311 wobec rekombinantowych ludzkich izoenzymów P450. Związek nie ulegał transformacji w badanych warunkach, natomiast wykazano, że ma zdolność hamowania aktywności izoezymów CYP1A2 i CYP3A4.
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Metabolic activation of adriamycin by NADPH-cytochrome P450 reductase; overview of its biological and biochemical effects
PublicationOmówione zostały efekty aktywacji metabolicznej adriamycyny przez NADPH-zależną reduktazę cytochromu P450. Wykazano, że ten rodzaj aktywacji zwiększa aktywność biologiczną tego związku, a przy tym powoduje jego wiązanie się kowalencyjne z ważnymi biologicznie makromolekułami komórkowymi.
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Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners
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Positive Regulation of Macromolecule Metabolic Process Belongs to the Main Mechanisms Crucial for Porcine Oocytes Maturation
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Expression Changes in Fatty acid Metabolic Processrelated Genes in Porcine Oocytes During in Vitro Maturation
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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation
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Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides
PublicationA series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids. Some of them showed anticancer activity toward the human cancer cell lines MCF-7, HCT-116 and HeLa, with the growth percentages (GPs) in the range from 7% to 46%. Quantitative structure-activity relationship...
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Cell Metabolism
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Molecular Metabolism
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Endocrinology and Metabolism
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Cancer & Metabolism
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Heart and Metabolism
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Obesity and Metabolism
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Nutrition & Metabolism
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Nature Metabolism
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The Opoka-Rock from the Mesozoic/Neogene Contact Zone in the Bełchatów Lignite Deposit – Characteristics of a Petrographic Nature and as a Raw Material
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Lapping of flat surfaces with two metallic tools.
PublicationPrzedstawiono opis docierania powierzchni płaskich docierakami aktywizowanymi w sposób swobodny i wymuszony oraz narzędziami dwumetalowymi i ściernometalowymi. Wyznaczono zużycie docieraków stalowo-żeliwnych oraz wydajność obróbki żeliwa sferoidalnego niestopowego i stali NC6.
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Nucleate pool boiling on porous metallic coatings
PublicationPrzedstawiono wyniki systematycznych badań eksperymentalnych przejmowania ciepła podczas wrzenia pęcherzykowego wody destylowanej w stanie nasycenia od płaskich i cylindrycznych powierzchni o specjalnie przygotowanej powierzchni: gładkiej, chropowatej oraz pokrytej warstwą porowatą.
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Microbiological corossion of metallic products as a result of biofilm
PublicationWarunkiem do pojawienia się korozji mikrobiologicznej jest utworzenie na powierzchni metalu biofilmu. Zawiera on biologicznie czynne mikroorganizmy wraz z produktami ich przemian metabolicznych. Biofilm ogranicza dyfuzję produktów metabolizmu wytwarzanych przez poszczególne komórki mikrokolonii. Powoduje to, że produkty uboczne tych przemian gromadzą się w bezpośrednim sąsiedztwie metalu. Gdy powierzchnia metalu nie jest odporna...
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Biocompatibility and bioactivity of bearing loaded metallic implants
PublicationPresentation of developed titanium alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behavior for bearing loaded implants, e.g. hip joint and knee joint endoproshtesis.
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Multigap superconducting state in molecular metallic hydrogen
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Biocompatibility and bioactivity of load-bearing metallic implants
PublicationThe main objective of here presented research is to develop the titanium (Ti) alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behaviour for load-bearing implants, e.g. hip joint and knee joint endoprosthesis. The development of such materials is performed through: modeling the material behaviour in biological environment in long time and developing of new procedures for such evaluation;...
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Biocompatibility and Bioactivity of Load-Bearing Metallic Implants
PublicationThe main objective of here presented research is to develop the titanium (Ti) alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behaviour for load-bearing implants, e.g. hip joint and knee joint endoprosthesis. The development of such materials is performed through: modeling the material behaviour in biological environment in long time and developing of new procedures for such evaluation;...
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29 Metabolic Syndrome and Selected Coronary Heart Disease Risk Factors in the Group of Krakow Adult Residents
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Exposure to non-continuous rotating magnetic field induces metabolic strain-specific response of Komagataeibacter xylinus
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The Co-Culture of Staphylococcal Biofilm and Fibroblast Cell Line: The Correlation of Biological Phenomena with Metabolic NMR1 Footprint
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The Impact of Intraspecies Variability on Growth Rate and Cellular Metabolic Activity of Bacteria Exposed to Rotating Magnetic Field
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Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
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Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis
PublicationProtein derived bioactive peptides not only serve as nutrients but can also exert drug-like activity, e.g. antidiabetic, antihypertensive, or antimicrobial, to name a few. Most biopeptides have beneficial effects on health that make them attractive for nutraceutical applications. The majority of bioactive peptides have been obtained from food proteins, but protein-rich by-products generated by agriculture...
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Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism
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Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells
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