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Search results for: NEURONAL PROTEOSTASIS
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Neuronal Signaling
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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NEURON
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Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors
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Evidence for consolidation of neuronal assemblies after seizures in humans
PublicationThe establishment of memories involves reactivation of waking neuronal activity patterns and strengthening of associated neural circuits during slow-wave sleep (SWS), a process known as "cellular consolidation" (Dudai and Morris, 2013). Reactivation of neural activity patterns during waking behaviors that occurs on a timescale of seconds to minutes is thought to constitute memory recall (O'Keefe and Nadel, 1978), whereas consolidation...
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Neural Development
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NEURAL NETWORKS
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Neural Computation
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Combined Single Neuron Unit Activity and Local Field Potential Oscillations in a Human Visual Recognition Memory Task
PublicationGOAL: Activities of neuronal networks range from action potential firing of individual neurons, coordinated oscillations of local neuronal assemblies, and distributed neural populations. Here, we describe recordings using hybrid electrodes, containing both micro- and clinical macroelectrodes, to simultaneously sample both large-scale network oscillations and single neuron spiking activity in the medial temporal lobe structures...
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Neuronal Nitric Oxide Synthase Induction in the Antitumorigenic and Neurotoxic Effects of 2-Methoxyestradiol
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Frontiers in Neural Circuits
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Neuron Glia Biology
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NEURAL COMPUTING & APPLICATIONS
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Neural Regeneration Research
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Neural Network World
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NEUROREHABILITATION AND NEURAL REPAIR
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NEURAL PROCESSING LETTERS
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Neuronal Nitric Oxide Synthase-Mediated Genotoxicity of 2-Methoxyestradiol in Hippocampal HT22 Cell Line
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Justyna Signerska-Rynkowska dr inż.
PeopleI am currently an assistant professor (adjunct) at Gdansk University of Technology (Department of Differential Equations and Mathematics Applications). My scientific interests include dynamical systems theory, chaos theory and their applications to modeling of biological phenomena, especially to neurosciences. In June 2013 I completed PhD in Mathematics at the Institute of Mathematics of Polish Academy of Sciences (IMPAN) (thesis...
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DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol
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International Journal of Neural Networks
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IEEE TRANSACTIONS ON NEURAL NETWORKS
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JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
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NETWORK-COMPUTATION IN NEURAL SYSTEMS
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International Journal of Neural Systems
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Towards neural knowledge DNA
PublicationIn this paper, we propose the Neural Knowledge DNA, a framework that tailors the ideas underlying the success of neural networks to the scope of knowledge representation. Knowledge representation is a fundamental field that dedicates to representing information about the world in a form that computer systems can utilize to solve complex tasks. The proposed Neural Knowledge DNA is designed to support discovering, storing, reusing,...
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Neural networks and deep learning
PublicationIn this chapter we will provide the general and fundamental background related to Neural Networks and Deep Learning techniques. Specifically, we divide the fundamentals of deep learning in three parts, the first one introduces Deep Feed Forward Networks and the main training algorithms in the context of optimization. The second part covers Convolutional Neural Networks (CNN) and discusses their main advantages and shortcomings...
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Comparison of single best artificial neural network and neural network ensemble in modeling of palladium microextraction
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Creating neural models using an adaptive algorithm for optimal size of neural network and training set.
PublicationZaprezentowano adaptacyjny algorytm generujący modele neuronowe liniowych układów mikrofalowych, zdolny do oszacowania optymalnego rozmiaru zbiory uczącego i sieci neuronowej. Stworzono kilka modeli nieciągłości falowodowych i mokropaskowych, a następnie zweryfikowano ich poprawność porównując wyniki analiz metodą dopasowania rodzajów i metodą momentów filtrów pasmowo-przepustowych.
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Personality Type and Neural Circulatory Control
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Neural Networks and the Evolution of Environmental Change
PublicationZmiany środowiskowe na Ziemii są odwieczne i liczą około 4 miliardy lat. Homo sapiens wpłynął na każdy aspekt środowiska ziemskiego w wyniku rozwoju ludzkości na przestrzeni ostatnich milionów lat. Ale nic tak nie wpłynęło na wzrost i szybkość zmian na Ziemi jak ludzka aktywność w ciągu ostatnich dwóch stuleci. Po raz pierwszy zmiany ekosystemów były tak intensywne i zachodziły na tka wielką skalę i z taką szybkością jak nigdy...
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Artificial Neural Networks for Comparative Navigation
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Resource constrained neural network training
PublicationModern applications of neural-network-based AI solutions tend to move from datacenter backends to low-power edge devices. Environmental, computational, and power constraints are inevitable consequences of such a shift. Limiting the bit count of neural network parameters proved to be a valid technique for speeding up and increasing efficiency of the inference process. Hence, it is understandable that a similar approach is gaining...
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Neural simulator of steam power unit.
PublicationZbadano możliwości zbudowania neuronowego symulatora turbinowego bloku energetycznego. Zamodelowano ten obieg i sprawdzono konfiguracje sztucznych sieci neuronowych (SSN) zapewniające dużą dokładność symulatora neuronowego. Zwrócono uwagę na problemy dotyczące węzłów siłowni, w których następuje mieszanie się strumieni czynnika o zróżnicowanych parametrach cieplno-przepływowych. Wskazano na zastosowanie takiego symulatora w diagnostyce.
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Neural reliability model of diesel engines
PublicationW artykule przedstawiono wyniki weryfikacji hipotezy zakładającej celowość zastosowania modelu niezawodnościowego silnika tłokowego z zapłonem samoczynnym w postaci sztucznej sieci neuronowej. Weryfikację przeprowadzono w oparciu o wyniki badań eksploatacyjnych.
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Adding Interpretability to Neural Knowledge DNA
PublicationThis paper proposes a novel approach that adds the interpretability to Neural Knowledge DNA (NK-DNA) via generating a decision tree. The NK-DNA is a promising knowledge representation approach for acquiring, storing, sharing, and reusing knowledge among machines and computing systems. We introduce the decision tree-based generative method for knowledge extraction and representation to make the NK-DNA more explainable. We examine...
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JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
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Concept of Neural Model of the Sea Bottom Surface
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Effects of Sleep Deprivation on Neural Circulatory Control
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Sympathetic neural responses to smoking are age dependent
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An improved adaptive neural voltage controller for turbogenerator
PublicationOpracowano model adaptacyjnego neuronowego regulatora napięcia z nastrojonym współczynnikiem wzmocnienia funkcji przynależności i z nastrojonym współczynnikiem uczenia sieci neuronowej w zależnosci od stanu obciążenia turbogeneratora. Przedstawiono wyniki symulacji mające na celu badania efektywności proponowanego regulatora. Te wyniki porównano z wynikami uzyskanymi z regulatorem o stałym współczynnikiem wzmocnienia funkcji przynależności...
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Ship Resistance Prediction with Artificial Neural Networks
PublicationThe paper is dedicated to a new method of ship’s resistance prediction using Artificial Neural Network (ANN). In the initial stage selected ships parameters are prepared to be used as a training and validation sets. Next step is to verify several network structures and to determine parameters with the highest influence on the result resistance. Finally, other parameters expected to impact the resistance are proposed. The research utilizes...
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Differential models versus neural models in optimisation
PublicationW pracy porównano zastosowanie modeli różniczkowych i modeli neuronowych dla celów optymalizacji.
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Approximation task decomposition for artificial neural network.
PublicationW pracy przedstawiono wpływ dekompozycji zadania na czasochłonność projektowania oraz dokładność i szybkość obliczeń sztucznej sieci neuronowej wykorzystanej do rozwiązania rzeczywistego problemu technicznego, którego matematyczny model był znany. Celem obliczeń prowadzonych przez sieć neuronową było określenie wartości współczynnika przepływu m na podstawie znajomości wartości: przewodności dźwiękowej C i średnicy przewodu d (a...
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Neural nets application in diagnostics of industrial robots
PublicationPrzedstawiono wyniki wstępnych badań nad możliwością zastosowania sztucznych sieci neuronowych w procesie diagnozowania stanu technicznego robotów przemysłowych z napędem elektrycznym. Omówiono proces projektowania sieci neuronowych, za pomocą których realizowano liniową predykcję zmian dokładności pozycjonowania jednokierunkowego robota IRB 6 powstających przy różnych obciążeniach i prędkościach manipulatora podczas pracy z celowo...
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Artificial Neural Network for Multiprocessor Tasks Scheduling
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Neural Modelling of Steam Turbine Control Stage
PublicationThe paper describes possibility of steam turbine control stage neural model creation. It is of great importance because wider application of green energy causes severe conditions for control of energy generation systems operation Results of chosen steam turbine of 200 MW power measurements are applied as an example showing way of neural model creation. They serve as training and testing data of such neural model. Relatively simple...
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Robustness in Compressed Neural Networks for Object Detection
PublicationModel compression techniques allow to significantly reduce the computational cost associated with data processing by deep neural networks with only a minor decrease in average accuracy. Simultaneously, reducing the model size may have a large effect on noisy cases or objects belonging to less frequent classes. It is a crucial problem from the perspective of the models' safety, especially for object detection in the autonomous driving...
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Neural Architecture Search for Skin Lesion Classification
PublicationDeep neural networks have achieved great success in many domains. However, successful deployment of such systems is determined by proper manual selection of the neural architecture. This is a tedious and time-consuming process that requires expert knowledge. Different tasks need very different architectures to obtain satisfactory results. The group of methods called the neural architecture search (NAS) helps to find effective architecture...