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DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublikacjaImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublikacjaThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Automated high-capacity sorption probe for extraction of organic compounds in aqueous samples followed by gas chromatographic analysis.
PublikacjaOpracowano zautomatyzowany zestaw wyposażony w próbnik o dużej pojemności sorpcyjnej do oznaczania związków śladowych z zastosowaniem chromatografii gazowej. Zestaw łączy prostotę SPME z wysoką wydajnością techniki ekstrakcji z zastosowaniem ruchomego elementu sorpcyjnego (SBSE). Procedura pobierania próbek była przeprowadzana z zastosowaniem podajnika automatycznego. Ze względu na pełną automatyzację zestawu, możliwa jest bezobsługowa...
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Sample handling and determination of physico-chemical parameters in rime, hoarfrost, dew, fog and cloud water samples - a review
PublikacjaW pracy przedstawiono różne typy próbników stosowanych do pobierania próbek osadów atmosferycznych (szron, szadź, rosa, mgła i woda z chmur). Zaprezentowano urządzenia o różnym stopniu automatyzacji. W pracy przedstawiono również informacje literaturowe na temat oznaczania parametrów fizyko-chemicznych w próbkach osadów atmosferycznych z zastosowaniem odpowiednich technik pomiarowych.
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Construction of an innovative adsorbent bed configuration in the adsorption chiller part 2. experimental research of coated bed samples
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Comparison of the Usefulness of SPE Cartridges for the Determination ofβ-Blockers andβ-Agonists (Basic Drugs) in Environmental Aqueous Samples
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Dimethyl(3,3,3-trifluoropropyl)silyldiethylamine—A new silylating agent for the derivatization of β-blockers and β-agonists in environmental samples
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Matrix effects and recovery calculations in analyses of pharmaceuticals based on the determination of β-blockers and β-agonists in environmental samples
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Application of ionic liquid-based microwave-assisted extraction of malachite green and crystal violet from water samples
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Application of Dispersive Liquid-Liquid Microextraction in Narrow-Bore Tube for Preconcentration and Spectrophotometric Determination of Cadmium in Aqueous Samples
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Rapid and sensitive determination of fluoride in toothpaste and water samples using headspace single drop microextraction-gas chromatography
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Monoterpenes emissions from different samples of wood-based materials – laminated chipboards and medium-density fiberboards (MDF)
PublikacjaThe paper presents the results of studies on emission rates of monoterpenes, carried out with the use of a new type of device - Markes’ Micro-Chamber/Thermal Extractor™ (μ-CTE250). Subject of studies were different types of wood-based materials such as: laminated chipboards and medium-density fiberboards (MDF). Based on the results obtained one can conclude that the laminated chipboards may affect the indoor air quality in much...
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Sound Field Intensity Measurements and Visualization around the Human Head Model . Rozkłąd natężenia pola akustycznego w komorze bezechowej obecności sztucznej głowy i w przypadku braku jej obecności
PublikacjaThe main goal of this research study was to measure and visualize sound field intensity distribution in and without presence of the human head model. Measurements were performed in the anechoic chamber with the 5 cm grid. Experimental setup consisted of a multitone generator, two loudspeakers, human head model, intensimetric probe, the Cartesian robot applied for precise positioning of the acoustic sensor, and an analyzer. Based...
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When Biobanks Meet Religion: Association Between Religiosity and Attitudes of Polish Medical Students Toward Biobanking of Human Biological Material for Research Purposes
PublikacjaWhile biobanking is expanding globally, the empirical evidence concerning the impact of religion on future healthcare professionals’ awareness and willingness to donate biospecimens for biobank research is lacking. To understand how medicalstudents’ religious beliefs can fuel their questions regarding how biospecimens would be stored, cared for, and used, we conducted a survey among 1500 medical students at Poznań University...
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublikacjaPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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Antibiotic resistance, virulence, and phylogenetic analysis of Escherichia coli strains isolated from free-living birds in human habitats
PublikacjaWild birds can be colonized by bacteria, which are often resistant to antibiotics and have various virulence profiles. The aim of this study was to analyze antibiotic resistance mechanisms and virulence profiles in relation to the phylogenetic group of E. coli strains that were isolated from the GI tract of wildfowl. Out of 241 faecal samples, presence of E. coli resistant to a cephalosporin (ESBL/AmpC) was estimated for 33 isolates...
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Distillation cleanup preceded gc determination of short-chain monocarboxylic acids in aqueous and solid samples of wastewater origin = Oznaczanie krótkołańcuchowych kwasów monokarboksylowych w próbkach wodnych i stałych pochodzących z oczyszczalni ścieków z wykorzystaniem chromatografii gazowej poprzedzonej destylacją
PublikacjaShort-chain monocarboxylic acids (SCMAs) (C2-C5) formed in the process of aerobic biodegradation of larger organic molecules should often be monitored to optimize wastewater biological treatment and study the processes of converting organic waste matter into methane, etc. Gas chromatography (GC) seems a method of choice for such a task. Majority of samples require clean up before they can be injected into GC system. In this work...
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Human poverty - measuring relative deprivation from basic achievements: a comparative study for 144 countries over the period 1990-2010
PublikacjaPoverty – differently defined and measured – still remains one the crucial parts of the world development debate. It`s broadly perceived as multidimensional phenomenon which deprives people from basic capabilities and freedoms, limits their opportunity to educate and fully participate in the labor market contributing to overall country`s socioeconomic performance. Referring to seminal works of Sen and many others(see e.g. Morris...
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Fluorescence studies by quenching and protein unfolding on the interaction of bioactive compounds in water extracts of kiwi fruit cultivars with human serum albumin
PublikacjaThe main aim of this investigation was to characterize new kiwi fruit cultivars after cold storage treatment and to determine the similarities and differences between them, using spectroscopic methods. The chemometric comparison of kiwi fruit cultivars based on physicochemical indices during cold storage was carried out. All kiwi fruit cultivars showed a high level of correlation between the contents of phenolic compounds (polyphenols,...
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Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and chemometrics study
PublikacjaIn the early stages of drug discovery, beyond the biological activity screening, determining the physicochemical properties that affect the distribution of molecules in the human body is an essential step. Plasma protein binding (PPB) is one of the most important investigated endpoints. Nevertheless, the methodology for measuring %PPB is significantly less popular and standardized than other physicochemical properties, like lipophilicity....
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Influence of adalimumab on interleukin 12/23 signalling pathways in human keratinocytes treated with lipopolysaccharide A
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Apoptosis induction in C32 human melanoma cells by Jasione montana and its main phytoconstituents
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Local anaesthetics upregulate nitric oxide generation in cord blood and adult human neutrophils
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A methodology for incorporating human factors in fuzzy-probabilistic modelling and risk analysis of industrial systems
PublikacjaPraca dotyczy wybranych zagadnień rozmyto-probabilistycznych modelowania złożonych systemów przemysłowych. Do obliczeń związanych z analizą ryzyka stosuje się diagramy wpływu i hierarchiczny proces decyzyjny.
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Induction of apoptosis by triazoloacridinone derivative - C-1533 in HL60 and MOLT4 human leukemia cells.
PublikacjaPrzeprowadzone badania miały na celu określenie zdolności triazoloakrydonu C-1533 do indukcji śmierci komórek nowotworowych MOLT4 i HL60 na drodze apoptozy. Badanie zjawiska apoptozy przeprowadzono z wykorzystaniem techniki cytofluorymetrii przepływowej, mikroskopii fluorescencyjnej i elektroforezy agarozowej. Badania wykazały, że zarówno w komórkach MOLT4 jak i HL60, spadek mitochondrialnego potencjału błonowego oraz translokacja...
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The effect of new non-cross resistant antitumor agents on the energy state of human erythrocytes
PublikacjaPrzebadano pochodne benzoperimidynowe i antrapirydonowe odnośnie ich wpływu na stan energetyczny ludzkich erytrocytów. Stwierdzono, że poziom nukleotydów jak i wartość AEC erytrocytów nie zmienił się w ciągu 24 h inkubacji z powyższymi związkami. Jest to wynik obiecujący w odniesieniu do ich zastosowania jako związków aktywnych w pokonywaniu oporności wielolekowej.
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Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
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Forms of mercury in the Baltic mussel (Mytilus trossulus): Human and ecosystem health risk assessment
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Mercury in marine fish, mammals, seabirds, and human hair in the coastal zone of the southern Baltic
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Response of a New Low-Coherence Fabry-Perot Sensor to Hematocrit Levels in Human Blood
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublikacjaAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells
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Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?
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The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model
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Sensitivity of personalized ventilation air terminal device geometry with regard to a human thermal sensation
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Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
PublikacjaIncreased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...
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Wavelet transform analysis to assess oscillations in pial artery pulsation at the human cardiac frequency
PublikacjaPial artery adjustments to changes in blood pressure (BP)may last only seconds in humans. Using a novelmethod called near-infrared transillumination backscattering sounding (NIR-T/BSS) that allows for the non-invasive measurement of pial artery pulsation (cc-TQ) in humans, we aimed to assess the relationship between spontaneous oscillations in BP and cc-TQ at frequencies between 0.5 Hz and 5 Hz. We hypothesized that analysis of...
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A Study in Experimental Methods of Human-Computer Communication for Patients After Severe Brain Injuries
PublikacjaExperimental research in the domain of multimedia technology applied to medical practice is discussed, employing a prototype of integrated multimodal system to assist diagnosis and polysensory stimulation of patients after severe brain injury. The system being developed includes among others: eye gaze tracker, and EEG monitoring of non-communicating patients after severe brain injuries. The proposed solutions are used for collecting...
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Effect of Maximal Breath Hold Apnea on Pial Artery Pulsation and Subarachnoid Width in Human
PublikacjaLittle is known about intracranial pressure (ICP)-cerebral hemodynamic interplay during maximal breath-hold apnea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Changes in sas-TQ correlate with ICP to a considerable extent, whereas cc-TQ reflects the functional...
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Electroporation with Cisplatin against Metastatic Pancreatic Cancer:In VitroStudy on Human Primary Cell Culture
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Combination of therapy with 5-fluorouracil and cisplatin with electroporation in human ovarian carcinoma model in vitro
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The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells
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Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
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Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells
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Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)
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Novel Potential Binding Sites for Selective Inhibitor Design of Human Soluble Epoxide Hydrolase
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Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs
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The role of colour preattentive processing in human–computer interaction task efficiency: A preliminary study
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Bio-enriched Pleurotus mushrooms for deficiency control and improved antioxidative protection of human platelets?
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