Filtry
wszystkich: 2350
wybranych: 956
-
Katalog
- Publikacje 956 wyników po odfiltrowaniu
- Czasopisma 495 wyników po odfiltrowaniu
- Konferencje 51 wyników po odfiltrowaniu
- Wydawnictwa 14 wyników po odfiltrowaniu
- Osoby 69 wyników po odfiltrowaniu
- Wynalazki 9 wyników po odfiltrowaniu
- Projekty 40 wyników po odfiltrowaniu
- Zespoły Badawcze 16 wyników po odfiltrowaniu
- Kursy Online 209 wyników po odfiltrowaniu
- Wydarzenia 4 wyników po odfiltrowaniu
- Dane Badawcze 487 wyników po odfiltrowaniu
Filtry wybranego katalogu
Wyniki wyszukiwania dla: pe
-
Solid phase synthesis and biological activity of linear tuftsin and retro-tuftsin derivatives
PublikacjaPrzedstawiono syntezę na fazie stałej nowych pochodnych tuftsyny i retro-tuftsyny i ich mikrobiologiczne właściwości. Otrzymane pochodne zawierały wiązanie izopeptydowe między epsilon-aminową grupą lizyny a takimi aminokwasami jak: Ala, beta-Ala, Val, Ile, Gly.
-
Solid phase synthesis of conjugates of tuftsin analogues with 1-nitro-acridine derivatives
PublikacjaZsyntetyzowano na fazie stałej koniugaty 1-nitro-akrydyny z pochodnymi tuftsyny modyfikowanymi na grupie epsilon-aminowej lizyny prostymi aminokwasami, np. alaniną, valiną, beta-alaniną. Końcowe produkty były charakteryzowane za pomocą MS, NMR, analizy elementarnej i przekazane do badań ich aktywności przeciwnowotworowej.
-
Solid phase synthesis of 4,5,8-trihydroxy-9,10-anthraquinone-1-yl-(tuftsin or retro-tuftsin) derivatives
PublikacjaPrzedstawiono syntezę na fazie stałej połączeń leuko-1,4,5,8-tetra-hydroksyantrachinonów z pochodnymi tuftsyny i retro-tuftsyny zawierającymi wiązanie izopeptydowe. Do syntezy wykorzystano standardową metodę Fmoc i DIC jako odczynnik aktywujący.
-
In vitro evaluation of novel lipopeptides with potential therapeutic application
PublikacjaThe synthesis of derivatives of Gly-His-Lys was elaborated followed by their antimicrobial activity investigation.
-
Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
-
Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublikacjaA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
-
Lipopeptides - synthesis and their properties
PublikacjaZaprezentowano syntezę nowych pochodnych tripeptydu Gly-Hyp-Lys o potencjalnie lepszych właściwościach lipofilowych. Modyfikacje polegały na acylowaniu N-końca glicyny kwasami tłuszczowymi (np. palmitynowym i stearynowym). Syntezę lipopeptydów zawierających fragment Gly-X-Y (gdzie: X= Met,Hyp,Hyp-Met,Gly-Hyp; Y=Lys,D-Lys) przeprowadzono na fazie stałej z zastosowaniem procedury Fmoc. Do wydłużanie łańcucha peptydowego zastosowano...
-
Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublikacjaZaprezentowano immunomodulacyjne właściwości nowych koniugatów batracyliny (BAT) z pochodnymi muramylodipeptydów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek linii nowotworowych. Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników. Zbadane koniugaty MDP lub nor-MDP z batracyliną wykazały silniejsze własności hamujące proliferację komórek wybranych linii nowotworowych (K562,...
-
Synthesis of conjugates of muramyl dipeptide and nor-muramyl dipeptide derivatives with adenosine as potential immunosuppressant
PublikacjaZaprezentowano syntezę koniugatów adenozyny z pochodnymi muramylo- i nor-muramylodipeptydów zawierających w części peptydowej D-aminokwasy (D-Ala, D-Val, D-Ser, D-Pro, D-2-ABA). Jako substrat zastosowano rybozyd 6-chloropuryny, który łączono poprzez 1,2-diaminoetan z odpowiednimi pochodnymi MDP lub nor-MDP w obecności EDCI i HOBt. Struktury otrzymanych związków zostały potwierdzone widmami 1H i 13C NMR (500 MHz), widmami MS oraz...
-
Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity
PublikacjaA number of monocyclic SFTI-1 analogues modified in the conserved inhibitor P1 position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogues...
-
Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublikacjaA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
-
Design and synthesis of new analogues of batracylin linked to tuftsin and retro-tuftsin derivatives
PublikacjaThe synthesis of derivatives of batracylin with several peptides was elaborated followed by their cytotoxic activity investigation.
-
New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocytes-derived dendritic cells
PublikacjaMuramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little is known about tuftsin influence on these cells. Therefore it seemed vital to access whether tuftsin or its derivatives conjugated...
-
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
Publikacja -
‘Personas for lighting’. Three methods to develop personas for the indoor lighting environment
PublikacjaThe objective of this research is to describe and compare three different methods of generating ‘persona for lighting’ to envision users’ behaviour within the lighting environment. ‘Personas’ are used to represent typical users, highlighting their needs, perspectives, and expectations to aid user-centric design approaches. The researchers looked for the most useful method of shaping ‘personas for lighting’ to learn about users’...
-
DZIECIĘCA METEOROLOGIA. EWOLUCJA SPOSOBU OCENIANIA STANU POGODY U DZIECI 6- I 9-LETNICH
Publikacja -
Embracing silence: Creating inclusive spaces for autistic employees
PublikacjaI concur with Asselineau et al. (2024) that workplace silence profoundly impacts individual and organizational processes. Although they have detailed its significance across different contexts, a vital aspect merits deeper investigation. Namely, many autistic individuals exhibit hypersensitivity to sensory stimuli, such as noise. For this demographic, as well as for nonautistic individuals with sensory processing disorders, exposure...
-
Histological Features of Neovaginal Epithelium after Vaginoplasty in Mayer-Rokitansky-Küster-Hauser Syndrome
Publikacja -
Type 1 diabetes in an adolescent with social problems and mental disorders – case report
Publikacja -
Craniofacial proportions in children with adenoid or adenotonsillar hypertrophy are related to disease duration and nasopharyngeal obstruction
Publikacja -
Single median maxillary central incisor syndrome and variant in SMO gene associated with SHH pathway
Publikacja -
Reasons for the discontinuation of therapy of personal insulin pump in children with type 1 diabetes
Publikacja -
PM10 concentration and microbiological assessment of air in relation to the number of acute cases of type 1 diabetes mellitus in the Lubelskie Voivodeship. Preliminary report
Publikacja -
Long-Term Follow-Up after Laparoscopic Uterovestibular Anastomosis in Patients with Cervical Atresia and Complete Absence of the Vagina
Publikacja -
Streptococcus intermedius Acute Meningitis in an Immunocompetent Child
Publikacja -
The Influence of SARS-CoV-2 Variants B.1.1.7 and B.1.617.2 on a Different Clinical Course and Severity of COVID-19 in Children Hospitalized in 2021 Compared With 2020
Publikacja -
A 10-Year-old Girl With Late Acute Lymphoblastic Leukemia Recurrence Diagnosed With COVID-19 and Treated With Remdesivir
Publikacja -
Clinical Presentation of Herpes Zoster in Immunocompetent and Immunocompromised Hospitalized Children Treated With Acyclovir
Publikacja -
The cytokine profile of mature milk from smoking and non-smoking mothers
PublikacjaZweryfikowano wpływ palenia kobiet na poziom cytokin (IL-1α, IL-1β, IL-6, IL-8, IL-10 i TNF-α) w mleku ludzkim w 30-32 dni po porodzie. Badana grupa składała się z 24 kobiet po porodzie, które deklarowały palenie więcej niż pięciu papierosów dziennie. Grupę kontrolną stanowiło 45 niepalących kobiet. W porównaniu do kobiet niepalących w mleku kobiet palących stwierdzono znacznie wyższe stężenia cytokiny IL-1α (P = 0,04). Nie stwierdzono...
-
Neurotrophic factors in human milk in early lactation and the effect of Holder and microwave pasteurization on their concentrations
PublikacjaObjective: The objective of this study was to determine the level of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in human milk in the first two weeks of breastfeeding and compare of the effects of Holder pasteurization (HoP, 62.5°C, 30 minutes) and microwave pasteurization (MP) at constant temperature (62.5°C) on the concentraion of both neurotrophic factors (NFs). Methods: Concentration...
-
Nutrients and Bioactive Components of Human Milk After one Year of Lactation. Implication for Human Milk Banks
PublikacjaObjective: Specifying the nutrient content and bioactive compounds in milk from long-term lactation for the purpose of finding additional sources of donors’ milk for HMBs. Method: Human milk samples were collected from 43 mothers of term infants (term infant human milk, TIHM) (3–6 weeks of lactation) and 50 mothers who have breastfed for over a year (long-nursing human milk, LNHM). The milk collection time was 24 hours. The analyses...
-
No Evidence for Sex-specificity in Vitamin C, E and Fatty Acid Content of Human Milk from Healthy Polish Mothers
PublikacjaHuman milk (HM) is a complex fluid that meets the nutritional needs of infants. Its composition idrfs associated with environmental, maternal, and foetal variables. It provides nutrients and bioactive substances, including cytokines, immunoglobulins, and constituents with antioxidative properties. Boys are reportedly more susceptible to oxidative stress. This study aimed to determine the relationship between infant sex and the...
-
Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
Publikacja -
The contingent nature of warehouse flexibility
Publikacja -
Changes of Power Output and Velocity During Successive Sets of the Bench Press With Different Duration of Eccentric Movement
Publikacja -
Informal projects management with volunteers participation
PublikacjaThe article briefly presents some experiences and results of research which has been conducted in order to identify key elements influencing the success of projects managed in informal way with volunteers’ participation. These experiences were collected during the realization of several “soft” projects. The general aims of these projects were sports competitions’ organisation, cultural events and charity projects for...
-
Challenges associated with bariatric surgery – a multi-center report
Publikacja -
CEACAM6 as a Novel Therapeutic Target to Boost HO-1—mediated Antioxidant Defense in COPD
Publikacja -
Digital competence learning in secondary adult education in Finland and Poland
Publikacja -
Digital Innovations for Sustainable Development in the Time of Crisis
Publikacja -
Encouraging pro-environmental behaviour through an educational mobile application: Preliminary insights from early adopters
PublikacjaThis article aims to explore the extent to which the educational mobile application PULA supports and promotes pro-environmental behaviours, identify the most utilised functionalities by early adopters, and explore the least engaged functionalities. The study employs a quantitative approach based on data collected from the application. The analysis provides a comprehensive understanding of users' experiences and behaviours within...
-
Encouraging Pro-environmental Behaviour Through an Educational Mobile Application: Preliminary Insights from Early Adopters
PublikacjaThis article aims to explore the extent to which the educational mobile application PULA supports and promotes pro-environmental behaviours, identify the most utilised functionalities by early adopters, and explore the least engaged functionalities. The study employs a quantitative approach based on data collected from the application. The analysis provides a comprehensive understanding of users' experiences and behaviours within...
-
Does previous abdominal surgery affect the course and outcomes of laparoscopic bariatric surgery?
Publikacja -
Association between use of enhanced recovery after surgery protocols and postoperative complications in colorectal surgery in Europe: The EuroPOWER international observational study
Publikacja -
Analysis and improvement attempt of prof. Alan Fowler’s negotiation game
PublikacjaThe main goal of the following article is to design an improved version of the negotiation game created by prof. Alan Fowler (Fowler, 1997). I have tried to achieve this by constructing four separate versions of the game which represent different approaches while preserving rules, chosen basic technical assumptions and the simplicity of the base game. Each version of the game is supposed to i.a. make it less obvious, create new...
-
Revisional operations among patients after surgical treatment of obesity: a multicenter Polish Revision Obesity Surgery Study (PROSS)
Publikacja -
Programming, tunning and automatic parallelization of irregular divide and conquer applications in DAMPVM/DAC.
PublikacjaArtykuł prezentuje nowy, obiektowo zorientowany wzorzec programowy DAMPVM/DAC, który zimplementowany został z użyciem systemu DAMPVM i umożliwia automatyczny podział nieregularnych aplikacji "Dziel i zwyciężaj" (DAC) w czasie ich działania.
-
Databases and Information Systems: Contributions from ADBIS 2023 Workshops and Doctoral Consortium
Publikacja -
Rapid Screening of Antimicrobial Synthetic Peptides
Publikacja -
Citropin 1.1 Trifluoroacetate to Chloride Counter-Ion Exchange in HCl-Saturated Organic Solutions: An Alternative Approach
Publikacja