Filtry
wszystkich: 317
wybranych: 263
Wyniki wyszukiwania dla: PLACEMAKING, THERAPEUTIC LANDSCAPES
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Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex
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Purinergic implication in amyotrophic lateral sclerosis—from pathological mechanisms to therapeutic perspectives
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Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies
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Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublikacjaPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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CEACAM6 as a Novel Therapeutic Target to Boost HO-1—mediated Antioxidant Defense in COPD
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Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?
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Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target
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Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives
PublikacjaNucleic acids in the form of aptamers play a growing and significant role in the targeted and rapid analysis of environmental sample composition and medical analyses. In this paper, the review of both aptamers synthesis methods as well as application of these short chain oligonucleotides (with critical comments on their strong and weak features) are given. The first ones include: systematic evolution of ligands by exponential enrichment...
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Positive results of serological tests for syphilis in pregnancy – diagnostic and therapeutic problems, report of two cases
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Angiotensin receptor - neprilysin inhibiton (ARNI) – A novel therapeutic concept for management of hypertension and heart failure
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Hepatitis D, B and C virus (HDV/HBV/HCV) coinfection as a diagnostic problem and therapeutic challenge
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Assessing therapeutic relevance of biologically interesting, ampholytic substances based on their physicochemical and spectral characteristics with chemometric tools
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Applications of Cannabis Sativa L. in Food and Its Therapeutic Potential: From a Prohibited Drug to a Nutritional Supplement
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Abdominoplasty Skin-Based Dressing for Deep Wound Treatment—Evaluation of Different Methods of Preparation on Therapeutic Potential
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Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process
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Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublikacjaLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
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MO‐F‐214‐06: Linear Energy Transfer Response of Polymer Gel Dosimeters in Therapeutic Proton Beams
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Lead Airgun Projectiles Inside the Maxillary Sinuses—Therapeutic Approaches through the Years: A Systematic Review of Case Reports
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A Comprehensive Review on the Medicinal Importance; Biological and Therapeutic Efficacy of Lagenaria siceraria (Mol.) (Bottle Gourd) Standley Fruit
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Legal and economic identification and assessment of pharmacy substitution in narrow therapeutic index drugs, on the example of epileptic medications in Poland
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Assessment of the mean time in the therapeutic INR range and the SAME-TT2R2 score in patients with atrial fibrillation and cognitive impairment
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Ocena wpływu inwestycji na zdrowie w świetle badań nad terapeutycznymi właściwościami krajobrazu. Health Impact Assessment and the investigations of landscape therapeutic features.
PublikacjaPraca przedstawia tematykę oceny wpływu inwestycji na zdrowie w świetle badań nad terapeutycznym wpływem krajobrazu na zdrowie człowieka. Ocenę wpływu inwestycji na zdrowie – uzupełniającą stosowaną w Unii Europejskiej procedurę ocen oddziaływania na środowisko (OOŚ) – zaprezentowano jako narzędzie umożliwiające ochronę zdrowia człowieka w przypadku realizacji szkodliwych dla niego inwestycji. Wiele działań, jak oddzielenie budynków...
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Biochemical Profile and In Vitro Therapeutic Properties of Two Euhalophytes, Halocnemum strobilaceum Pall. and Suaeda fruticosa (L.) Forske., Grown in the Sabkha Ecosystem in the Algerian Sahara
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Big Beautiful Buildings: Eine Schönheit, viele Maßstäbe - urbane Landschaften der Nachkriegsmoderne in Europa / Big Beautiful Buildings: one beauty, many scales - urban landscapes of the post-war modernism across Europe
PublikacjaMassive urbanization in Europe is not a phenomenon that began only in the 20th century. The roots of this process can be traced back two centuries. With the end of the Second World War the specific conjunction of powerful forces together changed the landscape of European cities. Urbanization was undoubtedly one of them. Among other factors, Musterd and van Kempen (2005) correctly itemized not only objective processes that can be...
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TU-D-BRB-09: Dosimetric Validation of the Proton-Sensitive BANG® 3 PRO-2 Polymer Gel Dosimeter Irradiated by Single Field Therapeutic Proton Beams
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Acute myocardial infarction reparation/regeneration strategy using Wharton’s jelly multipotent stem cells as an ‘unlimited’ therapeutic agent: 3-year outcomes in a pilot cohort of the CIRCULATE-AMI trial
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Transformacja tożsamości miejsca jako efekt interwencji artystycznych w przestrzeni publicznej
PublikacjaThe subject of a paper is connected with art in public space as an element of shaping identity of a place. This issue is related to finding out new and effective urban regeneration’s tools, rebuilding the identity of degraded areas by art. In the article, the idea of an American “creative placemaking” is presented and compared with polish urban regeneration case study. The specific issues discussed in the article are: the role...
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Pancreatic neuroendocrine neoplasms — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne trzustki — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]
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Colorectal neuroendocrine neoplasms — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne jelita grubego — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]
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A. Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease(2020). Focused on analysis of the Medicinal plants that have potential therapeutic ability against COVID-19.
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Gastroduodenal neuroendocrine neoplasms including gastrinoma — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma — uaktualnione zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]
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Neuroendocrine neoplasms of the small intestine and the appendix — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne jelita cienkiego i wyrostka robaczkowego — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]
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Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours) [Aktualizacja zaleceń ogólnych dotyczących postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]
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Photodynamic therapy of cancer with liposomal photosensitizers
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Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
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Visual Capacity Assessment of the Open Landscape in Terms of Protection and Shaping: Case Study of a Village in Poland
PublikacjaThis article describes the methodology and results of research on landscape visual capacity. The aim of the project was to develop a tool that would support planning and design decisions at the level of communal management in rural areas in Poland through systematic application of visual criteria. Their importance in the protection, management and shaping of space is underlined by the document produced at the European Landscape...
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Container
PublikacjaThe main aim of the project is to improve interpersonal communication and promote better functionality in the City of Hamburg. An important element is to satisfy the needs of people living and working in diff erent districts. In our project, we sought to give people an outlet and enabled the possibility of creating landscapes. The unusual advantage of the city is that it allows the use of waterways, which in turn become a link...
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SENSORY GARDENS INCLUSIVELY DESIGNED FOR VISUALLY IMPAIRED USERS.
PublikacjaThis paper discusses the design of sensory gardens, created especially to provide for the needs of sight impaired children and youth. These gardens should be inclusively available to general public. A sensory garden may have both therapeutic and educational effects. The research findings concerning therapeutic effects of contact with nature on children and youth are reviewed. The design problems related to providing a space for...
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Modifications of total synthesis of mycophenolic acid
PublikacjaThe total synthesis of mycophenolic acid (MPA), a potent immunosuppressant, was modified. The obtained mycophenolic acid was suitable for further preparation of new prospective immunosuppressants with improved therapeutic properties.
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Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
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Inhibitors of cathepsin G: a patent review (2005 to present)
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Biophilic Design: A Trend Watch
PublikacjaDuring the 20th century, many people migrated to cities for employment and economic opportunities, abandoning farming and natural landscapes so their direct connection to the countryside and nature was lost. This process continues to this day with unprecedented urban growth, in fact, it’s estimated 68% of the world population will live in urban areas by 2050. Due to the evolutionary disposition of humans, when people live in an...
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Pier of the future- investigation of green and blue strategies as tools for modernization of Gdynia's public waterfront
PublikacjaBetween rising water levels and global migration to cities, architects and designers need to critically reimagine the relationship between coastal landscapes and public space. Cities are facing entirely new risks and environmental conditions. Resiliency, infrastructure, and ecology are increasingly common terms, reflecting the growing demand to address the spatial and formal challenges faced by cities worldwide. Rethinking boundaries...
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Nanomaterials for photothermal and photodynamic cancer therapy
PublikacjaIn recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by toxic heat generation and photodynamic therapy (PDT) by reactive oxygen species, are...
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Classification of Landscape Physiognomies in Rural Poland: The Case of the Municipality of Cekcyn
PublikacjaThis article presents a methodology and the results of the classification of the rural landscapes physiognomies conducted on the study area located in the municipality of Cekcyn, Poland. The study aimed to develop a landscape identification method that would combine natural, cultural, and visual criteria with which to implement the provisions of the European Landscape Convention. The realization of the European Landscape Convention...
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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
PublikacjaDespite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...
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Quality 5.0: A Paradigm Shift Towards Proactive Quality Control in Industry 5.0
PublikacjaIndustry 5.0, the latest wave of industrial revolution, is redefining the traditional manufacturing and production landscapes by leveraging advanced technologies, promoting sustainability, and fostering a human-centric approach. An inevitable consequence of this progression is Quality 5.0, the next phase of quality control and assurance. Quality 5.0 aims to transcend the limitations of conventional quality control techniques, which...
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EPILEPTIC BEHAVIOR WITH A DISTINGUISHED PREICTAL PERIOD IN A LARGE-SCALE NEURAL NETWORK MODEL
PublikacjaWe present a neural network model capable of reproducing focal epileptic behavior. An important property of our model is the distinguished preictal state. This novel feature may shed light on the pathologi-cal mechanisms of seizure generation and, in perspective, help develop new therapeutic strategies to manage refractory partial epilepsy.