Filtry
wszystkich: 727
-
Katalog
Wyniki wyszukiwania dla: UGT METABOLIC TRANSFORMATIONS
-
Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability
PublikacjaA series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 M. It was found that for the analogues 36–38...
-
Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals
PublikacjaThe physico-chemical and interfacial properties of fat emulsions influence lipid digestion and may affect postprandial responses. The aim of the present study was to determine the effects of the modification of the interfacial layer of a fat emulsion by cross-linking on postprandial metabolic and appetite responses. A total of fifteen healthy individuals (26·5 (sem 6·9) years and BMI 21·9 (sem 2·0) kg/m2) participated in a cross-over...
-
Bariatric and Metabolic Surgery in Patients Older than 65 Years – a Multicenter Study
Publikacja -
Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis
Publikacja -
Delving into the Nutraceutical Benefits of Purple Carrot against Metabolic Syndrome and Cancer: A Review
Publikacja -
Spectrum of Bacterial Pathogens from Urinary Infections Associated with Struvite and Metabolic Stones
Publikacja -
The Effects of Two Kinds of Dietary Interventions on Serum Metabolic Profiles in Haemodialysis Patients
Publikacja -
Fluorescence use in minimally invasive metabolic and bariatric surgery — a systematic review of the literature
Publikacja -
Oscillatory Mechanism of α-Fe(N) ↔ γ’-Fe4N Phase Transformations during Nanocrystalline Iron Nitriding
Publikacja -
Bypassing the stereoselectivity issue: transformations of Kinugasa adducts from chiral alkynes and non-chiral acyclic nitrones
Publikacja -
Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability
PublikacjaA series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, 11–13, molecular hybrids containing benzenesulfonamide...
-
International Journal of Osteoporosis and Metabolic Disorders
Czasopisma -
Clinical Immunology, Endocrine and Metabolic Drugs
Czasopisma -
Current Opinion in Endocrine and Metabolic Research
Czasopisma -
Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
Czasopisma -
Theoretical Studies on the Structure, Stability, Ability To Undergo Internal Transformations, and Tautomerization, as Well as Reactivity, of H2PPH2 and HPPH3 Molecules
Publikacja -
Metabolic Gene Expression in the Muscle and Blood Parameters of Broiler Chickens Stimulated In Ovo with Synbiotics
Publikacja -
Effect of GO-Fe3O4 and rotating magnetic field on cellular metabolic activity of mammalian cells
Publikacja -
Identification of the metabolic fingerprints in women with polycystic ovary syndrome using the multiplatform metabolomics technique
Publikacja -
Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women
Publikacja -
Resting metabolic rate is increased after a series of whole body vibration in young men
Publikacja -
Ability of Yeast Metabolic Activity to Reduce Sugars and Stabilize Betalains in Red Beet Juice
Publikacja -
Cellular Turnover: A Potential Metabolic Rate–Driven Mechanism to Mitigate Accumulation of DNA Damage
Publikacja -
The influence of different expression of CYP3A4 izoenzymes on metabolic pathway derivatives in human hepatoma cells
PublikacjaCelem przeprowadzonych badań było określenie różnic w metabolizmie pochodnych C-857 i C-1748 w komórkach ludzkiego nowotworu wątroby HepG2 oraz określenie wpływu na ich biotransformację w podwyższonej ekspresji izoenzymu CYP3A4 w tejże linii. Uzyskane wyniki wskazały, że związek C-857, jak również C-1748 metabolizuje w komórkach HepG2 oraz Hep3A4 do wielu reaktywnych, niestabilnych metabolitów. Różnice w biotransformacji były bardzo...
-
HORMONE AND METABOLIC RESEARCH
Czasopisma -
Transformations in Business & Economics
Czasopisma -
Energy landscape and structural transformations of C38 penta-fullerene: The stabilizing role of octagons and insights into penta-octa-penta-fullerene
PublikacjaTheoretical investigations were conducted to study the stability and energy landscape of C38 penta-fullerene, a structure comprising six penta-graphene unit cells. Vibrational analysis at the B3LYP/def2SVP level revealed 18 negative frequencies, indicating the dynamic instability of penta-fullerene. Analyzing the energy profiles for these vibrational modes led to the identification of six energetically favourable isomers, featuring...
-
Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublikacjaA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
-
Metabolic activation of adriamycin by NADPH-cytochrome P450 reductase; overview of its biological and biochemical effects
PublikacjaOmówione zostały efekty aktywacji metabolicznej adriamycyny przez NADPH-zależną reduktazę cytochromu P450. Wykazano, że ten rodzaj aktywacji zwiększa aktywność biologiczną tego związku, a przy tym powoduje jego wiązanie się kowalencyjne z ważnymi biologicznie makromolekułami komórkowymi.
-
GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
Publikacja -
Comparison of RP-HPLC columns used for determination of nucleoside metabolic patterns in urine of cancer patients
Publikacja -
Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: A pilot study
Publikacja -
Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners
Publikacja -
Positive Regulation of Macromolecule Metabolic Process Belongs to the Main Mechanisms Crucial for Porcine Oocytes Maturation
Publikacja -
Expression Changes in Fatty acid Metabolic Processrelated Genes in Porcine Oocytes During in Vitro Maturation
Publikacja -
New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation
Publikacja -
Acute Effects of Whole-Body Vibration on Resting Metabolic Rate and Substrate Utilisation in Healthy Women
Publikacja -
Whole-Body Cryotherapy Is an Effective Method of Reducing Abdominal Obesity in Menopausal Women with Metabolic Syndrome
Publikacja -
Kultura - Edukacja - Przemiany
Czasopisma -
Effect of Nitrogen Ion Implantation on the Cavitation Erosion Resistance and Cobalt-Based Solid Solution Phase Transformations of HIPed Stellite 6
Publikacja -
Effect of Nitrogen Ion Implantation on the Cavitation Erosion Resistance and Cobalt-Based Solid Solution Phase Transformations of HIPed Stellite 6
Publikacja -
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Czasopisma -
Diabetes & Metabolic Syndrome-Clinical Research & Reviews
Czasopisma -
Endocrine Metabolic & Immune Disorders-Drug Targets
Czasopisma -
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases
Czasopisma -
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Czasopisma -
Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells
Publikacja -
Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity
Publikacja -
Genetic response to metabolic fluctuations: correlation between central carbon metabolism and DNA replication in Escherichia coli
Publikacja -
29 Metabolic Syndrome and Selected Coronary Heart Disease Risk Factors in the Group of Krakow Adult Residents
Publikacja