Wyniki wyszukiwania dla: medicinal chemistry
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BIOORGANIC & MEDICINAL CHEMISTRY
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CURRENT MEDICINAL CHEMISTRY
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JOURNAL OF MEDICINAL CHEMISTRY
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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Medicinal Chemistry
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MEDICINAL CHEMISTRY RESEARCH
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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Future Medicinal Chemistry
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Perspectives in Medicinal Chemistry
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RSC Medicinal Chemistry
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ACS Medicinal Chemistry Letters
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International Journal of Medicinal Chemistry
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Open Medicinal Chemistry Journal
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Annual Reports in Medicinal Chemistry
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MINI-REVIEWS IN MEDICINAL CHEMISTRY
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CURRENT TOPICS IN MEDICINAL CHEMISTRY
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Cardiovascular and Hematological Agents in Medicinal Chemistry
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World Research Journal of Applied Medicinal Chemistry
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Central Nervous System Agents in Medicinal Chemistry
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Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
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Anti-Cancer Agents in Medicinal Chemistry
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Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
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INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
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Antitumor Activity of Novel Benzensulfonamide Derivatives in View of their Physiochemical Properties Searched by Principal Component Analysis
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The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena
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Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublikacjaNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents
PublikacjaAbstract: Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that introduction of bulky substituents at the amino sugar moiety of the antibiotic may result in diminishment of mammalian vitro toxicity of thus prepared AmB derivatives. Methods:...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublikacjaAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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The Chemistry of Mycophenolic Acid-Synthesis and Modifictions Towards Desired Biological Activity
PublikacjaDokonano przeglądu literatury chemicznej na temat metod syntezy kwasu mykofenolowego oraz jego pochodnych, a także zależności pomiędzy ich strukturą i aktywnością biologiczną.
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Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
PublikacjaSiderophores are low molecular weight compounds produced by microorganisms to scavenge iron in iron-deficient environments. Rhodotorulic acid, a natural hydroxamate siderophore, plays a vital role in iron acquisition for fungi and bacteria. As the simplest natural hydroxamate siderophore, it exhibits a high affinity for ferric ions, enabling it to form stable complexes that facilitate iron uptake and transport within microorganisms....
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Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
PublikacjaSiderophores are low molecular weight compounds produced by microorganisms to scavenge iron in iron-deficient environments. Rhodotorulic acid (RA), a natural hydroxamate siderophore, plays a vital role in iron acquisition for fungi and bacteria. As the simplest natural hydroxamate siderophore, RA exhibits a high affinity for ferric ions, enabling it to form stable complexes that facilitate iron uptake and transport within microorganisms....
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Absolute Configuration Determination by Quantum Mechanical Calculation of Chiroptical Spectra: Basics and Applications to Fungal Metabolites
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Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus
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Essentials and Perspectives of Computational Modelling Assistance for CNS-oriented Nanoparticle-based Drug Delivery Systems
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Matriptase-2: monitoring and inhibiting its proteolytic activity
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Comparative evaluation of new dihydropyrimidine and dihydropyridine derivatives perturbing mitotic spindle formation
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Structure-activity relationship study of a small cyclic peptide H-c[Lys-Pro-Glu]-Arg-OH: a potent inhibitor of Vascular Endothelial Growth Factor interaction with Neuropilin-1
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Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones
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Activity evaluation of some psychoactive drugs with the application of QSAR/QSPR modeling methods
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The comparison of semiempirical and ab initio molecular modeling methods in activity and property evaluation of selected antimicrobial sulfonamides
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QSPR analysis of some agonists and antagonists of α-adrenergic receptors
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Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension
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Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
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Synthesis and Biological Activity of Strongly Fluorescent Tricyclic Analogues of Acyclovir and Ganciclovir
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In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
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Fluorescent Tricyclic Analogues of Acyclovir and Ganciclovir. A Structure−Antiviral Activity Study
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Phthalocyanine Derivatives Possessing 2-(Morpholin-4-yl)ethoxy Groups As Potential Agents for Photodynamic Therapy
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Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin
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