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Wyniki wyszukiwania dla: secondary metabolites
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Wpływ rodzaju kwaśnego dodatku do eluentu oraz właściwości fazy stacjonarnej na rozdzielanie średnio i nisko hydrofobowych kwaśnych organicznych związków chemicznych w odwróconych układach faz kolumnowej elucyjnej wysokosprawnej chromatografii cieczowej - RP HPLC
Publikacjaedna z serii prac badawczych nad opracowaniem optymalnych warunków rozdzielania, identyfikacji i oznaczania względnie, średnio i nisko polarnych składników mieszanin organicznych związków chemicznych otrzymywanych z procesu konwersji biomasy lignocelulozowej, lub suszu roślinnego z wykorzystaniem wysokosprawnej kolumnowej elucyjnej chromatografii cieczowej w odwróconych układach faz (RP-HPLC) z elucją izokratyczną, a wówczas gdy...
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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublikacjaJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
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Reakcje izotiocyjanianów z heterocyklicznymi aminami aromatycznymi i ich rola w inaktywacji kancerogenów w żywności
PublikacjaWyniki licznych badań epidemiologicznych wskazują na pozytywny wpływ diety bogatej w warzywa na zdrowie człowieka. Szczególne znaczenie roślin z rodziny kapustowatych, a wśród nich najważniejszej dietetycznie kapusty, wiąże się z obecnością w tych warzywach biologicznie aktywnych składników: glukozynolanów i produktów ich rozpadu - związków indolowych i izotiocyjanianów. Na zainteresowanie zasługują izotiocyjaniany ze względu na...
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublikacjaThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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Distribution and bioavailability of mercury in the surface sediments of the Baltic Sea
PublikacjaThe study aimed to determine the level of mercury (Hg) and its labile and stable forms in the surface sediments of the Baltic Sea. The work considers the impact of current and historical sources of Hg on sediment pollution, together with the influence of different environmental parameters, including water inflows from the North Sea. Surface sediments (top 5 cm) were collected in 2016–2017 at 91 stations located in different...
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On the differential effect of temperature on the Nusselt-Rayleigh relationship in free convection
PublikacjaThe aim of and inspiration behind this paper was to explain the reasons, also observed by other researchers, of the discrepancy in the results of experimental free convection, which for small Rayleigh and Nusselt numbers in the initial phase of research can sometimes reach several hundred percent. These discrepancies decrease with increasing heating power and plate surface temperature, in proportion to the increase in Ra and Nu,...
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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting beta-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c
PublikacjaD-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical or enzymatic isomerization of D-galactose obtained by a beta-D-galactosidase-catalyzed hydrolysis of milk sugar lactose and the separation of...
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Ontological Modeling for Contextual Data Describing Signals Obtained from Electrodermal Activity for Emotion Recognition and Analysis
PublikacjaMost of the research in the field of emotion recognition is based on datasets that contain data obtained during affective computing experiments. However, each dataset is described by different metadata, stored in various structures and formats. This research can be counted among those whose aim is to provide a structural and semantic pattern for affective computing datasets, which is an important step to solve the problem of data...
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Two-Rate Based Low-Complexity Variable Fractional-Delay FIR Filter Structures
PublikacjaThis paper considers two-rate based structures for variable fractional-delay (VFD) finite-length impulse response (FIR) filters. They are single-rate structures but derived through a two-rate approach. The basic structure considered hitherto utilizes a regular half-band (HB) linear-phase filter and the Farrow structure with linear-phase subfilters. Especially for wide-band specifications, this structure is computationally efficient...
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Noise Analysis of Continuous GPS Time Series of Selected EPN Stations to Investigate Variations in Stability of Monument Types
PublikacjaThe type of monument that a GPS antenna is placed on plays a significant role in noise estimation for each permanent GPS station. In this research 18 Polish permanent GPS stations that belong to the EPN (EUREF Permanent Network) were analyzed using Maximum Likelihood Estimation (MLE). The antennae of Polish EPN stations are placed on roofs of buildings or on concrete pillars. The analyzed data covers a period of 5 years from 2008...
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Measurements of Thermal Conductivity of LWC Cement Composites Using Simplified Laboratory Scale Method
PublikacjaThe implementation of low-energy construction includes aspects related to technological and material research regarding thermal insulation. New solutions are sought, firstly, to reduce heat losses and, secondly, to improve the environment conditions in isolated rooms. The effective heat resistance of insulating materials is inversely proportional to temperature and humidity. Cement composites filled with lightweight artificial...
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Bridge of Knowledge: an Internet platform for R2R and R2B transfer of knowledge and promotion of cooperation
PublikacjaCurrently, the European Commission puts emphasis on supporting collaboration between universities and business. There are many possible ways to create a strong relationship between both these parties. Positive results of such cooperation lead to increased competitiveness of the global market and, in consequence, bring significant growth of innovation. The cooperation between research-to-research (R2R) and research-to-business (R2B)...
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Glukuronidacja leków przeciwnowotworowych – detoksyfikacja, mechanizm oporności czy sposób na formę proleku?*
PublikacjaKsenobiotyki podlegają w organizmie biotransformacji I i II fazy, której celem jest ich detoksyfikacja i ułatwienie wydalania. UDP-glukuronylotransferazy (UGT) – enzymy należące do II fazy metabolizmu katalizują przyłączenie kwasu glukuronowego do lipofilowego substratu zawierającego nukleofilową grupę funkcyjną. Nadrodzina UGT składa się z izoenzymów o różnej swoistości substratowej oraz odmiennym profilu ekspresji w poszczególnych tkankach....
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Human poverty - measuring relative deprivation from basic achievements: a comparative study for 144 countries over the period 1990-2010
PublikacjaPoverty – differently defined and measured – still remains one the crucial parts of the world development debate. It`s broadly perceived as multidimensional phenomenon which deprives people from basic capabilities and freedoms, limits their opportunity to educate and fully participate in the labor market contributing to overall country`s socioeconomic performance. Referring to seminal works of Sen and many others(see e.g. Morris...
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Operation of the Hybrid Photovoltaic-Battery System on the Electricity Market—Simulation, Real-Time Tests and Cost Analysis
PublikacjaThis paper presents research on a hybrid photovoltaic-battery energy storage system, declaring its hourly production levels as a member of a balancing group submitting common scheduling unit to the day-ahead market. It also discusses the variability of photovoltaic system generation and energy storage response. The major research questions were whether the operation of a hybrid photovoltaic-battery energy storage system is viable...
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Gossiping by energy-constrained mobile agents in tree networks
PublikacjaEvery node of an edge-weighted tree network contains a data packet. At some nodes are placed mobile agents, each one possessing an amount of energy (not necessarily the same for all agents). While walking along the network, the agents spend the energy proportionally to the distance traveled and collect copies of the data packets present at the visited network nodes. An agent visiting a node deposits there copies of all currently...
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Appunti di corporate governance
PublikacjaIl libro pone la proprietà al centro di tutte le scelte rilevanti che l’impresa compie: in particolare affronta il «problema» del governo il tema della corporate governance dalla prospettiva della proprietà e in un’accezione più ampia e articolata rispetto agli studi di matrice anglosassone. In questo contesto, si analizza il tema delle relazioni tra proprietà, governo corporate governance e strategia corporate delle imprese, con...
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Wpływ rodzaju kwasu jako dodatku do eluentu na parametry rozdzielania polifenoli techniką chromatografii cieczowej w odwróconych układach faz (RP-HPLC)
PublikacjaChromatografia cieczowa jest jedną z technik wykorzystywanych w badaniach składu mieszanin, a także do wydzielania czystych składników z mieszanin w postaci frakcji eluatu. Z punktu widzenia współczesnej chemii, farmakologii, a także medycyny, czy biotechnologii, chromatografia pełni ważną rolę, w zakresie analityki jakościowej i ilościowej. Dzięki możliwości otrzymywania naturalnych składników biologicznie czynnych w czystej...
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CROWDFUNDING OF RESEARCH PROJECTS IN POLAND
PublikacjaCrowdfunding recently became a very popular way of funding, which allows funding almost everything, from minor personal projects to expensive commercial ones, as long as we can find investors. It may also be a new opportunity for entrepreneurial researchers, who may attract capital investment in companies that are promised to own developed technologies. Social financing of science is well suited to reduce some of the biggest problems...
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Usability of mobile applications: a systematic literature study
PublikacjaSince the release of the first mobile devices, the usability of on-board applications has been the concern not only of software vendors but hardware manufacturers as well. The academia community later willingly joined the discussion on usability in terms of theory and empirical measurement, having experience and knowledge in desktop settings. At first sight, such a background should guarantee a solid foundation to conduct research...
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A Framework for Searching in Graphs in the Presence of Errors
PublikacjaWe consider a problem of searching for an unknown target vertex t in a (possibly edge-weighted) graph. Each vertex-query points to a vertex v and the response either admits that v is the target or provides any neighbor s of v that lies on a shortest path from v to t. This model has been introduced for trees by Onak and Parys [FOCS 2006] and for general graphs by Emamjomeh-Zadeh et al. [STOC 2016]. In the latter, the authors provide...
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DATA INTEROPERABILITY AND THE OPEN DATA ECOSYSTEM: ROLES AND RESEARCH AREAS
PublikacjaSustainability and value-creation are considered important parameters to measure the success of an open data system. Unfortunately, existing open data systems are not meeting their promises to achieve a sustainable and value-based open data system. Van Loenen et al. (2021) proposed a sustainable and value-creating open data ecosystem. According to their study, the open data ecosystem needs to be user-driven, inclusive, circular,...
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Autonomous port management based AGV path planning and optimization via an ensemble reinforcement learning framework
PublikacjaThe rapid development of shipping trade pushes automated container terminals toward the direction of intelligence, safety and efficiency. In particular, the formulation of AGV scheduling tasks and the safety and stability of transportation path is an important part of port operation and management, and it is one of the basic tasks to build an intelligent port. Existing research mainly focuses on collaborative operation between...
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Underground Water Level Prediction in Remote Sensing Images Using Improved Hydro Index Value with Ensemble Classifier
PublikacjaThe economic sustainability of aquifers across the world relies on accurate and rapid estimates of groundwater storage changes, but this becomes difficult due to the absence of insitu groundwater surveys in most areas. By closing the water balance, hydrologic remote sensing measures offer a possible method for quantifying changes in groundwater storage. However, it is uncertain to what extent remote sensing data can provide an...
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Search for identity of Pomeranian house by means of educational activities
PublikacjaArchitecture is a universal phenomenon and is a culture-creating field closely related to other fields of art. Hence, experiencing and feeling identity are also conditioned by the proper formation of architectural objects, which are carriers specific values which co-decide about the possibility of this experience occurring in connection with a specific place and the fulfilment of a specific need in it. In the era of ubiquitous...
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Thermodynamic Analysis of Negative CO2 Emission Power Plant Using Aspen Plus, Aspen Hysys, and Ebsilon Software
PublikacjaAbstract: The article presents results of thermodynamic analysis using a zero-dimensional mathematical models of a negative CO2 emission power plant. The developed cycle of a negative CO2 emission power plant allows the production of electricity using gasified sewage sludge as a main fuel. The negative emission can be achieved by the use this type of fuel which is already a “zeroemissive” energy source. Together with carbon capture...
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Effect of slag coal ash and foamed glass on the mechanical properties of two-stage concrete
PublikacjaTwo-stage concrete (TSC) is known by various names such as colcrete, Polcrete, preplaced aggregate concrete and prepacked concrete. It is different from traditional concrete in two fundamental ways, namely method of construction and mix proportion. Two-stage concrete (TSC) is defined as firstly, coarse aggregates are placed into the formwork and grout is applied to fill in the between coarse aggregate particles voids. Secondly,...
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Fazy stacjonarne na bazie pochodnych kaliks[4]arenów w konformacji 1,3-naprzemianległej chemicznie związanych z żelem krzemionkowym, jako nowy typ wypełnień w chromatografii cieczowej
PublikacjaW prezentowanym opracowaniu monograficznym przedstawione zostały wyniki badań autorki dotyczące wykorzystania pochodnych kaliks[4]arenów w konformacji 1,3-naprzemianległej do otrzymywania nowego typu wypełnień kolumn chromatograficznych. Pierwsza część pracy jest przeglądem literaturowym dotyczącym syntezy kaliksarenów, ich budowy, różnorodności konformacyjnej, a także możliwości modyfikacji zarówno w obrębie górnej, jak i dolnej...
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Dzielnica Reprezentacyjna Gdyni i jej powojenne oraz współczesne interpretacje
PublikacjaThe concept of the Premiere District in Gdynia was first conceived in the 1920s and from that time on it constantly accompanied the history of the city. It derivated from the idea of creating a symbol of Poland's regaining independence after the first World War and the successful creation of the new port and city on the Baltic coast. As the result of that development, Gdynia was named the maritime capital of Poland and was treated...