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Wyniki wyszukiwania dla: cb1 receptor
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The FMO analysis of the molecular interaction of fentanyl derivatives with the μ-opioid receptor
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Angiotensin II receptor blocker combinations: From guidelines to clinical practice
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The surge of Japanese studies supporting the use of angiotensin receptor blockers in hypertension
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Computational methods for calculation of binding free energy for ligand-receptor complexes
PublikacjaAccurate description of the molecular complexes energetic influence is required for understanding of many biological functions carried out by proteins. Therefore, estimation of binding free energy for ligand-receptor complexes is of highest importance for structure-based ligand design and drug discovery approaches.Experimental methods of determination of difference in Gibbs'es free energy have many limitations. Thus, computational...
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Salicylaldimine-based receptor as a material for iron(III) selective optical sensing
Publikacjaα,α-Bis(salicylimino)-m-xylene (L) was prepared using both conventional and microwave-assisted procedure. The compound exhibits ability to colorimetric recognition of iron(III) ions in aqueous environment, what is shown by significant color change from yellow to purple. In DMSO : water (9:1 v/v) solvent system receptor creates with iron(III) cations complexes of 2:1 stoichiometry (L:Fe3+) with stability constant (log K) 7.54±0.21....
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Receptor for advanced glycation end‐products: Biological significance and imaging applications
PublikacjaThe receptor for advanced glycation end-products (RAGE or AGER) is a transmembrane, immunoglobulin-like receptor that, due to its multiple isoform structures, binds to a diverse range of endo- and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory...
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Olfactory receptor-based biosensors as potential future tools in medical diagnosis
PublikacjaThe detection of biomarkers is the future of non-invasive medical diagnosis and screening. Discovery and identification of reliable disease specific volatile organic compounds is dependent on repeatable, accurate analysis of trace level gaseous analytes mainly in breath samples. Natural variety of the olfactory systems and the compounds capable of gas molecules binding creates wide possibilities of acquisition and implementation...
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Selection of hardware platform for CBM Common Readout Interface
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Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
PublikacjaCoordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During...
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Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants
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Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor
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CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations
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Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding
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Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma
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NK1 receptor binding of a few low molecular weight 3,5-bistrifluoromethylbenzene derivatives
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Structural Insights into σ1 Receptor Interactions with Opioid Ligands by Molecular Dynamics Simulations
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Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
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Will we ever use angiotensin receptor neprilysin inhibition (ARNi) for the treatment of hypertension?
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new analogues of agmatine with higher activity to imidazoline receptors
PublikacjaOpracowano syntezę nowych pochodnych imidazoliny, będących kompilacją struktury agmatyny i imidazoliny w wyniku zaprojektowanej przez nas drogi syntezy. Kluczowymi substratami w syntezie były pochodne 1,2,4 -triaminobutanu, otrzymane z chronionego kwasu glutaminowego. Otrzymane nowe pochodne imidazoliny wykazywały zróżnicowane powinowactwo do receptorów imidazolinowych I1, I2 oraz do receptorów alfa -adrenergicznych.
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Expression of hCG and GnRHs and Their Receptors in Endometrial Carcinoma and Hyperplasia
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Expression of α and β Estrogen Receptors in the Chicken Ovary
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Acceptor doping of barium cerate
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Design of versatile ASIC and protocol tester for CBM readout system
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Versatile prototyping platform for Data Processing Boards for CBM experiment
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Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
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Inhibition Ability of Natural Compounds on Receptor-Binding Domain of SARS-CoV2: An In Silico Approach
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Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor
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Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants
PublikacjaFamilial hypercholesterolemia (FH) is an autosomal-dominant disorder caused mainly by substitutions in the low-density lipoprotein receptor (LDLR) gene, leading to an increased risk of premature cardiovascular diseases. Tremendous advances in sequencing techniques have resulted in the discovery of more than 3000 variants of the LDLR gene, but not all of them are clinically relevant. Therefore, functional studies of selected variants...
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Molecular Modeling of Interaction of the Vasopressin Analogs with Vasopressin and Oxytocin Receptors
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Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
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Estrogen receptors genes polymorphisms and age at menarche in idiopathic scoliosis
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QSPR analysis of some agonists and antagonists of α-adrenergic receptors
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Chromogenic amides of pyridine-2,6-dicarboxylic acid as anion receptors
PublikacjaThe synthesis of simple, chromogenic pyridine-2,6-dicarboxylic acid amides, derivates of isomeric nitroanilines and aminonitrophenols, and their ion binding properties are described. The ligands' response to ionic species was examined by naked eye and was studied with the use of UV-Vis spectroscopy in DMSO and its mixture with water. The effect of the localisation and the type of the substituents in aromatic rings were discussed....
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Measurement of rare probes with the silicon tracking system of the CBM experiment at FAIR
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Wspomaganie projektowania automatyki siłowni statku przy zastosowaniu metody CBR.
PublikacjaW referacie zaprezentowano metodologię CBR (wnioskowania na podstawie przypadków), zastosowano w systemie ekspertowym wspomagania projektowania automatyki okrętowej na podstawie informacji o statkach zbudowanych oraz modelu dziedzinowego.
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Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis
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Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties
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Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublikacjaThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Angiotensin receptor - neprilysin inhibiton (ARNI) – A novel therapeutic concept for management of hypertension and heart failure
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublikacjaThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Molecular Dynamics Study of the Internal Water Molecules in Vasopressin and Oxytocin Receptors
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Estrogen receptors 1 and 2 genotypes and age at menarche in idiopathic scoliosis
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Zastosowanie metodologii CBR do wyznaczania optymalnego zaopatrzenia punktu sprzedaży detalicznej.
PublikacjaW artykule rozważane jest zagadnienie optymalnego doboru asortymentu towarów dla punktu sprzedaży detalicznej. Scharakteryzowano podstawowe czynniki ekonomiczne determinizujące przychody i koszty detalisty. Dla rozpatrywanego problemu zbudowano model matematyczny w formie zadania programowania liniowego, w którym poszukiwane jest maksimum zysku detalisty z uwzględnieniem najistotniejszych ograniczeń w handlu: ilości dostępnego...
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Ryzykowna recepta na zarządzanie ryzykiem
PublikacjaCzy zaawansowana metodologia wyznaczania i alokacji kapitału ekonomicznego w bankach, wsparta przez odpowiednie normy regulacyjne, stanowi panaceum na bolączki związane z systemowymi ryzykami sektora bankowego? Idealizowanie tej recepty jest dość ryzykowne. Kapitał ekonomiczny to ciekawe narzędzie, ma ono jednak swoje niedoskonałości i pułapki.
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Reception of GNSS Signals Under Jamming Conditions
PublikacjaThe article focuses on performance of Global Navigation Satellite System receivers in environment where intentional interference is present. First part is a general description of GNSS systems. Secondly, types of positioning service disturbances are specified. In the third part authors present a scheme of measurement stand which is used to evaluate the influence of interference on reception of navigation signals. Next, research...
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Replication study of estrogen receptor 1 XbaI polymorphism in adolescent idiopathic scoliosis (AIS) Caucasian population
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Docking is not enough: 17-trifluoromethylphenyl trinor PGF2α is only a very weak ligand of neurokinin-1 receptor
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Correcting a widespread error: Neuroprotectant N-acetyl-L-tryptophan does not bind to the neurokinin-1 receptor
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Angiotensin receptor blockers and cancer – Relationship dismissed by VALUE data while waiting for EMA and FDA reports
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