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Wyniki wyszukiwania dla: PROTON AFFINITY
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C-reactive protein as a diagnostic and prognostic factor of endometrial cancer
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Structural Analysis of a Peptide Fragment of Transmembrane Transporter Protein Bilitranslocase
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Quantitative determination of mechanical stability in the novel coronavirus spike protein
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Delay induced oscillations in gene expression of Hes1 protein model
PublikacjaW pracy został omówiony model produkcji białka Hes1. Stężenie Hes1 jest kontrolowane przez ujemne sprzężenie zwrotne wbudowane w białko i jego mRNA. Przeprowadzona analiza potwierdziła znane wyniki numeryczne, że oscylacje wywołane są przez opóźnienie. Pokazaliśmy również, że jeśli współczynnik Hilla jest większy niż 1, to istnieje krytyczna wartość opóźnienia, dla której ma miejsce bifurkacja Hopfa i pojawiają się rozwiązania...
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Axial piston pumps with cam driven commutation unit. z.
PublikacjaPrzedstawiono wyniki badań i podstawowe dane techniczne typowego szeregu pomp wielotłoczkowych osiowych wdrażanych do produkcji seryjnej.
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The Unfolded Protein Response: A Double-Edged Sword for Brain Health
PublikacjaEfficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially to age-related cognitive decay and even neurodegenerative diseases. The regulation of this system requires a complex monitoring network to maintain proper oxygen homeostasis. Furthermore,...
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Analysis of the KZK equation solution for fixed pressure distributions at the piston
PublikacjaPraca dotyczy zagadnienia oddziaływania fal o dużej amplitudzie, generowanych przez przetwornik kołowy o gaussowskim rozkładzie ciśnienia. Model matematyczny zbudowano w oparciu o równania KZK. Do rozwiązania zagadnienia zastosowano metodę różnic skończonych. Badano zmiany ciśnienia fal różnych częstotliwości w obrębie wiązki akustycznej. Wyniki obliczeń numerycznych porównano z odpowiednimi rozwiązaniami analitycznymi
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Mechanism of antifreeze protein functioning and the “anchored clathrate water” concept
PublikacjaIn liquid water, there is a natural tendency to form aggregates that consist of water molecules linked by hydrogen bonds. Such spontaneously formed aggregates are surrounded by a "sea" of disordered water molecules, with both forms remaining in equilibrium. The process of creating water aggregates also takes place in the solvation water of proteins, but in this case the interactions of water molecules with the protein surface shift...
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MutL protein as a constituent of vsp, ner and mmr repair systems
PublikacjaMutS and MutL proteins are renowned mostly for their functions in well-characterized, post-DNA replication mis- match repair system (MMR). However, there is growing evidence that MMR system is not the only field of action for these pro- teins. Moreover, the participation in MMR does not even have to be their primary function. There are some reports indicat- ing involvement of MutL in BER, NER and VSP (very short patch repair)....
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MP3vec: A Reusable Machine-Constructed Feature Representation for Protein Sequences
Publikacja—Machine Learning (ML) methods have been used with varying degrees of success on protein prediction tasks, with two inherent limitations. First, prediction performance often depends upon the features extracted from the proteins. Second, experimental data may be insufficient to construct reliable ML models. Here we introduce MP3vec, a transferable representation for protein sequences that is designed to be used specifically for sequence-to-sequence...
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SrCe0.9In0.1O3-δ-based reversible symmetrical Protonic Ceramic Cell
PublikacjaIn-doped SrCe0.9In0.1O3-δ (SCI) perovskite-type oxide is utilized as the solid electrolyte, as well as a component, together with SrFe0.75Mo0.25O3-δ (SFM) compound, in the composite-type electrodes to construct symmetrical Protonic Ceramic Fuel Cells (PCFC). With good mutual stability of SCI and SFM at high temperatures in water vapor-containing reducing and oxidizing conditions, as well as sufficient ionic conductivity with high...
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Molecular targets for antifungals in amino acid and protein biosynthetic pathways
PublikacjaFungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...
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X-ray and UV Radiation Damage of dsDNA/Protein Complexes
PublikacjaRadiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g.,...
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Sprawność elastycznych protez stóp w kontekście współczesnych materiałów
PublikacjaKlasyfikacja protez stóp opiera się głównie na ich zachowaniu w momencie kontaktu z podłożem. Pod tym względem wyróżniamy stopy sztywne oraz sprężyste, charakteryzujące się możliwością tłumienia drgań i magazynowania oraz uwalniania energii. Współczesne elastyczne protezy stóp przeznaczone dla osób wykazujących wysoką i bardzo wysoką aktywność wytwarzane są z materiałów kompozytowych zawierających włókna węglowe. W zależności od...
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Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
PublikacjaWe present the results for CAPRI Round 50, the 4th joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of 12 targets, including 6 dimers, 3 trimers, and 3 higher-order oligomers. Four of these were easy targets, for which good structural templates were available either for the full assembly, or for the main interfaces (of the higher-order oligomers). Eight were difficult targets for which only distantly...
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Bounds on the cover time of parallel rotor walks
PublikacjaThe rotor-router mechanism was introduced as a deterministic alternative to the random walk in undirected graphs. In this model, a set of k identical walkers is deployed in parallel, starting from a chosen subset of nodes, and moving around the graph in synchronous steps. During the process, each node successively propagates walkers visiting it along its outgoing arcs in round-robin fashion, according to a fixed ordering. We consider...
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Variable Size Twin-Rotor Wind Turbine
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Rotor Blade Geometry Optimisation in Kaplan Turbine
PublikacjaThe paper presents the description of method and results of rotor blade shape optimisation. The rotor blading constitutes a part ofturbine flow path. Optimisation consists in selection of the shape that minimises ratio of polytrophic loss. Shape of the blade isdefined by the mean camber line and thickness of the airfoil. Thickness is distributed around the camber line based on the ratio ofdistribution. Global optimisation was done...
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Bounds on the Cover Time of Parallel Rotor Walks
PublikacjaThe rotor-router mechanism was introduced as a deterministic alternative to the random walk in undirected graphs. In this model, a set of k identical walkers is deployed in parallel, starting from a chosen subset of nodes, and moving around the graph in synchronous steps. During the process, each node maintains a cyclic ordering of its outgoing arcs, and successively propagates walkers which visit it along its outgoing arcs in...
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Photo-acoustic response of active biological systems
PublikacjaZbadano dwie próbki organiczne gatunku Trunculariopsis trunculus,jedną wilgotną, drugą - suchą. W obu przypadkach zaobserwowanointensywne szerokie pasma absorpcyjne w zakresie widzialnym (żółtymi poniżej 330 nm). Widma foto-akustyczne zawierają wszystkie pasma uznane za związane z aktywnością biologiczną.
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Dependence of Power Characteristics on Savonius Rotor Segmentation
PublikacjaSavonius rotors are large and heavy because they use drag force for propulsion. This leads to a larger investment in comparison to horizontal axis wind turbine (HAWT) rotors using lift forces. A simple construction of the Savonius rotor is preferred to reduce the production effort. Therefore, it is proposed here to use single-segment rotors of high elongation. Nevertheless, this rotor type must be compared with a multi-segment...
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Dissociative photo-double-ionization of the isoxazole molecules
PublikacjaThe five-membered heterocyclic rings are incorporated into a wide variety of structures that play a vital role in many biochemical processes. In particular, the isoxazole molecule appears in many bioactive compounds due to its unique ring structure that consists of one oxygen atom and one nitrogen atom at adjacent positions. The unique atomic composition and bond arrangement of isoxazole imply its specific electronic properties...
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Core/Shell Quantum Dots Encapsulated in Biocompatible Oil-Core Nanocarriers as Two-Photon Fluorescent Markers for Bioimaging
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The thermoluminescence characteristics and the glow curves of Thulium doped silica fiber exposed to 10MV photon and 21MeV electron radiation
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Thermoluminescent response of differently doped lithium magnesium phosphate (LiMgPO4, LMP) crystals to protons, neutrons and alpha particles
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Two-dimensional gel-based serum protein profile of growing piglets
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Effect of Functionalization of Carbon Nanotubes with Psychosine on Complement Activation and Protein Adsorption
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Micellar aggregation of Triton X-100 surfactant in imidazolium ionic liquids
PublikacjaIn this work we investigated aggregation behavior of a nonionic surfactant Triton X-100 in eighteen imidazolium ionic liquids (ILs) with two to eight carbon atoms in cations alkyl chain, namely 1-ethyl-3-methylimidazolium, [EMIM], 1-butyl-3-methylimidazolium, [PrMIM], 3-methyl-1-propylimidazolium, [BMIM], 1-hexyl-3-methylimidazolium, [PMIM], 3-methyl-1-pentyl-imidazolium, [HMIM], and 1-octyl-3-methylimidazolium, [OMIM], and with...
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RESEARCH OF HYDRAULIC PISTON PUMPS’ START-UP IN LOW AMBIENT TEMPERATURES
PublikacjaStarting hydraulic pumps in low ambient temperatures may cause: decreased hydraulic-mechanical efficiency, larger vibration of hydraulic installation, faster wear and more frequent damage to the elements of pumps, change of material properties of elements, increase of pressure drop. As a result of increase of resistance of cold oil flow in the suction pipe, large underpressure may be experienced, causing incomplete filling of pump...
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Trial Proteomic Qualitative and Quantitative Analysis of the Protein Matrix of Submandibular Sialoliths
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Riboflavin binding protein—Chiral stationary phase: Investigation of retention mechanism
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The Nutritional Value and Biological Activity of Concentrated Protein Fraction of Potato Juice
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Serum Fatty Acid-Binding Protein 4 is Increased in Patients with Psoriasis
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Survivin DEx3 as a biomarker of thyroid cancers: A study at the mRNA and protein level
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Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
PublikacjaWe propose the generalisation of the p53-Mdm2 protein gene expression model introduced by Monk (2003). We investigate the stability of a unique positive steady state and formulate conditions which guarantee the occurrence of the Hopf bifurcation. We show that oscillatory behaviour can be caused not only by time lag in protein transcription process, but also can be present in the model without time delay. Moreover, we investigate...
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Functional Protein Composition in Femoral Glands of Sand Lizards (Lacerta agilis)
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Zeta potential and droplet size of n-tetradecane/ethanol (protein) emulsions
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CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures
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BALCONY: an R package for MSA and functional compartments of protein variability analysis
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Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines
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C-reactive protein as a diagnostic and prognostic factor in inflammatory bowel diseases
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Simulation of Protein Structure and Dynamics with the Coarse-Grained UNRES Force Field
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Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines
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Blind prediction of homo‐ and hetero‐protein complexes: The CASP13‐CAPRI experiment
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TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma
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Stability of delay induced oscillations in gene expression of Hes1 protein model
PublikacjaW pracy prezentowana jest matematyczna analiza modelu ekspresji genu białka Hes1. Rozważamy układ równań z dwoma opóźnieniami - w produkcji białka Hes1 oraz jego mRNA. Dowodzimy istnienia i jednoznaczności oraz nieujemności rozwiązań. Pokazujemy istnienie dokładnie jednego dodatniego stanu stacjonarnego. Wykazujemy, że stabilność stanu stacjonarnego zależy od sumy opóźnień. Podajemy warunek dostateczny na wystąpienie bifurkacji...
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Novel primosomal protein B from thermophilic bacterium Thermoanerobacter tengcongensis
PublikacjaWe report the identification and characterization of theprimosomal protein B (PriB) from thermophilic bacteriumThermoanerobacter tengcongensis (TtePriB). It is the largestknown bacterial PriB protein consisting 216 amino acidresidues with a calculated molecular mass of 25 kDa. Surprisingly,it is functional as monomer containing two single-stranded DNA binding domain (OB-fold) and it is thecompletely new kind structure of SSB protein....
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Use of waste heat to improve the conditions of the piston engines start up
PublikacjaZespoły prądotwórcze z tłokowymi silnikami spalinowymi są obecnie powszechne stosowane jako awaryjne źródła energii elektrycznej albo elektrownie uzupełniające niedobory energii czy stabilizujące częstotliwość. Ich czas rozruchu powinien być krótki - poniżej 5 minut w przypadku dużych mocy. Zużycie silnika, zużycie paliwa i emisji spalin są silnie uzależnione od stanu cieplnego przed rozruchem. Przedstawiono pomiary laboratoryjne...
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Relationship between Milk Protein Polymorphism and Selected Cows’ Reproductive Indices
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DSC and electrophoretic studies on protein denaturation of Anodonta woodiana (Lea, 1834)
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