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Wyniki wyszukiwania dla: POLONIA HARBIŃSKA
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From chemoresistance to cancer stem cells: the case of BRCP/ABCG2 half transporter
PublikacjaLudzkie białko ABCG2 jest pompą typu ABC tworzącą homodimery i aktywnie transportującą leki i inne substraty naturalne i syntetyczne. Nadekspresja tego białko prowadzi do oporności na leki przeciwnowotworowe. Białko ABCG2 występuje w wielu formach zmutowanych, różniących się własnościami substratowymi, stąd istotne dla oporności na leki jest jaka forma genu i białka ABCG2 ulega nadekspresji w komórce. Ostatnie badania wskazują,...
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The cellular response of human hepatoma cells with different expression of CYP3A4 isoenzyme to treatment with triazoloacridinone derivative C-1305
PublikacjaCelem badań było określenie w jaki sposób ekspresja enzymów odpowiedzialnych za metabolizm pochodnej triazoloakrydonu C-1305 wpływa na odpowiedź komórek ludzkiego raka wątroby HepG2 i Hep3A4. W komórkach HepG2 triazoloakrydon C-1305 indukuje proces starzenia, podczas gdy w przypadku linii Hep3A4, komórki ulegają apoptozie oraz nekrozie.
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Imidazoacridinone antitumor agent, c-1311, as a selective mechanism-based inactivator of human recombinant cytochrome P450 1A2
PublikacjaPrzedmiotem badań była przeciwnowotworowa pochodna imidazoakrydonu, C-1311, która pod nazwą Symadex R, znajduje się aktualnie w II fazie badań klinicznych. Wcześniejsze wyniki pozwoliły stwierdzić, że związek ten jest selektywnym inhibitorem niektórych enzymów cytochromowych. Podjęto zatem próbę wyjaśnienia mechanizmu inhibicji izoenzymów cytochromu P450 przez C-1311. Wykazano, że utrata aktywności katalitycznej obu izoenzymów...
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Cellular senescence induced by DNA damage and its role in carcinogenesis and chemotherapy
PublikacjaUszkodzenia DNA indukują w komórce różne procesy, w tym starzenie komórkowe, co może uruchamiać proces karcinogenezy jak i być związane z odpowiedzią na leki przecinowotworowe. Biologiczna rola starzenia komórkowego nie jest jednak jasna. Zasugerowano, że proces starzenia komórkowego może hamować proces karcinogenezy poprzez indukcję nieodwracalnego zahamowania wzrostu przez czynniki genotoksyczne. Indukcja starzenia komórkowego...
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Interactions of antitumor triazoloacridinones with DNA
PublikacjaW niniejszej pracy zbadano oddziaływanie sześciu wybranych pochodnych triazoloakrydonu z DNA. Analiza wiskozymetryczna pokazała, że związki te interkalują do DNA. Jednocześnie dalsze badania wykazały, że proces interkalacji nie jest istotny aktywności cytotoksycznej tej grupy związków. Badania z wykorzystaniem fibroblastów dowiodły, że jedna z pochodnych triazoloakrydonu, związek C-1305, po uprzedniej metabolicznej aktywacji indukuje...
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublikacjaWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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Association between uridin diphosphate glucuronosylotranserase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia
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From Weak to Strong Coupling Superconductivity: Collective Modes in a Model with Local Attraction
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Ab Initio Analysis of a Quantum Dot Induced by a Local External Potential in a Semiconducting Carbon Nanotube
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Effects of Coulomb Interactions Between Fermions on Superconductivity in Boson-Fermion Model
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The Effects of Silver Ion Implantation on Structural and Morphological Performance of Hydroxyapatite Coatings
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Optical Diffraction Strain Sensor Prepared by Interference Lithography
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AFM, XRD and HRTEM studies of annealed FePd thin films
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Direct laser interference patterning: theory and application
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Vitamin D in the skin physiology and pathology.
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Determination of norflurazon concentration in wheat leaves using a modified QuEChERS method
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SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children.
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Molecular factors involved in the development of diabetic foot syndrome.
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The Escherichia coli RNA polymerase alpha subunit and transcriptional activation by bacteriophage lambda CII protein.
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Genistein modulates gene activity in psoriatic patients
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An introduction to DNA chips: principles, technology, applications and analysis.
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Simultaneous siRNA-mediated silencing of pairs of genes coding for enzymes involved in glycosaminoglycan synthesis.
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Comparison of siRNA-mediated silencing of glycosaminoglycan synthesis genes and enzyme replacement therapy for mucopolysaccharidosis in cell culture studies.
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Studies of Transport Properties of Single Layer Devices Based on the Polyazomethine Thin Films
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The Investigation of Thermal and Optical Properties of Semiconducting Nanostructural Hybrid Films
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PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis
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Stability of Diodes with Poly(3-hexylthiophene) and Polyazomethines Thin Organic Layer
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Density Functional Theory Studies on Ir Spectra of the Triphenylene Derivatives. A Scaled Quantum Mechanical Force Field Approach
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The Influence of PEDOT to PSS Ratio on the Optical Properties of PEDOT:PSS Thin Solid Films - Insight from Spectroscopic Ellipsometry
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Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells
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Expression of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9) in THP-1 macrophages cultured with three-dimensional titanium mini-plate systems used for surgical treatment of condylar fractures
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Order-Disorder Transition in 2D Conserved Spin System with Cooperative Dynamics
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Study of the High-Pressure Superconducting State in H3Se at 300 GPa
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Optimization of a Fabry-Perot Sensing Interferometer design for an optical fiber sensor of hematocrit level
PublikacjaContinuous measurement of the hemato crit level in blo o d can p otentially b e p erformed using optical bre sensors. The FabryPerot interferometric sensors are a promising candidate in this application. The most imp ortant step in the design of the sensor is design of the sensing interferometer. Adequate cavity length and high interference contrast are two most imp ortant requirements in this application. The design metho d of...
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Characterization of single-stranded DNA-binding proteins from the psychrophilic bacteria
PublikacjaSingle-stranded DNA-binding proteins (SSBs) are indispensable elements in the cells of all living organisms. SSB proteins interact with ssDNAinsequence in an independent manner, preventing them from forming secondary structures and from degradation by nucleases. In this way, SSB-binding proteins participate in all processes involving ssDNA, such as replication, repair and recombination.Although there are differences in amino acid...
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Novel primosomal protein B from Clostridium pasteurianum
PublikacjaPriB is a primosomal protein that catalyzes DNA replication in Procaryota. The replication pathway starts with PriA protein - the initiator protein that binds to a DNA replication fork, unwinds double-stranded DNA and role of PriB is to stabilize PriA on the DNA. However there are many biochemical differences in replication mechanism in bacteria and only some of them use PriB proteins. A few of PriB proteins were published and...
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The use of a one-step PCR method for the identification of Microsporum canis and Trichophyton mentagrophytes infection of pets
PublikacjaIntroduction: Dermatophytes are a closely related group of keratinophilic fungi. They encompass important etiological agents of superficial fungal infections. These fungi are able to invade keratinized tissues of humans and animals, causing dermatophytosis (ringworm) of hair, nails or skin. The aim: Traditional diagnostics of ringworm is based on morphological identification of cultured fungi and is time-consuming. Materials and methods:...
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Wymiana handlowa Polski z Armenią, Azerbejdźanem i Gruzją
PublikacjaHandel zagraniczny Polski, w porównaniu z pozostałymi krajami Kaukazu Południowego, najszybciej rozwijał się z Gruzją. W 2001 roku największe obroty handlowe Polska zanotowała z Azerbejdżanem, a w 2012 roku – z Gruzją. Ogółem obroty handlowe Polski w latach 2001–2012 były większe z Gruzją niż Azerbejdżanem. Stało się tak z powodu niepodjęcia realizacji projektu przedłużenia rurociągu Odessa-Brody do Płocka i Gdańska, co umożliwiłoby...
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Nanocrystalline CVD Diamond Coatings on Fused Silica Optical Fibres: Optical Properties Study
Publikacjapre-treatment by dip coating in two detonation nanodiamond (DND) seeding media has been studied. The DND suspension in ethyl alcohol and dispersion of DND in dimethyl sulfoxide (DMSO) with polyvinyl alcohol (PVA) were chosen for the seeding purpose. The grain size distribution of nanodiamond particles in both seeding media was kept at the same level (approximately 1050 nm). After the seeding nanocrystalline diamond lms were deposited...
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Increased concentration of Taq DNA polymerase as a solution for GC-rich templates from clinical and environmental samples
PublikacjaDNA polymerase is an enzyme which plays crucial role in replication and DNA repair. It found application in PCR (polymerase chain reaction) where catalyses process of in vitro DNA synthesis. To meet the demands posed by mod- ern diagnostic, molecular biology or genetic engineering it is necessary to improve DNA polymerases to obtain new or better features useful in these fields. So far implemented modifications in majority are...
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Phytoecdysteroid containing plants – a source of bioactive compounds with potential anticarcinogenic effects
PublikacjaEcdysteroids are a group of steroids synthesized in inver- tebrates as molting hormones and also in some plants as secondary metabolites acting as a defense against parasites. These compounds do not naturally occur in mammals and are not structurally related to mammalian steroid hor- mones, consequently do not activate mammalian hormone receptors. Ecdysteroids exhibit very low toxicity to mam- mals and to date no serious side effects...
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Phospholipids as potential prevention factor in carcinogenesis
PublikacjaPhospholipids are a group of complex lipids, which can be used in cancer chemoprevention. Glicerophospholipids are composed of fatty acids esterified to a glycerol backbone, a phosphate group and a hydrophilic residue such as: cho- line, ethanoloamine, serine or inositol. In the sn-2 position of glicerophospholipid usually there are unsaturated fatty acids, i.e. linolenic acid, while in the sn-1 position more typi- cal are saturated...
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Relationship between the betalain composition in Opuntia ficus indica and Beta vulgaris varieties and biological activity of their extracts
PublikacjaBetalains are a class of pigments that are much less com- monly found in nature than anthocyanins or carotenoids. They occur only in a few edible plants such as red beetroot (Beta vulgaris), prickly pears (Opuntia ficus indica), amaranth (Amaranthus sp.) and some mushrooms. This group of pig- ments can be divided into two major groups: yellow vulgax- anthins and red betanins. Despite their structural similarity to compounds from...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublikacjaPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublikacjaPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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The role of the sawage treatment plant in the removal of genotoxic compounds from the environment
PublikacjaOne reason for increased incidence of various types of cancer are environmental pollutants particularly of anthropogenic origin. All human activities may pollute the environment, but some have significant impact, just to mention energy industry, mining, transportation, chemical and petrochemical industries and housing. Environmental pollutants are a large group of compounds in terms of their physicochemical properties, some of...
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MutS3: a MutS homologue of unknown biological function
PublikacjaThe homologues of MutS proteins are widespread among both Prokaryotes and Eukaryotes. MutS designated as MutS1 is a part of MMR (mismatch repair) system which is responsible for removal of mispaired bases and small insertion/deletion loops in DNA. Initially, the only MutS homologues known were those engaged in mismatch repair and these were later designated as MutS1. Subsequently, the MutS2 homologue was distinguished. MutS2 does...
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The influence of food phytochemicals on cyclic phosphodiesterase 4 (PDE4) activity
PublikacjaCyclic phosphodiesterase 4 (PDE4) belongs to family of cyclic phosphodiesterases, which are expressed predominantly in inflammatory cells, airway smooth muscles, cardiovascular tissues and brain. Inhibitors of this family of enzymes found medicinal applications as antidepressants, antiinflamatory drugs (mainly in airway diseases) or antiasthmatics (Ibudilast). PDE4 inhibitors are also being tested for preventing the development...
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Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublikacjaThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublikacjaThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...