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Wyniki wyszukiwania dla: mtDNA genome
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Analysis of Keratoconus genetic factors within Keratoconus Loci and mtDNA
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Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p
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Phylogenetics and phylogeography of red deer mtDNA lineages during the last 50 000 years in Eurasia
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Odpowiedzialny biznes- modna koncepcja czy odrodzenie wartości?
PublikacjaOpracowanie porządkuje wiedzę na temat koncepcji społecznej odpowiedzialności biznesu oraz jej specyfiki w kontekście małych i średnich przedsiębiorstw. Omówione zostały różnice pomiędzy zastosowaniem CSR w dużych organizacjach i w MŚP, ze szczególnym uwzględnieniem przedsiębiorstw polskich. Predyspozycje do zaangażowania społecznego przedsiębiorcy przedstawione zostały na kilku modelach teoretycznych, a konkretne przykłady dobrych...
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublikacjaMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity
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Chemometric Method of Spectra Analysis Leading to Isolation of Lysozyme and CtDNA Spectra Affected by Osmolytes
PublikacjaW niniejszej pracy zaprezentowana została chemometryczna metoda analizy danych widmowych, prowadząca do wyizolowania widm FTIR biomakrocząsteczek (lizozymu z białka jaja kurzego i ctDNA) zaburzonych przez wybrane osmolity (TMAO, betainę) w roztworach wodnych. Została ona oparta na metodzie widm różnicowych, wykorzystywanej pierwotnie do określania struktury rozpuszczalnika wokół cząsteczek substancji rozpuszczonej. Cykliczne wykorzystanie...
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Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups
PublikacjaMastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach. A total of 234 patients were enrolled in our study, including 141 with cutaneous mastocytosis (CM; 78 children and 63 adults) and 93 with systemic mastocytosis (SM, all adults)....
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First recurrent large genomic rearrangement in the BRCA1 gene found in Poland
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Analysis of the complete genome sequence of the lactococcal bacteriophage bIBB29
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Identification of Mitochondrial DNA (NUMTs) in the Nuclear Genome of Daphnia magna
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Efficient Agrobacterium-mediated transformation and genome editing of Fagopyrum tataricum
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Draft Genome Sequence of the Type Strain Pseudomonas jessenii DSM 17150
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Draft Genome Sequence of the Type Strain Pseudomonas umsongensis DSM 16611
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Draft Genome Sequence of the Type Strain Sphingopyxis witflariensis DSM 14551
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Draft Genome Sequence of the Type Strain Sphingopyxis bauzanensis DSM 22271
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Whole-genome sequencing and antimicrobial potential of bacteria isolated from Polish honey
PublikacjaThe aim of this study was the whole-genome analysis and assessment of the antimicrobial potential of bacterial isolates from honey harvested in one geographical location—the north of Poland. In total, 132 strains were derived from three honey samples, and the antimicrobial activity of CFAM (cell-free after-culture medium) was used as a criterion for strain selection and detailed genomic investigation. Two of the tested isolates...
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Genome Sequence of the Probiotic Strain Lactobacillus rhamnosus (Formerly Lactobacillus casei) LOCK900
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Genome Sequence of the Probiotic Strain Lactobacillus rhamnosus (Formerly Lactobacillus casei) LOCK908
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An accurate assignment test for extremely low‐coverage whole‐genome sequence data
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An accurate assignment test for extremely low-coverage whole-genome sequence data
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Complete Genome Sequence of the Probiotic Strain Lactobacillus casei (Formerly Lactobacillus paracasei) LOCK919
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Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome
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Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains
PublikacjaAims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between...
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Wykorzystanie reakcji PCR do badania charakterystycznych obszarów genomu
PublikacjaW pracy zostały opisane metody wykorzystujące technię PCR do długo- i krótkoterminowych badań epidemiologicznych. Typowanie szczepów oparte jest na analizie fragmentów genów, bądź całego genomu w zależności od potrzeby posiadania potencjału różnicującego metody. Przez ostatnie 30 lat rozwijały się nie tylko metody badawcze, doszło również do rozwoju międzynarodowych baz danych i przepływu informacji o obecnych sytuacjach epidemiologicznych...
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Adhesion of the genome-sequenced Lactococcus lactis subsp. cremoris IBB477 strain is mediated by specific molecular determinants
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Whole genome sequencing of Fowl aviadenovirus A - a causative agent of gizzard erosion and ulceration, in adult laying hens
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Draft genome sequence of antimicrobial producing Paenibacillus alvei strain MP1 reveals putative novel antimicrobials
PublikacjaA Paenibacillus strain isolated in previous research exhibited antimicrobial activity against relevant human pathogens including Staphylococcus aureus and Listeria monocytogenes. In this study, the genome of the aforementioned strain, designated as MP1, was shotgun sequenced. The draft genome of strain MP1 was subject to multiple genomic analyses to taxonomically characterize it and identify the genes potentially responsible for...
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Discrimination of hospital isolates of Acinetobacter baumannii using repeated sequences and whole genome alignment differential analysis
PublikacjaAn optimized method for bacterial strain differentiation, based on combination of Repeated Sequences and Whole Genome Alignment Differential Analysis (RS&WGADA), is presented in this report. In this analysis, 51 Acinetobacter baumannii multidrug-resistance strains from one hospital environment and patients from 14 hospital wards were classified on the basis of polymorphisms of repeated sequences located in CRISPR region, variation...
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Badanie i porównanie zdolności wybranych leków i związków przeciwnowotworowych do międzyłańcuchowego sieciowania DNA mitochondrialnego i jądrowego w komórkach nowotworowych
PublikacjaCelem pracy było zbadanie zdolności przeciwnowotworowych związków do indukowania międzyłańcuchowych wiązań sieciujących DNA mitochondrialne w ludzkich komórkach nowotworowych oraz porównanie ze zdolnością do sieciowania DNA jądrowego. Pochodna 4-metylo-1-nitroakrydyny C-1748, Ledakrin i mitomycyna C wykazują zdolność do sieciowania mtDNA i jDNA w komórkach raka okrężnicy HCT-8 w sposób zależny od dawki; C-1748 w komórkach raka...
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Molecular differences in mitochondrial DNA genomes of dogs with malignant mammary tumours
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Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse
PublikacjaThe MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TpsiCloop of the tRNA methionine gene...
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Analysis of Mitochondrial Genome from Labrador (Canis lupus familiaris) with Mammary Gland Tumour Reveals Novel Mutations and Polymorphisms
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Characterization of Rosa canina Fruits Collected in Urban Areas of Slovakia. Genome Size, iPBS Profiles and Antioxidant and Antimicrobial Activities
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Genome Mining Revealed a High Biosynthetic Potential for Antifungal Streptomyces sp. S-2 Isolated from Black Soot
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublikacjaRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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Ochrobactrum quorumnocens sp. nov., a quorum quenching bacterium from the potato rhizosphere, and comparative genome analysis with related type strains
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Świetlna przestrzeń jako fenomen miasta nocą
PublikacjaW artykule opisano nowy trend w oświetleniu przestrzeni publicznej i tworzeniu spektakularnych scenografii. Przytoczono przykłady realizacji festiwali i warsztatów oświetleniowych, które zmieniają nocną scenerię miast europejskich.
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Correction: Ochrobactrum quorumnocens sp. nov., a quorum quenching bacterium from the potato rhizosphere, and comparative genome analysis with related type strains
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Pseudomonas silesiensis sp. nov. strain A3T isolated from a biological pesticide sewage treatment plant and analysis of the complete genome sequence
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In Silico Safety Assessment of Bacillus Isolated from Polish Bee Pollen and Bee Bread as Novel Probiotic Candidates
PublikacjaBacillus species isolated from Polish bee pollen (BP) and bee bread (BB) were characterized for in silico probiotic and safety attributes. A probiogenomics approach was used, and in-depth genomic analysis was performed using a wide array of bioinformatics tools to investigate the presence of virulence and antibiotic resistance properties, mobile genetic elements, and secondary metabolites. Functional annotation and Carbohydrate-Active...
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A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence
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Genome Mining and Evaluation of the Biocontrol Potential of Pseudomonas fluorescens BRZ63, a New Endophyte of Oilseed Rape (Brassica napus L.) against Fungal Pathogens
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Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients
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Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence
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A study of possibility the air conditioning system in a car to become a bioaerosol generator
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GENOMIC ANALYSIS OF PLANT-ASSOCIATED BACTERIA AND THEIR POTENTIAL IN ENHANCING PHYTOREMEDIATION EFFICIENCY
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Genome-Wide Identification of Dickeya solani Transcriptional Units Up-Regulated in Response to Plant Tissues From a Crop-Host Solanum tuberosum and a Weed-Host Solanum dulcamara
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Music Genre Recognition in the Rough Set-Based Environment
PublikacjaThe aim of this paper is to investigate music genre recognition in the rough set-based environment. Experiments involve a parameterized music data-base containing 1100 music excerpts. The database is divided into 11 classes cor-responding to music genres. Tests are conducted using the Rough Set Exploration System (RSES), a toolset for analyzing data with the use of methods based on the rough set theory. Classification effectiveness...
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Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability
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