Wyszukiwarka
Filtry
wszystkich: 562
-
Katalog
Wyniki wyszukiwania dla: METABOLITES IN KIWIFRUITS
-
Covalent DNA modification by products of myrosinase catalysed glucosinolate degradation in cell-free system
PublikacjaThe bioactive phytochemicals found in Brassica vegetables belonging to glucosinolates (GLS) and especially the products of their degradation isothiocyanates (ITC) and indoles are regarded as the most promising cancer chemopreventive compounds. These secondary metabolites constitute defence system repelling or preventing the development of agrophages attacking brassica plants. The antibiological properties of these compounds suggest...
-
Fatal N-Ethylhexedrone Intoxication
PublikacjaN-Ethylhexedrone [2-(ethyloamino)-1-phenylhexan-1-one; α-ethylaminohexanophenone; NEH] is one of the most recent synthetic cathinones that appeared on the illegal market in late 2015. The majority of information concerning the model of consumption of NEH and its impact on the body originates only from self-reports from grey literature websites and drug forums. There are only limited data associated with the concentrations of NEH...
-
Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublikacjaA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
-
Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublikacjaOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
-
Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
-
Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublikacjaBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
-
Substancje groźne, niebezpieczne i pożyteczne.Tom 1: Pierwiastki i związki nieorganiczne
PublikacjaLudzie od początku swojego istnienia byli narażeni na działanie szkodliwych substancji chemicznych. Pierwotnie były to groźne dla życia opary wulkaniczne, toksyczne minerały – takie, jak arszenik, rudy ołowiu czy rtęci, szkodliwe metabolity wtórne (toksyny) wytwarzane przez mikroorganizmy, rośliny i zwierzęta, a także produkty spalania substancji organicznych, w tym dymy z palących się lasów czy stepów, zawierające czad, dioksyny,...
-
UDP-glukuronylotransferazy - białka siateczki śródplazmatycznej. Struktura i mechanizm działania
PublikacjaIzoenzymy UDP-glukuronylotransferazy (EC. 2.4.1.17), UGT, katalizują w organizmach ssaków reakcję koniugacji grupy glikozylowej pochodzącej z nukleotydu UDPGA z aglikonem. UDPGA jest przyłączany do odpowiedniej grupy funkcyjnej metabolitu I fazy, rzadziej związku wyjściowego, przez co polarność aglikonu i zdolność jego wydalania z komórki zwiększa się, a to w konsekwencji obniża efekt toksyczny.Struktura UGT zawiera 2 domeny. Domena...
-
3. E-TECH: Online education in practice for teachers. Advanced
Kursy OnlineTo enroll to this course please write an e-mail at: alina.guzik@pg.edu.pl
-
2 - E-TECH: Online education in practice for teachers. Intermediate
Kursy Online -
[ILiT, IŚGiE] Process engineering in circular economy 20/21 Summer
Kursy OnlineKurs jest przeznaczony dla doktorantów szkoły doktorskiej w dyscyplnach: inżynieria lądowa i transport (SzD), III stopnia, stacjonarne inżynieria środowiska, górnictwo i energetyka (SzD), III stopnia, stacjonarne The course is addressed to PhD students of the doctoral school in disciplines: civil engineering and transport environmental engineering, mining and power engineering Course type: lecture Total hours of...
-
1 - E-TECH: Online education in practice for teachers. Foundations
Kursy OnlineThis module has been designed to help teachers to get the very best out of online learning education. We've created it to support many aspects of your learning online. The aim is to provide skills to create and engage with your teaching materials online. After completion the course you can download your Certifacte.
-
[Soft Skills] 2022 Didactic methods in the modern teaching process
Kursy Online -
NEW AND FAST ANALYTICAL TECHNIQUES IN FOOD QUALITY ANALYSIS 2024
Kursy Online -
[NCh, ICh] Physical Chemistry of Organic Compounds in Natural Waters
Kursy Online{mlang pl} Dyscyplina: Nauki chemiczne Zajęcia obieralne dla doktorantów Prowadzący: prof. dr hab. Tadeusz Górecki Liczba godzin: 15 {mlang} {mlang en} Discipline: Chemical science Elective course for PhD students Academic teacher: prof. dr hab. inż. Tadeusz Górecki Total hours of training: 15 teaching hours {mlang}
-
Safety and risk in transportation systems - summer semester 2023/2024
Kursy OnlinePodstawy teorii bezpieczeństwa i ryzyka w kontekście aplikacji w systemach transportowych.
-
Application of Mathematics in Technology 2 [Energy Technologies][2024/25]
Kursy Online -
Source and Channel Coding in Radio Communication Systems 2023/2024
Kursy OnlineKurs służy jako narzędzie pomocnicze do realizacji przedmiotu.
-
Design of measurement systems in integrated programming environments [2024/25]
Kursy OnlineThe winter school on "Design of Measurement Systems in Integrated Programming Environments" as a part of the educational offering of the INNOVATIVE LEARNING CAMPUS within the ENHANCE+ Alliance.
-
Możliwość wykorzystania różnych materiałów biologicznych pobranych od człowieka w analityce jonów cyjankowych pochodzących z dymu tytoniowego, oraz ich metabolitów-jonów rodankowych.
ProjektyProjekt realizowany w Katedra Chemii Analitycznej zgodnie z porozumieniem 0321/IP3/2015/73 z dnia 2015-03-19
-
Optimal conditions of ramentaceone and plumbagin separation and isolation from carnivorous plants extracts using reverse phase-high performance liquid chromatography (RP-HPLC)
PublikacjaPreparatywna chromatografia cieczowa jest szczególnie przydatną techniką do rozdzielania i izolacji użytecznych ilości substancji z różnych skomplikowanych mieszanin. Praca prezentuje optymalne warunki rozdzielania i izolacji ramentaceonu i plumbaginy uwzględniając maksymalną selektywność rozdzielania naftochinonów od substancji balastowych z chloroformowych ekstraktów roślinnych D. aliciae i D. capensis z zastosowaniem techniki...
-
imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublikacjaLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
-
Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublikacjaIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
-
Selected topics in electrical engineering – modelling of, electrical machines [2021/22]
Kursy Online -
CAD. Integrated Architectural Design BSc in Arch., sem 3 2022/2023
Kursy OnlineDuring the course students will learn how to use BIM (Building Information Modelling) tools to model the project site and to develop preliminary design concept.Students will work in pairs or groups, using Autodesk Revit software for terrain, site and building modelling.
-
Environmental Protection in Energetics, L, E, sem.01, zimowy 22/23
Kursy Online -
Environmental Protection in Energetics, W, E, sem.01, zimowy 22/23
Kursy OnlineThe principle of sustainable development. Non-renewable and renewable energy sources. Environmental aspects of the use of different energy sources. Atmospheric pollution. Methods of reducing the emission of pollutants into the atmosphere. Waste and hazardous waste. Water and Wastewater. Legal aspects of environmental protection.
-
Supplementary Course in Higher Physics DPE tutorial (PG_00056611) zima 21/22
Kursy Online -
Advances in materials engineering instrumentation: new trends and applications 2022/2023
Kursy Online -
[Soft Skills] 2 YEAR Didactic methods in the modern teaching process
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów 2 roku Prowadząca: dr hab. Joanna Mytnik, prof. uczelni Liczba godzin: 15 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: all disciplines Obligatory course for 2nd-year PhD students Academic teacher: Joanna Mytnik, Ph.D., ass. prof. Total hours of training: 15 teaching hours Course type: workshop {mlang} Soft skills, area I - didactic...
-
Environmental Protection in Energetics, L, E, sem.1, zimowy 24/25
Kursy Online -
[Soft Skills] Workshop in research ethics gr.2 AEEITK, ITIT, IMe
Kursy Online{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
-
[Soft Skills] Workshop in research ethics gr.3 NCh, IMa, NF
Kursy Online{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
-
Application of Mathematics in Technology, ET, sem 3, 23/24, (PG_00049767)
Kursy OnlineApplication of Mathematics MOODLE ENV localdevtestprod
-
Environmental Protection in Energetics, L, E, sem.1, zimowy 23/24
Kursy Online -
DAYLIGHT IN ARCHITECTURE (Elective Project I: MSc term 1) - 23-24
Kursy OnlineThe objectives of this course are: To familiarize students with the role and importance of daylight in shaping building spaces and interiors. To learn about the basics of daylight simulations in the context of complex design decisions and for LEED and BREEAM, integrated design purposes. Proposed assignments 1 & 2: 1. Daylight analysis exterior, the interior of the iconic building (sunlight provision, daylight factor, and...
-
Blue-berried honeysuckle a promising cancer preventing fruit; Polish genotypes as a source of bioactive phytochemicals
PublikacjaFrom the ancient times, plants containing health-oriented compounds in their matrices are used in the treatment of different complaints and diseases. One of these groups are plant secondary metabolites (PSM), especially phenolic compounds, terpenes and terpenoids. A large number of PSM exhibit cytotoxicity against a variety of tumor cells, as well as cancer preventive and anticancer efficacy in preclinical animal models. For this...
-
Effects of Addictive Substances During Pregnancy and Infancy and Their Analysis in Biological Materials
PublikacjaThe use of addictive substances during pregnancy is a serious social problem, not only because of effects on the health of the woman and child, but also because drug or alcohol dependency it detracts from childcare and enhances the prospect of child neglect and family breakdown. Developing additive substance abuse treatment programs for pregnant women is socially important and can help ensure the health of babies, prevent subsequent...
-
Contamination of runoff waters from roads with high traffic intensity in the urban region of Gdańsk, Poland
PublikacjaW ramach pracy prowadzone były badania zanieczyszczeń w próbkach wód spływnych z arterii komunikacyjnych. Próbki pobierano z sześciu stałych punktów zlokalizowanych wzdłuż szlaku komunikacyjnego prowadzącego z Redy do Gdańska (z miejsc o dużym natężeniu ruchu pojazdów) oraz z ulicy M. Buczka w Redzie (o mniejszym natężeniu ruchu). Próbki pobierane były przez okres dwóch miesięcy (okres deszczów jesiennych: 24.10 - 18.12.2000) oraz...
-
Impact of low temperature on bacterial community dynamics and process efficiency in anaerobic ammonia removal: A network analysis of metagenomic data
PublikacjaThe implementation of anaerobic ammonia removal has potential for reducing the operating costs in wastewater treatment plants. However, the application of this process in mainstream treatment presents various challenges, particularly due to the sensitivity of anammox bacteria to low temperatures. To address these challenges, changes in the bacterial community were investigated under decreasing temperatures (from 30 to 12 °C) within...
-
Elective design I: Waterfront Areas in a Changing Climate – Solutions for Gdańsk
Kursy OnlineElective design I:Waterfront Areas in a Changing Climate – Solutions for Gdańsk for MSc in Arch. Seminars & assignments: 30 hTeacher: Lucyna Nyka, Jakub Szczepański, Justyna Borucka + assist. teacher from Gdańsk Tech Waterfront Areas in a Changing Climate – Solutions for Gdańsk – This course explores challenges, conflicts and concepts in waterfront areas, their connection to architectural and urban design in the time of...
-
XII edition – 2019-21, International MBA in Strategy, Programme and Project Management
Kursy Online -
XV edition 2022-24, International MBA in Strategy, Programme and Project Management
Kursy Online1 2 3
-
Application of Mathematics in Technology, ET, sem. 3, winter 2022/2023, (PG_00049767)
Kursy OnlineApplication of Mathematics lectures and exercises
-
X edition 2018-20, International MBA in Strategy, Programme and Project Management
Kursy Online -
IX edition 2017-19, International MBA in Strategy, Programme and Project Management
Kursy Online -
XI edition – 2019-21, International MBA in Strategy, Programme and Project Management
Kursy Online -
XIV edition 2021-23, International MBA in Strategy, Programme and Project Management
Kursy Online1 2 3
-
Environmental Protection in Energetics (PG_00049751), W, ET, sem.1, winter 2024/2025
Kursy OnlineEnvironmental aspects of energy production and processing.
-
XIII edition – 2020-22, International MBA in Strategy, Programme and Project Management
Kursy Online