wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: METABOLIC NEOTENY
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Iranian Journal of Endocrinology and Metabolism
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Annals of Pediatric Endocrinology and Metabolism
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Journal of Nutrition and Intermediary Metabolism
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Turkish Journal of Endocrinology and Metabolism
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Drug Metabolism and Personalized Therapy
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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International Journal of Secondary Metabolite
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Chinese Journal of Endocrinology and Metabolism
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JOURNAL OF BONE AND MINERAL METABOLISM
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JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
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International Journal of Diabetes and Metabolism
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Effects of metallic silver particles on resonance energy transfer between fluorophores bound to DNA.
PublikacjaZbadano wpływ filmów wysepek metalicznego srebra na rezonansowe przekazywanie energii między fluoroforami związanymi z DNA. Donorem i akceptorem były odpowiednio 4´,6 diamidyno-2-fenylindon i jodek propydyny. Zmierzone dla tego układu czasy zaniku i widma fluorescencji pokazują, że sąsiedztwo cząstek srebra dramatycznie zwiększa promień Forstera, a tym samym i przekazywanie energii w znakowanym DNA.
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Nanomechanical Properties of Metallic fcc Nanorods from Molecular Simulations with the Sutton-Chen Potential
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Donor–acceptor nonradiative energy transfer mediated by surface plasmons on ultrathin metallic films
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Synthesis of Fatty Acid Esters of Selected Higher Polyols Over Homogeneous Metallic Catalysts
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Teeth as an Indicator of the Environmental Exposure of Silesia Province’s Inhabitants in Poland to Metallic Trace Elements
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Fading Analysis in Off-Body Channels in a Straight Metallic Corridor in a Passenger Ferry Environment
PublikacjaThis paper presents a fading analysis for Body Area Networks off-body communications at 2.45 GHz in a passenger ferry environment. The results are based on measurements performed for dynamic scenarios in a straight metallic corridor. Two components, extracted from instantaneous system loss values, have been analysed: small- and large-scales fading, separately for each scenario. Well-known probability distribution functions have...
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Selective determination of cocaine and its metabolite benzoylecgonine in environmental samples by newly developed sorbent materials
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Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
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Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3
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Serum Metabolite Profiles in Participants of Lung Cancer Screening Study; Comparison of Two Independent Cohorts
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Seasonal pattern of vitamin D hydroxyl metabolite concentrations and their association with cardiac medications – An observational study
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Photosynthesis and sucrose metabolism in leaves of Arabidopsis thaliana aos, ein4 and rcd1 mutants as affected by wounding
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublikacjaPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublikacjaBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Integrating conventional nitrogen removal with anammox in wastewater treatment systems: Microbial metabolism, sustainability and challenges
PublikacjaThe various forms of nitrogen (N), including ammonium (NH4+), nitrite (NO2−), and nitrate (NO3−), present in wastewaters can create critical biotic stress and can lead to hazardous phenomena that cause imbalances in biological diversity. Thus, biological nitrogen removal (BNR) from wastewaters is considered to be imperatively urgent. Therefore, anammox-based systems, i.e. partial nitrification and anaerobic ammonium oxidation (PN/anammox)...
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Adenylate Kinase 4—A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublikacjaDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublikacjaA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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MRI assessment of ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with the presence of central obesity and metabolic syndrome
PublikacjaPurpose: Obesity, defined as a body mass index (BMI) exceeding 30 kg/m2, is a serious health problem, which can be called an epidemic on a global scale and is one of the most important causes of preventable death. The aim of this study was to assess ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with metabolic syndrome (MetS). Patients and methods:...
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Interface diffusion between metallic nanoparticles and silicon substrate
Dane BadawczeInterface diffusion between metallic nanoparticles and silicon substrate was detected by EDX method. Metallic nanostructures were manufactured by thermal annealing of thin films. Gold and silver nanostructures were chosen for measurements. Samples were annealed for 15 and 60 minutes at 550 deg.
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Recent Patents on Endocrine Metabolic & Immune Drug Discovery
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KOVOVE MATERIALY-METALLIC MATERIALS
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Effects of metallic silver particles on resonance energy transfer in label-led bovine serum albumin
PublikacjaZbadano wpływ cząstek metalicznego srebra na rezonansowe przekazywanie energii od wewnętrznych residów tryptofanowych w proteinie do zewnętrznie dowiązanego akceptora. W tych warunkach zaobserwowano istotny wzrost odległości Fórstera z 28,6 A do 63 A, co wskazuje na możliwość użycia cząstek srebra przy mierzeniu dużych odległości między molekułami i ich o przydatność w zastosowaniach biotechnologicznych.
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Increased resonance energy transfer between fluorophores bound to DNA in proximity to metallic silver particles.
PublikacjaZbadano wpływ nanocząstek metalicznego srebra na rezonansowe przekazywanie energii między fluoroforami związanymi z DNA. Donor (pochodna kumaryny) i akceptor (Cy3) umieszczono na przeciwległych końcach DNA o strukturze podwójnej helisy i o 23 parach bazowych. W nieobecności cząstek srebra wydajność przekazywania energii w tym układzie wynosiła ok. 9%, zaś po umieszczeniu go między kwarcowymi płytkami pokrytymi filmem wysepek...
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Crack Detection in Metallic Surfaces Based on Dumbbell-Shaped Defected Ground Structures in Microstrip Technology
PublikacjaIn this paper, a novel crack detection sensor using a microstrip loaded with a Dumbbell-Shaped Defected Ground Structure (DS-DGS) is proposed. The sensing element is etched in the ground plane of a microstrip line and it is easy to fabricate. The electromagnetic (EM) field of the microstrip couples to the DS-DGS, thus demonstrating a bandstop behavior. It is shown that in the presence of a crack in a metallic surface underneath the...
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Regional effects of amphetamine, cocaine, nomifensine and GBR 12909 on the dynamics of dopamine release and metabolism in the rat brain
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γ-Butyrolactone-sensitive and -insensitive dopamine release, and their relationship to dopamine metabolism in three rat brain regions
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GC-MS analysis, antidiabetic and antioxidant activity of methanolic extract of pluteus cervinus: an in vitro and in silico approach
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Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review
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A comparative study of water distribution, free radical production and activation of antioxidative metabolism in germinating pea seeds
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Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity
PublikacjaIn the last few years,increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds whichare highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance....
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Disorders of iron metabolism - Female, 34 - Tissue image [4120730022894191]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Disorders of iron metabolism - Female, 34 - Tissue image [4120730022896351]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Disorders of iron metabolism - Female, 34 - Tissue image [4120730022893891]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Disorders of iron metabolism - Female, 34 - Tissue image [4120730022892091]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Disorders of iron metabolism - Female, 34 - Tissue image [4120730022892341]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublikacjaOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
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Metabolism of antitumor 9-amino-1-nitroacridine derivatives in HepG2 cells and its influence on cytochrome P450 isoenzymes
PublikacjaCelem przeprowadzonych badań było określenie wpływu pochodnych C-857 i C-1748 na poziom enzymów cytochromu P450 w powiązaniu z kinetyką metabolizmu badanych związków. Eksperymenty zostały przeprowadzone na komórkach ludzkiego nowotworu wątroby HepG2. Uzyskane wyniki metodą Western blotting wykazały, że za metaboliczną transformacje pochodnych C-857 i C-1748 odpowiada izoenzym CYP3A4.Analiza metabolitów (Western blotting, HPLC)...
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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublikacjaJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...