Iwona Gabriel - Publications - Bridge of Knowledge

Search

Filters

total: 32

  • Category
  • Year
  • Options

clear Chosen catalog filters disabled

Catalog Publications

Year 2024
Year 2023
Year 2022
Year 2021
Year 2020
  • ‘Acridines’ as New Horizons in Antifungal Treatment
    Publication

    - MOLECULES - Year 2020

    Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical...

    Full text available to download

Year 2019
Year 2018
Year 2017
Year 2016
Year 2015
  • Characterization of two aminotransferases from Candida albicans
    Publication

    Aminoadipate aminotransferase (AmAA) is an enzyme of α-aminoadipate pathway (AAP) for l-lysine biosynthesis. AmAA may also participated in biosynthesis or degradation of aromatic amino acids and in d-tryptophan based pigment production. The AAP is unique for fungal microorganisms. Enzymes involved in this pathway have specific structures and properties. These features can be used as potential molecular markers. Enzymes catalyzing...

    Full text available to download

  • Inhibitors of amino acids biosynthesis as antifungal agents
    Publication

    Fungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...

    Full text available to download

Year 2014
  • Phenotypic consequences of LYS4 gene disruption in Candida albicans
    Publication

    - YEAST - Year 2014

    A BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...

    Full text to download in external service

Year 2013

seen 3309 times