Jacek Czub - Publications - MOST Wiedzy

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2019
  • Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70
    Publication
    • O. Shrestha
    • R. Sharma
    • B. Tomiczek
    • W. Lee
    • M. Tonelli
    • G. Cornilescu
    • M. Stolarska
    • Ł. Nierzwicki
    • J. Czub
    • J. Markley
    • J. Marszalek
    • S. Ciesielski
    • E. Craig

    - PLOS ONE - 2019

    The J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...

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