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Search results for: BREAST CANCER DIAGNOSTICS
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Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublicationEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
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Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study
PublicationAmino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing...
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CDKN2A common variant and multi-organ cancer risk—a population-based study
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Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
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A personalised approach to prostate cancer screening based on genotyping of risk founder alleles
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Quantum issues in diagnostics of marine energy machines and devices
PublicationW artykule podjęto zagadnienie możliwości uwzględniania części dorobku mechaniki kwantowej w diagnostyce okrętowych urządzeń energetycznych. Wykazano, że są zbieżne spostrzeżenia mechaniki kwantoweji diagnostyki technicznej uzyskane w obszarze wiedzy z zakresu badań empirycznych. Uzasadniono konieczność wykonywania podczas badań empirycznych, nie tylko rachunku błędów, lecz także określania niedokładności wyników badań (pomiarów)...
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Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics
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Neural networks in the diagnostics of induction motor rotor cages.
PublicationW środowisku Lab VIEW została stworzona aplikacja służąca do pomiaru, prezentacji i zapisu przebiegów widma prądu stojana z uwzględnieniem potrzeb pomiarowych występujących podczas badania wirników silników indukcyjnych przy użyciu sieci neuronowych. Utworzona na bazie zbioru uczącego sieć Kohonena z powodzeniem rozwiązała stawiany przed nią problem klasyfikacji widm prądu stojana, a co za tym idzie również diagnozy stanu...
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Diagnostics of induction motors by means of current supplying measurements
PublicationSkładowe prądu zasilającego silnik, które związane są z uszkodzeniami łożysk są małe w porównaniu z dominującą składową sieciową. Zaproponowano układ pomiarowy do ich pomiaru i przedstawiono wyniki badań diagnostycznych na obiektach rzeczywistych.
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Diagnostics of cvd process by means of optical emission spectroscopy.
PublicationZastosowano optyczną spektroskopię emisyjną do badania w trybie in-situ dysocjacji cząsteczek oraz wzbudzenia i jonizacji atomów wodoru podczas procesu syntezy cienkich warstw diamentowych metodą chemicznego osadzania z par gazowych wspomaganego plazmą mikrofalową (mPACVD). Zbudowano tor światłodowy, umożliwiający sprzężenie komory CVD z systemem spektroskopowym i wykonywanie pomiarów bezinwazyjnych. Wykonano pomiary spektralne...
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Formulation of the inverse problem in thermal tomography for burn diagnostics.
PublicationZdefiniowano zagadnienie odwrotne w analizie przepływów ciepła w strukturach biologicznych, którego rozwiązanie jest niezbędne w tomografii termicznej. Celem jest rekonstrukcja rozkładu właściwości cieplnych w strukturze geometrycznej badanych obiektów. Wektor decyzyjny może być zdefiniowany na podstawie wiedzy o badanym obiekcie. Można wybrać liczbę nieznanych parametrów modelu termicznego tego obiektu. Dla małej liczby niezbędna...
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Experimental studies of circuit breaker drives and mechanisms diagnostics
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Observation value analysis - integral part of Bayesian diagnostics
PublicationDetailed subject of the research is to analyse the value of the observation, which is a part of preposterior analysis. For the presented network, the main objective was to determine, conducting of which of three tests is the most valuable from the perspective of determining possible need or possibility to omission expensive technical expertise. The main advantage of preposterior analysis is answering the question which of the considered...
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Observation Value Analysis – Integral Part of Bayesian Diagnostics
PublicationThe decision making process, in general, is understood as a process of selecting one of the available solutions to the problem. One of possible approaches supporting the process is Bayesian statistical decision theory providing a mathematical model to make decisions of a technical nature in conditions of uncertainty. Regarding above, a detailed subject of the research is to analyze the value of the observation, which is a part...
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Active Dynamic Thermography - Problems of implementation in medical diagnostics
PublicationW pracy przedstawiono wybrane problemy implementacji aktywnej termografii termicznej w aplikacjach medycznych. Podano przykłady związane z diagnostyką raka piersi i głębokości oparzeń.
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Advances and Challenges in Diagnostics of Toxoplasmosis in HIV-Infected Patients
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Graphene-based electrochemical biosensing system for medical diagnostics
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Self diagnostics using smart glasses - preliminary study
Publicationn this preliminary study we analyzed the possibility of the reliable measurement of biomedical signals with some potential hardware extensions of smart glasses. Using specially designed experimental prototypes four category of biomedical signals were measured: electrocardiograms, electromyograms, electroencephalograms and respiration waveforms. Experi- ments with volunteers proved that using even simple construc- tion of sensors...
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The content of conjugated linoleic acid and vaccenic acid in the breast milk of women from Gdansk and the surrounding district, as well as in, infant formulas and follow-up formulas. Nutritional recommendation for nursing women
PublicationFatty acids are some of the most important components of human milk. Polyunsaturated fatty acids (PUFAs) are essential nutrients required for the optimal growth and development of infants, especially the central nervous system, brain and retina. AIM: To determine the conjugated linolenic acid (CLA) and vaccenic acid (VA) content of human breast milk from mothers consuming different diets, and to compare the results with CLA and...
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The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population
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Metabolomics in urogenital cancer
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Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer
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Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges
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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
PublicationCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative...
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublicationNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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Fault detection and diagnostics of complex dynamic systems using Gaussian Process Models - nuclear power plant case study
PublicationThe article examines the use of Gaussian Process Models to simulate the dynamic processes of a Pressurized Water nuclear Reactor for fault detection and diagnostics. The paper illustrates the potential of Gaussian Process Models as a tool for monitoring and predicting various fault conditions in Pressurized Water nuclear Reactor power plants, including reactor coolant flow and temperature variations, deviations from nominal working...
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Melanoma skin cancer detection using mask-RCNN with modified GRU model
PublicationIntroduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic...
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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma
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Digital Imaging and Communication in Medicine Standard for Breast Thermal Imaging
PublicationOmówiono znaczenie normy DICOM w obrazowaniu medycznym. Zaproponowano metodę opisu danych w diagnostyce terminczej piersi dla potrzeb normy DICOM. Zaprojektowano i wykonano algorytmy automatycznej konwersji danych oraz tworzenia struktur danych w hierarchiczno-obiektowym modelu danych.
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Prognostic relevance of demographics and surgical practice for patients with gastric cancer in two centers: in Poland versus Germany
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublicationC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases
PublicationAnthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions,...
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Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
PublicationTargeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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In-situ optical diagnostics of boron-doped diamond films growth
PublicationInterferometry is a desirable method for in-situ measurement of thin, dielectric film growth, as it don't modify conditions of film deposition. Here we present interferometrical measurements of thickness of doped diamond films during Chemical Vapor Deposition (CVD) process. For this purpose we used a semiconductor laser with a 405nm wavelength. Additional ex-situ measurement using spectral interferometry and ellipsometry...
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Vibration Diagnostics of Rolling Mills Based on Nonlinear Effects in Dynamics
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Methods of Springs Failures Diagnostics in Ore Processing Vibrating Screens
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Review of Research and Development on the Technical Diagnostics in the Field of Electric Traction
PublicationPrzedstawiono funkcje i oprzyrządowanie stanowiska diagnostycznego do badania lokomotyw elektrycznych serii EU07. Zaproponowano nową metodę kontroli charakterystyki statycznej odbieraka prądu. Przedstawiono kompleksowy system diagnostyki sieci jezdnej DST.
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Optical excitation methods in active dynamic thermography in medical diagnostics.
PublicationArtykuł zawiera opis metod pobudzania cieplnego badanych obszarów ciała ludzkiego w technice aktywnej termografii dynamicznej. Jako źródła pobudzenia cieplnego mogą być stosowane lampy podczerwieni, lampy halogenowe dużej mocy, a także lasery. W artykule opisano również algorytmy obliczeń obrazów parametrycznych.
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Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring
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Advances of thermal tomography in non-destructive testing and medical diagnostics
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Structural analysis of a wheeled tractor oriented towards damage diagnostics
PublicationThis study analyses the structure of a wheeled tractor whith the aim of evaluating the available options for diagnosing four types of defects affecting the vehicle's functions, exhaust gas emissions, engine performance and safety.
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Integrated Application of GPR and Ultrasonic Testing in the Diagnostics of a Historical Floor
PublicationThe paper presents the results of integrated ground penetrating radar (GPR) and ultrasonic testing (UT) measurements conducted on a historical floor in St. Nicholas’ Church, Gdańsk, Poland. The described inspection was the first stage of the technical state assessment of the building. The aim of the study was the detection of underfloor air gaps, which were observed in a few trial pits. The condition of the ground under the floor...
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Microbiota-derived metabolites in colorectal cancer patients in preoperative period
PublicationShort-chain fat-ty acids (SCFAs) are microbial derived metabo-lites, which have multiple beneficial properties. The amount of SCFAs depends on several fac-tors, such as age, diet (mainly intake of dietary fiber), and overall health condition. The normal proportion between SCFAs is 3:1:1 for acetate, proprionate and butyrate, respectively. In col-orectal cancer (CRC) patients, microbiota alter-ations have been shown. Consequently,...
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Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...