Search
Filters
total: 3144
displaying 1000 best results Help
Search results for: ANTI-CANDIDA ACTIVITY
-
Contribution of Tonic Chemoreflex Activation to Sympathetic Activity and Blood Pressure in Patients With Obstructive Sleep Apnea
Publication -
A twin study of heritability of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity
Publication -
An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans
Publication -
Impact of Subsurface Application of Compound Mineral Fertilizer on Soil Enzymatic Activity under Reduced Tillage
Publication -
Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism
Publication -
Quantitative structure–activity relationships in enzymatic single-electron reduction of nitroaromatic explosives: implications for their cytotoxicity
Publication -
Antiplasmodial Activity of Nitroaromatic and Quinoidal Compounds: Redox Potential vs Inhibition of Erythrocyte Glutathione Reductase
Publication -
Iron and other metal species as phase-composition controllers influencing the photocatalytic activity of TiO2 materials
Publication -
Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives
Publication -
Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima
Publication -
Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
Publication -
No apparent effect of invasive alien goldenrod on soil microbial communities or soil fauna feeding activity
Publication -
Surface Properties and Photocatalytic Activity of KTaO3, CdS, MoS2 Semiconductors and Their Binary and Ternary Semiconductor Composites
Publication -
Potential Role of Bioactive Compounds: In Vitro Evaluation of the Antioxidant and Antimicrobial Activity of Fermented Milk Thistle
Publication -
Sustainable Activity of Cultural Service Consumers in Social Media - Influence on the Brand Capital of Cultural Institutions
Publication -
Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers
Publication -
Cement Clinker Modified by Photocatalyst—Selected Mechanical Properties and Photocatalytic Activity during NO and BTEX Decomposition
Publication -
New Method for Photoactive Cement Preparation—Selected Mechanical Properties and Photocatalytic Activity of New Materials
Publication -
Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients: Extraction Optimization, Chemical Characterization, and Biological Activity
Publication -
Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
Publication -
Effect of Tytanit® on the Physiological Activity of Wild Strawberry (Fragaria vesca L.) Grown in Salinity Conditions
Publication -
Application of QSAR Analysis and Different Quantum Chemical Calculation Methods in Activity Evaluation of Selected Fluoroquinolones
Publication -
Antitumor Activity of Novel Benzensulfonamide Derivatives in View of their Physiochemical Properties Searched by Principal Component Analysis
Publication -
Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ
PublicationThe last decade has witnessed a renewed interest in antimicrobial agents. Plants have received particular attention and frequently rely on the spontaneous enzymatic conversion of an inactive precursor to an active agent. Such two-component substrate/enzyme defence systems can be reconstituted ex vivo. Here, the alliin/alliinase system from garlic seems to be rather effective against Saccharomyces cerevisiae, whilst the glucosinolate/myrosinase...
-
Betaine and L-carnitine ester bromides: Synthesis and comparative study of their thermal behaviour and surface activity
PublicationSix esters of both betaine and L-carnitine bromides, featuring alkyl groups ranging from C8 to C18 in length, have been synthesized. The thermal behaviour of these twelve bio-based salts has been analyzed and compared by thermal gravimetric analysis and differential scanning calorimetry. The L-carnitine alkyl ester bromides melted below 100 C and can hence be considered ionic liquids (ILs) with full rights. Conversely, the betaine...
-
Gold(III) complexes with chloride and cyanopyridines: Facilitated hydrolysis of nitrile ligand to amide and antibacterial activity
PublicationA range of novel simple gold(III) compounds has been synthesized in their monocrystalline form, including two previously unknown chloro-complexes of Au3+ with 2-cyanopyridine or 3-cyanopyridine, respectively. Our investigations have revealed the intricate nature of the reaction between 2-cyanopyridine and tetrachloroauric acid, yielding at least three distinct products. The main product, obtained in high yield, is a salt featuring...
-
TiO2 nanotubes modification by photodeposition with noble metals: Characterization, optimization, photocatalytic activity, and by-products analysis
PublicationSelf-organized TiO2 nanotubes (TNTs) with 4 µm length were obtained by anodization method and calcined to obtain anatase crystallite phase. The photocatalysts were further decorated with Au, Ag, Pt or Pd nanoparticles (NPs), varying the metal loads (0.50, 0.75, 1, 2 and 5 mol%) by photodeposition. The material characterization confirmed the presence of nanoparticles in the TNTs surface, signs of the localized surface plasmon resonance...
-
Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii
PublicationIn this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. The bioinformatic analysis allowed us to determine the spatial architecture of MLE-15, whose components were bactericidal peptide cecropin A connected via a flexible linker to the cell wall binding domain (CBD) of mesophilic 201ϕ2 − 1 endolysin and catalytic domain...
-
Antimutagenic activity of white cabbage, raw and processed, juices towards food mutagens MeIQx and PhIP.
PublicationPrezentowane badania pokazały, że soki z kapusty wykazują bardzo silne właściwości przeciwutleniające. Najaktywniejszy był sok ze świeżej kapusty, który eliminował działanie użytych mutagenów w ponad 80%. Obróbka kulinarna nieco obniżała przeciwmutagenne właściwości pozostałych soków, ale i tak wykazywały one silne działanie ochronne.
-
Non-enzymatic glutathione-mediated conjugation of unsymmetrical bisacridine C-2028 with anticancer activity
Open Research DataThe presented data complement the studies on the interplay between C-2028 (anticancer-active unsymmetrical bisacridine) and the glutathione S-transferase/glutathione (GST/GSH) system.
-
Quasistatic and fatigue behavior of an AISI H13 steel obtained by additive manufacturing and conventional method
PublicationThis work aims to compare the mechanical behavior of an AISI H13 steel obtained by additive manufacturing with that obtained by conventional manufacturing methods. The average values of the ultimate tensile strength (UTS) and ductility obtained for the specimens produced by the conventional method were equal to 658 MPa and 18%, respectively, which compares with 503 MPa and 0.75% registered for the selective laser melting (SLM)...
-
Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublicationThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
-
C-1311 (Symadex), a potential anti-cancer drug, intercalates into DNA between A and G moieties. NMR-derived and MD-refined stereostructure of the d(GAGGCCTC) 2 :C-1311 complex
PublicationImidazoacridinone C-1311 (Symadex®) is an antitumor agent which has been recommended for Phase II clinical trials a few years ago. Previously, it was shown experimentally that during the initial stage of its action C-1311 forms stable intercalation complexes with DNA duplexes. Herein, a NMR-derived stereostructure of d(GAGGCCTC)2:C-1311 complex was reported. The ligand was found locating itself between A and G moieties, forming...
-
The first study on the usefulness of recombinant tetravalent chimeric proteins containing fragments of SAG2, GRA1, ROP1 and AMA1 antigens in the detection of specific anti-Toxoplasma gondii antibodies in mouse and human sera
PublicationThis study presents an evaluation of four tetravalent recombinant chimeric proteins containing fragments of the Toxoplasma gondii antigens, SAG2, GRA1, ROP1 and AMA1, as potential replacements of a the soluble, whole-cell tachyzoite lysate (TLA) used in serological assays. Recombinant chimeric proteins (SAG2-GRA1-ROP1-AMA1N, AMA1N-SAG2-GRA1-ROP1, AMA1C-SAG2-GRA1-ROP1, and AMA1-SAG2-GRA1-ROP1) obtained by genetic engineering were...
-
Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies
PublicationA series of novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(6-substituted-4-chloro-1,3,5-triazin-2-ylamino)guanidine derivatives 9–20 have been synthesized by substitution of chlorine atom at the 1,3,5-triazine ring in compounds 5–8 with 3- or 4-aminobenzenesulfonamide and 4-(aminomethyl)benzenesulfonamide hydrochloride. All the synthesized compounds were evaluated for their inhibitory activity toward hCA I, II,...
-
The antitumor derivatives, C1305 and C1748, were different in effects on CYP3A4 expression and catalytic activity in HepG2 cells
PublicationCytochromy P450 (CYP) należą do grupy enzymów biorących udział w 70-80% metabolizmu fazy I większości stosowanych klinicznie leków. Z tego powodu oddziaływanie leków z enzymami cytochromu P450 stało się istotnym elementem w projektowaniu chemoterapeutyków, szczególnie tych, które są stosowane w terapii wielolekowej. Znajomość substratów, induktorów i inhibitorów poszczególnych izoenzymów P450, nie tylko może obniżać częstość występowania...
-
The impact of 3,3',5,5'-tetrabromobisphenol-A (TBBPA) solution pretreatment by ozonolysis and photocatalysis on the activated sludge respirometric activity
Publication -
Reduced graphene oxide nanocomposites with different diameters and crystallinity of TiO2 nanoparticles – synthesis, characterization and photocatalytic activity
Publication -
Effect of Water Activity and Titania P25 Photocatalyst on Inactivation of Pathogenic Fungi - Contribution to the Protection of Public Health
Publication -
The Impact of Intraspecies Variability on Growth Rate and Cellular Metabolic Activity of Bacteria Exposed to Rotating Magnetic Field
Publication -
The Evaluation of Phenolic Acids and Flavonoids Content and Antiprotozoal Activity of Eryngium Species Biomass Produced by Biotechnological Methods
Publication -
How do institutions from Pomerania Province support professional activity of people aged 50 and over?
PublicationThe article presents the solutions that were implemented in last years in the pomorskie province with regard to the economic activation of individuals aged 50+. The author presents the priorities in this area included in regional policy and specific initiatives of different types of institutions operating in the region.
-
Insecticidal activity of Bacillus thuringiensis towards Agrotis exclamationis larvae–A widespread and underestimated pest of the Palearctic zone
Publication -
Chocolate desserts with ricotta hydrolysates: In vitro study of inhibitory activity against angiotensin‐converting enzyme and cholinesterase
Publication -
Factors Determining Staphylococcus aureus Susceptibility to Photoantimicrobial Chemotherapy: RsbU Activity, Staphyloxanthin Level, and Membrane Fluidity
Publication -
Nanocomposites of Graphene Oxide—Silver Nanoparticles for Enhanced Antibacterial Activity: Mechanism of Action and Medical Textiles Coating
Publication -
Biological Activity and Antibiofilm Molecular Profile of Citrus aurantium Essential Oil and Its Application in a Food Model
Publication -
Antimicrobial and anticancer photodynamic activity of a phthalocyanine photosensitizer with N -methyl morpholiniumethoxy substituents in non-peripheral positions
Publication -
Dendrimeric Sulfanyl Porphyrazines: Synthesis, Physico-Chemical Characterization, and Biological Activity for Potential Applications in Photodynamic Therapy
Publication -
Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands
Publication