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Search results for: actin
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Numerical Simulation of Temperature Field in Steel under Action of Electron Beam Heating Source
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State action aimed at limiting financial exclusion in Poland in terms of sustainable and inclusive development
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The Action Mechanisms, Anti-Cancer and Antibiotic-Modulation Potential of Vaccinium myrtillus L. Extract
PublicationHerbal medicinal products containing Vaccinium myrtillus L. (bilberry) fruits and fruit extracts are widely available in the market. Although bilberry leaves and stems are considered as bio-waste, they contain much higher levels of phenolic compounds than fruits. The study aimed to investigate the antimicrobial and anticancer potential of aerial part extracts from Vaccinium myrtillus L. (V. myrtillus, VM) plants harvested at high...
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Overcoming Challenges of Virtual Scrum Teams: Lessons Learned Through an Action Research Study
PublicationAfter the COVID-19 breakout, agile teams found themselves in situations that “pure agilists” and textbooks on agile methods had preferred to ignore. Whereas agile mindsets helped them to quickly shift to remote work, mere virtualization of agile practices often proved insufficient, and several challenges emerged. This paper reports on an Action Research project carried out in Lufthansa Systems Poland with the aim of (1) revisiting...
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Thermal self-action effects for acoustic beams containing fronts in a Maxwell relaxing fluid
PublicationThis paper examines the thermal self-action of acoustic beams in a Maxwell relaxing fluid. This type of thermal self-action differs from that in a Newtonian fluid and behaves differently depending on a ratio of sound period and time of thermodynamic relaxation. The self-action which relates to sound beams containing shock fronts is also discussed. In addition, stationary and non-stationary types of self-action are considered.
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THE POSSIBILITIES OF ESTIMATING THE RELIABILITY OF SHIP PIPELINES’ ELEMENTS INCLUDING DESTRUCTIVE PHENOMENA ACTING ON THEM
PublicationIn the article an approach to the problem of estimating reliability data based on physical models is proposed. The possibility of reliability assessment for selected elements of ship pipelines, based on the recognition of the destructive physical phenomena taking place in them, is discussed. To do this, an overview of these phenomena has been made. In addition, a preliminary review of existing measures of destruction of materials...
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Wpływ smarowności na działania układu tribologicznego (impact of lubricity on the tribological system action)
Publicationthe paper presents analysis and evaluation, based on tests results, of the impact of lubricity of the used lubricating oils (shell argina t 40) on the action of boundary layer of sulzer 6zl40/48 engines aboard the ''włocławek'' sea-going ship. for comparison purposes, the same oils were tested with the ceramizer four-stroke engine (all types of the vidar four-stroke engines) regeneration agent added. so understood boundary layer...
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A Ship Domain-Based Method of Determining Action Distances for Evasive Manoeuvres in Stand-On Situations
PublicationA ship encounter can be considered safe if neither of ships’ domains (defined areas around ships) is intruded by other ships. Published research on this includes optimising collision avoidancemanoeuvres fulfilling domain-based safety conditions.However, until recently there was no method, using ship’s domain to determine exact moment when a particular collision avoidance manoeuvre can still be successfully performed. The authors...
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Thermal Self-Action Effects of Acoustic Beam in a Gas with Reversible or Irreversible Chemical Reaction
PublicationThermal self-action of acoustic beam in a gas where an exothermic chemical reaction takes place, is studied. This kind of thermal self-action differs from that in a newtonian fluid. In dependence on the type of a chemical reaction, reversible or not, heating or cooling of a medium occurs. A beam in the case of the irreversible reaction may be unusually self-focusing. The self-action effects relating to wave beams containing shock...
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Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
PublicationInositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...
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Characteristics of microstructural phenomena occurring on the surface of protective gloves by the action of mechanical and chemical factors
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Synergistic action of extracts from carnivorous plants and synthetic peptides against plant pathoghenic bacteria
Publicationw pracy przedstawiono rezultaty badań nad sprawdzeniem aktywności przeciwbakteryjnej ekstraktów z roślin Drosera capensis i Dionaea muscipula w połączeniu z dwoma syntetycznymi peptydami: CAMEL oraz pexiganan. Najwyższą aktywnością przeciwbakteryjną odznaczał się chloroformowy ekstrakt z D. muscipula z peptydem CAMEL.
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Polymer-free cubosomes for simultaneous bioimaging and photodynamic action of photosensitizers in melanoma skin cancer cells
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NON-STATIONARY THERMAL SELF-ACTION OF ACOUSTIC BEAMS CONTAINING SHOCK FRONTS IN THERMOCONDUCTING FLUID
PublicationNon-stationary thermal self-action of a periodic or impulse acoustic beam containing shock fronts in a thermoconducting Newtonian fluid is studied. Self-focusing of a saw-tooth periodic and impulse sound is considered, as well as that of a solitary shock wave which propagates with the linear sound speed. The governing equations of the beam radius are derived. Numerical simulations reveal that the thermal conductivity weakens the...
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Selected symmetrically substituted carbazoles: Investigation of anticancer activity and mechanisms of action at the cellular and molecular levels
PublicationDNA topoisomerases play a critical role as essential enzymes in controlling alterations in the topology of DNA. They achieve this by orchestrating the coordinated process of breaking and rejoining DNA strands, which is crucial for maintaining the proper structure of DNA during regular cellular development. The search for and development of new potential anticancer drugs is a challenging yet immensely important area of research...
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Analysis of muscles behaviour. Part II. The computational model of muscles group acting on the elbow joint
PublicationThe purpose of this paper is to present the computational model of muscles' group describing the movements of flexion/extension at the elbow joint in the sagittal plane of the body when the forearm is being kept in the fixed state of supination/pronation. The method ofevaluating the muscle forces is discussed in detail. This method is the basis for the quantitative and qualitative verification of the proposed computational model...
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Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies
PublicationMangiferin is a strong antioxidant that presents a wide range of biological activities. The aim of this study was to evaluate, for the first time, the influence of mangiferin on tyrosinase, an enzyme responsible for melanin synthesis and the unwanted browning process of food. The research included both the kinetics and molecular interactions between tyrosinase and mangiferin. The research proved that mangiferin inhibits tyrosinase...
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The Palais–Smale condition for the Hamiltonian action on a mixed regularity space of loops in cotangent bundles and applications
PublicationWe show that the Hamiltonian action satisfies the Palais-Smale condition over a “mixed regular- ity” space of loops in cotangent bundles, namely the space of loops with regularity H^s, s ∈ (1/2, 1), in the baseand H^{1−s} in the fiber direction. As an application, we give a simplified proof of a theorem of Hofer-Viterbo on the existence of closed characteristic leaves for certain contact type hypersufaces in cotangent bundles.
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Self-Organising map neural network in the analysis of electromyography data of muscles acting at temporomandibular joint.
PublicationThe temporomandibular joint (TMJ) is the joint that via muscle action and jaw motion allows for necessary physiological performances such as mastication. Whereas mandible translates and rotates [1]. Estimation of activity of muscles acting at the TMJ provides a knowledge of activation pattern solely of a specific patient that an electromyography (EMG) examination was carried out [2]. In this work, a Self-Organising Maps (SOMs)...
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Ribes nigrum L. Extract-Mediated Green Synthesis and Antibacterial Action Mechanisms of Silver Nanoparticles
PublicationSilver nanoparticles (Ag NPs) represent one of the most widely employed metal-based engineered nanomaterials with a broad range of applications in different areas of science. Plant extracts (PEs) serve as green reducing and coating agents and can be exploited for the generation of Ag NPs. In this study, the phytochemical composition of ethanolic extract of black currant (Ribes nigrum) leaves was determined. The main components...
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The exposure to UV filters: Prevalence, effects, possible molecular mechanisms of action and interactions within mixtures
PublicationSubstances that can absorb sunlight and harmful UV radiation such as organic UV filters are widely used in cosmetics and other personal care products. Since humans use a wide variety of chemicals for multiple purposes it is common for UV filters to co-occur with other substances either in human originating specimens or in the environment. There is increasing interest in understanding such co-occurrence in form of potential synergy, antagonist,...
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Nanocomposites of Graphene Oxide—Silver Nanoparticles for Enhanced Antibacterial Activity: Mechanism of Action and Medical Textiles Coating
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The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria
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Isoform-specific inhibition of DNA topoisomerase II as the mechanism of action of novel anticancer agent C-1305
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Tribological and thermal behavior with wear identification in contact interaction of the Ti6Al4V-sintered carbide with AlTiN coatings pair
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Folic acid-conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action
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Pedestrian protection, speed enforcement and road network structure the key action for implementing Poland's Vision Zero
PublicationSince 1991 Poland's road safety has been systematically improving with a 60% reduction in road deaths. Despite the progress Poland continues to be one of the European Union' worst performing countries. The country's main road safety problems remain unchanged: dangerous behaviour of road users, underdeveloped system of road safety management and low quality of road infrastructure. This is why subsequent road safety programmes (implemented...
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Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase
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UN DECADE OF ACTION FOR ROAD SAFETY IN THE NATIONAL ROAD SAFETY STRATEGY UNTIL 2020 – POLISH APPROACH
PublicationPoland continues to have the highest number of road deaths per one million population in the European Union, according to a 2012 European Commission report – in 2011 the rate in Poland was 109 fatalities compared to the EU average of 61 killed. Adopted by the government in 2005 Poland’s National Road Safety Programme GAMBIT 2005 was the response to the EU’s 3rd Road Safety Action Programme. Despite extensive road safety efforts,...
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Smart and resilient cities- new challanges for Polish cities in terms of 2020 energy efficiency and climate action
PublicationGlobal climate change action along with energy efficiency optimizations are becoming increasingly pressing principles in terms of moving towards sustainable development. As a member of EU and UN Poland is also obliged to follow restricted rules concerning energy efficiency of buildings which come to force in 2020. To meet new goals, innovative approaches - like moving towards smart and resilient cities -may be required. Through...
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Looking Up to the Stars. A Call for Action to Save New Zealand’s Dark Skies for Future Generations to Come
PublicationThe rapid development of technology coupled with humanity’s desire to reach beyond terra firma, has resulted in more than 60 years of Outer Space activities. Although the exploration of space has provided many advantages and benefits to society so far, including vast, new information that has greatly added to our understanding of our planet and beyond, unfortunately, mankind’s footprint has negative aspects that need to be minimised...
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Scaled agile framework. Dealing with software process‐related challenges of a financial group with the action research approach
PublicationThis article reports on a domain-specific software development venture at Nordea. We explore organizational constraints, challenges, and corrective actions undertaken when scaling the agile development approach of their Core Banking Platform program. The fit and required customizations of the rather complex and rigid SAFe framework in a policy-heavy financial institution are audited against the organic growth of the program. In...
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Action Research - przygotowanie sądu do zmiany poprzez uczenie się - współpraca praktyków i badaczy
PublicationW praktyce zarządzanie sądem na ogół jest oddalone od teorii zarządzania. Prezesi sądów rzadko zwracają się do naukowców z prośbą o rozwiązanie ich problemów w zarządzaniu. W sądach brakuje nie tylko stałych form współpracy z naukowcami zajmującymi się zarządzaniem, ale także z innymi interesariuszami. Jedyną formą komunikacji, i to z ograniczoną liczbą interesariuszy, są formalne środki wyznaczone przez procedurę cywilną lub karną....
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N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins
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Chemical composition and antifungal activity of Chelidonium majus extracts – antagonistic action of chelerythrine and sanguinarine against Botrytis cinerea
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SPRAWOZDANIE Z MIĘDZYNARODOWEJ KONFERENCJI NAUKOWEJ „ORAL HISTORY IN ACTION”, KRAKÓW 28–30 MARCA 2019 R.
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The importance of anchoring ligands of binuclear sensitizers on electron transfer processes and photovoltaic action in dye-sensitized solar cells
PublicationThe relatively low photon-to-current conversion efficiency of dye-sensitized solar cells is their major drawback limiting widespread application. Light harvesting, followed by a series of electron transfer processes, is the critical step in photocurrent generation. An in-depth understanding and fine optimization of those processes are crucial to enhance cell performance. In this work, we synthesize two new bi-ruthenium sensitizers...
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Visible light-induced photocatalytic reaction of gold-modified titanium(IV) oxide particles: action spectrum analysis
PublicationAnalizy spektrum działania wykazały, ze wzbudzenie powierzchniowego plazmonu złota inicjuje utlenianie 2-propanolu w świetle widzialnym w napowietrzonej zawiesinie tlenku(IV) tytanu zmodyfikowanego zlotem. Badania przeprowadzone z użyciem światła polichromatycznego wykazały, ze szybkość reakcji foto-utleniania zależy od właściwości tlenku(IV) tytanu, takich jak rozmiar ziaren, pola powierzchni właściwej, formy krystalicznej (anataz...
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Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment
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Analytical approach for membrane action in laterally-restrained reinforced concrete square slabs under uniformly distributed loads
PublicationLaterally-restrained reinforced concrete slabs can mobilise compressive membrane action and subsequent tensile membrane action under extreme loading conditions, thereby enhancing the load resistance under uniformly distributed loads. Previous analytical study focuses primarily on tensile membrane action in simply-supported slabs. This paper describes an analytical approach for membrane action in laterally-restrained square slabs....
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Dataset Relating Collective Angst, Identifications, Essentialist Continuity and Collective Action for Progressive City Policy among Gdańsk Residents
PublicationThis dataset contains the individual responses of 456 residents of Gdańsk who participated in the study. The study was conducted before the second term of the presidential election in Poland in 2020. Demographic variables as well as psychological measures of angst, place attachment, identification in-group continuity and willingness to engage in collective action were collected. We also measured the perception of the risk of...
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Neutrocyte-to-lymphocyte ratio predicts the presence of a replicative hepatitis C virus strand after therapy with direct-acting antivirals
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The Unsteady Low-Frequency Forces Acting on the Rotor Blade in the First Stage on an Axial Compressor of SO-3 Jet Engine
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SMART AND RESILIENT CITIES – NEW CHALLENGES FOR POLISH CITIES IN TERMS OF 2020 BUILDING ENERGY EFFICIENCY AND CLIMATE CHANGE ACTION.
PublicationGlobal climate change action along with energy efficiency optimizations are becoming increasingly pressing principles in terms of moving towards sustainable development. As a member of EU and UN Poland is also obliged to follow restricted rules concerning energy efficiency of buildings which come to force in 2020. To meet new goals, innovative approaches - like moving towards smart and resilient cities -may be required. Through...
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Enhancement of Inhibition of the Pseudomonas sp. Biofilm Formation on Bacterial Cellulose-Based Wound Dressing by the Combined Action of Alginate Lyase and Gentamicin
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Softly switched robustly feasible mpc for constrained linear systems under set bounded uncertainty- LQ-MPC with IC action
PublicationNie jest możliwe efektywne sterowanie procesem w szerokim zakresie zmian warunków operacyjnych przy użyciu jednego uniwersalnego regulatora. W pracy zaproponowano koncepcję sposobu regulacji polegającego na przełączaniu wielu regulatorów uzależnionego od stanu operacyjnego systemu. Często twarde przełączanie regulatorów nie jest pożądane lub wręcz możliwe, alternatywą jest ich miękkie przełączanie. W pracy rozważany jest problem...
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Recent progress in research on the cutting processes of wood. A review COST Action E35 2004-2008: Wood machining - micromechanics and fracture
PublicationZaprezentowano postępy w badaniach przecinania drewna ze szczególnym uwzględnieniem nowych metod dedykowanych zwiększeniu wydajności materiałowej w tartacznictwie. Zademonstrowano przydatność współczesnej mechaniki pękania do szacowania mocy skrawania dla pił, których wartości rozwarcia są różne od pił użytych w badaniach skrawalnościowych. W tych ostatnich wyznaczano wiązkość materiału obrabianego oraz naprężenia tnące. Badania...
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Recent progress in research on the cutting processes of wood. A review COST Action E35 2004–2008: Wood machining – micromechanics and fracture
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Polar localization of new flavonoids from aerial parts of Scleranthus perennis and Hottonia palustris and their modulatory action on lipid membranes properties
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Recent progress in research on the cutting processes of wood. A review COST Action E35 2004-2008: Wood machining - micromechanics and fracture
PublicationZaprezentowano postępy w badaniach przecinania drewna ze szczególnym uwzględnieniem nowych metod dedykowanych zwiększeniu wydajności materiałowej w tartacznictwie. Zademonstrowano przydatność współczesnej mechaniki pękania do szacowania mocy skrawania dla pił, których wartości rozwarcia są różne od pił użytych w badaniach skrawalnościowych. W tych ostatnich wyznaczano wiązkość materiału obrabianego oraz naprężenia tnące. Badania...