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Search results for: 5-FLUOROURACIL
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Authors’ response (March 5, 2019) to the letter to the Editor concerning the paper “Impact of air pollution on depression and suicide”
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Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles
PublicationHalogenated uracil derivatives are of great interest in modern cancer therapy, either as chemotherapeutics or radiosensitisers depending on their halogen atom. This work applies UV-Vis spectroscopy to study the radiation damage of uracil, 5-bromouracil and 5- uorouracil dissolved in water in the presence of gold nanoparticles upon irradiation with an Nd:YAG ns-pulsed laser operating at 532nm at dierent uences. Gold nanoparticles...
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Bożena Kostek prof. dr hab. inż.
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Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus
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Analiza właściwości 5-segmentowego łożyska średnicy 80 i 140mm wirnika turbozespołu C-101T w Niżniekamsku
PublicationProjekt geometrii dwóch łożysk z klockami wahliwymi.
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Badania odporności warystorów z wykorzystaniem wymagań pomiarowych zawartych w normie PN EN 61000-4-5
PublicationBadania odporności w EN 61000-4-5 są jednymi z podstawowych badań wykonywanych w ramach testów EMC na portach wejścia wyjścia urządzeń elektronicznych. W referacie przedstawiono uproszczoną metodykę doboru warystorów stanowiących zazwyczaj jeden z elementów ochronnych stosowanych na badanych portach. Proponowana metoda doboru powinny być wykonywana przez projektanta/konstruktora na początku procesu projektowego danego urządzenia....
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5-Thiocyanato-2′-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerization
PublicationIn this work, we have synthesized 5-thiocyanato-2′-deoxyuridine (SCNdU) along with the C6-deuterated nucleobase 5-thiocyanatouracil (6-D-SCNU) and studied their reactions with radiation-produced electrons. ESR spectra in γ-irradiated nitrogen-saturated frozen homogeneous solutions (7.5 M LiCl in H2O or D2O) of these compounds show that electron-induced S–CN bond cleavage occurs to form a thiyl radical (dU-5-S˙ or 6-D-U-5-S˙) and...
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Porphyrazine with bulky 2-(1-adamantyl)-5-phenylpyrrol-1-yl periphery tuning its spectral and electrochemical properties
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Phthalocyanines functionalized with 2-methyl-5-nitro-1H-imidazolylethoxy and 1,4,7-trioxanonyl moieties and the effect of metronidazole substitution on photocytotoxicity
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A new Thermus sp. class-IIS enzyme subfamily: isolation of a ''twin'' endo nuclease TspDTI with a novel specificity 5´-ATGAA(N11/9)-3´, related to TspGWI, Taqll and Tth111II. 5´-ATGAA(N11/9)-3´, spokrewnionej z TspGWI, TaqII i Tth111II.
PublicationOdkryto i scharakteryzowano nową subrodzinę enzymów klasy IIS z Thermus sp.
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Orthodontic characteristics of maxillary arch deficiency in 5-year-old patientsundergoing unilateral cleft lip and palate repair with and withoutearly gingivoplasty
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Analiza SWOT i analiza 5 sił Portera dla rynku podstawowej opieki medycznej na obszarze miasta Gdańska
PublicationIn recent years we have seen the dynamic development of medical services sector inPoland. Private health centres focus on aggressive development strategy. The role of primaryhealth care facilities, which provide services financed from public funds, declined. The purpose of article is to describe medical services market in Gdańsk, especially in Gdańsk-South district. Itincludes demographics, the number and characteristics...
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A Zn-Dependent Metallopeptidase Is Responsible for Sensitivity to LsbB, a Class II Leaderless Bacteriocin of Lactococcus lactis subsp. lactis BGMN1-5
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P.1.a.027 Association between the polymorphism of 5-HTTLPR gene and affective temperament dimensions using the TEMPS-A scale in obesity
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Functionalization of the transition metal oxides FeO, CoO, and NiO with alkali metal atoms decreases their ionization potentials by 3–5 eV
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Zachowanie poprzez sieciowanie w przedsiębiorczości społecznej w odpowiedzi na trudne otoczenie instytucjonalne – przypadek 5 spółdzielni socjalnych
PublicationCelem niniejszego artykułu jest zobrazowanie procesów, jakimi są zachowania przedsiębiorców, zachodzących w przedsiębiorczości społecznej w odpowiedzi na trudne otoczenie instytucjonalne. Opisano zachowania przedsiębiorcze przedstawicieli pięciu spółdzielni socjalnych na podstawie pogłębionych wywiadów i obserwacji . Za pomocą metody ciągłego porównywania wyodrębniono 3 główne kategorie zachowań badanych przedsiębiorców, które...
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Mechanism of the Reaction of Amines with 5-[(Aryl- or Alkylamino)hydroxymethylene]-2,2-dimethyl-1,3-dioxane-4,6-diones in the Presence of Chlorotrimethylsilane (Me3SiCl);
PublicationAddition of chlorotrimethylsilane (Me3SiCl) to the mixture of a carbamoyl‐substituted Meldrum's acid, i.e., a 5‐[(arylamino)hydroxymethylene]‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione of type 1 and a secondary amine as nucleophile strongly accelerated the rate of their reaction. The reason for this phenomenon observed, during our previous research, remained, however, unclear. To elucidate the mechanism of this reaction, we assumed and...
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Alternative method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-one—a substrate for the preparation of phosphodiesterase (5) inhibitors
PublicationImidazo[5,1-f][1,2,4]triazin-4(3H)-ones, as isosteres of purine, are of interest for pharmaceutical research as potential substrates for the synthesis of cGMP-PDE5 inhibitors. We present a novel, alternative method for the synthesis of imidazotriazinones, that differs from the previously reported ones with respect to the method of construction of the triazinone ring in the molecule. The key step in our approach is condensation...
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La 15 Nb x Ge 9 : a superstructure of the Mn 5 Si 3 structure type with interstitial Nb atoms
PublicationThe crystal structure and elementary properties of La15NbxGe9 are reported. Single-crystal X-ray diffraction,from a crystallite with only 0.12 Nb/formula unit, reveals that this compound, although transition metal deficient, crystallizes in a hexagonal “15-1-9”-like structure type, space group P63mc (no. 186) with lattice parameters a = b = 15.5017(2) Å, c = 6.9173(2) Å. The physical properties were examined by specific heat and resistivity...
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UV-induced electron transfer between triethylamine and 5-bromo-2′-deoxyuridine. A puzzle concerning the photochemical debromination of labeled DNA
Publication5-Bromo-2'-deoxyuridine (BrdU) photosensitizes DNA to strand break formation. However, this type of photodamage is completely quenched by the presence of triethylamine (TEA) which originates from RP-HPLC purification commonly employed by oligonucleotide providers. While the presence of TEA in oligonucleotide samples does not interfere with PCR or other molecular biology applications, the mechanism of photochemical reaction proceeding...
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Surgical Site Infection after Breast Surgery: A Retrospective Analysis of 5-Year Postoperative Data from a Single Center in Poland
PublicationBackground and Objectives: Surgical site infection (SSI) is a significant complication of non-reconstructive and reconstructive breast surgery. This study aimed to assess SSI after breast surgery over five years in a single center in Poland. The microorganisms responsible for SSI and their antibiotic susceptibilities were determined. Materials and Methods: Data from 2129 patients acquired over five years postoperatively by the...
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Opinia techniczna dotycząca stateczności i sposobu zabezpieczenia skarpy przy budynku mieszkalnym ul. Majkowskiego 5 w Gdyni.
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Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5‑HT2C receptor agonists
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Cross-sections for electron-scattering from 2-methyl-1-buten-3-yne, C 5 H 6 , molecules
PublicationtCross-sections for electron collisions with the 2-methyl-1-buten-3-yne [H2C C(CH3)C CH] moleculewere measured and calculated. Absolute grand-total electron-scattering cross-section (TCS) was takenat impact energies from 0.6 to 300 eV in the linear electron-transmission experiment. The TCS energydependence for the electron–C5H6collision has two prominent enhancements separated with a deepminimum located near 1.8 eV. In addition,...
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Peryferia elektryki. Biul. Oddz. Białost. SEP**2002 nr 14 s. 29-33, 5 rys.bibliogr. 3 poz.
PublicationPrzedstawiono sposób odwzorowania fragmentu krwioobiegu za pomocą obwoduelektrycznego. Podano zmiany przepływu krwi w przypadku marskości wątroby.
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The Quaternization Reaction of 5-O-Sulfonates of Methyl 2,3-o-Isopropylidene-β-D-Ribofuranoside with Selected Heterocyclic and Aliphatic Amines
PublicationThe synthesis of N-((methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside)-5-yl) ammonium salts are presented. To determine the effect of the nucleophile type and outgoing group on the quaternization reaction, selected aliphatic and heterocyclic aromatic amines reacted with: methyl 2,3-O-isopropylidene-5-O-tosyl-β-D-ribofuranoside or methyl 2,3-O-isopropylidene-5-O-mesyl-β-D -ribofuranoside or methyl 2,3-O-isopropylidene-5-O-triflyl-β-D-ribofuranoside...
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Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5‑HT2C receptor agonists
PublicationA series of indole based novel Schiff bases was designed as potential agonists of 5‑HT2C receptor that was supported by docking studies in silico. These compounds were synthesized via Amberlyst-15 catalysed condensation of an appropriate pyrazole based primary amine with the corresponding indole-3-aldehyde under ultrasound irradiation at ambient temperature. A number of target Schiff bases were obtained...
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Recreation of Construction Patterns by 4-, 5- and 6-year-old Children 70 Years Ago and Today. Comparison of Test Results
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Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail
PublicationG-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...
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Thermally induced formation of zinc oxide nanostructures with tailoring morphology during metal organic framework (MOF-5) carbonization process
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Rozdział 5. Nowoczesne metody diagnostyki zakażeń grzybiczych wywoływanych przez dermatofity = Novel diagnostic methods of funfal infections caused by dermatophytes
PublicationDermatofity są głównym czynnikiem etiologicznym grzybic powierzchownych. Do tej klasy grzybów należą przedstawiciele trzech rodzajów: Epidermophyton, Microsporum i Trichophyton. Klasyczne metody diagnostyczne polegają na bezpośredniej ocenie mikroskopowej oraz badaniu hodowlanym. Identyfikacja gatunkowa jest możliwa na podstawie cech makroskopowych kolonii: ich struktury, koloru, kształtu, oraz obserwacji mikroskopowych (kształt...
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5- epi -Incensole: synthesis, X-ray crystal structure and absolute configuration by means of ECD and VCD studies in solution and solid state
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High-symmetry compact structures are preferred equilibrium configurations of Li n F n+1 − ( n = 2–5) superhalogen anions
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Enormously large (approaching 14 eV!) electron binding energies of [HnFn+1]- (n= 1–5, 7, 9, 12) anions
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Methyl 3-[(1,1-dioxo-1λ<sup>6</sup>,2-benzothiazol- 3-yl)amino]-5-nitrothiophene-2-carboxylate
PublicationTytułowy związek został otrzymany przez nitrowanie odpowiedniej pochodnej tiofenu. Wyznaczono i opisano jego strukturę rentgenowską w ciele stałym. Związek wykazuje pewne właściwości inhibicyjne w stosunku do enzymu ludzkiej elastazy leukocytowej (HLE).
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New imidazoline/alpha2-adrenoceptors affecting compounds - 4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. synthesis and receptor affinity studies
Publicationpołączenie struktury agmatyny i imidazoliny pozwoliło na otrzymanie nowej grupy ligandów receptorów imidazolinowych i alfa2-adrenergicznych, pochodnych 4(5)-(2-aminoetylo)imidazoliny. otrzymano oraz zbadano oddziaływanie nowych pochodnycch jak i analogów znanych ligandów - klonidyny, rilmenidyny, idazoksanu i antazoliny w stosunku do receptorów imidazolinowych oraz alfa2-adrenergicznych.
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4-[(tert-Butyldimethylsilyl)oxy]-6-methoxy-7-methyl-5-(oxiran-2-ylmethyl)-2-benzofuran-3(1H)-one
PublicationThe title compound, C19H28O5Si, was obtained in the reaction of 1,3-dihydro-4-[(tert-butyldimethylsilyl)oxy]-6-methoxy-7-methyl-3-oxo-5-(prop-2-enyl)isobenzofuran with meta-chloroperbenzoic acid. This reaction is one of the stages of the total synthesis of mycophenolic acid, which we attempted to modify. The title compound forms crystals with only weak intermolecular interactions. The strongest stacking interaction is found between...
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Practical Method for the Preparation of 2,2-Dimethyl-5- {aryl[(hetero)aryl]methyl}-1,3-dioxane-4,6-diones: Synthesis and Mechanistic Study
PublicationAn efficient practical synthetic procedure has been developed for the synthesis of 2,2-dimethyl-5-{aryl[(hetero)aryl]methyl}- 1,3-dioxane-4,6-diones through Friedel–Crafts alkylation. The scope and limitation of the reaction of 2,2-dimethyl-5-arylidene-1,3-dioxane- 4,6-diones with π-excess aromatic systems have been delineated.
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Acid–base properties of 3-[2-(pyridyl)benzoxazol-5-yl]alanine derivatives in the ground and excited state. Experimental and theoretical studies
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Conformation-activity relationships of cyclo-constrained μ/5 opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin
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Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin
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Crystallographic studies of (Z) and (E) isomers of 2-amino-5-(2-chlorobenzylidene)-1-methyl-1H-imidazol-4(5H)-one
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SKUTECZNOŚĆ DZIAŁANIA 5-FLUOROCYTOZYNY W STOSUNKU DO KLINICZNYCH IZOLATÓW CANDIDA ALBICANS I CANDIDA GLABRATA OPORNYCH NA FLUKONAZOL
PublicationCelem prowadzonych badań było sprawdzenie skuteczność działania 5-fluorocytozyny (5-FC) w stosunku do klinicznych izolatów C. albicans i C. glabrata wyizolowanych od pacjentów z trzech polskich szpitali. W przebadanej populacji wszystkie przebadane szczepy C. albicans były wrażliwe na działanie 5-FC, natomiast w przypadku gatunku C. glabrata wystąpiły 3 szczepy oporne i 4 średniooporne. Zjawisko nabywania lekooporności jest coraz...
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Poly(vinylidene fluoride) and Carbon Derivative Structures from Eco-Friendly MOF-5 for Supercapacitor Electrode Preparation with Improved Electrochemical Performance
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Orthodontic characteristics of maxillary arch deficiency in 5-year-old patients undergoing unilateral cleft lip and palate repair with and without early gingivoplasty
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Influence of Solvent Polarizability on the Keto-Enol Equilibrium in 4-[5-(naphthalen-1-ylmethyl)-1,3,4-thiadiazol-2-yl]benzene-1,3-diol
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Mosaic Structure of p1658/97, a 125-Kilobase Plasmid Harboring an Active Amplicon with the Extended-Spectrum β-Lactamase Gene bla SHV-5
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Raport z badań podczas próbnego obciążenia wiaduktu drogowego WA-5 w ciągu obwodnicy Kościerzyny w ciągu DK 20
PublicationW pracy przedstawiono metodykę pomiarów i wyniki badań statycznych i dynamicznych podczas próbnego obciążenia wiaduktu drogowego WA-5 w ciągu obwodnicy Kościerzyny w ciągu DK 20. Sformułowano wnioski dotyczące rzeczywistej pracy konstrukcji i warunków dalszej eksploatacji obiektu.
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A DFT/TD DFT study of the structure and spectroscopic properties of 5-methyl-2-(8-quinolinyl)benzoxazole and its complexes with Zn(II) ion
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Acid-base properties of 3-[2-(n-quinolinyl)benzoxazol-5-yl]alanine derivatives in the ground and excited state. Experimental and theoretical studies
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