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Search results for: ibuprofen and its metabolites
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XML-based monitoring and its implementation in Perl
PublicationArtykuł ten omawia w sposób ogólny problem monitorowania systemów informacyjnych oraz opisuje system monitoringu wytworzony w firmie Lufthansa Systems w celu monitorowania systemów informatycznych swoich klientów. Artykuł koncentruje się głównie na XMLowym mechaniźmie przetwarzania danych użytym w tym systemie, opisuje on jednak również skrótowo pozostałe zasady jego działania. Zostały również omówione podstawy przetwarzania danych...
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Sleep Paralysis - Cultural Significance and Its Management.
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Onychophagia: A Synopsis of Nail Biting and Its Management
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Sleep Paralysis - Cultural Significance and Its Management.
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Biological activity of tuftsin and its two analogues
PublicationPrzedstawiono badania, których celem była ocena wpływu analogów tuftsyny na żywotność mononuklearnych komórek krwi obwodowej (PBMC), limfocytów krwi obwodowej (PBL) i monocytów, ocena wpływu sekrecji czynnika martwicy nowotworu alfa (TNF) i interleukiny 6 (IL6) oraz zbadanie wpływu badanych związków na cytotoksyczność nuturalnych komórek zabójczych (NK).
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THE FUNCTION OF GREENERY IN A SKYSCRAPER: THE PLACEMENT AND ITS INFLUENCE
PublicationThe contrast between the high rise buildings; with their mostly geometric shapes, and the organic form of the greenery was visible even in the idea of a skyscraper. Yet the realizations and recent projects show emerging interest and the link between them. To better understand the developing function of the greenery in the context of a skyscraper, both literature and case studies are conducted. The aim is to relate the location...
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Kształtowanie programu projektów ITS - studium przypadku
PublicationInteligentne systemy transportowe ang. intelligent transportation systems (ITS) to nie jednorazowe wdrożenia, ale program projektów którym należy zarządzać. Istnieją metodologie dotyczące zarządzania wieloma projektami. Nie odpowiadają one w pełni potrzebom zarządzania programem projektów ITS. Rodzi się zatem pytanie, jak dokładać nowe projekty i działania o charakterze operacyjnym do programu inteligentnych systemów transportowych?...
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Religious social action and its organizational profiles
PublicationPurpose Social action implemented by the Church via its affiliated entities, foundations and associations may be viewed as a uniform activity. In reality, however, several organizational profiles exist that depend on the origin of these organizations (lay or religious), the scope of their activities (local or general) and their dependence on resources (whether from public administration or civil society). The paper aims to discuss...
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The culture of excellence and its dimensions in higher education
PublicationPurpose To recognize the existing state of knowledge on a culture of excellence (CoE) in higher education institutions (HEIs) and to define the CoE in HEI and the dimensions that make up that culture. A subsidiary goal is to propose a qualitative tool to measure CoE maturity. Design/methodology/approach The study was based on the qualitative method, the preferred reporting system of systematic reviews and meta-analysis (PRISMA)....
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On symmetric extendibility of quantum states and its applications
PublicationThis dissertation is focused on analysis of the symmetric extendibility of quantum states and its applications in the quantum information theory, with special attention paid to the area of quantum entanglement distillation, quantum channels theory, quantum security, and monogamy of quantum entanglement in time. We analyze geometry of the set of symmetric extendible states, i.e. such states that possess symmetric extensions and...
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ZEUS Concept and Its Wider European Application
PublicationThe objectives of the ZEUS project and the resulting concept of an integrated system of transport safety are recapitulated in the article. The context for transport safety management that has evolved since this became a concern of the European Union under the Treaty of Union in 1993 is outlined, and some issues related to applying the ZEUS concept across Europe are discussed. It is concluded that there is scope for exploring ways...
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General Cytotoxicity and Its Application in Nanomaterial Analysis
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International Journal for Housing Science and Its Applications
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Advances in the Theory of Nonlinear Analysis and its Applications
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The possibility to use multi-walled carbon nanotubes as a sorbent for dispersive solid phase extraction of selected pharmaceuticals and their metabolites: Effect of extraction condition
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Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes
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Human red blood cells targeted metabolome analysis of glycolysis cycle metabolites by capillary electrophoresis using an indirect photometric detection method
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Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
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Differences in the Concentration of Vitamin D Metabolites in Plasma Due to the Low-Carbohydrate-High-Fat Diet and the Eastern European Diet—A Pilot Study
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublicationPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Non-Targeted Metabolite Profiling Reveals Host Metabolomic Reprogramming during the Interaction of Black Pepper with Phytophthora capsici
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Redundantly Actuated 3RRR Parallel Planar Manipulator - Numerical Analyses of its Dynamics Sensitivity on Modifications of its Platform’s Inertia Parameters
PublicationIn the paper, numerical analyses, as well as dynamics of a complex mechanism, are presented. Two objectives are crucial for the paper: inverse dynamic model is needed (dedicated to be use in the model predictive controller); an identification method is searched (some trajectory parameters are controlled, when specific trajectory is tracked under an open-loop model-based control), as selected parameters must be identified for the...
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Levels of hemoglobin and lipid peroxidation metabolites in blood, catalase activity in erythrocytes and peak expiratory flow rate in subjects with passive exposure to tobacco smoke
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
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Phototransformation of Amlodipine: Degradation Kinetics and Identification of Its Photoproducts
PublicationNowadays, monitoring focuses on the primary compounds and does not include degradation products formed during various biological and chemical processes. Transformation products may have the same effects to human health and the environment or sometimes they can be more toxic than the parent compound. Unfortunately, knowledge about the formation of degradation products is still limited, however, can be very important for the environmental...
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Examination of influence of fixing circular saw on its stiffness
PublicationW artykule przedstawiono badania wpływu kształtu tarcz mocujących na sztywność ostrzy wybranych pił. Wyniki badań wykazały wykazały wpływ wielkości, kształtu i jakości powierzchni styku tarcz mocujących z korpusem piły na sztywność ostrzy piły.
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Functionalization of Parylene During Its Chemical Vapor Deposition
PublicationTwo possible mechanisms for the reaction of four halogenated (metha)acrylate-based molecules with Parylene [poly (paraxylylene)] during its chemical vapor deposition were proposed. The chemical reactivity of acrylate double bond with the paraxylylene biradical was calculated for all four (metha)acrylate-based molecules. These calculations allowed the evaluation of the energetically favorable mechanism and indeed a direct correlation...
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Densimetric and ultrasonic characterization of urea and its derivatives in water
PublicationW oparciu o pomiary gęstości dla serii roztworów jak i rozpuszczalnika wykonanych w temperaturach 15, 20, 25, 30 i 35oC wyznaczono pozorne molowe objętości mocznika, N-metylomocznika, N,N'-dimetylomocznika, N,N,N',N'-tetrametylomocznika, N-etylomocznika, N,N'-dietylomocznika jak i N-butylomocznika w wodzie. Dodatkowe pomiary szybkości dźwięku przeprowadzone w temperaturze 25oC pozwoliły obliczyć ściśliwości adiabatyczne, pozorne...
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Characteristics of orthopaedic implants damage and mechanisms of its initiation
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Matriptase-2: monitoring and inhibiting its proteolytic activity
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Entrepreneurial Failure: A Synthesis and Conceptual Framework of its Effects
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
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Geotechnical Properties of Phosphogypsum and Its Use in Road Engineering
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The photophysics of β-homo-tyrosine and its simple derivatives
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Internet of Robotic Things: Its Domain, Methodologies, and Applications
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Route vertical alignment design in the process of its regulation
PublicationRegulacja toru kolejowego ma za zadanie dostosowanie niewłaściwego lub też zdeformowanego położenia osi toru do położenia odpowiadającego parametrom technicznym wymaganym dla danej linii kolejowej. Projekt regulacji wykonywany jest na podstawie pomiaru geodezyjnego wysokości toków szynowych metodą punktów stałych, tzn. w oparciu o umieszczone na słupach wskaźniki regulacji osi toru, których wysokość jest znana. Wykonany w ten sposób...
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Amphotericin B and Its New Derivatives - Mode of Action
PublicationAmphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the clinic for several decades. Clinicalapplications of AmB, however, are limited by its nephrotoxicity and many other acute side effects which are not acceptable by patientswhen their life is not threaten. In order to improve the therapeutic index of this drug, lipid formulations have been introduced and manyefforts have been made to obtain less...
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Route vertical alignment design in the process of its regulation
PublicationW monografii przedstawiona została metoda opracowania projektu niwelety toru kolejowego na podstawie pomierzonych nierówności pionowych oraz praktyczny przykład jej zastosowania w procesie utrzymaniu dróg szynowych, a w szczególności w projektowaniu robót związanych z regulacją osi toru. Wykonany w ten sposób profil istniejącej linii kolejowej jest podstawą do obliczenia wartości podnoszeń toru. Wartości te nanosi się w terenie...
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Tick-borne encephalitis – lipid peroxidation and its consequences
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Tick-borne encephalitis - lipid peroxidation and its consequences
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Targeting of p53 and its homolog p73 by protoporphyrin IX
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Hydration of urea and its derivatives - Volumetric and compressibility studies
PublicationThe densities and sound velocities at T = (288.15, 293.15, 298.15, 303.15 and 308.15) K have been measured for aqueous solutions of urea, N,N-dimethylurea, N,N-diethylurea, N-propylurea, N-butylurea. From these data the apparent molar volumes, V the apparent molar isentropic compressions, KS,, and the Passynski solvation numbers of solutes have been determined. The concentration dependencies of the calculated quantities, their...
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Potential for ITS/ICT Solutions in Urban Freight Management
PublicationThe article presents a study on applying ITS solutions in planning and management of urban freight transport in Gdynia. The traffic management system Tristar which is under implementation and its related systems show a potential to assist in development of freight transport measures. Recommendations for urban freight policy development supplementing Gdynia's Sustainable Urban Mobility Plan were used as a basis for identification...
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Tyre rolling resistance and its influence on fuel consumption
PublicationRolling resistance of tyres is one of the major resistive forces acting on any wheeled vehicle. Unfortunately, it is also one of the forces very difficult to measure. It is estimated that in certain traffic conditions (like for example constant speed driving with slow or moderate speed) so called Rolling Resistance Impact Factor may be as high as 0.3. This means that reduction of rolling resistance by 50% would lead to 15% of energy...
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Has EGNOS its own place in maritime navigation?
PublicationGNSS (in fact it usually means GPS) is at the moment the fundamental means of positioning for any variants of navigation. However some attributes of it can be not sufficient for every users or in some tasks, so there are any cases when this system needs support. From the mariner point of view pure GPS properties perfectly fulfils expectations of sailors at the open sea, however there are lot of cases, when accuracy of the system...
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Flow maldistribution and its mitigation in mini heat exchangers
PublicationIn the present paper, a detailed numerical investigation has been carried out to analyze the flow maldistribution in 50 parallel 1 mm x 1 mm rectangular minichannels and 1 mm depth minigap section with rectangular, trapezoidal, triangular or concave mani-folds in Z-type flow configuration (16 different cases). The working medium was ethanol and the mass flow rate was 5×10-4 kg/s. Both sections was heated from the bottom side. Heat...
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Sound engineering as our commitment to its creators in Poland
PublicationSound engineering is an interdisciplinary and rapidly expanding domain. It covers many aspects, such as sound perception, studio and sound mastering technology, music information retrieval including content-based search systems and automatic music transcription frameworks, sound synthesis, sound restoration, electroacoustics, and other ones constituting multimedia technology. Moreover, machine learning methods applied to the topics...
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Serum fatty acid profile in psoriasis and its comorbidity
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