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Search results for: metabolomika
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Current Metabolomics
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Metabolomics in urogenital cancer
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Metabolomics for laboratory diagnostics
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Metabolomics in cardiovascular diseases
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Weronika Hewelt-Belka dr hab. inż.
PeopleI am specializing in analytical chemistry with a primary focus on lipidomics and metabolomics. My research centers on the development and application of cutting-edge analytical techniques, particularly high-performance liquid chromatography coupled with mass spectrometry (LC-MS), to explore complex biological matrices and deepen our understanding of human metabolism and health. A significant part of my work is dedicated to studying...
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Design of Experiments in metabolomics-related studies: An overview
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Multilevel pharmacokinetics-driven modeling of metabolomics data
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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview
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Metabolomic Status of The Oral Cavity in Chronic Periodontitis
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Metabolomics
Open Research DataWiff and Wiff2 files of untargeted metabolomics for E. coli strains (4 different experiments)
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Different detection and stacking techniques in capillary electrophoresis for metabolomics
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Perspectives and challenges in extracellular vesicles untargeted metabolomics analysis
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Sample preparation procedures utilized in microbial metabolomics: An overview
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Proton Transfer Reaction Mass Spectrometry for Plant Metabolomics
PublicationVolatile organic compounds (VOCs) emitted by plants are a valuable source of information on their growth, theirresponse to stress, and the condition of their habitat. The recent trend in the analysis of low-mass molecules ofplant origin is metabolomics, which in the context of volatiles is often referred to as volatolomics. It requires theuse of modern analytical instrumentation...
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Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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METABOLOMICS
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Zastosowanie metabolomiki jako przyszłego narzędzia w szybkiej diagnostyce ran przewlekłych
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Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension
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Untargeted metabolomics in gastric and colorectal cancer patients – preliminary results
PublicationIntroduction: Recent years, microbiota-associated aspects have been analysed in multiple disorders regarding cancers. Existing evidence pints that gut microorganisms might take part in tumour origin and therapy efficacy. Nevertheless, to date, data on faecal metabolomics in cancer patients is still strongly limited. Therefore, we aimed to analyse gut untargeted metabolome in gastrointestinal cancer patients (i.e., gastric and colorectal...
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Metabolomic and antioxidant properties of different varieties and origins of Dragon fruit
PublicationDragon fruit has appealed much concern from consumers as a novelty fruit with potent nutritional and medicinal benefits. Dragon fruit quality warrants comprehensive evaluation, based on the contents of pigments and health- promoting natural compounds in different varieties. This study was aimed to evaluate the differences among dragon fruit varieties extracted with methanol–water (CD3OD-D2O) and methanol (CD3OD) by proton nuclear magnetic...
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Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease
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Comprehensive Metabolic Signature of Renal Dysplasia in Children. A Multiplatform Metabolomics Concept
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Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach
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The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of Arthrospira platensis
PublicationDrying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of Arthrospira platensis were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD′ and AD″), infrared drying at 40 and 75 °C (IRD′ and IRD″), and vacuum drying at 40 and 75 °C (VD′ and VD″). Results gathered by...
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Arquivos Brasileiros de Endocrinologia e Metabologia
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HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium
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The Application of Metabolomics in Forensic Science with Focus on Forensic Toxicology and Time-of-Death Estimation
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How to model temporal changes in nontargeted metabolomics study? A Bayesian multilevel perspective
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Untargeted metabolomics coupled with genomics in the study of sucrose and xylose metabolism in Pectobacterium betavasculorum
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State of the art in sample preparation for human breast milk metabolomics—merits and limitations
PublicationHuman breast milk (HBM) contains metabolites that are diverse in chemical structure and concentration. These metabolites range from high-abundance to low-abundance compounds and from polar to nonpolar. This complex nature of HBM makes HBM samples difficult to analyze, especially in global metabolomic studies for the determination and characterization of complete sets of metabolites. In this review, the state of the art in sample...
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New supervised alignment method as a preprocessing tool for chromatographic data in metabolomic studies
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A Robust Method for Sample Preparation of Gastrointestinal Stromal Tumour for LC/MS Untargeted Metabolomics
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Paraffin-Embedded Tissue as a Novel Matrix in Metabolomics Study: Optimization of Metabolite Extraction Method
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Metabolomics analysis of the effect of time and oxygen on the fibrosarcoma cell line (HT1080) - model studies
PublicationOxygen molecular effect on cancer cells metabolism has been a concern for decades,at the beginning with Louis Pasteur’s and his understanding of glucose fermentation.In the 1930s, Otto Warburg came with his new understanding of cancer biology by introducingthe alteration of cancer cells' metabolism in the presence or absence of oxygen moleculesby increasing glucose uptake and producing lactate through...
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Identification of the metabolic fingerprints in women with polycystic ovary syndrome using the multiplatform metabolomics technique
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Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment
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Strategia analizy niecelowanej w metabolomice i lipidomice. Cz. 1. Aspekty praktyczne
PublicationStrategia analizy niecelowanej jest powszechnie wykorzystywana do analizy różnego rodzaju próbek biologicznych, takich jak tkanki czy płyny ustrojowe, w celu otrzymania „odcisku palca” oraz określenia różnic w składzie jakościowym oraz ilościowym pomiędzy badanymi próbkami. Wskazanie różnic w zawartości różnych biocząsteczek (peptydy, metabolity, lipidy) pozwala na uzyskanie informacji na temat powiązania składu biochemicznego...
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Strategia analizy niecelowanej w metabolomice i lipidomice – aspekty praktyczne cz.2
PublicationStrategia analizy niecelowanej jest powszechnie wykorzystywana do analizy różnego rodzaju próbek biologicznych, takich jak tkanki czy płyny ustrojowe, w celu otrzymania „odcisku palca” oraz określenia różnic w składzie jakościowym oraz ilościowym pomiędzy badanymi próbkami. Wskazanie różnic w zawartości różnych biocząsteczek (peptydów, metabolitów, lipidów) pozwala na uzyskanie informacji na temat powiązania składu biochemicznego...
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Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics
PublicationMetabolomics offers a unique approach to study biological systems. Liquid chromatography coupled to mass spectrometry serves as a powerful analytical tool to analyze complex mixtures of metabolites. However, successful metabolomic analysis relies on sample preparation. While untargeted analysis traditionally favors nonselective procedures like liquid-liquid extraction (LLE), these methods can compromise analytical performance due...
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Searching for the primary metabolic alterations of polycystic ovary syndrome by application of the untargeted metabolomics approach
PublicationDespite a large number of studies, the pathogenesis of polycystic ovary syndrome (PCOS) still remains unexplained. In light of ambiguous observations reported in metabolomics, there is a need to carry out studies focusing on confirming the discriminating power of the proposed metabolomics biomarkers. Our research aimed to perform a validation study of metabolites detected in our previous study from serum samples, on the new set...
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Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage
PublicationMetabolomics is the field of omics research that offers valuable insights into the complex composition of biological samples. It has found wide application in clinical diagnostics, disease investigation, therapy prediction, monitoring of treatment efficiency, drug discovery, or in-depth analysis of sample composition. A suitable study design constitutes the fundamental requirements to ensure robust and reliable results from the...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublicationPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Metabolomic approach for determination of urinary nucleosides as potential tumor markers using electromigration techniques
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GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
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PLS-Based and Regularization-Based Methods for the Selection of Relevant Variables in Non-targeted Metabolomics Data
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Main strategies, analytical trends and challenges in LC-MS and ambient mass spectrometry-based metabolomics
PublicationA plethora of analytical LC-MS-based methods have been successfully applied to analyses of complex samples of various origin for metabolomics investigations. Over the last ten years, the substantial evolution of ambient mass spectrometry (AMS) techniques has highlighted their tremendous potential in metabolomic studies due to the minimal sample pretreatment requirement and the ability to analyse samples in their native state. This...
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Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
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A targeted metabolomic protocol for quantitative analysis of volatile organic compounds in urine of children with celiac disease
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Targeted metabolomics in bladder cancer: From analytical methods development and validation towards application to clinical samples
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