Łukasz Nierzwicki - Publikacje - MOST Wiedzy

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Katalog Publikacji

Rok 2023
Rok 2022
  • A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
    Publikacja
    • M. Szadkowska
    • M. Olewniczak
    • A. Kloska
    • E. Jankowska
    • M. Kapusta
    • B. Rybak
    • D. Wyrzykowski
    • W. Zmudzinska
    • A. Gieldon
    • A. Kocot... i 5 innych

    - Microbiology Spectrum - Rok 2022

    This work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...

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  • Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9
    Publikacja
    • Ł. Nierzwicki
    • P. R. Arantes
    • M. Jinek
    • G. Lisi
    • G. Palermo
    • K. East
    • J. Binz
    • R. Vsu
    • A. Mohd
    • E. Skeens
    • M. Pacesa

    - Nature Catalysis - Rok 2022

    At the core of the CRISPR–Cas9 genome-editing technology, the endonuclease Cas9 introduces site-specific breaks in DNA. However, precise mechanistic information to ameliorate Cas9 function is still missing. Here, multimicrosecond molecular dynamics, free energy and multiscale simulations are combined with solution NMR and DNA cleavage experiments to resolve the catalytic mechanism of target DNA cleavage. We show that the conformation...

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Rok 2021
Rok 2020
Rok 2019
Rok 2017
  • Localization and Orientation of Xanthophylls in a Lipid Bilayer
    Publikacja

    - Scientific Reports - Rok 2017

    Xanthophylls (polar carotenoids) play diverse biological roles, among which are modulation of the physical properties of lipid membranes and protection of biomembranes against oxidative damage. Molecular mechanisms underlying these functions are intimately related to the localization and orientation of xanthophyll molecules in lipid membranes. In the present work, we address the problem of localization and orientation of two xanthophylls...

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Rok 2016
Rok 2015

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