Filtry
wszystkich: 277
wybranych: 275
Filtry wybranego katalogu
Wyniki wyszukiwania dla: HUMAN EXPOSURE
-
Environmental Tobacco Smoke: Exposure, Health Effects, and Analysis
PublikacjaTobacco smoke contains more than 4,000 chemicals, and 44 compoundshave been classified as human carcinogens. Toxicity can beboth mainstream smoke as well as the constituents of environmentaltobacco smoke. In the light of this evidence, work is intensifyingon assessing exposure on the basis of the results of tests performedto quantify the amounts of suitable environmental tobacco smokeconstituent biomarkers in samples of biological...
-
A new methodological approach to the noise threat evaluation based on the selected physiological properties of the human hearing system
PublikacjaA new way of assessment of noise-induced harmful effects on human hearing system is presented in the paper. The method takes into consideration properties of the selected physiological human hearing system. On the basis of the hearing examinations and noise measurements results and psychoacoustical noise dosimeter performance the new indicators of the noise harmfulness were proposed. The evaluation of the proposed indicators were...
-
Polybrominated diphenyl ether (PBDE) concentrations in dust from various indoor environments in Gdańsk, Poland: Prediction of concentrations in indoor air and assessment of exposure of adults
PublikacjaMonitoring of polybrominated diphenyl ethers (PBDEs) in indoor environments involves the determination of their concentrations in air, airborne particles, and settled dust. Each of these is a source of human exposure to PBDEs. In this study, we attempted to model PBDEs concentrations in various typical indoor environments on the basis of real PBDEs measurements in dust collected from them. The analytical procedure for determining...
-
Determination of thiocyanate as a biomarker of tobacco smoke constituents in selected biological materials of human origin
Publikacjan order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half‐life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations...
-
A framework for Air Quality Management Zones - Useful GIS-based tool for urban planning: Case studies in Antwerp and Gdańsk
PublikacjaThere is a growing recognition of the importance of proper urban design in the improvement of air flow and pollution dispersion and in reducing human exposure to air pollution. However, a limited number of studies have been published so far focusing on the development of standard procedures which could be applied by urban planners to effectively evaluate urban conditions with respect to air quality. To fill this gap, a new approach...
-
Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
PublikacjaLow-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evaluated experimentally in terms of their lipophilicity by means of reverse-phase and immobilized artificial membrane high-performance liquid chromatography. Subsequently, the selected compounds...
-
Computed aided system for separation and classification of the abnormal erythrocytes in human blood
PublikacjaThe human peripheral blood consists of cells (red cells, white cells, and platelets) suspended in plasma. In the following research the team assessed an influence of nanodiamond particles on blood elements over various periods of time. The material used in the study consisted of samples taken from ten healthy humans of various age, different blood types and both sexes. The markings were leaded by adding to the blood unmodified...
-
Influence of the Spectral Quality of Light on Daytime Alertness Levels in Humans
PublikacjaExposure to light is very important for human health. However, the characteristics of the light stimulus and the appropriate timing of such exposure are essential. Studies that have used monochromatic light exposure have shown no systematic patterns for the effects of blue light compared to longer wavelengths. Previous studies have shown that red light exposure increases objective and subjective measures of alertness at night without...
-
Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublikacjaAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
-
Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography–tandem mass spectrometry
PublikacjaChemicals showing structural or functional similarity to bisphenol A (BPA), commonly called BPA analogues, have recently drawn scientific attention due to their common industrial and commercial application as a substitute for BPA. In the European Union, the use of BPA has been severely restricted by law due to its endocrine disrupting properties. Unfortunately, it seems that all BPA analogues show comparable biological activity,...
-
Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage
PublikacjaExposure to high levels of different environmental pollutants is known to be associated with induction of DNA damage in humans. Thus DNA repair is of great importance in preventing mutations and contributes crucially to the prevention of cancer. In our study we have focused on quantitative analysis of Gentiana asclepiadea aqueous or methanolic extracts obtained from flower and haulm, their antioxidant potency in ABTS post-column...
-
Impacts on human health in the Arctic owing to climate-induced changes in contaminant cycling – The EU ArcRisk project policy outcome
PublikacjaResults of the EU ArcRisk project on human health impacts in the Arctic owing to climate-induced changes in contaminant cycling are summarized in the context of their policy application. The question on how will climate change affect the transport of selected persistent organic pollutants (POPs) and mercury, both to and within the Arctic has been addressed, as well as the issue of human health impacts of these pollutants in the...
-
Application of analytical procedure based on accelerated solvent extraction and ion chromatography technique for determination of thiocyanate and other inorganic ions in human placenta samples
PublikacjaExposure of a pregnant woman during pregnancy is a special case of exposure to toxic substances. Samples of placenta collected for the studies had been prepared with the technique of accelerated solvent extraction and later analyzed for the presence of thiocyanate ion and other inorganic ions, with the use of the technique of ion chromatography. The concentration of thiocyanate ion in placenta samples collected from active smokers...
-
Determining the noise impact on hearing using psychoacoustical noise dosimeter
PublikacjaThis research study presents the designed noise dosimeter based on psychoacoustical properties of the human hearing system and, at the same time. evaluation of time and frequency characteristics of noise. The designed noise dosimeter enables assessing temporary threshold shift (TTS) in critical hands in real time. In this way it is possible monitoring the hearing threshold shift continuously for people who stay in the harmful noise...
-
Daily diet containing canned products significantly increases serum concentrations of endocrine disruptor bisphenol A in young women
PublikacjaNowadays, exposure to environmental factors is considered to be one of the possible causes of several lifestyle diseases, such as obesity, type 2 diabetes, cardiovascular disease, and cancer. Particularly noteworthy are endocrine‑disrupting chemicals (EDCs), which affect the metabolism of hormones and interact with their receptors, thus exerting adverse health effects. One of the most ubiquitous EDC in daily life is bisphenol A...
-
Determination of thiocyanate (biomarkers of ETS) and other inorganic ions in human nasal discharge samples using ion chromatography
PublikacjaEnvironmental tobacco smoke (ETS) is a mixture of air and tobacco smoke containing more than 4000 chemical substances. In view of the health risks of many of these substances, studies are needed to determine biomarkers of exposure to ETS constituents in people who actively or passively are exposed to the toxic compounds. The methodologies for determining most biomarkers from saliva, urine and blood samples are known, but methods...
-
Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublikacjaDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
-
Analysis of the influence of polystyrene microplastics and their derivatives on the DNA of human colon epithelial cells HT29 with the comet assay
PublikacjaWe have been using plastic for almost a century and nowadays a lot of them circulates as pollutants in the environment and still defragmenting to micro and nanoscale. The exposition through the food chain and its precise impact on human health is still not clear. In our study, we tested real food packaging after contact with food products and real thermoinsulation and environmental samples of polystyrene in different model liquids,...
-
Evaluation of excessive noise effects on hearing employing psychoacoustic dosimetry
PublikacjaResearch results regarding the noise impact on hearing applying the concept of the Psychoacoustic Noise Dosimetry (PND) are presented. The general characteristics of the PND algorithm are discussed. Additionally, the results of hearing examinations conducted in the laboratory conditions are shown. The main objective of the research was to determine the time needed for the Temporary Threshold Shift to reverse. The results were used...
-
Frequently updated noise threat maps created with use of supercomputing grid
PublikacjaAn innovative supercomputing grid services devoted to noise threat evaluation were presented. The services described in this paper concern two issues, first is related to the noise mapping, while the second one focuses on assessment of the noise dose and its influence on the human hearing system. The discussed services were developed within the PL-Grid Plus Infrastructure which accumulates Polish academic supercomputer centers....