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Wyniki wyszukiwania dla: antitumor drug resistance
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Fabrication, Microstructure and High Temperature Corrosion Resistance of Porous Alloys for Solid Oxide Fuel Cells
PublikacjaPorous alloys find use in modern Solid Oxide Fuel Cells as the supporting structures. As they are exposed to high temperatures (> 500°C) an oxide scale forms on their surface due to high temperature corrosion phenomena. Since the ratio between the surface area and volume is much higher than for planar samples, formation of the oxide can lead to a breakaway oxidation after relatively short times. Therefore corrosion properties of...
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Comparison of buckling resistance of columns modelled by beam and shell elements using non-linear analysis
PublikacjaThe aim of the paper is to investigate the stability process in the axially compressed columns modelled by beam and shell elements using static and dynamic finite element analysis by taking both the geometric and material non-linearity into account. The perfect columns and columns with geometric imperfections were analysed. The differences between the results of static and dynamic analyses in shell and beam models were discussed.
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The effect of the wood temperature upon specific cutting resistance during machining with narrow-kerf saws
PublikacjaW pracy przedstawiono wyniki badań eksperymentalnych właściwego powierzchniowego oporu skrawania drewna sosny w funkcji wilgotności drewna, temperatury drewna oraz prędkości posuwu podczas przecinania cienkimi piłami. Proces cięcia prowadzono na pilarce ramowej wielopiłowej PRW15M. Sosnowe próbki przed badaniami mrożono w komorze klimatycznej - temperatura drewna -5 C deg., -20 C deg., +20 C deg. Czas wymrażania przed próbami określano...
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Effects of Laser Remelting at Cryogenic Conditions on Microstructure and Wear Resistance of the Ti6Al4V Alloy Applied in Medicine
PublikacjaThe titanium and its alloys can be subjected to surface treatment, including laser treatment. In this work a new laser treatment at cryogenic conditions of Ti6Al4V alloy has been described. The work has been aimed at establishing whether such surface treatment could be suitable for implants working under wear in biological corrosive environment. The remelting has been made with the use of CO2 continuous work laser at laser power...
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Two small RNAs conserved in Enterobacteriaceae provide intrinsic resistance to antibiotics targeting the cell wall biosynthesis enzyme glucosamine-6-phosphate synthase
PublikacjaFormation of glucosamine-6-phosphate GlcN6P) by enzyme GlcN6P synthase (GlmS) represents the first step in bacterial cell envelope synthesis. In Escherichia coli, expression of glmS is controlled by small RNAs (sRNAs) GlmY and GlmZ. GlmZ activates the glmS mRNA by base-pairing. When not required, GlmZ is bound by adapter protein RapZ and recruited to cleavage by RNase E inactivating the sRNA. The homologous sRNA GlmY activates...
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Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
PublikacjaThe ends of chromosomes in mammals are composed of telomeric DNA containing TTAGGG repeats, which bind specific proteins called shelterins. This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage and from chromosomal fusions. Many very successful antitumor drugs used in the treatment of cancer patients bind to DNA, some of them with a prominent sequence...
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The influence of microstructure on the corrosion resistance for some titanium-based alloys
Dane BadawczeThis dataset contains scanning electron microscopy (SEM) micrographs revealing the microstructure of some Ti-based alloys, namely: Ti-6Al-4V (file name: TiV), Ti-6Al-7Nb (file name: TiNb) and TC21 (file name: TiAlSnZrMoCrNbSi) alloys and their localized corrosion as a result of passive layer breakdown in a corrosive environment, ie. 0.9% NaCl solution...
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Non-invasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients: effects on home blood pressure in the BEAUTY study
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Production of the anticancer drug taxol by the endophytic fungus Epicoccum nigrum TXB502: enhanced production by gamma irradiation mutagenesis and immobilization technique
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How do sterols determine the antufungal activitiy of amphotericin B? Free energy of binding between the drug and its membrane targets.
PublikacjaAmphotericin B (AmB) is a well-known polyene antibiotic used to treat systemic fungal infections. It is commonly accepted that the presence of sterols in the membrane is essential for the AmB biological activity, that is, for the formation of transmembrane ion channels. The selective toxicity of AmB for fungal cells is attributed to the fact that it is more potent against fungal cell membranes containing ergosterol than against...
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Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells
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Reactive metabolites of acridinone antitumor agents, C-1311 and C-1305, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzymes inactivation
PublikacjaZwiązki C-1305 i C-1311, zsyntetyzowane w Katedrze Technologii Leków i Biochemii, wykazują najsilniejsze właściwości przeciwnowotworowe wśród pochodnych, odpowiednio, triazolo- i imidazoakrydonu. Obecnie prowadzone są badania mające na celu określenie biochemicznego mechanizmu działania, jak również potencjalnych szlaków biotransformacji C-1305 i C-1311.W bieżącym etapie podjęto próbę określenia mechanizmu obserwowanej inhibicji...
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Effect of plasma nitriding process on the fatigue and high temperature corrosion resistance of Inconel 740H nickel alloy
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Impact of movement tempo on bar velocity and time under tension in resistance exercises with different external loads
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Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings
PublikacjaZbadano aktywność cytotoksyczną, in vitzo dwóch nowych grup cytostatyków akrydynowych zawierających skondensowane pierścienie heterocykliczne w stosunku do komórek nowotworowych linii wrażliwych i opornych. Otrzymane wyniki potwierdziły naszą wcześniejszą hipotezę o istotnej roli pierścieni hetero-cyklicznych w pokonywaniu krzyżowej oporności wielolekowej.
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Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes
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Corrigendum: Contrast Tempo of Movement and Its Effect on Power Output and Bar Velocity During Resistance Exercise
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Linezolid-Resistant Enterococcus spp. Isolates from Foods of Animal Origin—The Genetic Basis of Acquired Resistance
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Antimicrobial Resistance and Virulence Characterization of Listeria monocytogenes Strains Isolated from Food and Food Processing Environments
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Application possibilities of the low-temperature repairs on creep-resistance turbine components from material GX23CrMoV12-1
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Non-Gaussian Resistance Fluctuations in Gold-Nanoparticle-Based Gas Sensors: An Appraisal of Different Evaluation Techniques
PublikacjaVolatile organic compounds, such as formaldehyde, can be used as biomarkers in human exhaled breath in order to non-invasively detect various diseases, and the same compounds are of much interest also in the context of environmental monitoring and protection. Here, we report on a recently-developed gas sensor, based on surface-functionalized gold nanoparticles, which is able to generate voltage noise with a distinctly non-Gaussian...
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Selected metrological aspects of permeation cells used for testing the resistance of polymeric materials to penetration by liquid chemicals
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FE-modeling of shear resistance degradation in granular materials during cyclic shearing under CNS condition
PublikacjaW artykule przedstawiono wyniki numerycznej analizy degradacji wytrzymałości na ścinanie w materiałach granulowanych podczas cyklicznego ścinania z warunkiem stałej sztywności normalnej. Obliczenia wykonano przy zastosowaniu metody elementów skończonych i mikropolarnego modelu hipoplastycznego.
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Microbial acetylcholinesterase inhibitors for Alzheimer’s therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery
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Analysis of pharmacotherapy regimen and costs in patients with drug-resistant epilepsy following vagus nerve stimulation therapy: a single-center study (Poland)
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Contribution of UDP-glucuronosyltransferases (UGTs) in metabolism of acridinone antitumor agents, C-1311, C-1305, and their less active structural analogues, C-1330 and C-1299
PublikacjaCelem prowadzonych badań było określenie roli UDP-glukuronylotransferaz, uważanych za najważniejsze enzymy detoksykujące, w metabolizmie pochodnych imidazo- i triazoloakrydonu. Wykazano, że najbardziej aktywne przeciwnowotworowo związki z obu grup, tj. C-1311 i C-1305 są transformowane do O-glukuronidów, w przeciwieństwie do ich metoksylowych analogów, odpowiednio związku C-1330 i C-1299. Analiza składu mieszanin reakcyjnych zawierających...
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CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
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Endocrine Metabolic & Immune Disorders-Drug Targets
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Expert Review of Precision Medicine and Drug Development
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International Journal of Computational Biology and Drug Design
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Recent Patents on Inflammation & Allergy Drug Discovery
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Japanese Journal of Alcohol Studies and Drug Dependence
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Recent Patents on Anti-Infective Drug Discovery
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Recent Patents on Anti-Cancer Drug Discovery
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Recent Advances in Inflammation & Allergy Drug Discovery
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Journal of Aerosol Medicine and Pulmonary Drug Delivery
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Recent Advances in Anti-Infective Drug Discovery
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Blowing Kinetics, Pressure Resistance, Thermal Stability, and Relaxation of the Amorphous Phase of the PET Container in the SBM Process with Hot and Cold Mold. Part I: Research Methodology and Results
PublikacjaThe technology of filling drinks without preservatives (such as fresh juices, iced tea drinks, vitaminized drinks) is carried out using hot filling. Mainly due to the production costs and lower carbon footprint, polyethylene terephthalate bottles, commonly called PET, are increasingly used in this technology. In this paper, the main aim is to describe the statistical analysis methodology of the influence of the temperature of the...
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Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate
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A.D.A.M. test (Antibiofilm Dressing's Activity Measurement) — Simple method for evaluating anti-biofilm activity of drug-saturated dressings against wound pathogens
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Distinction of clenbuterol intake from drug or contaminated food of animal origin in a controlled administration trial – the potential of enantiomeric separation for doping control analysis
PublikacjaThe differentiation of clenbuterol abuse and unintentional ingestion by contaminated meat is crucial with respect to the valuation of an adverse analytical finding in human sports doping control. The proportion of the two enantiomers of clenbuterol may serve as potential discriminating parameter. For the determination of the individual enantiomers, specific methods were developed and validated for the different matrices under investigation...
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The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA
PublikacjaMatrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide-DOX, the product of the MMPs' cleavage of carrier-linked DOX, into dsDNA was investigated using stationary and time-resolved fluorescence spectroscopy, UV-Vis...
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The influence of plasma-sprayed coatings on surface properties and corrosion resistance of 316L stainless steel for possible implant application
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Corrosion Resistance and Mechanical Properties of TIG and A-TIG Welded Joints of Lean Duplex Stainless Steel S82441 / 1.4662
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Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance
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N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins
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Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer
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Can Post-Activation Performance Enhancement (PAPE) Improve Resistance Training Volume during the Bench Press Exercise?
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Assessment of antibiotic resistance and biofilm formation of Enterococcus species isolated from different pig farm environments in Poland
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