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Wyniki wyszukiwania dla: drugs underelectrochemical transformations
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The landscape transformations of post-industrial areas based on selected examples
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Anthropogenic transformations of the Bytom area relief in the period of 1883-1994
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Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field
PublikacjaThe physics-based united-residue (UNRES) model of proteins ( www.unres.pl ) has been designed to carry out large-scale simulations of protein folding. The force field has been derived and parameterized based on the principles of statistical-mechanics, which makes it independent of structural databases and applicable to treat nonstandard situations such as, proteins that contain D-amino-acid residues. Powered by Langevin dynamics...
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BASICS OF THE MANAGEMENT SYSTEM FOR TRANSFORMATIONS OF PRODUCTION PLANNING AND CONTROL PROCESSES
PublikacjaIntensive development of technologies, in particular of the spinotronics, nanotechnology, robotics, and ICT, shapes the new generation production systems. Their distinctive feature is the flexi-bility associated with production intelligence. It is required from all processes, including the production planning and control processes (PPCP). The article is of conceptual character. It was prepared based on literature research. It encompasses...
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Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
PublikacjaIntestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively...
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Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application
PublikacjaBenzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...
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Machine learning applied to bi-heterocyclic drugs recognition
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Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs
PublikacjaHypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack...
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Applying ground penetrating radar to tracking of ancient architectural transformations: the case of the monastery St. Peter on the Island of Rab (Croatia)
PublikacjaThe ground-penetrating radar (GPR) method has been used for many years in archaeological research. However, thismethod is still not widely used in studies of past architecture. The biggest problem with the implementation of the GPRmethod at such sites is usually connected with extensive debris layers, plant cover and standing relics of walls and otherfeatures that restrict the available measurement area. Despite of these, properly...
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PANTOGRAPH AS AN EXAMPLE OF THE USE OF GEOMETRIC TRANSFORMATIONS IN CONSTRUCTING OF OLD DRAWING INSTRUMENTS = PANTOGRAF JAKO PRZYKŁAD ZASTOSOWANIA PRZEKSZTAŁCEŃ GEOMETRYCZNYCH W KONSTRUOWANIU DAWNYCH PRZYRZĄDÓW KREŚLARSKICH
PublikacjaThe article describes the pantograph, considered to be the ancestor of today's photocopier. This instrument draws the copies, enlarges or reduces any figure. The author presents its genesis, the scope of application in the past, explains the structure and geometrical transformations used during its action. Based on a specific example, the work illustrates practical application of geometry in the past inventions for designing.
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Marine Drugs
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The Impact of Administrative Reform on Labour Market Transformations in Large Polish Cities
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Reversible transformations from pure to mixed states and the unique measureof information.
PublikacjaWprowadzono protokół w którym kwantowe stany czyste są w sposób odwracalny przeprowadzane w stany mieszane. W oparciu o analizę protokołu wyprowadzono jednoznaczną miarę informacji. Dokonano porównania z innymi nieodwracalnymi protokółami przeprowadzającymi stany czyste w mieszane.
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Influence of heat transformations on microstructure and properties of some wrought aluminium alloys.
PublikacjaOmówiono wpływ spawania na podatność do korozji naprężeniowej stopów Al-Mg i Al-Zn-Mg stwierdzając, że wzrost zawartości cynku wywołuje wzrost właściwości mechanicznych i spadek odporności na korozję naprężeniową. Wykazano, że obróbka cieplna złożona z retrogresji i powtórnego starzenia w przypadku stopów Al-Zn-Mg nie powoduje szczególnych zmian odporności na korozję naprężeniową, co pozostaje w związku z niewielką zmianą struktur...
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Vision of the development of transformations in the district – Lower Sopot (Dolny Sopot) district case study, study proposal no 1, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Lower Sopot (Dolny Sopot) district, study proposal no 1, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located in Lower...
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Vision of the development of transformations in the district – Lower Sopot (Dolny Sopot) district case study, study proposal no 3, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Lower Sopot (Dolny Sopot) district, study proposal no 3, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located in Lower...
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Vision of the development of transformations in the district – Lower Sopot (Dolny Sopot) district case study, study proposal no 4, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Lower Sopot (Dolny Sopot) district, study proposal no 4, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located in Lower...
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Vision of the development of transformations in the district – Lower Sopot (Dolny Sopot) district case study, study proposal no 2, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Lower Sopot (Dolny Sopot) district, study proposal no 2, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located in Lower...
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Vision of the development of transformations in the district – Lower Sopot (Dolny Sopot) district case study, study proposal no 5, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Lower Sopot (Dolny Sopot) district, study proposal no 5, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located in Lower...
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Vision of the development of transformations in the district – Lower Sopot (Dolny Sopot) district case study, study proposal no 6, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Lower Sopot (Dolny Sopot) district, study proposal no 6, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located in Lower...
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DRUGS IN R&D
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Drugs and Alcohol Today
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Clinical Cancer Drugs
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Drugs and Therapy Perspectives
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INVESTIGATIONAL NEW DRUGS
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Journal of Psychoactive Drugs
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Journal of Drugs in Dermatology
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Vision of the development of transformations in the district – Gdańsk-Lower City (Dolne Miasto) district case study, study proposal no 2, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Gdańsk-Lower City (Dolne Miasto) district, study proposal no 2, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located...
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Vision of the development of transformations in the district – Gdańsk-Lower City (Dolne Miasto) district case study, study proposal no 1, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Gdańsk-Lower City (Dolne Miasto) district, study proposal no 1, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located...
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Vision of the development of transformations in the district – Gdańsk-Lower City (Dolne Miasto) district case study, study proposal no 3, April 2021
Dane BadawczeThe data presents results of work within the studies of the vision of the district in the context of the city, Gdańsk-Lower City (Dolne Miasto) district, study proposal no 3, from April 2021. The goal of the research process was to present the future image of the neighborhood and initial ideas of the development of transformations of the area located...
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Issues in the development of new combinations of blood pressure lowering drugs
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The Effect of Antihypertensive Drugs on NADH in Newly Diagnosed Primary Hypertension
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Akrydyny jako związki aktywne przeciwnowotworowo = Acridines as antitumor drugs
PublikacjaAkrydyny należą do grupy policyklicznych związków heteroaromatycznych. Wykazują szeroki zakres aktywności biologicznej obejmujący aktywność przeciwpierwotniakową, przeciwbakteryjną,przeciwwirusową i przeciwnowotworową. Pochodne akrydyny o działaniu przeciwnowotworowym wykazują zróżnicowany mechanizm działania na poziomie molekularnym. Z uzyskanych dotychczas danych wynika, że jednym z podstawowych etapów działania jest tworzenie...
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Poszukiwanie nowych leków immunosupresyjnych = Quest for new immunosuppressive drugs
PublikacjaNiniejsza praca przeglądowa dotyczy znanych leków immunosupresyjnych, a także nowych związków o potencjalnym zastosowaniu klinicznym. Wybrane pochodne przedstawiono z uwzględnieniem mechanizmu ich działania oraz metod otrzymywania.
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Inhibitors of glucosamine-6-phosphate synthase as potential antifungal drugs.
PublikacjaPrzedstawiono stan obecny i perspektywy zastosowania inhibitorów enzymu syntazy GlcN-6-P jako leków skutecznych w leczeniu grzybic układowych. Używając metod modelowania molekularnego zaprojektowano struktury inhibitorów enzymu należących do dwóch grup strukturalnych: analogów glutaminy oraz analogów stanu przejściowego reakcji katalizowanej przez enzym. Opracowano metody syntezy pochodnych zoptymalizowanych inhibitorów, wykazujących...
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Conformers and hydrogen bond transformations in N-methylpiperidine betaine 2,4-dinitrophenolate crystals
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Scale transformations in model exchange potentials in low energy electron-atom scattering
PublikacjaModel exchange potentials are particularly interesting to account for the indistinguishability between the projectile and target electrons in electron-atom scattering in vacuo and plasma environments. It is well known that their performance is pretty satisfactory in the high energies but also that discrepancies from the results obtained with exact exchange are found toward the zero energy limit. In this article, we examine how...
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On fault diagnosis of analogue electronic circuits based on transformations in multi-dimensional spaces.
PublikacjaPrzedstawiono ideę nowej klasy metod diagnostycznych opartej na przekształceniu transformującym zmiany parametru układu na krzywe identyfikacyjne w przestrzeniach wielowymiarowych. Rozszerzono również klasę tych metod na diagnostykę uszkodzeń wielokrotnych. Dla takich metod omówiono algorytm lokalizacji i identyfikacji pojedynczych i wielokrotnych uszkodzeń parametrycznych w liniowych układach elektronicznych. Przedstawiono rezultaty...
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Nitrogen transformations and mass balances in anaerobic/anoxic/aerobic batch experiments with full-scale biomasses from BNR activated sludge systems.
PublikacjaThe aim of this study was to investigate nitrogen mass balances occurring inside full-scale BNR activated sludge systems, with special attention to colloidal and dissolved organic nitrogen (CON and DON) transformations. For this purpose, laboratory experiments were carried out using process biomass from two large BNR plants in northern Poland. Two parallel batch reactors were operated in a 3-phase (anaerobic/anoxic/aerobic) cycle....
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Nitrogen transformations and mass balances in anaerobic/anoxic/aerobic batch experiments with full-scale biomasses from BNR activated sludge systems.
PublikacjaThe aim of this study was to investigate nitrogen mass balances occurring inside full-scale BNR activated sludge systems, with special attention to colloidal and dissolved organic nitrogen (CON and DON) transformations. For this purpose, laboratory experiments were carried out using process biomass from two large BNR plants in northern Poland. Two parallel batch reactors were operated in a 3-phase (anaerobic/anoxic/aerobic) cycle....
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Fentanyl and its derivatives as a group of new psychoactive substances (designer drugs)
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Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
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Assessment of sleep disorders and use of psychoactive drugs among Polish students
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New data on antihypertensive drugs and risk of cancer: should we worry?
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TIME to face the reality about evening dosing of antihypertensive drugs in hypertension
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Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublikacjaWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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Transformations of Tetrahydrocannabinol, tetrahydrocannabinolic acid and cannabinol during their extraction from Cannabis sativa L.
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Studies of human and veterinary drugs' fate in environmental solid samples- analytical problems.
PublikacjaW różnych ośrodkach naukowych na całym świecie trwają prace nad poznaniem losu środowiskowego zanieczyszczeń z grupy farmaceutyków. Obecność pozostałości farmaceutycznych w poszczególnych elementach środowiska stanowi nowe wyzwanie zarówno z punktu widzenia technologii oczyszczania wód i ścieków jak i analityków, których zadaniem jest opracowanie nowych metodyk analitycznych. W publikacji przedstawiono problemy z jakimi stykają...