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Substrate specificity and inhibitory study of human airway trypsin-like protease
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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
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The influence of substrate peptide length on human β‐tryptase specificity
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Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro
PublikacjaThis article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays, while qRT-PCR was employed to analyze the expression of genes associated with the p53 signaling pathway to elucidate the effect of the extract on cancer cells. Furthermore, HPLC-ESI-QTOF-MS/MS...
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Inhibitors of Matriptase‐2 Based on the Trypsin Inhibitor SFTI‐1
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Effect of Ethanol Extracts of Propolis (EEPs) against Staphylococcal Biofilm—Microscopic Studies
PublikacjaStaphylococci growing in the form of biofilm exhibit high resistance to a plethora of antibiotics. The aim of the study was to assess the influence of ethanolic extract of propolis (EEPs) on S. epidermidis ATCC 35984 biofilm using fluorescent microscopy. Propidium iodide (PI) and SYTO 9 were used for differentiation of live and dead cells, and calcofluor white was used to stain the extracellular matrix, the self-produced extracellular...
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Innowacyjne systemy wyrównywania napięć na 12-woltowych akumulatorach ołowiowych pracujących w połączeniu szeregowym
PublikacjaW artykule omówiono problematykę wyrównywania napięć na szeregowo połączonych 12-woltowych akumulatorach ołowiowych zbudowanych na bazie sześciu ogniw 2-woltowych. Skupiono się na rozwiązaniu z zastosowaniem dodatkowego akumulatora energii. Należy tu podkreślić fakt, że prezentowany proces wyrównywania dotyczy napięć na poszczególnych akumulatorach, a nie na ich poszczególnych ogniwach. Omówiono i przedyskutowano zalety, wynikające...
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Innowacyjne systemy wyrównywania napięć na 12-woltowych akumulatorach ołowiowych pracujących w połączeniu szeregowym
PublikacjaW artykule omówiono problematykę wyrównywania napięć na szeregowo połączonych 12-woltowych akumulatorach ołowiowych zbudowanych na bazie sześciu ogniw 2-woltowych. Skupiono się na rozwiązaniu z zastosowaniem dodatkowego akumulatora energii. Należy tu podkreślić fakt, że prezentowany proces wyrównywania dotyczy napięć na poszczególnych akumulatorach, a nie na ich poszczególnych ogniwach. Omówiono i przedyskutowano zalety,...
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Effect of Aging on the Lower Limb Kinematics in Karate Practitioners: Comparing Athletes and Their Senseis
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Stellate cells in livers of dogs with portal vein hypoperfusion
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The FT-IR and Raman Spectroscopies as Tools for Biofilm Characterization Created by Cariogenic Streptococci
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Rozpoznawanie ruchów i gestów wykonywanych ustami w obrazie wizyjnym z użyciem sieci neuronowych
PublikacjaUstomysz jest interfejsem komputerowym, umożliwiającym sterowanie kursorem ekranowym za pomocą ruchów ust i gestów wykonywanych ustami. Główną grupą docelową użytkowników interfejsu są osoby, które z dowolnego powodu nie mogą lub nie chcą posługiwać się tradycyjną klawiaturą i myszką komputerową. W związku z tym, może on umożliwić osobom niepełnosprawnym ruchowo, np. z niedowładem kończyn posługiwanie się komputerem, a przez to...
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Evaluation of Chemical Changes in Laboratory-Induced Colistin-Resistant Klebsiella pneumoniae
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Highly selective impedimetric determination of Haemophilus influenzae protein D using maze-like boron-doped carbon nanowall electrodes
PublikacjaThis study reports a novel impedimetric immunosensor for protein D detection in purified and bacterial (Haemophilus influenzae, Hi) samples. The detection was based on antigen recognition by anti-protein D antibodies (apD) immobilised at the maze-like boron-doped carbon nanowall electrodes (B:CNW). The B:CNW electrodes were synthesised, and their surface was characterised by scanning electron microscopy (SEM) and X-ray photoelectron...
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Formulation and evaluation of hydrogel containing dry extract of Tormentillae rhizoma designed for periodontal disease
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Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges
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Inhibitory activity of double‐sequence analogues of trypsin inhibitor SFTI‐1 from sunflower seeds: an example of peptide splicing
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Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry
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Modeling and Simulation of Electric Motors Using Lightweight Materials
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The impact of cold plasma on the phenolic composition and biogenic amine content of red wine
PublikacjaThe effect of cold plasma (CP) on phenolic compound (PC) and biogenic amine (BA) contents of red wine was investigated for the first time. The influence of CP was compared with the effects of a wine preservation using potassium metabisulfite and a combined method. The PC profile was determined by UPLC-PDA-MS/MS while BAs using DLLME-GC–MS. Chemometric analysis also was used. The content of PCs was 3.1% higher in the sample preserved...
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Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
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Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?
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Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Assessment of Clinical Usefulness of Resting Electrocardiogram (PH-ECG Score) in Monitoring the Efficacy of Balloon Pulmonary Angioplasty (BPA) in Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
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Innovative system for energy collection and management integrated within a photovoltaic module
PublikacjaThe dynamic development of battery technology and design based on the flow of lithium ions, mainly driven by the needs of the automotive industry, leads to the conclusion that these batteries are becoming a more viable alternative to traditional lead-acid batteries. Their use is driven by the ability to quickly charge and discharge, a higher durability, maintenance-free operation, much smaller dimensions and lighter weight. The...
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A Case Study on the Desired Selectivity in Solid‐State Mechano‐ and Slow‐Chemistry, Melt, and Solution Methodologies
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How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests – Cyclotides as a Comprehensive Plant Host Defense System
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The Effect of a Gear Oil on Abrasion, Scuffing, and Pitting of the DLC-Coated 18CrNiMo7-6 Steel
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In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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Effective phospholipid removal from plasma samples by solid phase extraction with the use of copper (II) modified silica gel cartridges
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Conformational studies of [Nphe5]SFTI-1 by means of 2D NMR spectroscopy in conjunction with molecular dynamics calculations
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublikacjaA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
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Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines
PublikacjaA series of compounds containing either non-proteinogenic beta-/gamma-amino acids or N-substituted beta-alanine residues (beta-peptoid units) in P-1 specificity position were synthesized based on the structure of sunflower trypsin inhibitor 1 (SFTI-1). The compounds were synthesized on a solid support; the N-substituted beta-alanines (beta Nhlys and beta Nhphe) were introduced into a peptidomimetic chain via a two-step approach...
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Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity
PublikacjaA number of monocyclic SFTI-1 analogues modified in the conserved inhibitor P1 position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogues...
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Self-Sensitized Photocatalytic Degradation of Colorless Organic Pollutants Attached to Rutile Nanorods—Experimental and Theoretical DFT+D Studies
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Hybrid-Excited Permanent Magnet-Assisted Synchronous Reluctance Machine
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Research on a permanent magnet assisted synchronous reluctance machine with hybrid excitation
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Spliced analogues of trypsin inhibitor SFTI‐1 and their application for tracing proteolysis and delivery of cargos inside the cells
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Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublikacjaRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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High prevalence of carriers of variant c.1528G>C of HADHA gene causing long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) in the population of adult Kashubians from North Poland
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Design and synthesis of new substrates of HtrA2 protease
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PEGylated substrates of NSP4 protease: A tool to study protease specificity
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Relationship between copper(ii) complexes with FomA adhesin fragments ofF. nucleatumand colorectal cancer. Coordination pattern and ability to promote ROS production
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Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis
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Copper(II) complexes with Fusobacterium nucleatum adhesin FadA: Coordination pattern, physicochemical properties and reactivity
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Podatkowe determinanty sukcesu przedsiębiorcy
PublikacjaW rozdziale pierwszym omówiono różne definicje pojęcia „przedsiębiorczość” funkcjonujące w literaturze przedmiotu. Wskazano także istotę analizowanego zjawiska oraz uwarunkowania jego rozwoju. W drugim rozdziale omówiono kwestie związane z problematyką podatkową, z którą styka się niemal codziennie prawie każdy przedsiębiorca prowadzący działalność gospodarczą. Zaprezentowana tutaj między innymi możliwość wyboru formy prawnej i...