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Wyniki wyszukiwania dla: TRANSCRIPTIONAL PROFILING
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublikacjaAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective.
PublikacjaThe RpoE sigma factor is essential for the viability of Escherichia coli. RpoE regulates extracytoplasmic functions including lipopolysaccharide (LPS) translocation and some of its non-stoichiometric modifications. Transcription of the rpoE gene is positively autoregulated by EσE and by unknown mechanisms that control the expression of its distally located promoter(s). Mapping of 5′ ends of rpoE mRNA identified five new transcriptional...
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Region-Specific Methylation Profiling in Acute Myeloid Leukemia
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mRNA profiling for vaginal fluid and menstrual blood identification
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Substrate profiling of Zika virus NS2B‐NS3 protease
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Fecal Serine Protease Profiling in Inflammatory Bowel Diseases
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Methodology and technology for the polymodal allophonic speech transcription
PublikacjaA method for automatic audiovisual transcription of speech employing: acoustic and visual speech representations is developed. It adopts a combining of audio and visual modalities, which provide a synergy effect in terms of speech recognition accuracy. To establish a robust solution, basic research concerning the relation between the allophonic variation of speech, i.e. the changes in the articulatory setting of speech organs for...
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Methodology and technology for the polymodal allophonic speech transcription
PublikacjaA method for automatic audiovisual transcription of speech employing: acoustic, electromagnetical articulography and visual speech representations is developed. It adopts a combining of audio and visual modalities, which provide a synergy effect in terms of speech recognition accuracy. To establish a robust solution, basic research concerning the relation between the allophonic variation of speech, i.e., the changes in the articulatory...
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublikacjaPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
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Oxylipin profiling for clinical research: Current status and future perspectives
PublikacjaOxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies...
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RDF dataset profiling - a survey of features, methods, vocabularies and applications
PublikacjaThe Web of Data, and in particular Linked Data, has seen tremendous growth over the past years. However, reuse and take-up of these rich data sources is often limited and focused on a few well-known and established RDF datasets. This can be partially attributed to the lack of reliable and up-to-date information about the characteristics of available datasets. While RDF datasets vary heavily with respect to the features related...
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Noise profiling for speech enhancement employing machine learning models
PublikacjaThis paper aims to propose a noise profiling method that can be performed in near real-time based on machine learning (ML). To address challenges related to noise profiling effectively, we start with a critical review of the literature background. Then, we outline the experiment performed consisting of two parts. The first part concerns the noise recognition model built upon several baseline classifiers and noise signal features...
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Overview of the Virtual Transcription Laboratory Usage Scenarios and Architecture
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Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?
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Salt Stress Reveals a New Role for ARGONAUTE1 in miRNA Biogenesis at the Transcriptional and Posttranscriptional Levels
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Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
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Transcriptome profiling and environmental linkage to salinity across Salicornia europaea vegetation
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Is Black Titania a Promising Photocatalyst?
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Transcriptional profile of in vitro expanded human epidermal progenitor cells for the treatment of non-healing wounds
PublikacjaBackground Epidermal progenitor cells (EPCs) have been under extensive investigation due to their increasing potential of application in medicine and biotechnology. Cultured human EPCs are used in the treatment of chronic wounds and have recently became a target for gene therapy and toxicological studies. One of the challenges in EPCs culture is to provide a high number of undifferentiated, progenitor cells displaying high viability...
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The Escherichia coli RNA polymerase alpha subunit and transcriptional activation by bacteriophage lambda CII protein.
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The role of Snail1 transcription factor in colorectal cancer progression and metastasis
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Material for Automatic Phonetic Transcription of Speech Recorded in Various Conditions
PublikacjaAutomatic speech recognition (ASR) is under constant development, especially in cases when speech is casually produced or it is acquired in various environment conditions, or in the presence of background noise. Phonetic transcription is an important step in the process of full speech recognition and is discussed in the presented work as the main focus in this process. ASR is widely implemented in mobile devices technology, but...
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Profiling of polar ionogenic metabolites in Polish wines by capillary electrophoresis-mass spectrometry
PublikacjaThe composition of wine is determined by a complex interaction between environmental factors, genetic factors (i.e., grape varieties), and winemaking practices (including technology and storage). Metabolomics using NMR spec-troscopy, GC-MS, and/or LC-MS has shown to be a useful approach for assessing the origin, authenticity, and quality of various wines. Nonetheless, the use of additional analytical techniques with complementary...
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Phytochemical Profiling of Extracts from Rare Potentilla Species and Evaluation of Their Anticancer Potential
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LC-ESI-MS profiling of Potentilla norvegica and evaluation of its biological activities
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Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
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Description of the Dataset Hanow – Praecepta de Arte Disputandi – Transcription and Photographs
PublikacjaThis article briefly characterises the “Hanow – Praecepta de arte disputandi – transcription and photographs” research dataset. The dataset was created based on photographs and transcriptions of the manuscript of the Latin lectures on the rules of effective discussion (the title of the manuscript: Praecepta de arte disputandi) by Michael Chris-toph Hanow (1695–1773), professor of Gdańsk Academic Gymnasium. The original document...
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Expression of Selected Epithelial-Mesenchymal Transition Transcription Factors in Endometrial Cancer
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MicroRNA profiling in a case-control study of African American women with uterine serous carcinoma
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Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line
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Spectral profiling of radicals in polymer degradation based on electron spin resonance imaging (ESRI)
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Identification of antioxidant polyphenolics from Jasione montana based on a preliminary LC-MS profiling
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Proteomic profiling of exosomes derived from pancreatic beta-cells cultured under hyperglycemia
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Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies
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Phytochemical Profiling, Mineral Elements, and Biological Activities of Artemisia campestris L. Grown in Algeria
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SEI Growth and Depth Profiling on ZFO Electrodes by Soft X-Ray Absorption Spectroscopy
PublikacjaZnFe2O4 (ZFO) Li-ion batteries (LIBs) represent a reliable, affordable, and safe energy storage technology for use in portable application. However, current LIB active materials (graphite, lithium/transition metal spinel or layered oxides, olivine structures) can store only limited energy since they rely on insertion storage based on solid-state host-guest interactions. Moreover, performances and durability of the cells are strongly...
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The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation
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DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
PublikacjaWe present a physics-based machine learning approach to predict in vitro transcription factor binding affinities from structural and mechanical DNA properties directly derived from atomistic molecular dynamics simulations. The method is able to predict affinities obtained with techniques as different as uPBM, gcPBM and HT-SELEX with an excellent performance, much better than existing algorithms. Due to its nature, the method can...
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Cerium-doped orthophosphates: new promising scintillators
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Sanguiins—Promising Molecules with Broad Biological Potential
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Enhanced Remote Control Providing Medical Functionalities
PublikacjaThis paper presents the enhanced remote control and its role in pervasive healthcare in the home. The device was equipped with health-related measurement modules and a message-processing unit. Preliminary results are presented for monitoring of a pulse, hand tremors, grip forces, and for self evaluation procedures. The interaction of the device with the smart environment is presented and discussed.
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Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains
PublikacjaAims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between...
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Extracellular Matrix Proteins Expression Profiling in Chemoresistant Variants of the A2780 Ovarian Cancer Cell Line
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Transcriptomic profiling of the salt stress response in excised leaves of the halophyte Beta vulgaris ssp. maritima
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Phytochemical Profiling and Larval Control of Erythrina variegata Methanol Fraction against Malarial and Filarial Vector
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Uncertainty of antioxidant profiling in complex mixtures using liquid chromatography involving post-column derivatisation
PublikacjaThe main goal of this paper is to discuss the problems associated with antioxidant profiling in complex samples using a high-throughput HPLC system coupled with post-column derivatisation reactor. Based on the experimental data reported in the literature, we demonstrated that improper optimisation of temperature and/or pH assay conditions performed using an on-line derivatisation reactor may substantially change the antioxidant...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublikacjaBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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The optimisation of analytical parameters for routine profiling of antioxidants in complex mixture by HPLC coupled post-column derivatisation
PublikacjaIntroduction: The wide application of natural and artificial antioxidants in food, cosmetic and pharmaceutical industry as well as the recognition of the importance of food antioxidants for supporting human health created demand for reliable and industrially applicable methods of determining antioxidative activity. This requirement can be fullfilled with the recently proposed HPLC-post-column derivatisation approach enabling the...
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Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism
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