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Wyniki wyszukiwania dla: GEOCHEMICAL BACKGROUND
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Predicting sulfanilamide solubility in the binary mixtures using a reference solvent approach
PublikacjaBackground. Solubility is a fundamental physicochemical property of active pharmaceutical ingredients. The optimization of a dissolution medium aims not only to increase solubility and other aspects are to be included such as environmental impact, toxicity degree, availability, and costs. Obtaining comprehensive...
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To donate or not to donate? Future healthcare professionals’ opinions on biobanking of human biological material for research purposes
PublikacjaBackground Over the last few decades biobanks have been recognised as institutions that may revolutionisebiomedical research and the development of personalised medicine. Poland, however, still lacks clear regulationsregarding the running of biobanks and the conducting of biomedical research. While the awareness of the generalpublic regarding biobanks is low, healthcare professions and medical students also...
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
PublikacjaIntroduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...
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Segmentation-Based BI-RADS ensemble classification of breast tumours in ultrasound images
PublikacjaBackground: The development of computer-aided diagnosis systems in breast cancer imaging is exponential. Since 2016, 81 papers have described the automated segmentation of breast lesions in ultrasound images using arti- ficial intelligence. However, only two papers have dealt with complex BI-RADS classifications. Purpose: This study addresses the automatic classification of breast lesions into binary classes (benign vs. ma- lignant)...
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Circulating miRNA profiles and the risk of hemorrhagic transformation after thrombolytic treatment of acute ischemic stroke: a pilot study
PublikacjaBackground: Hemorrhagic transformation (HT) in acute ischemic stroke is likely to occur in patients treated with intravenous thrombolysis (IVT) and may lead to neurological deterioration and symptomatic intracranial hemorrhage (sICH). Despite the complex inclusion and exclusion criteria for IVT and some useful tools to stratify HT risk, sICH still occurs in approximately 6% of patients because some of the risk factors for this...
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Direct injection liquid chromatography-mass spectrometry (DI-LC-MS) analysis for rapid lipidomic profiling of extracellular vesicles
PublikacjaExtracellular vesicles (EVs) are small, spherical particles produced by eukaryotic and prokaryotic cells, surrounded by a bilayer membrane and carrying various bioactive molecules, such as proteins, surface receptors, membrane and soluble proteins, lipids, and nucleic acids. EVs are of substantial interest because of their important roles in cell communication, epigenetic regulation and possible application in disease diagnosis...
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Buried Object Characterization by Data-Driven Surrogates and Regression-Enabled Hyperbolic Signature Extraction
PublikacjaThis work addresses artificial-intelligence-based buried object characterization using FDTD-based electromagnetic simulation toolbox of a Ground Penetrating Radar (GPR) to generate B-scan data. In data collection, FDTD-based simulation tool, gprMax is used. The task is to estimate geophysical parameters of a cylindrical shape object of various radii, buried at different positions in the dry soil medium simultaneously and independently...
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Cerclage cable augmentation does not increase stability of the fixation of intertrochanteric fractures. A biomechanical study
PublikacjaBackground: Intertrochanteric fractures with a posteromedial intermediate fragment are unstable because of the loss of medial support. Additional fixation with a cerclage is used in subtrochanteric fractures, but not in intertrochanteric fractures. The aim of this biomechanical study is to evaluate whether cerclage fixation improves stability of intertrochanteric fractures. Hypothesis: Our hypothesis is that the cerclage fixation...
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TIME- AND FREQUENCY-DOMAIN QUASI-2D SMALL-SIGNAL MOSFET MODELS
PublikacjaA novel approach to small-signal MOSFET modeling is presented in this book. As a result, time- and frequency-domain physics-based quasi-2D NQS four-terminal small-signal MOSFET models are proposed. The time-domain model provides the background to a novel DIBL-included quasi‑2D NQS four-terminal frequency-domain small-signal MOSFET model. Parameters and electrical quantities of the frequency-domain model are described by explicit...
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Theory of Architectural Design I. Introduction 2022
Kursy OnlineLectures are held online on Wednesdays from 19:15 to 20:00 Theory of Architectural Design I 1 https://teams.microsoft.com/l/meetup-join/19%3ameeting_YWVkZWJiZWUtYzY2Yy00NzNiLThlMzctNWY3Y2U2YjgxODc4%40thread.v2/0?context=%7b%22Tid%22%3a%2286760356-0022-486f-b793-a2d470bba5a5%22%2c%22Oid%22%3a%22ca4e7f4e-c85d-4f86-914f-456ee1702ebe%22%7d Our course aims to teach you how to design architecture. The process of...
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Glossary [Intellectual Output 1] Glossary as a method for reflection on complex research questions
PublikacjaGlobalization and digitization are strongly influencing the process of shaping the built environment. The latter is causing the new design tools to emerge faster than ever before in history, while the former is speeding up not only the development, but also the broad roll-out of more agile and interdisciplinary methodologies and work approaches. The design process is also becoming more and more inter- and trans-disciplinary. This...
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublikacjaThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
PublikacjaAbstract Background: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE) in numerous pathological processes, aroused the demand for RAGE targeted imaging in various diseases. In the study, we evaluated the use of a diagnostic imaging agent for RAGE quantification...
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Architektura i woda - przekraczanie granic
PublikacjaPublikacja daje wgląd w procesy kształtowania połączeń wody i form zbudowanych. W obserwowanych współcześnie eksperymentach struktury budynków przeplatają się z zarysami pól wodnych, powstają konstrukcje architektoniczne unoszące się na różnego rodzaju platformach pływających. Woda jest także coraz częściej włączana w projekty urbanistyczne. Linie styku pomiędzy lądem i wodą ulegają modyfikacjom, przywraca się dawne kanały i tworzy...
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[IMa] Materials technologies - 2023/24
Kursy Online{mlang pl} Dyscyplina: inżynieria materiałowa Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: prof. dr hab. inż. Maria Gazda, prof. dr hab. inż. Józef Haponiuk, dr hab. inż. Sebastian Molin, dr hab. inż. Jacek Ryl, dr hab. inż. Robert Bogdanowicz Liczba godzin: 15 Forma zajęć: wykład/seminarium {mlang} {mlang en} Discipline: materials engineering Obligatory course for 1st year PhD students Academic teachers: prof....
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Solubility of dapsone in deep eutectic solvents: Experimental analysis, molecular insights and machine learning predictions
PublikacjaBackground. Dapsone (DAP) is an anti-inflammatory and antimicrobial active pharmaceutical ingredient used to treat, e.g., AIDS-related diseases. However, low solubility is a feature hampering its efficient use. Objectives. First, deep eutectic solvents...
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublikacjaIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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The role of organic and mineral constituents on kerogen transformation ratio
PublikacjaThe main aim of this dissertation is to determine the role of mineral and organic matter constituents in kerogen transformation ratio. Practical aspects of the work include application of the results in the assessment of hydrocarbon production potential; to make process of hydrocarbon recovery more predictable consistent and efficient. The work used shale from the Vaca Muerta formation from the Nequen basin in Argentina. The formation...
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[soft skills] Commercialization of scientific outcomes
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów II roku Prowadzący: Damian Kuźniewski, Agnieszka Krawczyk-Kłos, Centrum Transferu Wiedzy i Technologii na PG Liczba godzin: 5 Forma zajęć: wykład {mlang} {mlang en} Discipline: all disciplinesObligatory course for the 2nd-year PhD students Academic teacher: Damian Kuźniewski, Agnieszka Krawczyk-Kłos, Centre for Knowledge and Technology Transfer...
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[IMe] Advanced numerical methods in mechanics
Kursy Online{mlang pl} Dyscyplina: inżynieria mechaniczna Zajęcia obowiązkowe dla doktorantów I i II roku Prowadzący: dr hab. inż. Krzysztof Tesch, prof. PG, dr hab. inż. Arkadiusz Żak, prof. PG Liczba godzin: 45 Forma zajęć: wykład {mlang} {mlang en} Discipline: mechanical engineering Obligatory course for 1st and 2nd-year PhD students Academic teachers: dr hab. inż. Krzysztof Tesch, prof. PG, dr hab. inż. Arkadiusz Żak, prof....
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Inter Applied Chemistry Programme 6 A practical approach to novel industrial enzymes Dr Natasha Bozic
Kursy OnlineInter Applied Chemistry Programme 6 - A practical approach to novel industrial enzymes Dr Natasha Bozic The purpose of the course is to introduce students to the technologies of industrial enzymes discovery and manufacturing and to provide in depth insight about the advantages of using enzyme preparations in industry. Lectures will cover the common workflows of industrial enzymology including following topics: general enzyme...
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[AEiE] Selected topics of electrical engineering - models of electrical machines
Kursy Online{mlang pl} Dyscyplina: automatyka, elektronika i elektrotechnika Zajęcia fakultatywne dla doktorantów II roku Prowadzący: dr hab. inż. Andrzej Wilk, prof. PG, prof. dr hab. inż. Zbigniew Krzemiński Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: control, electronic and electrical engineering Facultative course for 2nd-year PhD students Academic teachers: dr hab. inż. Andrzej Wilk, prof. PG, prof....
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Marek Czachor prof. dr hab.
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[soft skills] Didactic methods in the modern teaching process
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów II roku Prowadzący: dr hab. Joanna Mytnik, prof. PG, mgr Alina Guzik, Centrum Nowoczesnej Edukacji Liczba godzin: 15 Forma zajęć: wykład Kurs realizowany w zakładce Centrum Nowoczesnej Edukacji: https://enauczanie.pg.edu.pl/moodle/course/view.php?id=10875 Na kurs należy zapisać się samodzielnie: https://enauczanie.pg.edu.pl/moodle/enrol/index.php?id=10875 Hasło...
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Techniki plastyczne i prezentacyjne 2023
Kursy OnlineCelem zajęć jest zapoznanie studentów z różnorodnymi technikami plastycznymi stosowanymi do prezentacji opracowań studyjnych i projektów w różnych fazach. Zajęcia odbywają się w trybie stacjonarnym w Sali 365 we wtorki Grupa I. od 11:15 do 13:00 Grupa II. od 13:15 do 15:00 Pracujemy na formacie poziomym A4 papieru rysunkowego o grub. minimum 160g. Prace graficzne umieszczamy przy prawej krawędzi. Margines wokół arkusza 1cm,...